HDAC7 (histone deacetylase 7)

Gene

• Entrez ID: 51564
• Gene name: Histone deacetylase 7
• Gene symbol: HDAC7
• Synonyms (NCBI Gene): HD7, HD7A, HDAC7A
• Chromosome: 12
• Chromosome location: 12q13.11
• Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene h

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT045413	hsa-miR-149-5p	CLASH	23622248
MIRT040075	hsa-miR-615-3p	CLASH	23622248
MIRT438365	hsa-miR-140-5p	Luciferase reporter assay, Western blot	24530397
MIRT438365	hsa-miR-140-5p	Luciferase reporter assay, Western blot	24530397
MIRT438365	hsa-miR-140-5p	Luciferase reporter assay, Western blot	24530397
MIRT438365	hsa-miR-140-5p	Luciferase reporter assay, Western blot	24530397
MIRT732960	hsa-miR-1260a	Immunofluorescence, Immunohistochemistry (IHC), RNA-seq, qRT-PCR, Western blotting	34256779
MIRT1042526	hsa-miR-3171	CLIP-seq
MIRT1042527	hsa-miR-3663-3p	CLIP-seq
MIRT1042528	hsa-miR-4278	CLIP-seq
MIRT1042529	hsa-miR-4459	CLIP-seq
MIRT1042530	hsa-miR-4685-5p	CLIP-seq
MIRT1042531	hsa-miR-4686	CLIP-seq
MIRT1042532	hsa-miR-4700-3p	CLIP-seq
MIRT1042533	hsa-miR-4716-3p	CLIP-seq
MIRT1042534	hsa-miR-4733-3p	CLIP-seq
MIRT1042535	hsa-miR-4761-3p	CLIP-seq
MIRT1042536	hsa-miR-665	CLIP-seq
MIRT1042537	hsa-miR-767-3p	CLIP-seq
MIRT1042538	hsa-miR-2467-3p	CLIP-seq
MIRT1042539	hsa-miR-3170	CLIP-seq
MIRT1042540	hsa-miR-3678-3p	CLIP-seq
MIRT1042541	hsa-miR-4667-5p	CLIP-seq
MIRT1042542	hsa-miR-4700-5p	CLIP-seq
MIRT1042543	hsa-miR-637	CLIP-seq
MIRT2009002	hsa-miR-1224-3p	CLIP-seq
MIRT2009003	hsa-miR-125a-3p	CLIP-seq
MIRT2009004	hsa-miR-1260	CLIP-seq
MIRT2009005	hsa-miR-1260b	CLIP-seq
MIRT2009006	hsa-miR-1280	CLIP-seq
MIRT2009007	hsa-miR-1307	CLIP-seq
MIRT2009008	hsa-miR-150	CLIP-seq
MIRT2009009	hsa-miR-1910	CLIP-seq
MIRT2009010	hsa-miR-2115	CLIP-seq
MIRT2009011	hsa-miR-2117	CLIP-seq
MIRT2009012	hsa-miR-3126-5p	CLIP-seq
MIRT2009013	hsa-miR-3127-3p	CLIP-seq
MIRT1042526	hsa-miR-3171	CLIP-seq
MIRT2009014	hsa-miR-3180-5p	CLIP-seq
MIRT2009015	hsa-miR-342-3p	CLIP-seq
MIRT2009016	hsa-miR-3529	CLIP-seq
MIRT1042527	hsa-miR-3663-3p	CLIP-seq
MIRT2009017	hsa-miR-3665	CLIP-seq
MIRT2009018	hsa-miR-377	CLIP-seq
MIRT2009019	hsa-miR-379	CLIP-seq
MIRT2009020	hsa-miR-3919	CLIP-seq
MIRT2009021	hsa-miR-4273	CLIP-seq
MIRT2009022	hsa-miR-4451	CLIP-seq
MIRT1042529	hsa-miR-4459	CLIP-seq
MIRT2009023	hsa-miR-4481	CLIP-seq
MIRT2009024	hsa-miR-4496	CLIP-seq
MIRT2009025	hsa-miR-4638-5p	CLIP-seq
MIRT2009026	hsa-miR-4643	CLIP-seq
MIRT2009027	hsa-miR-4650-3p	CLIP-seq
MIRT1042530	hsa-miR-4685-5p	CLIP-seq
MIRT1042531	hsa-miR-4686	CLIP-seq
MIRT1042532	hsa-miR-4700-3p	CLIP-seq
MIRT2009028	hsa-miR-4713-5p	CLIP-seq
MIRT1042534	hsa-miR-4733-3p	CLIP-seq
MIRT2009029	hsa-miR-4742-3p	CLIP-seq
MIRT2009030	hsa-miR-4745-5p	CLIP-seq
MIRT1042535	hsa-miR-4761-3p	CLIP-seq
MIRT2009031	hsa-miR-4768-5p	CLIP-seq
MIRT2009032	hsa-miR-4772-5p	CLIP-seq
MIRT2009033	hsa-miR-520a-5p	CLIP-seq
MIRT2009034	hsa-miR-525-5p	CLIP-seq
MIRT2009035	hsa-miR-532-3p	CLIP-seq
MIRT1042536	hsa-miR-665	CLIP-seq
MIRT1042537	hsa-miR-767-3p	CLIP-seq
MIRT2009036	hsa-miR-767-5p	CLIP-seq
MIRT2009037	hsa-miR-873	CLIP-seq
MIRT2009038	hsa-miR-942	CLIP-seq
MIRT2009009	hsa-miR-1910	CLIP-seq
MIRT2009011	hsa-miR-2117	CLIP-seq
MIRT2009021	hsa-miR-4273	CLIP-seq
MIRT2241369	hsa-miR-4687-3p	CLIP-seq
MIRT2241370	hsa-miR-574-3p	CLIP-seq
MIRT2545034	hsa-miR-1178	CLIP-seq
MIRT2545035	hsa-miR-1202	CLIP-seq
MIRT2545036	hsa-miR-1237	CLIP-seq
MIRT2545037	hsa-miR-1248	CLIP-seq
MIRT2545038	hsa-miR-1254	CLIP-seq
MIRT2009011	hsa-miR-2117	CLIP-seq
MIRT2545039	hsa-miR-3116	CLIP-seq
MIRT2545040	hsa-miR-326	CLIP-seq
MIRT2545041	hsa-miR-330-3p	CLIP-seq
MIRT2545042	hsa-miR-330-5p	CLIP-seq
MIRT2009015	hsa-miR-342-3p	CLIP-seq
MIRT2545043	hsa-miR-3667-5p	CLIP-seq
MIRT2545044	hsa-miR-3675-3p	CLIP-seq
MIRT2545045	hsa-miR-3690	CLIP-seq
MIRT2009018	hsa-miR-377	CLIP-seq
MIRT2545046	hsa-miR-3972	CLIP-seq
MIRT2009021	hsa-miR-4273	CLIP-seq
MIRT2545047	hsa-miR-4488	CLIP-seq
MIRT2545048	hsa-miR-4489	CLIP-seq
MIRT2545049	hsa-miR-4509	CLIP-seq
MIRT2545050	hsa-miR-4514	CLIP-seq
MIRT2545051	hsa-miR-4635	CLIP-seq
MIRT2009026	hsa-miR-4643	CLIP-seq
MIRT2545052	hsa-miR-4650-5p	CLIP-seq
MIRT2241369	hsa-miR-4687-3p	CLIP-seq
MIRT2545053	hsa-miR-4690-5p	CLIP-seq
MIRT2545054	hsa-miR-4692	CLIP-seq
MIRT2545055	hsa-miR-4697-5p	CLIP-seq
MIRT2545056	hsa-miR-4709-3p	CLIP-seq
MIRT2545057	hsa-miR-4744	CLIP-seq
MIRT2545058	hsa-miR-4755-3p	CLIP-seq
MIRT2545059	hsa-miR-526b	CLIP-seq
MIRT2545060	hsa-miR-548u	CLIP-seq
MIRT2545061	hsa-miR-606	CLIP-seq
MIRT2545062	hsa-miR-711	CLIP-seq
MIRT2545063	hsa-miR-940	CLIP-seq
MIRT2545034	hsa-miR-1178	CLIP-seq
MIRT2545035	hsa-miR-1202	CLIP-seq
MIRT2545036	hsa-miR-1237	CLIP-seq
MIRT2545037	hsa-miR-1248	CLIP-seq
MIRT2545038	hsa-miR-1254	CLIP-seq
MIRT2545039	hsa-miR-3116	CLIP-seq
MIRT2009015	hsa-miR-342-3p	CLIP-seq
MIRT2545045	hsa-miR-3690	CLIP-seq
MIRT2009018	hsa-miR-377	CLIP-seq
MIRT2545046	hsa-miR-3972	CLIP-seq
MIRT2545051	hsa-miR-4635	CLIP-seq
MIRT2009026	hsa-miR-4643	CLIP-seq
MIRT2545052	hsa-miR-4650-5p	CLIP-seq
MIRT2545056	hsa-miR-4709-3p	CLIP-seq
MIRT2545059	hsa-miR-526b	CLIP-seq
MIRT2545062	hsa-miR-711	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
BCL6	Repression	11929873
MEF2D	Unknown	15171250
NFKB1	Unknown	21243522
RELA	Unknown	21243522

