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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q9UPN9 |
| Protein name |
E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) |
| Protein function |
Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as |
| PDB |
3U5M
, 3U5N
, 3U5O
, 3U5P
, 5MR8
, 7ZDD
, 8BD8
, 8BD9
, 8BDY
|
| Family and domains |
Pfam
| Accession |
ID |
Position in sequence |
Description |
Type |
| PF13445 |
zf-RING_UBOX |
125 → 182 |
RING-type zinc-finger |
Domain |
| PF00643 |
zf-B_box |
271 → 312 |
B-box zinc finger |
Domain |
| PF00628 |
PHD |
889 → 933 |
PHD-finger |
Domain |
| PF00439 |
Bromodomain |
966 → 1051 |
Bromodomain |
Domain |
|
| Tissue specificity |
TISSUE SPECIFICITY: Expressed in stem cells at the bottom of the crypts of the colon (at protein level). Expressed in colon adenomas and adenocarcinomas (at protein level). Expressed in brain, lung, liver, spleen, thymus, prostate, kidney, testis, heart, |
| Sequence |
|
| Sequence length |
1127 |
| Interactions |
View interactions |
|
|
| Disease Name |
Relationship Type |
References |
| Adenocarcinoma of Lung |
Inhibit |
36261009 |
| Arthritis Rheumatoid |
Associate |
36301038 |
| Breast Neoplasms |
Associate |
26040677, 27561848, 30952871 |
| Breast Neoplasms |
Inhibit |
30896800 |
| Carcinogenesis |
Stimulate |
22046087 |
| Carcinogenesis |
Associate |
27561848, 37612308 |
| Carcinoma Intraductal Noninfiltrating |
Associate |
34985683 |
| Carcinoma Non Small Cell Lung |
Associate |
30261900 |
| Carcinoma Renal Cell |
Associate |
25381221, 34985683 |
| Colonic Neoplasms |
Associate |
22046087 |
| Colorectal Neoplasms |
Associate |
22046087 |
| Dermatomyositis |
Associate |
27561848, 34043263, 34873015, 35454323 |
| Endometrial Neoplasms |
Associate |
37859625 |
| Hereditary pancreatitis |
Associate |
22046087 |
| Infections |
Associate |
22205733 |
| Inflammation |
Inhibit |
36301038 |
| Lung Diseases Interstitial |
Associate |
27888997 |
| Lung Neoplasms |
Associate |
32669959 |
| Muscle Neoplasms |
Associate |
29149307 |
| Myositis |
Associate |
28663002, 29149307, 37769433 |
| Neoplasm Metastasis |
Associate |
30261900, 34985683, 36301038 |
| Neoplasm Metastasis |
Inhibit |
36261009 |
| Neoplasms |
Inhibit |
21828134, 22231120, 24425785, 30896800, 37859625 |
| Neoplasms |
Associate |
22046087, 27432991, 29149307, 30952871, 32669959, 37573347 |
| Neoplasms |
Stimulate |
34043263 |
| Non Muscle Invasive Bladder Neoplasms |
Inhibit |
37859625 |
| Prostatic Neoplasms |
Associate |
35785414 |
| Prostatitis |
Associate |
35785414 |
| Rufous oculocutaneous albinism |
Stimulate |
22046087 |
| Salivary Gland Neoplasms |
Associate |
33135196 |
| Secretory breast carcinoma |
Associate |
34985683 |
| Squamous Cell Carcinoma of Head and Neck |
Inhibit |
24425785 |
| Squamous Cell Carcinoma of Head and Neck |
Associate |
37573347 |
| Thyroid Cancer Papillary |
Associate |
30664823 |
| Triple Negative Breast Neoplasms |
Associate |
27561848 |
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