Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
51593
Gene name Gene Name - the full gene name approved by the HGNC.
Serrate, RNA effector molecule
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SRRT
Synonyms (NCBI Gene) Gene synonyms aliases
ARS2, ASR2, serrate
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7q22.1
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT026028 hsa-miR-196a-5p Sequencing 20371350
MIRT030477 hsa-miR-24-3p Microarray 17686970
MIRT049730 hsa-miR-92a-3p CLASH 23622248
MIRT026028 hsa-miR-196a-5p CLASH 23622248
MIRT046768 hsa-miR-222-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000398 Process MRNA splicing, via spliceosome TAS
GO:0003677 Function DNA binding ISS
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0005515 Function Protein binding IPI 17500595, 20858735, 23793891, 26382858
GO:0005654 Component Nucleoplasm IDA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
614469 24101 ENSG00000087087
Protein
UniProt ID Q9BXP5
Protein name Serrate RNA effector molecule homolog (Arsenite-resistance protein 2)
Protein function Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA proces
PDB 5OO6 , 6F7J , 6F7P , 6F7S , 6F8D , 8PMP
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12066 SERRATE_Ars2_N 153 262 SERRATE/Ars2, N-terminal domain Domain
PF04959 ARS2 646 851 Arsenite-resistance protein 2 Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:18086880}.
Sequence
MGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDR
NRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPTYGPPQPWGHPDV
HIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAVKRYNDYKLDFR
RQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGWFDNLLLDI
DKADAIVKMLDAAVIKMEGGTE
NDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGER
KTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDD
SFDEGSVSESESESESGQAEEEKEEAEEALKEKEKPKEEEWEKPKDAAGLECKPRPLHKT
CSLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSVNIKEICW
NLQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDDRTQLWAS
EPGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGNPAEINVE
RDEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRISHGEVL
EWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGK
KFKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQILPPG
LTPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGRGNYDAFR
GQGGYPGKPRN
RMVRGDPRAIVEYRDLDAPDDVDFF
Sequence length 876
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    RNA polymerase II transcribes snRNA genes
mRNA Splicing - Major Pathway
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Glioblastoma Glioblastoma, Glioblastoma Multiforme rs121913500, rs886042842, rs1555138291, rs1558518449, rs1567176006, rs1558650888 30542699
Unknown
Disease term Disease name Evidence References Source
Mental depression Unipolar Depression, Major Depressive Disorder 22373040 ClinVar
Associations from Text Mining
Disease Name Relationship Type References
Dementia Associate 28600779
Depressive Disorder Major Associate 22373040
Intellectual Disability Associate 28600779
Precursor Cell Lymphoblastic Leukemia Lymphoma Associate 21224467
Uterine Cervical Neoplasms Associate 15919944