IL23A (interleukin 23 subunit alpha)

Gene
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
51561
Gene name Gene Name - the full gene name approved by the HGNC.
Interleukin 23 subunit alpha
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
IL23A
Synonyms (NCBI Gene) Gene synonyms aliases
IL-23, IL-23A, IL23P19, P19, SGRF
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q13.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific su
Transcription factors
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(7)
Transcription factor Regulation Reference
CEBPD Activation 23028973
E2F1 Unknown 17707233
JUN Unknown 17569750;22904313
NFKB1 Activation 17569750
NFKB1 Unknown 17707233
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(53)
GO ID Ontology Definition Evidence Reference
GO:0001916 Process Positive regulation of T cell mediated cytotoxicity ISS
GO:0002230 Process Positive regulation of defense response to virus by host IDA 12421946
GO:0002230 Process Positive regulation of defense response to virus by host ISS
GO:0002827 Process Positive regulation of T-helper 1 type immune response IDA 15114670
GO:0002827 Process Positive regulation of T-helper 1 type immune response ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
605580 15488 ENSG00000110944
Protein
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q9NPF7
Protein name Interleukin-23 subunit alpha (IL-23 subunit alpha) (IL-23-A) (Interleukin-23 subunit p19) (IL-23p19)
Protein function Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity (PubMed:11114383). Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric
PDB 3D85 , 3D87 , 3DUH , 3QWR , 4GRW , 5MJ3 , 5MJ4 , 5MXA , 5MZV , 5NJD , 6UIB , 6WDQ , 8CR8 , 8OE4
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16649 IL23 28 → 184 Interleukin 23 subunit alpha Domain
Tissue specificity TISSUE SPECIFICITY: Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level). {ECO:0000269|PubMed:11114383, ECO:0000269|PubMed:16424222}.
Sequence
Sequence length 189
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
C-type lectin receptor signaling pathway
JAK-STAT signaling pathway
Th17 cell differentiation
Pertussis
Tuberculosis
Pathways in cancer
Inflammatory bowel disease
Rheumatoid arthritis 		  Interleukin-4 and Interleukin-13 signaling
Interleukin-23 signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (2)
Causal
Disease term Disease name dbSNP ID References
Psoriasis Psoriasis rs281875215, rs587777763, rs281875213, rs281875212 19169254, 20953190
Rheumatoid arthritis Rheumatoid Arthritis rs587776843 19192274
Show/Hide Text Mining Associations (224)
Associations from Text Mining
Disease Name Relationship Type References
Acanthosis Nigricans Associate 38301504
Acne Vulgaris Associate 25153527
Acute On Chronic Liver Failure Associate 34869773
Addison Disease Associate 24614117
Adenocarcinoma Associate 34724890, 35800186
Airway Obstruction Associate 33486314
Albuminuria Associate 39768851
Alopecia Areata Associate 33099386
Amyotrophic Lateral Sclerosis Associate 31118040
Aneurysm Associate 30686933