Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
51631
Gene name Gene Name - the full gene name approved by the HGNC.
LUC7 like 2, pre-mRNA splicing factor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
LUC7L2
Synonyms (NCBI Gene) Gene synonyms aliases
CGI-59, CGI-74, LUC7B2
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7q34
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein that contains a C2H2-type zinc finger, coiled-coil region and arginine, serine-rich (RS) domain. A similar protein in mouse interacts with sodium channel modifier 1, and the encoded protein may be involved in the recognition of
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT002509 hsa-miR-373-3p Microarray 15685193
MIRT002509 hsa-miR-373-3p Microarray;Other 15685193
MIRT020489 hsa-miR-155-5p Proteomics 18668040
MIRT025632 hsa-miR-7-5p Microarray 17612493
MIRT046734 hsa-miR-222-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22681889
GO:0003729 Function MRNA binding IBA
GO:0003729 Function MRNA binding IEA
GO:0005515 Function Protein binding IPI 16169070, 20562859, 21900206, 23602568, 25416956, 31515488, 32296183, 32707033, 32814053, 33961781
GO:0005634 Component Nucleus IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
613056 21608 ENSG00000146963
Protein
UniProt ID Q9Y383
Protein name Putative RNA-binding protein Luc7-like 2
Protein function May bind to RNA via its Arg/Ser-rich domain.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03194 LUC7 5 257 LUC7 N_terminus Family
Sequence
Sequence length 392
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Nasopharyngeal Carcinoma Nasopharyngeal carcinoma Overexpression of LUC7L2 in NPC cells promoted cell viability following exposure to ionizing radiation (IR), while knockdown of LUC7L2 significantly slowed down the DNA replication and impaired cell survival, sensitized NPC-radioresistant cells to IR. 34907164 CBGDA
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Mesothelioma Malignant Associate 34294080
Myelodysplastic Syndromes Associate 31680297
Neoplasms Associate 33852859
Ovarian Neoplasms Associate 35343831