Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	51585
Gene name	PCF11 cleavage and polyadenylation factor subunit
Gene symbol	PCF11
Synonyms (NCBI Gene)	-
Chromosome	11
Chromosome location	11q14.1
Summary	The protein encoded by this gene binds to CLP1 to form pre-mRNA cleavage factor IIm. The encoded protein is necessary for efficient Pol II transcription termination and may be involved in degradation of the 3` product of polyA site cleavage. [provided by

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miRTarBase ID	miRNA	Experiments	Reference
MIRT051836	hsa-let-7c-5p	CLASH	23622248
MIRT051315	hsa-miR-15a-5p	CLASH	23622248
MIRT1217374	hsa-miR-139-5p	CLIP-seq
MIRT1217375	hsa-miR-3622a-3p	CLIP-seq
MIRT1217376	hsa-miR-3622b-3p	CLIP-seq
MIRT1217377	hsa-miR-3662	CLIP-seq
MIRT1217378	hsa-miR-377	CLIP-seq
MIRT1217379	hsa-miR-4496	CLIP-seq
MIRT1217380	hsa-miR-4738-3p	CLIP-seq
MIRT1217381	hsa-miR-507	CLIP-seq
MIRT1217382	hsa-miR-513a-3p	CLIP-seq
MIRT1217383	hsa-miR-548k	CLIP-seq
MIRT1217384	hsa-miR-548n	CLIP-seq
MIRT1217385	hsa-miR-557	CLIP-seq
MIRT2062733	hsa-miR-4781-3p	CLIP-seq
MIRT1217374	hsa-miR-139-5p	CLIP-seq
MIRT1217375	hsa-miR-3622a-3p	CLIP-seq
MIRT1217376	hsa-miR-3622b-3p	CLIP-seq
MIRT1217378	hsa-miR-377	CLIP-seq
MIRT2291141	hsa-miR-548c-3p	CLIP-seq
MIRT2291142	hsa-miR-548p	CLIP-seq
MIRT2392195	hsa-miR-1270	CLIP-seq
MIRT2392196	hsa-miR-1284	CLIP-seq
MIRT2392197	hsa-miR-2117	CLIP-seq
MIRT2392198	hsa-miR-3144-3p	CLIP-seq
MIRT2392199	hsa-miR-4254	CLIP-seq
MIRT2392200	hsa-miR-4683	CLIP-seq
MIRT2392201	hsa-miR-4684-5p	CLIP-seq
MIRT2392202	hsa-miR-576-3p	CLIP-seq
MIRT2392203	hsa-miR-619	CLIP-seq
MIRT2392204	hsa-miR-620	CLIP-seq
MIRT2392205	hsa-miR-875-5p	CLIP-seq
MIRT2588761	hsa-miR-1184	CLIP-seq
MIRT2588762	hsa-miR-1205	CLIP-seq
MIRT2588763	hsa-miR-1291	CLIP-seq
MIRT2588764	hsa-miR-2682	CLIP-seq
MIRT2588765	hsa-miR-3157-5p	CLIP-seq
MIRT2588766	hsa-miR-3158-5p	CLIP-seq
MIRT2588767	hsa-miR-3173-5p	CLIP-seq
MIRT1217377	hsa-miR-3662	CLIP-seq
MIRT2588768	hsa-miR-4477a	CLIP-seq
MIRT2588769	hsa-miR-4493	CLIP-seq
MIRT1217379	hsa-miR-4496	CLIP-seq
MIRT2588770	hsa-miR-449c	CLIP-seq
MIRT2588771	hsa-miR-4514	CLIP-seq
MIRT2588772	hsa-miR-4691-3p	CLIP-seq
MIRT2588773	hsa-miR-4692	CLIP-seq
MIRT1217380	hsa-miR-4738-3p	CLIP-seq
MIRT2588761	hsa-miR-1184	CLIP-seq
MIRT2588762	hsa-miR-1205	CLIP-seq
MIRT2588763	hsa-miR-1291	CLIP-seq
MIRT2588764	hsa-miR-2682	CLIP-seq
MIRT2588765	hsa-miR-3157-5p	CLIP-seq
MIRT2588766	hsa-miR-3158-5p	CLIP-seq
MIRT2588767	hsa-miR-3173-5p	CLIP-seq
MIRT1217377	hsa-miR-3662	CLIP-seq
MIRT2588768	hsa-miR-4477a	CLIP-seq
MIRT2588769	hsa-miR-4493	CLIP-seq
MIRT1217379	hsa-miR-4496	CLIP-seq
MIRT2588770	hsa-miR-449c	CLIP-seq
MIRT2588771	hsa-miR-4514	CLIP-seq
MIRT2588772	hsa-miR-4691-3p	CLIP-seq
MIRT2588773	hsa-miR-4692	CLIP-seq
MIRT1217380	hsa-miR-4738-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000993	Function	RNA polymerase II complex binding	IBA
GO:0000993	Function	RNA polymerase II complex binding	IDA	29196535
GO:0000993	Function	RNA polymerase II complex binding	IEA
GO:0003729	Function	MRNA binding	IBA
GO:0003729	Function	MRNA binding	IEA
GO:0005515	Function	Protein binding	IPI	33961781, 35177536
GO:0005634	Component	Nucleus	IDA	29196535
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0005739	Component	Mitochondrion	IDA
GO:0005849	Component	MRNA cleavage factor complex	IBA
GO:0005849	Component	MRNA cleavage factor complex	IEA
GO:0005849	Component	MRNA cleavage factor complex	NAS	11060040
GO:0006369	Process	Termination of RNA polymerase II transcription	IBA
GO:0006369	Process	Termination of RNA polymerase II transcription	IDA	29196535
GO:0006369	Process	Termination of RNA polymerase II transcription	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0031124	Process	MRNA 3'-end processing	IEA
GO:0180010	Process	Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway	NAS	11060040

