PDGFA (platelet derived growth factor subunit A)

Gene

• Entrez ID: 5154
• Gene name: Platelet derived growth factor subunit A
• Gene symbol: PDGFA
• Synonyms (NCBI Gene): PDGF-A, PDGF1
• Chromosome: 7
• Chromosome location: 7p22.3
• Summary: This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor sub

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT005549	hsa-let-7d-5p	ELISA, Immunoblot, Microarray, qRT-PCR	21266476
MIRT053724	hsa-miR-221-3p	Microarray	22942087
MIRT438915	hsa-miR-29b-3p	Luciferase reporter assay, qRT-PCR	23354167
MIRT438915	hsa-miR-29b-3p	Luciferase reporter assay, qRT-PCR	23354167
MIRT622855	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT622854	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT622853	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT655311	hsa-miR-203a-5p	HITS-CLIP	23824327
MIRT655310	hsa-miR-1273g-5p	HITS-CLIP	23824327
MIRT622852	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT622851	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT622850	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT622849	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT622848	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT622847	hsa-miR-514a-3p	HITS-CLIP	23824327
MIRT622846	hsa-miR-514b-3p	HITS-CLIP	23824327
MIRT622855	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT622854	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT622853	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT622852	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT622851	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT622850	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT622849	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT622848	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT622847	hsa-miR-514a-3p	HITS-CLIP	23824327
MIRT622846	hsa-miR-514b-3p	HITS-CLIP	23824327
MIRT732495	hsa-miR-29a-5p	Western blotting, Immunocytochemistry (ICC), Luciferase reporter assay, qRT-PCR	31482267
MIRT053724	hsa-miR-221-3p	Luciferase reporter assay, Western blotting, Microarray, qRT-PCR	32898999
MIRT622855	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT622854	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT622853	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT655311	hsa-miR-203a-5p	HITS-CLIP	23824327
MIRT655310	hsa-miR-1273g-5p	HITS-CLIP	23824327
MIRT622852	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT622851	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT622850	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT622849	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT622848	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT622847	hsa-miR-514a-3p	HITS-CLIP	23824327
MIRT622846	hsa-miR-514b-3p	HITS-CLIP	23824327
