Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
51586
Gene name Gene Name - the full gene name approved by the HGNC.
Mediator complex subunit 15
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MED15
Synonyms (NCBI Gene) Gene synonyms aliases
ARC105, CAG7A, CTG7A, PCQAP, TIG-1, TIG1, TNRC7
Chromosome Chromosome number
22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
22q11.21
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT047371 hsa-miR-34a-5p CLASH 23622248
MIRT045202 hsa-miR-186-5p CLASH 23622248
MIRT042961 hsa-miR-324-3p CLASH 23622248
MIRT042132 hsa-miR-484 CLASH 23622248
MIRT037735 hsa-miR-744-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003712 Function Transcription coregulator activity IEA
GO:0005515 Function Protein binding IPI 16799563, 16904669, 17500595, 18385733, 18568018, 24882805
GO:0005654 Component Nucleoplasm IDA
GO:0005654 Component Nucleoplasm TAS
GO:0005737 Component Cytoplasm IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
607372 14248 ENSG00000099917
Protein
UniProt ID Q96RN5
Protein name Mediator of RNA polymerase II transcription subunit 15 (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a) (Mediator complex subunit 15) (Positive cofactor 2 glutamine/Q-rich-associated protein) (PC2 glutamine/Q-rich-associat
Protein function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RN
PDB 2GUT , 7EMF , 7ENA , 7ENC , 7ENJ , 7LBM , 8GXQ , 8GXS , 8J9A , 8T9D , 8TQW , 8TRH
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF09606 Med15 17 787 ARC105 or Med15 subunit of Mediator complex non-fungal Family
Tissue specificity TISSUE SPECIFICITY: Expressed in all tissues examined, including heart, brain, lung, spleen, thymus, pancreas, blood leukocyte and placenta. However, the level of expression varied, with highest expression in the placenta and peripheral blood and lowest i
Sequence
Sequence length 788
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    PPARA activates gene expression
Generic Transcription Pathway
Transcriptional regulation of white adipocyte differentiation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
12497610, 15318033
Unknown
Disease term Disease name Evidence References Source
Psoriasis Psoriasis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 25791637
Carcinogenesis Associate 31013839, 32439976
Carcinoma Embryonal Associate 26377566
Carcinoma Hepatocellular Associate 35069777
Carcinoma Renal Cell Associate 29400661, 29713041, 31828108
Colorectal Neoplasms Inhibit 21575264
Ectrodactyly cardiopathy dysmorphism Associate 40113094
Heart Defects Congenital Associate 25205790
Lymphatic Metastasis Stimulate 25791637
Mouth Neoplasms Associate 31013839