Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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51586
|
Gene name
Gene Name - the full gene name approved by the HGNC.
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Mediator complex subunit 15 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
MED15 |
Synonyms (NCBI Gene)
Gene synonyms aliases
|
ARC105, CAG7A, CTG7A, PCQAP, TIG-1, TIG1, TNRC7 |
Chromosome
Chromosome number
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22 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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22q11.21 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the |
UniProt ID |
Q96RN5
|
Protein name |
Mediator of RNA polymerase II transcription subunit 15 (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a) (Mediator complex subunit 15) (Positive cofactor 2 glutamine/Q-rich-associated protein) (PC2 glutamine/Q-rich-associat |
Protein function |
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RN |
PDB |
2GUT
,
7EMF
,
7ENA
,
7ENC
,
7ENJ
,
7LBM
,
8GXQ
,
8GXS
,
8J9A
,
8T9D
,
8TQW
,
8TRH
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF09606
|
Med15 |
17 → 787 |
ARC105 or Med15 subunit of Mediator complex non-fungal |
Family |
|
Tissue specificity |
TISSUE SPECIFICITY: Expressed in all tissues examined, including heart, brain, lung, spleen, thymus, pancreas, blood leukocyte and placenta. However, the level of expression varied, with highest expression in the placenta and peripheral blood and lowest i |
Sequence |
|
Sequence length |
788 |
Interactions |
View interactions
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Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Schizophrenia |
Schizophrenia |
rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 View all (12 more) |
12497610, 15318033 |
|
Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Psoriasis |
Psoriasis |
|
|
GWAS |
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|