DHRS7 (dehydrogenase/reductase 7)

Gene

• Entrez ID: 51635
• Gene name: Dehydrogenase/reductase 7
• Gene symbol: DHRS7
• Synonyms (NCBI Gene): CGI-86, SDR34C1, retDSR4, retSDR4
• Chromosome: 14
• Chromosome location: 14q23.1
• Summary: This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members in this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids a

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT935006	hsa-miR-1470	CLIP-seq
MIRT935007	hsa-miR-1825	CLIP-seq
MIRT935008	hsa-miR-199a-5p	CLIP-seq
MIRT935009	hsa-miR-199b-5p	CLIP-seq
MIRT935010	hsa-miR-3653	CLIP-seq
MIRT935011	hsa-miR-3925-3p	CLIP-seq
MIRT935012	hsa-miR-4287	CLIP-seq
MIRT935013	hsa-miR-4307	CLIP-seq
MIRT935014	hsa-miR-4469	CLIP-seq
MIRT935015	hsa-miR-4667-3p	CLIP-seq
MIRT935016	hsa-miR-4668-3p	CLIP-seq
MIRT935017	hsa-miR-4685-3p	CLIP-seq
MIRT935018	hsa-miR-4699-5p	CLIP-seq
MIRT935019	hsa-miR-4713-5p	CLIP-seq
MIRT935020	hsa-miR-4719	CLIP-seq
MIRT935021	hsa-miR-4781-3p	CLIP-seq
MIRT935022	hsa-miR-4795-3p	CLIP-seq
MIRT935023	hsa-miR-548a-5p	CLIP-seq
MIRT935024	hsa-miR-548ab	CLIP-seq
MIRT935025	hsa-miR-548ak	CLIP-seq
MIRT935026	hsa-miR-548b-5p	CLIP-seq
MIRT935027	hsa-miR-548c-5p	CLIP-seq
MIRT935028	hsa-miR-548d-5p	CLIP-seq
MIRT935029	hsa-miR-548h	CLIP-seq
MIRT935030	hsa-miR-548i	CLIP-seq
MIRT935031	hsa-miR-548j	CLIP-seq
MIRT935032	hsa-miR-548n	CLIP-seq
MIRT935033	hsa-miR-548w	CLIP-seq
MIRT935034	hsa-miR-548y	CLIP-seq
MIRT935035	hsa-miR-559	CLIP-seq
MIRT935036	hsa-miR-587	CLIP-seq
MIRT935037	hsa-miR-671-5p	CLIP-seq
MIRT935006	hsa-miR-1470	CLIP-seq
MIRT935007	hsa-miR-1825	CLIP-seq
MIRT935008	hsa-miR-199a-5p	CLIP-seq
MIRT935009	hsa-miR-199b-5p	CLIP-seq
MIRT935011	hsa-miR-3925-3p	CLIP-seq
MIRT935012	hsa-miR-4287	CLIP-seq
MIRT935013	hsa-miR-4307	CLIP-seq
MIRT935014	hsa-miR-4469	CLIP-seq
MIRT935015	hsa-miR-4667-3p	CLIP-seq
MIRT935017	hsa-miR-4685-3p	CLIP-seq
MIRT935019	hsa-miR-4713-5p	CLIP-seq
MIRT1976886	hsa-miR-548k	CLIP-seq
MIRT935032	hsa-miR-548n	CLIP-seq
MIRT1976887	hsa-miR-552	CLIP-seq
MIRT935036	hsa-miR-587	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004090	Function	Carbonyl reductase (NADPH) activity	IDA	24246760, 26466768, 28457967, 28687384
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	24246760, 28457967
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016616	Function	Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IDA	24246760, 26466768, 28457967, 28687384
GO:0042572	Process	Retinol metabolic process	IEA
GO:0052650	Function	All-trans-retinol dehydrogenase (NADP+) activity	IDA	26466768
GO:0052650	Function	All-trans-retinol dehydrogenase (NADP+) activity	IEA

Other IDs

• MIM: 612833
• HGNC: 21524
• e!Ensembl: ENSG00000100612

Protein

• UniProt ID: Q9Y394
• Protein name: Dehydrogenase/reductase SDR family member 7 (EC 1.1.1.-) (Retinal short-chain dehydrogenase/reductase 4) (retSDR4) (Short chain dehydrogenase/reductase family 34C member 1) (Protein SDR34C1)
• Protein function: NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including steroids, retinoids and xenobiotics (PubMed:24246760, PubMed:26466768, PubMed:28457967, PubMed:28687384). Catalyzes the redu
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00106	adh_short	51 → 250	short chain dehydrogenase	Domain

• Tissue specificity: TISSUE SPECIFICITY: Found predominantly in the adrenal glands, liver, thyroid, prostate, small intestine, colon, stomach, kidney and brain (PubMed:26466768). Lower levels observed in skeletal muscle, the lung and the spleen (PubMed:26466768). {ECO:0000269
• Sequence:

  MNWELLLWLLVLCALLLLLVQLLRFLRADGDLTLLWAEWQGRRPEWELTDMVVWVTGASS
  GIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLDLTDTGSHEA
  ATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSLTKCVLPHMIER
  KQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGIIVSNICPGPVQSN
  IVENSLAGEVTKTIGNNGDQSHKMTTSRCVRLMLISMANDLKEVWISEQPFLLVTYLWQY
  MPTWAWWITNKMGKKRIENFKSGVDADSSYFKIFKTKHD

• Sequence length: 339

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Gastric cancer	Uncertain significance	rs751714239	RCV005929250

Associations from Text Mining
Disease Name	Relationship Type	References
Neoplasms	Inhibit	26311046
Prostatic Neoplasms	Associate	26311046, 38201261
Prostatitis	Associate	38201261
Stomach Neoplasms	Associate	34773716