Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	51523
Gene name	CXXC finger protein 5
Gene symbol	CXXC5
Synonyms (NCBI Gene)	CF5HSPC195RINFWID
Chromosome	5
Chromosome location	5q31.2
Summary	The protein encoded by this gene is a retinoid-inducible nuclear protein containing a CXXC-type zinc finger motif. The encoded protein is involved in myelopoiesis, is required for DNA damage-induced p53 activation, regulates the differentiation of C2C12 m

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miRTarBase ID	miRNA	Experiments	Reference
MIRT021344	hsa-miR-9-5p	Microarray	17612493
MIRT043013	hsa-miR-324-3p	CLASH	23622248
MIRT659224	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT659223	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT659222	hsa-miR-1470	HITS-CLIP	23824327
MIRT659221	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT659220	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT659219	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT659218	hsa-miR-4469	HITS-CLIP	23824327
MIRT659217	hsa-miR-548q	HITS-CLIP	23824327
MIRT659216	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT659215	hsa-miR-4679	HITS-CLIP	23824327
MIRT659214	hsa-miR-3182	HITS-CLIP	23824327
MIRT659213	hsa-miR-7106-3p	HITS-CLIP	23824327
MIRT659212	hsa-miR-3907	HITS-CLIP	23824327
MIRT659224	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT659223	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT659222	hsa-miR-1470	HITS-CLIP	23824327
MIRT659221	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT659220	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT659219	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT659218	hsa-miR-4469	HITS-CLIP	23824327
MIRT659217	hsa-miR-548q	HITS-CLIP	23824327
MIRT659216	hsa-miR-4677-3p	HITS-CLIP	23824327
MIRT659215	hsa-miR-4679	HITS-CLIP	23824327
MIRT659214	hsa-miR-3182	HITS-CLIP	23824327
MIRT659213	hsa-miR-7106-3p	HITS-CLIP	23824327
MIRT659212	hsa-miR-3907	HITS-CLIP	23824327
MIRT918905	hsa-miR-25	CLIP-seq
MIRT918906	hsa-miR-3177-3p	CLIP-seq
MIRT918907	hsa-miR-32	CLIP-seq
MIRT918908	hsa-miR-3616-3p	CLIP-seq
MIRT918909	hsa-miR-363	CLIP-seq
MIRT918910	hsa-miR-367	CLIP-seq
MIRT918911	hsa-miR-3940-5p	CLIP-seq
MIRT918912	hsa-miR-4436b-3p	CLIP-seq
MIRT918913	hsa-miR-4507	CLIP-seq
MIRT918914	hsa-miR-4519	CLIP-seq
MIRT918915	hsa-miR-92a	CLIP-seq
MIRT918916	hsa-miR-92b	CLIP-seq
MIRT1972280	hsa-miR-1287	CLIP-seq
MIRT1972281	hsa-miR-188-5p	CLIP-seq
MIRT918905	hsa-miR-25	CLIP-seq
MIRT1972282	hsa-miR-3135b	CLIP-seq
MIRT918906	hsa-miR-3177-3p	CLIP-seq
MIRT918907	hsa-miR-32	CLIP-seq
MIRT918908	hsa-miR-3616-3p	CLIP-seq
MIRT918909	hsa-miR-363	CLIP-seq
MIRT918910	hsa-miR-367	CLIP-seq
MIRT918912	hsa-miR-4436b-3p	CLIP-seq
MIRT918914	hsa-miR-4519	CLIP-seq
MIRT1972283	hsa-miR-4780	CLIP-seq
MIRT1972284	hsa-miR-4786-5p	CLIP-seq
MIRT1972285	hsa-miR-623	CLIP-seq
MIRT918915	hsa-miR-92a	CLIP-seq
MIRT918916	hsa-miR-92b	CLIP-seq
MIRT1972280	hsa-miR-1287	CLIP-seq
MIRT1972281	hsa-miR-188-5p	CLIP-seq
MIRT1972282	hsa-miR-3135b	CLIP-seq
MIRT918914	hsa-miR-4519	CLIP-seq
MIRT1972283	hsa-miR-4780	CLIP-seq
MIRT1972284	hsa-miR-4786-5p	CLIP-seq
MIRT1972285	hsa-miR-623	CLIP-seq

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Transcription factor	Regulation	Reference
WT1	Activation	20220130

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	23303788
GO:0003677	Function	DNA binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0008270	Function	Zinc ion binding	IDA	29276034
GO:0008270	Function	Zinc ion binding	IEA
GO:0008327	Function	Methyl-CpG binding	IBA
GO:0008327	Function	Methyl-CpG binding	IDA	29276034
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	HMP	12761501
GO:0043467	Process	Regulation of generation of precursor metabolites and energy	IDA	23303788
GO:0043565	Function	Sequence-specific DNA binding	IDA	23303788
GO:0046872	Function	Metal ion binding	IEA
GO:0140297	Function	DNA-binding transcription factor binding	IDA	23303788

MIM	HGNC	e!Ensembl
612752	26943	ENSG00000171604

Q7LFL8

Protein name

CXXC-type zinc finger protein 5 (CF5) (Putative MAPK-activating protein PM08) (Putative NF-kappa-B-activating protein 102) (Retinoid-inducible nuclear factor) (RINF)

Protein function

May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphoryl

PDB

5W9S

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02008	zf-CXXC	255 → 296	CXXC zinc finger domain	Domain

Sequence

MSSLGGGSQDAGGSSSSSTNGSGGSGSSGPKAGAADKSAVVAAAAPASVADDTPPPERRN
KSGIISEPLNKSLRRSRPLSHYSSFGSSGGSGGGSMMGGESADKATAAAAAASLLANGHD
LAAAMAVDKSNPTSKHKSGAVASLLSKAERATELAAEGQLTLQQFAQSTEMLKRVVQEHL
PLMSEAGAGLPDMEAVAGAEALNGQSDFPYLGAFPINPGLFIMTPAGVFLAESALHMAGL
AEYPMQGELASAISSGKKKRKRCGMCAPCRRRINCEQCSSCRNRKTGHQICKFRKCEELK
KKPSAALEKVMLPTGAAFRWFQ

Sequence length

322

Interactions

View interactions

	Reactome
			Estrogen-dependent gene expression

CXXC5 (CXXC finger protein 5)