MIRT622855	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT622854	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT622853	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT622852	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT622851	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT622850	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT622849	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT622848	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT622847	hsa-miR-514a-3p	HITS-CLIP	23824327
MIRT622846	hsa-miR-514b-3p	HITS-CLIP	23824327
MIRT1221132	hsa-miR-1266	CLIP-seq
MIRT1221133	hsa-miR-1273g	CLIP-seq
MIRT1221134	hsa-miR-141	CLIP-seq
MIRT1221135	hsa-miR-151-5p	CLIP-seq
MIRT1221136	hsa-miR-151b	CLIP-seq
MIRT1221137	hsa-miR-200a	CLIP-seq
MIRT1221138	hsa-miR-2467-3p	CLIP-seq
MIRT1221139	hsa-miR-3613-3p	CLIP-seq
MIRT1221140	hsa-miR-3664-3p	CLIP-seq
MIRT1221141	hsa-miR-3686	CLIP-seq
MIRT1221142	hsa-miR-3687	CLIP-seq
MIRT1221143	hsa-miR-3689d	CLIP-seq
MIRT1221144	hsa-miR-4263	CLIP-seq
MIRT1221145	hsa-miR-4419a	CLIP-seq
MIRT1221146	hsa-miR-4442	CLIP-seq
MIRT1221147	hsa-miR-4476	CLIP-seq
MIRT1221148	hsa-miR-4509	CLIP-seq
MIRT1221149	hsa-miR-4510	CLIP-seq
MIRT1221150	hsa-miR-4518	CLIP-seq
MIRT1221151	hsa-miR-4652-3p	CLIP-seq
MIRT1221152	hsa-miR-4742-3p	CLIP-seq
MIRT1221153	hsa-miR-4744	CLIP-seq
MIRT1221154	hsa-miR-4799-5p	CLIP-seq
MIRT1221155	hsa-miR-561	CLIP-seq
MIRT1221156	hsa-miR-576-5p	CLIP-seq
MIRT1221157	hsa-miR-873	CLIP-seq
MIRT1221158	hsa-miR-885-3p	CLIP-seq
MIRT1221159	hsa-miR-922	CLIP-seq
MIRT1221133	hsa-miR-1273g	CLIP-seq
MIRT2063810	hsa-miR-4475	CLIP-seq
MIRT2063811	hsa-miR-4496	CLIP-seq
MIRT2063812	hsa-miR-494	CLIP-seq
MIRT2063813	hsa-miR-651	CLIP-seq
MIRT2292268	hsa-miR-135a	CLIP-seq
MIRT2292269	hsa-miR-135b	CLIP-seq
MIRT2292270	hsa-miR-221	CLIP-seq
MIRT2292271	hsa-miR-222	CLIP-seq
MIRT2292272	hsa-miR-2964a-5p	CLIP-seq
MIRT2292273	hsa-miR-3120-3p	CLIP-seq
MIRT2292274	hsa-miR-3150b-3p	CLIP-seq
MIRT2292275	hsa-miR-3152-3p	CLIP-seq
MIRT2292276	hsa-miR-326	CLIP-seq
MIRT2292277	hsa-miR-330-5p	CLIP-seq
MIRT2292278	hsa-miR-338-5p	CLIP-seq
MIRT2292279	hsa-miR-34b	CLIP-seq
MIRT2292280	hsa-miR-3660	CLIP-seq
MIRT2292281	hsa-miR-3665	CLIP-seq
MIRT2292282	hsa-miR-3977	CLIP-seq
MIRT2292283	hsa-miR-412	CLIP-seq
MIRT2292284	hsa-miR-4526	CLIP-seq
MIRT2292285	hsa-miR-4645-3p	CLIP-seq
MIRT1221151	hsa-miR-4652-3p	CLIP-seq
MIRT2292286	hsa-miR-4667-5p	CLIP-seq
MIRT2292287	hsa-miR-4685-5p	CLIP-seq
MIRT2292288	hsa-miR-4698	CLIP-seq
MIRT2292289	hsa-miR-4700-5p	CLIP-seq
MIRT2292290	hsa-miR-4733-3p	CLIP-seq
MIRT2292291	hsa-miR-4736	CLIP-seq
MIRT2292292	hsa-miR-4784	CLIP-seq
MIRT2292293	hsa-miR-486-3p	CLIP-seq
MIRT2292294	hsa-miR-509-3p	CLIP-seq
MIRT2292295	hsa-miR-5096	CLIP-seq
MIRT2292296	hsa-miR-548v	CLIP-seq
MIRT2292297	hsa-miR-550b	CLIP-seq
MIRT2292298	hsa-miR-584	CLIP-seq
MIRT2292299	hsa-miR-607	CLIP-seq
MIRT2292300	hsa-miR-637	CLIP-seq
MIRT2292301	hsa-miR-760	CLIP-seq
MIRT2292302	hsa-miR-764	CLIP-seq
