Gene Gene information from NCBI Gene database.
Entrez ID 51573
Gene name Glycerophosphodiester phosphodiesterase 1
Gene symbol GDE1
Synonyms (NCBI Gene)
363E6.2MIR16
Chromosome 16
Chromosome location 16p12.3
miRNA miRNA information provided by mirtarbase database.
1347
miRTarBase ID miRNA Experiments Reference
MIRT005236 hsa-let-7b-5p pSILAC 18668040
MIRT025463 hsa-miR-34a-5p Sequencing 20371350
MIRT029380 hsa-miR-26b-5p Microarray 19088304
MIRT005236 hsa-let-7b-5p Proteomics;Other 18668040
MIRT048644 hsa-miR-99a-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
33
GO ID Ontology Definition Evidence Reference
GO:0004622 Function Phosphatidylcholine lysophospholipase activity IEA
GO:0004622 Function Phosphatidylcholine lysophospholipase activity ISS
GO:0005515 Function Protein binding IPI 28514442, 32296183, 33961781
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605943 29644 ENSG00000006007
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NZC3
Protein name Glycerophosphodiester phosphodiesterase 1 (Glycerophosphoinositol glycerophosphodiesterase GDE1) (EC 3.1.4.44) (Lysophospholipase D GDE1) (EC 3.1.4.-) (Membrane-interacting protein of RGS16) (RGS16-interacting membrane protein)
Protein function Hydrolyzes the phosphodiester bond of glycerophosphodiesters such as glycerophosphoinositol (GroPIns) and glycerophosphoethanolamine (GroPEth), to yield a glycerol phosphate and an alcohol (By similarity). Hydrolyzes glycerophospho-N-acylethanol
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03009 GDPD 70 325 Glycerophosphoryl diester phosphodiesterase family Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:10760272}.
Sequence
Sequence length 331
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Glycerophospholipid catabolism
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
3
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Familial cancer of breast Uncertain significance rs200309947 RCV005937497
Malignant tumor of esophagus Uncertain significance rs1309765774 RCV005932204
Sarcoma Uncertain significance rs200309947 RCV005937498
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Abortion Spontaneous Associate 37373283
Adenocarcinoma of Lung Inhibit 19549910
Adenocarcinoma of Lung Associate 26061016
Adenoma Associate 29565480
Arthritis Rheumatoid Stimulate 18759964
Arthritis Rheumatoid Associate 20470394, 37506143
Arthritis Rheumatoid Inhibit 23897768
Asthma Associate 30942450
Atherosclerosis Stimulate 27846323
Atrial Fibrillation Associate 34100730