MIM	HGNC	e!Ensembl
608876	30097	ENSG00000165494

O94913

Protein name

Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11)

Protein function

Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II.

PDB

6WJH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04818	CID	20 → 134	CID domain	Domain

Sequence

MSEQTPAEAGAAGAREDACRDYQSSLEDLTFNSKPHINMLTILAEENLPFAKEIVSLIEA
QTAKAPSSEKLPVMYLMDSIVKNVGREYLTAFTKNLVATFICVFEKVDENTRKSLFKLRS
TWDEIFPLKKLYALDVRVNSLDPAWPIKPLPPNVNTSSIHVNPKFLNKSPEEPSTPGTVV
SSPSISTPPIVPDIQKNLTQEQLIRQQLLAKQKQLLELQQKKLELELEQAKAQLAVSLSV
QQETSNLGPGSAPSKLHVSQIPPMAVKAPHQVPVQSEKSRPGPSLQIQDLKGTNRDPRLN
RISQHSHGKDQSHRKEFLMNTLNQSDTKTSKTIPSEKLNSSKQEKSKSGEKITKKELDQL
DSKSKSKSKSPSPLKNKLSHTKDLKNQESESMRLSDMNKRDPRLKKHLQDKTDGKDDDVK
EKRKTAEKKDKDEHMKSSEHRLAGSRNKIINGIVQKQDTITEESEKQGTKPGRSSTRKRS
RSRSPKSRSPIIHSPKRRDRRSPKRRQRSMSPTSTPKAGKIRQSGAKQSHMEEFTPPSRE
DRNAKRSTKQDIRDPRRMKKTEEERPQETTNQHSTKSGTEPKENVENWQSSKSAKRWKSG
WEENKSLQQVDEHSKPPHLRHRESWSSTKGILSPRAPKQQQHRLSVDANLQIPKELTLAS
KRELLQKTSERLASGEITQDDFLVVVHQIRQLFQYQEGVREEQRSPFNDRFPLKRPRYED
SDKPFVDSPASRFAGLDTNQRLTALAEDRPLFDGPSRPSVARDGPTKMIFEGPNKLSPRI
DGPPTPASLRFDGSPGQMGGGGPLRFEGPQGQLGGGCPLRFEGPPGPVGTPLRFEGPIGQ
AGGGGFRFEGSPGLRFEGSPGGLRFEGPGGQPVGGLRFEGHRGQPVGGLRFEGPHGQPVG
GLRFDNPRGQPVGGLRFEGGHGPSGAAIRFDGPHGQPGGGIRFEGPLLQQGVGMRFEGPH
GQSVAGLRFEGQHNQLGGNLRFEGPHGQPGVGIRFEGPLVQQGGGMRFEGPSVPGGGLRI
EGPLGQGGPRFEGCHALRFDGQPGQPSLLPRFDGLHGQPGPRFERTPGQPGPQRFDGPPG
QQVQPRFDGVPQRFDGPQHQQASRFDIPLGLQGTRFDNHPSQRLESVSFNQTGPYNDPPG
NAFNAPSQGLQFQRHEQIFDSPQGPNFNGPHGPGNQSFSNPLNRASGHYFDEKNLQSSQF
GNFGNIPAPMTVGNIQASQQVLSGVAQPVAFGQGQQFLPVHPQNPGFVQNPSGALPKAYP
DNHLSQVDVNELFSKLLKTGILKLSQTDSATTQVSEVTAQPPPEEEEDQNEDQDVPDLTN
FTVEELKQRYDSVINRLYTGIQCYSCGMRFTTSQTDVYADHLDWHYRQNRTEKDVSRKVT
HRRWYYSLTDWIEFEEIADLEERAKSQFFEKVHEEVVLKTQEAAKEKEFQSVPAGPAGAV
ESCEICQEQFEQYWDEEEEEWHLKNAIRVDGKIYHPSCYEDYQNTSSFDCTPSPSKTPVE
NPLNIMLNIVKNELQEPCDSPKVKEERIDTPPACTEESIATPSEIKTENDTVESV

Sequence length

1555

Interactions

View interactions

	KEGG		Reactome
	mRNA surveillance pathway		RNA polymerase II transcribes snRNA genes mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute megakaryoblastic leukemia	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mediastinal germ cell tumor	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Neoplasms	Inhibit	30552333	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Associate	30552333	★★★★★ ★☆☆☆☆ Found in Text Mining only

PCF11 (PCF11 cleavage and polyadenylation factor subunit)