MIRT2292303	hsa-miR-765	CLIP-seq
MIRT2292304	hsa-miR-935	CLIP-seq
MIRT2392300	hsa-miR-1179	CLIP-seq
MIRT2392301	hsa-miR-1322	CLIP-seq
MIRT2392302	hsa-miR-153	CLIP-seq
MIRT2392303	hsa-miR-196a	CLIP-seq
MIRT2392304	hsa-miR-196b	CLIP-seq
MIRT2392305	hsa-miR-331-5p	CLIP-seq
MIRT2392306	hsa-miR-3927	CLIP-seq
MIRT2392307	hsa-miR-4310	CLIP-seq
MIRT2392308	hsa-miR-4678	CLIP-seq
MIRT2392309	hsa-miR-4706	CLIP-seq
MIRT2392310	hsa-miR-4734	CLIP-seq
MIRT2392311	hsa-miR-4749-5p	CLIP-seq
MIRT2392312	hsa-miR-744	CLIP-seq
MIRT1221139	hsa-miR-3613-3p	CLIP-seq
MIRT2392300	hsa-miR-1179	CLIP-seq
MIRT2590044	hsa-miR-1292	CLIP-seq
MIRT2590045	hsa-miR-1324	CLIP-seq
MIRT2292273	hsa-miR-3120-3p	CLIP-seq
MIRT2292275	hsa-miR-3152-3p	CLIP-seq
MIRT2590046	hsa-miR-3157-5p	CLIP-seq
MIRT2292276	hsa-miR-326	CLIP-seq
MIRT2292277	hsa-miR-330-5p	CLIP-seq
MIRT2590047	hsa-miR-3648	CLIP-seq
MIRT2292281	hsa-miR-3665	CLIP-seq
MIRT2590048	hsa-miR-382	CLIP-seq
MIRT2392307	hsa-miR-4310	CLIP-seq
MIRT2590049	hsa-miR-4471	CLIP-seq
MIRT2292285	hsa-miR-4645-3p	CLIP-seq
MIRT2292286	hsa-miR-4667-5p	CLIP-seq
MIRT2292287	hsa-miR-4685-5p	CLIP-seq
MIRT2590050	hsa-miR-4691-3p	CLIP-seq
MIRT2292289	hsa-miR-4700-5p	CLIP-seq
MIRT2392309	hsa-miR-4706	CLIP-seq
MIRT2292290	hsa-miR-4733-3p	CLIP-seq
MIRT2392310	hsa-miR-4734	CLIP-seq
MIRT2292291	hsa-miR-4736	CLIP-seq
MIRT2392311	hsa-miR-4749-5p	CLIP-seq
MIRT2292293	hsa-miR-486-3p	CLIP-seq
MIRT2590051	hsa-miR-512-5p	CLIP-seq
MIRT2292300	hsa-miR-637	CLIP-seq
MIRT2590052	hsa-miR-668	CLIP-seq
MIRT2392312	hsa-miR-744	CLIP-seq
MIRT2292301	hsa-miR-760	CLIP-seq
MIRT2292302	hsa-miR-764	CLIP-seq
MIRT2292304	hsa-miR-935	CLIP-seq
MIRT2392300	hsa-miR-1179	CLIP-seq
MIRT2590044	hsa-miR-1292	CLIP-seq
MIRT2590045	hsa-miR-1324	CLIP-seq
MIRT2292273	hsa-miR-3120-3p	CLIP-seq
MIRT2292275	hsa-miR-3152-3p	CLIP-seq
MIRT2590046	hsa-miR-3157-5p	CLIP-seq
MIRT2292276	hsa-miR-326	CLIP-seq
MIRT2292277	hsa-miR-330-5p	CLIP-seq
MIRT2590047	hsa-miR-3648	CLIP-seq
MIRT2292281	hsa-miR-3665	CLIP-seq
MIRT2590048	hsa-miR-382	CLIP-seq
MIRT2392307	hsa-miR-4310	CLIP-seq
MIRT2590049	hsa-miR-4471	CLIP-seq
MIRT2292285	hsa-miR-4645-3p	CLIP-seq
MIRT2292286	hsa-miR-4667-5p	CLIP-seq
MIRT2292287	hsa-miR-4685-5p	CLIP-seq
MIRT2590050	hsa-miR-4691-3p	CLIP-seq
MIRT2292289	hsa-miR-4700-5p	CLIP-seq
MIRT2392309	hsa-miR-4706	CLIP-seq
MIRT2292290	hsa-miR-4733-3p	CLIP-seq
MIRT2392310	hsa-miR-4734	CLIP-seq
MIRT2292291	hsa-miR-4736	CLIP-seq
MIRT2392311	hsa-miR-4749-5p	CLIP-seq
MIRT2292293	hsa-miR-486-3p	CLIP-seq
MIRT2590051	hsa-miR-512-5p	CLIP-seq
MIRT2292300	hsa-miR-637	CLIP-seq
MIRT2590052	hsa-miR-668	CLIP-seq
MIRT2392312	hsa-miR-744	CLIP-seq
MIRT2292301	hsa-miR-760	CLIP-seq
MIRT2292302	hsa-miR-764	CLIP-seq
MIRT2292304	hsa-miR-935	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
FOXF2	Repression	19562724
FOXO1	Unknown	19244250
HOXB7	Activation	21183939
WT1	Repression	1429549;7535092
WT1	Unknown	8415628

