Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	51596
Gene name	CutA divalent cation tolerance homolog
Gene symbol	CUTA
Synonyms (NCBI Gene)	ACHAPC6orf82
Chromosome	6
Chromosome location	6p21.32

Show/Hide all (51)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020652	hsa-miR-155-5p	Proteomics	18668040
MIRT041685	hsa-miR-484	CLASH	23622248
MIRT916764	hsa-miR-1275	CLIP-seq
MIRT916765	hsa-miR-3616-5p	CLIP-seq
MIRT916766	hsa-miR-3622a-3p	CLIP-seq
MIRT916767	hsa-miR-3622b-3p	CLIP-seq
MIRT916768	hsa-miR-3647-5p	CLIP-seq
MIRT916769	hsa-miR-4488	CLIP-seq
MIRT916770	hsa-miR-4665-5p	CLIP-seq
MIRT916771	hsa-miR-4697-5p	CLIP-seq
MIRT916772	hsa-miR-483-5p	CLIP-seq
MIRT916773	hsa-miR-573	CLIP-seq
MIRT916774	hsa-miR-619	CLIP-seq
MIRT2510927	hsa-miR-1272	CLIP-seq
MIRT916764	hsa-miR-1275	CLIP-seq
MIRT2510928	hsa-miR-3124-5p	CLIP-seq
MIRT916765	hsa-miR-3616-5p	CLIP-seq
MIRT916766	hsa-miR-3622a-3p	CLIP-seq
MIRT916767	hsa-miR-3622b-3p	CLIP-seq
MIRT916768	hsa-miR-3647-5p	CLIP-seq
MIRT2510929	hsa-miR-433	CLIP-seq
MIRT2510930	hsa-miR-4468	CLIP-seq
MIRT916769	hsa-miR-4488	CLIP-seq
MIRT916770	hsa-miR-4665-5p	CLIP-seq
MIRT916771	hsa-miR-4697-5p	CLIP-seq
MIRT2510931	hsa-miR-4706	CLIP-seq
MIRT2510932	hsa-miR-4749-5p	CLIP-seq
MIRT916772	hsa-miR-483-5p	CLIP-seq
MIRT2510933	hsa-miR-542-5p	CLIP-seq
MIRT916773	hsa-miR-573	CLIP-seq
MIRT916774	hsa-miR-619	CLIP-seq
MIRT2510934	hsa-miR-873	CLIP-seq
MIRT2510927	hsa-miR-1272	CLIP-seq
MIRT916764	hsa-miR-1275	CLIP-seq
MIRT2510928	hsa-miR-3124-5p	CLIP-seq
MIRT916765	hsa-miR-3616-5p	CLIP-seq
MIRT916766	hsa-miR-3622a-3p	CLIP-seq
MIRT916767	hsa-miR-3622b-3p	CLIP-seq
MIRT916768	hsa-miR-3647-5p	CLIP-seq
MIRT2510929	hsa-miR-433	CLIP-seq
MIRT2510930	hsa-miR-4468	CLIP-seq
MIRT916769	hsa-miR-4488	CLIP-seq
MIRT916770	hsa-miR-4665-5p	CLIP-seq
MIRT916771	hsa-miR-4697-5p	CLIP-seq
MIRT2510931	hsa-miR-4706	CLIP-seq
MIRT2510932	hsa-miR-4749-5p	CLIP-seq
MIRT916772	hsa-miR-483-5p	CLIP-seq
MIRT2510933	hsa-miR-542-5p	CLIP-seq
MIRT916773	hsa-miR-573	CLIP-seq
MIRT916774	hsa-miR-619	CLIP-seq
MIRT2510934	hsa-miR-873	CLIP-seq

Show/Hide all (10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005507	Function	Copper ion binding	IBA
GO:0005515	Function	Protein binding	IPI	20195357, 25416956, 31515488, 32296183, 33961781
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA	17924204
GO:0008104	Process	Intracellular protein localization	IDA	10800960
GO:0008104	Process	Intracellular protein localization	IEA
GO:0010038	Process	Response to metal ion	IEA
GO:0016020	Component	Membrane	IDA	10800960
GO:0019899	Function	Enzyme binding	IPI	10800960
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145

MIM	HGNC	e!Ensembl
616953	21101	ENSG00000112514

O60888

Protein name

Protein CutA (Acetylcholinesterase-associated protein) (Brain acetylcholinesterase putative membrane anchor)

Protein function

May form part of a complex of membrane proteins attached to acetylcholinesterase (AChE).

PDB

1XK8 , 2ZFH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03091	CutA1	69 → 167	CutA1 divalent ion tolerance protein	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. Widely expressed in brain. {ECO:0000269|PubMed:10800960}.

Sequence

MSGGRAPAVLLGGVASLLLSFVWMPALLPVASRLLLLPRVLLTMASGSPPTQPSPASDSG
SGYVPGSVSAAFVTCPNEKVAKEIARAVVEKRLAACVNLIPQITSIYEWKGKIEEDSEVL
MMIKTQSSLVPALTDFVRSVHPYEVAEVIALPVEQGNFPYLQWVRQVTESVSDSITVLP

Sequence length

179

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
HYPOTHYROIDISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHEUMATOID ARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (8)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Alzheimer Disease	Associate	22351782	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Associate	27898717	★★★★★ ★☆☆☆☆ Found in Text Mining only
Crohn Disease	Associate	31852111	★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Achalasia	Associate	34197731	★★★★★ ★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Associate	21119708	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma	Associate	31852111	★★★★★ ★☆☆☆☆ Found in Text Mining only
Seizures	Associate	21119708	★★★★★ ★☆☆☆☆ Found in Text Mining only
Tuberculosis	Associate	31852111	★★★★★ ★☆☆☆☆ Found in Text Mining only

CUTA (cutA divalent cation tolerance homolog)