DHRS7 (dehydrogenase/reductase 7)

Gene

• Entrez ID: 51635
• Gene name: Dehydrogenase/reductase 7
• Gene symbol: DHRS7
• Synonyms (NCBI Gene): CGI-86, SDR34C1, retDSR4, retSDR4
• Chromosome: 14
• Chromosome location: 14q23.1
• Summary: This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members in this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids a

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT935006	hsa-miR-1470	CLIP-seq
MIRT935007	hsa-miR-1825	CLIP-seq
MIRT935008	hsa-miR-199a-5p	CLIP-seq
MIRT935009	hsa-miR-199b-5p	CLIP-seq
MIRT935010	hsa-miR-3653	CLIP-seq
MIRT935011	hsa-miR-3925-3p	CLIP-seq
MIRT935012	hsa-miR-4287	CLIP-seq
MIRT935013	hsa-miR-4307	CLIP-seq
MIRT935014	hsa-miR-4469	CLIP-seq
MIRT935015	hsa-miR-4667-3p	CLIP-seq
MIRT935016	hsa-miR-4668-3p	CLIP-seq
MIRT935017	hsa-miR-4685-3p	CLIP-seq
MIRT935018	hsa-miR-4699-5p	CLIP-seq
MIRT935019	hsa-miR-4713-5p	CLIP-seq
MIRT935020	hsa-miR-4719	CLIP-seq
MIRT935021	hsa-miR-4781-3p	CLIP-seq
MIRT935022	hsa-miR-4795-3p	CLIP-seq
MIRT935023	hsa-miR-548a-5p	CLIP-seq
MIRT935024	hsa-miR-548ab	CLIP-seq
MIRT935025	hsa-miR-548ak	CLIP-seq
MIRT935026	hsa-miR-548b-5p	CLIP-seq
MIRT935027	hsa-miR-548c-5p	CLIP-seq
MIRT935028	hsa-miR-548d-5p	CLIP-seq
MIRT935029	hsa-miR-548h	CLIP-seq
MIRT935030	hsa-miR-548i	CLIP-seq
MIRT935031	hsa-miR-548j	CLIP-seq
MIRT935032	hsa-miR-548n	CLIP-seq
MIRT935033	hsa-miR-548w	CLIP-seq
MIRT935034	hsa-miR-548y	CLIP-seq
MIRT935035	hsa-miR-559	CLIP-seq
MIRT935036	hsa-miR-587	CLIP-seq
MIRT935037	hsa-miR-671-5p	CLIP-seq
MIRT935006	hsa-miR-1470	CLIP-seq
MIRT935007	hsa-miR-1825	CLIP-seq
MIRT935008	hsa-miR-199a-5p	CLIP-seq
MIRT935009	hsa-miR-199b-5p	CLIP-seq
MIRT935011	hsa-miR-3925-3p	CLIP-seq
MIRT935012	hsa-miR-4287	CLIP-seq
MIRT935013	hsa-miR-4307	CLIP-seq
MIRT935014	hsa-miR-4469	CLIP-seq
MIRT935015	hsa-miR-4667-3p	CLIP-seq
MIRT935017	hsa-miR-4685-3p	CLIP-seq
MIRT935019	hsa-miR-4713-5p	CLIP-seq
MIRT1976886	hsa-miR-548k	CLIP-seq
MIRT935032	hsa-miR-548n	CLIP-seq
MIRT1976887	hsa-miR-552	CLIP-seq
MIRT935036	hsa-miR-587	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004090	Function	Carbonyl reductase (NADPH) activity	IDA	24246760, 26466768, 28457967, 28687384
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	24246760, 28457967
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016616	Function	Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IDA	24246760, 26466768, 28457967, 28687384
GO:0042572	Process	Retinol metabolic process	IEA
GO:0052650	Function	All-trans-retinol dehydrogenase (NADP+) activity	IDA	26466768
GO:0052650	Function	All-trans-retinol dehydrogenase (NADP+) activity	IEA

Other IDs

• MIM: 612833
• HGNC: 21524
• e!Ensembl: ENSG00000100612

Protein

• UniProt ID: Q9Y394
• Protein name: Dehydrogenase/reductase SDR family member 7 (EC 1.1.1.-) (Retinal short-chain dehydrogenase/reductase 4) (retSDR4) (Short chain dehydrogenase/reductase family 34C member 1) (Protein SDR34C1)
• Protein function: NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including steroids, retinoids and xenobiotics (PubMed:24246760, PubMed:26466768, PubMed:28457967, PubMed:28687384). Catalyzes the redu
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00106	adh_short	51 → 250	short chain dehydrogenase	Domain

• Tissue specificity: TISSUE SPECIFICITY: Found predominantly in the adrenal glands, liver, thyroid, prostate, small intestine, colon, stomach, kidney and brain (PubMed:26466768). Lower levels observed in skeletal muscle, the lung and the spleen (PubMed:26466768). {ECO:0000269
• Sequence:

  MNWELLLWLLVLCALLLLLVQLLRFLRADGDLTLLWAEWQGRRPEWELTDMVVWVTGASS
  GIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLDLTDTGSHEA
  ATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSLTKCVLPHMIER
  KQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGIIVSNICPGPVQSN
  IVENSLAGEVTKTIGNNGDQSHKMTTSRCVRLMLISMANDLKEVWISEQPFLLVTYLWQY
  MPTWAWWITNKMGKKRIENFKSGVDADSSYFKIFKTKHD

• Sequence length: 339

<