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	TAS
GO:0001525	Process	Angiogenesis	IBA
GO:0001525	Process	Angiogenesis	IEA
GO:0001525	Process	Angiogenesis	ISS
GO:0001775	Process	Cell activation	TAS	10508235
GO:0001942	Process	Hair follicle development	IEA
GO:0001942	Process	Hair follicle development	ISS
GO:0002053	Process	Positive regulation of mesenchymal cell proliferation	IEA
GO:0002053	Process	Positive regulation of mesenchymal cell proliferation	ISS
GO:0005161	Function	Platelet-derived growth factor receptor binding	IBA
GO:0005161	Function	Platelet-derived growth factor receptor binding	IDA	2439522, 2836953
GO:0005161	Function	Platelet-derived growth factor receptor binding	IPI	2536956
GO:0005515	Function	Protein binding	IPI	7679113, 25241761, 32296183
GO:0005518	Function	Collagen binding	IDA	8900172
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	3754619
GO:0005615	Component	Extracellular space	IEA
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005796	Component	Golgi lumen	TAS
GO:0005902	Component	Microvillus	IEA
GO:0005902	Component	Microvillus	ISS
GO:0007267	Process	Cell-cell signaling	TAS	2842868
GO:0008083	Function	Growth factor activity	IDA	12070119
GO:0008083	Function	Growth factor activity	IEA
GO:0008283	Process	Cell population proliferation	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IBA
GO:0008284	Process	Positive regulation of cell population proliferation	IDA	16462734
GO:0008284	Process	Positive regulation of cell population proliferation	IDA	2439522, 2836953, 7073684, 10806482, 17470632
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0009611	Process	Response to wounding	IDA	2538439
GO:0009887	Process	Animal organ morphogenesis	IEA
GO:0009887	Process	Animal organ morphogenesis	ISS
GO:0009986	Component	Cell surface	IDA	291037, 2538439, 2836953
GO:0010512	Process	Negative regulation of phosphatidylinositol biosynthetic process	IDA	2538439
GO:0010544	Process	Negative regulation of platelet activation	IDA	2538439
GO:0014910	Process	Regulation of smooth muscle cell migration	IDA	9409235
GO:0016020	Component	Membrane	IEA
GO:0030031	Process	Cell projection assembly	IEA
GO:0030031	Process	Cell projection assembly	ISS
GO:0030036	Process	Actin cytoskeleton organization	IEA
GO:0030036	Process	Actin cytoskeleton organization	ISS
GO:0030335	Process	Positive regulation of cell migration	IBA
GO:0030335	Process	Positive regulation of cell migration	IDA	11788434, 17470632
GO:0031093	Component	Platelet alpha granule lumen	TAS
GO:0031954	Process	Positive regulation of protein autophosphorylation	IDA	12070119
GO:0032956	Process	Regulation of actin cytoskeleton organization	TAS	10508235
GO:0035790	Process	Platelet-derived growth factor receptor-alpha signaling pathway	NAS	7679113, 11297552
GO:0035793	Process	Positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway	IDA	19019919
GO:0042060	Process	Wound healing	TAS	10508235
GO:0042802	Function	Identical protein binding	IPI	20534510
GO:0042803	Function	Protein homodimerization activity	IDA	2836953, 3754619
GO:0043410	Process	Positive regulation of MAPK cascade	IMP	11788434
GO:0043588	Process	Skin development	IEA
GO:0043588	Process	Skin development	ISS
GO:0046982	Function	Protein heterodimerization activity	IPI	7073684
GO:0048008	Process	Platelet-derived growth factor receptor signaling pathway	IBA
GO:0048008	Process	Platelet-derived growth factor receptor signaling pathway	IDA	2439522, 2536956, 2836953
GO:0048008	Process	Platelet-derived growth factor receptor signaling pathway	NAS	7679113
GO:0048018	Function	Receptor ligand activity	IEA
GO:0048146	Process	Positive regulation of fibroblast proliferation	IDA	2439522, 10806482
GO:0048286	Process	Lung alveolus development	IEA
GO:0048286	Process	Lung alveolus development	ISS
GO:0048407	Function	Platelet-derived growth factor binding	IPI	7073684
GO:0048565	Process	Digestive tract development	IEA
GO:0050919	Process	Negative chemotaxis	IDA	9409235
GO:0051781	Process	Positive regulation of cell division	IEA
GO:0051897	Process	Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA
GO:0051897	Process	Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA	11788434, 19019919
GO:0060348	Process	Bone development	IEA
GO:0060683	Process	Regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling	IEA
GO:0060683	Process	Regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling	ISS
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IBA
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IDA	11788434
GO:0072124	Process	Regulation of glomerular mesangial cell proliferation	IDA	11788434
GO:1990265	Component	Platelet-derived growth factor complex	IPI	7679113
GO:1990270	Component	Platelet-derived growth factor receptor-ligand complex	IPI	11297552
GO:1990401	Process	Embryonic lung development	IEA
GO:1990401	Process	Embryonic lung development	ISS
GO:2000278	Process	Regulation of DNA biosynthetic process	IDA	11788434, 19019919