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000118	Component	Histone deacetylase complex	IEA
GO:0005080	Function	Protein kinase C binding	IPI	20188095
GO:0005515	Function	Protein binding	IPI	15161933, 15194749, 15778465, 17360565, 17962809, 18339811, 20224040, 22155184, 23565059, 23752268, 24658140, 28514442, 31980649
GO:0005634	Component	Nucleus	IDA	16980613, 17997710
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	16980613, 17997710
GO:0005829	Component	Cytosol	IDA
GO:0006476	Process	Protein deacetylation	IMP	30538141
GO:0019901	Function	Protein kinase binding	IPI	16980613
GO:0032041	Function	NAD-dependent histone deacetylase activity (H3-K14 specific)	IEA
GO:0032703	Process	Negative regulation of interleukin-2 production	IDA	17360565
GO:0033558	Function	Protein deacetylase activity	IDA	30538141
GO:0033613	Function	Activating transcription factor binding	IPI	20590529
GO:0045668	Process	Negative regulation of osteoblast differentiation	IMP	17997710
GO:0046872	Function	Metal ion binding	IEA
GO:0070491	Function	Repressing transcription factor binding	IPI	17360565
GO:0070932	Process	Histone H3 deacetylation	IEA
GO:0071889	Function	14-3-3 protein binding	IDA	16980613
GO:0090050	Process	Positive regulation of cell migration involved in sprouting angiogenesis	IMP	19351956
GO:1901223	Process	Negative regulation of NIK/NF-kappaB signaling	IMP	25411248