Other IDs

• MIM: 173430
• HGNC: 8799
• e!Ensembl: ENSG00000197461

Protein

• UniProt ID: P04085
• Protein name: Platelet-derived growth factor subunit A (PDGF subunit A) (PDGF-1) (Platelet-derived growth factor A chain) (Platelet-derived growth factor alpha polypeptide)
• Protein function: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formatio
• PDB: 3MJK
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04692	PDGF_N	21 → 95	Platelet-derived growth factor, N terminal region	Family
  PF00341	PDGF	96 → 179	PDGF/VEGF domain	Domain

• Sequence:

  MRTLACLLLLGCGYLAHVLAEEAEIPREVIERLARSQIHSIRDLQRLLEIDSVGSEDSLD
  TSLRAHGVHATKHVPEKRPLPIRRKRSIEEAVPAVCKTRTVIYEIPRSQVDPTSANFLIW
  PPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRKKPKLKEVQVRLEEHLECACA
  TTSLNPDYREEDTGRPRESGKKRKRKRLKPT

• Sequence length: 211

Pathways

KEGG:

EGFR tyrosine kinase inhibitor resistance
MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
Phospholipase D signaling pathway
PI3K-Akt signaling pathway
Focal adhesion
Gap junction
JAK-STAT signaling pathway
Regulation of actin cytoskeleton
Pathways in cancer
Transcriptional misregulation in cancer
MicroRNAs in cancer
Glioma
Prostate cancer
Melanoma
Choline metabolism in cancer
Fluid shear stress and atherosclerosis

Reactome:

Platelet degranulation
PIP3 activates AKT signaling
Downstream signal transduction
Signaling by PDGF
Constitutive Signaling by Aberrant PI3K in Cancer
Non-integrin membrane-ECM interactions
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Delayed gross motor development	Uncertain significance	rs1474112533	RCV004586514
Hepatic fibrosis	Uncertain significance	rs1474112533	RCV004586514
Splenomegaly	Uncertain significance	rs1474112533	RCV004586514