Other IDs

• MIM: 606542
• HGNC: 14067
• e!Ensembl: ENSG00000061273

Protein

• UniProt ID: Q8WUI4
• Protein name: Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) (Protein deacetylase HDAC7) (EC 3.5.1.-)
• Protein function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional re
• PDB: 3C0Y, 3C0Z, 3C10, 3ZNR, 3ZNS, 8Q9Q
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00850	Hist_deacetyl	541 → 859	Histone deacetylase domain	Domain

• Sequence:

  MDLRVGQRPPVEPPPEPTLLALQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVG
  PQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPL
  ETEGATRSMLSSFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKE
  SAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSV
  APFALPTVSLLPAITLGLPAPARADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGG
  TLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEP
  LPPSATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVV
  DDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRP
  LSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSR
  HPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLD
  NGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNG
  FAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQ
  DPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRI
  VVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALE
  GGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQR
  LASCPDSWVPRVPGADKEEVEAVTALASLSVGILAEDRPSEQLVEEEEPMNL

• Sequence length: 952

Pathways

KEGG:

Neutrophil extracellular trap formation
Alcoholism
Viral carcinogenesis

Reactome:

Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
SUMOylation of DNA damage response and repair proteins
Notch-HLH transcription pathway

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243
Inflammatory bowel disease	Inflammatory Bowel Diseases	rs137853579, rs137853580, rs121909601, rs149491038, rs368287711, rs387907326, rs587777338, rs758439420, rs1329427406, rs1264862631, rs1192830343, rs1373354533, rs1419560997, rs1591263883, rs1989014468	23128233
Psoriasis	Psoriasis	rs281875215, rs587777763, rs281875213, rs281875212	26974007

Unknown
Disease term	Disease name	Evidence	References	Source
Asthma	Asthma		30929738	ClinVar, GWAS
Chronic obstructive pulmonary disease	Chronic Obstructive Airway Disease		30940143	ClinVar
Crohn disease	Crohn Disease		26974007	ClinVar
Inflammatory Bowel Disease	Inflammatory Bowel Disease			GWAS
Sclerosing Cholangitis	Sclerosing Cholangitis			GWAS
Bipolar Disorder	Bipolar Disorder			GWAS
Ulcerative colitis	Ulcerative colitis			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Anemia Diamond Blackfan	Associate	34036344
Breast Neoplasms	Associate	22892281, 31081251
Carcinogenesis	Associate	35345359, 35595735
Carcinoma Pancreatic Ductal	Associate	29374219
Carcinoma Renal Cell	Associate	31088315
Cardiomegaly	Associate	32364532
Cartilage Diseases	Associate	19784544
Colitis Ulcerative	Associate	38274809
Colorectal Neoplasms	Stimulate	26423403
Colorectal Neoplasms	Associate	30076612
Death	Stimulate	25275504
Diabetes Mellitus	Associate	27796421
Diabetes Mellitus Type 2	Stimulate	27796421
Esophageal Squamous Cell Carcinoma	Associate	35595735
Glioma	Stimulate	30654849
Glioma	Associate	35545840, 37528157
Graves Ophthalmopathy	Associate	39329199
Heart Diseases	Associate	22865920
Heart Failure	Associate	32364532
Hematologic Diseases	Stimulate	36293392
Hypoxia	Associate	22172637
Inflammation	Associate	39329199
Latent Autoimmune Diabetes in Adults	Associate	26839444
Leprosy	Associate	24214631
Leukemia	Associate	28982308
Leukemia Lymphocytic Chronic B Cell	Associate	23108383, 29367434
Leukemia Myeloid Acute	Associate	28982308
Lichen Planus Oral	Stimulate	30329194
Midline granulomatosis	Associate	31989434
Multiple Sclerosis	Associate	36755464
Neoplasm Metastasis	Associate	35595735
Neoplasms	Associate	16638127, 22584896, 22865920, 30076612, 31081251, 31989434
Neoplasms	Inhibit	35345359
Osteoarthritis	Stimulate	19784544
Osteoarthritis Knee	Associate	19784544
Pancreatic Neoplasms	Associate	25275504, 29374219
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	20636436
Prostatic Neoplasms	Associate	37143720
Pulmonary Disease Chronic Obstructive	Associate	22172637
Stomach Neoplasms	Associate	32284070
Varicose Veins	Associate	36293392