Associations from Text Mining
Disease Name	Relationship Type	References
Acute Coronary Syndrome	Associate	34151742
Adenoma Pleomorphic	Associate	20379686
Aortic Aneurysm Abdominal	Stimulate	29439675
Aortic Aneurysm Thoracic	Stimulate	35563123
Astrocytoma	Associate	2164040
Atherosclerosis	Associate	8579107
Atrial Fibrillation	Associate	26774166
Biliary Atresia	Associate	32662506, 40665430
Binge Drinking	Associate	30038270
Breast Neoplasms	Associate	39302921
Calcinosis Cutis	Associate	23625689, 33524869
Carcinoma Basal Cell	Associate	34104083
Carcinoma Hepatocellular	Associate	23684136
Carcinoma Merkel Cell	Associate	18084259, 18408656
Carcinoma Non Small Cell Lung	Associate	19628565
Carcinoma Pancreatic Ductal	Associate	36047966
Carcinoma Squamous Cell	Associate	37746966
Cholangiocarcinoma	Associate	21492330
Cholangiocarcinoma	Stimulate	22733151
Chondrosarcoma	Associate	31809267
Chordoma	Associate	17549375
Colorectal Neoplasms	Associate	29342159, 30987352
Coxa Magna	Associate	31831773
Death	Associate	22733151
Denys Drash Syndrome	Associate	10586431
Desmoplastic Small Round Cell Tumor	Associate	15389255
Diabetes Mellitus Type 2	Associate	29728363
Emphysema	Associate	27104832
Epiretinal Membrane	Associate	19032953, 9486038
Esophageal Neoplasms	Associate	36588538
Esophageal Squamous Cell Carcinoma	Associate	34011067
Fatty Liver	Associate	29728363
Fibroma Desmoplastic	Associate	15365564
Fibrosis	Associate	28327812
Glioblastoma	Associate	27002148, 34987659, 35105853
Glioma	Associate	1653246, 19707201, 27002148, 31300060, 31428092
Gliosarcoma	Associate	16373964
Glomerulonephritis IGA	Stimulate	8995734
Heart Failure Diastolic	Associate	36184749
Hepatic Veno Occlusive Disease	Associate	21330458
Hyperinsulinism	Associate	29728363
Hypertension Pulmonary	Stimulate	9596101
Hypertrophy	Associate	2315311
Hypoxia	Stimulate	26800359, 35799115
Hypoxia	Associate	27104832
Idiopathic Pulmonary Fibrosis	Inhibit	21309737
Idiopathic Pulmonary Fibrosis	Stimulate	2347924
Idiopathic Pulmonary Fibrosis	Associate	27104832
Inflammation	Associate	11780721, 33154409, 37400519
Inflammation	Stimulate	31300060
Insulin Resistance	Associate	29728363
Kidney Diseases	Associate	10586431
Klippel Trenaunay Weber Syndrome	Associate	10586431
Leukemia T Cell	Stimulate	3479682
Liposarcoma Myxoid	Inhibit	33524869
Liver Cirrhosis	Associate	32662506, 35168183, 40665430
Lymphatic Metastasis	Stimulate	19628565
Lymphatic Metastasis	Associate	32235327, 9242335
Melanoma	Associate	2056188
Mesothelioma Malignant	Associate	1396665
Myeloproliferative Disorder Chronic with Eosinophilia	Stimulate	8995734
Neoplasm Metastasis	Stimulate	22733151, 33524869
Neoplasm Metastasis	Associate	26799588, 38171245, 9242335
Neoplasms	Associate	1396665, 1429549, 1829952, 18758297, 19628565, 2164040, 23684136, 25740390, 25767870, 30068339, 30987352, 34011067, 34715892, 36588538, 7564071, 7608673, 8349616
Neoplasms	Stimulate	3479682
Neoplasms Bone Tissue	Associate	31831773
Neuroblastoma	Associate	8376577
Orofacial Cleft 1	Associate	21052871
Ovarian Neoplasms	Associate	36758419
Pancreatic Neoplasms	Associate	18592007
Parathyroid Diseases	Associate	39519162
Plaque Atherosclerotic	Associate	7914837
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	8274753
Primary Myelofibrosis	Associate	26708839
Prostatic Neoplasms	Associate	25767870
Radiation Injuries	Associate	24512807
Renal Artery Obstruction	Associate	7564071
Sarcoma	Associate	33524869
Sarcoma Kaposi	Associate	1323124
Sarcoma Synovial	Stimulate	33524869
Squamous Cell Carcinoma of Head and Neck	Associate	23625689, 39375732
Stomach Neoplasms	Associate	2557315, 9527059
Stomatognathic Diseases	Associate	39519162
Testicular Neoplasms	Associate	1829952
Thrombocythemia Essential	Associate	15682418
Tooth Abnormalities	Associate	39519162
Triple Negative Breast Neoplasms	Associate	34104083
Vasculitis Central Nervous System	Associate	31474980
Vitreoretinopathy Proliferative	Associate	19032953
Wilms Tumor	Associate	1429549, 7564071
Wounds and Injuries	Associate	8697155