Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
51517
Gene name Gene Name - the full gene name approved by the HGNC.
NCK interacting protein with SH3 domain
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NCKIPSD
Synonyms (NCBI Gene) Gene synonyms aliases
AF3P21, DIP, DIP1, ORF1, SPIN90, VIP54, WASLBP, WISH
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3p21.31
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene contains a nuclear localization signal. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019269 hsa-miR-148b-3p Microarray 17612493
MIRT051609 hsa-let-7e-5p CLASH 23622248
MIRT045772 hsa-miR-125a-5p CLASH 23622248
MIRT036524 hsa-miR-1226-3p CLASH 23622248
MIRT630374 hsa-miR-3173-3p HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 15095401, 16189514, 16999739, 17474147, 19460367, 25416956, 31515488
GO:0005829 Component Cytosol TAS
GO:0005882 Component Intermediate filament NAS 10619843
GO:0007010 Process Cytoskeleton organization NAS 10619843
GO:0008092 Function Cytoskeletal protein binding NAS 10619843
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
606671 15486 ENSG00000213672
Protein
UniProt ID Q9NZQ3
Protein name NCK-interacting protein with SH3 domain (54 kDa VacA-interacting protein) (54 kDa vimentin-interacting protein) (VIP54) (90 kDa SH3 protein interacting with Nck) (AF3p21) (Dia-interacting protein 1) (DIP-1) (Diaphanous protein-interacting protein) (SH3 ad
Protein function Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (
PDB 6DEC , 6DED , 6DEE
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00018 SH3_1 3 50 SH3 domain Domain
PF09431 DUF2013 547 683 Protein of unknown function (DUF2013) Family
Tissue specificity TISSUE SPECIFICITY: Highest expression in heart, brain, skeletal muscle, kidney and liver. Lower levels in placenta, lung, small intestine and leukocytes. Weak expression in colon, thymus and spleen. {ECO:0000269|PubMed:10619843}.
Sequence
MYRALYAFRSAEPNALAFAAGETFLVLERSSAHWWLAARARSGETGYVPPAYLRRLQGLE
QDVLQAIDRAIEAVHNTAMRDGGKYSLEQRGVLQKLIHHRKETLSRRGPSASSVAVMTSS
TSDHHLDAAAARQPNGVCRAGFERQHSLPSSEHLGADGGLYQIPLPSSQIPPQPRRAAPT
TPPPPVKRRDREALMASGSGGHNTMPSGGNSVSSGSSVSSTSLDTLYTSSSPSEPGSSCS
PTPPPVPRRGTHTTVSQVQPPPSKASAPEPPAEEEVATGTTSASDDLEALGTLSLGTTEE
KAAAEAAVPRTIGAELMELVRRNTGLSHELCRVAIGIIVGHIQASVPASSPVMEQVLLSL
VEGKDLSMALPSGQVCHDQQRLEVIFADLARRKDDAQQRSWALYEDEGVIRCYLEELLHI
LTDADPEVCKKMCKRNEFESVLALVAYYQMEHRASLRLLLLKCFGAMCSLDAAIISTLVS
SVLPVELARDMQTDTQDHQKLCYSALILAMVFSMGEAVPYAHYEHLGTPFAQFLLNIVED
GLPLDTTEQLPDLCVNLLLALNLHLPAADQNVIMAALSKHANVKIFSEKLLLLLNRGDDP
VRIFKHEPQPPHSVLKFLQDVFGSPATAAIFYHTDMMALIDITVRHIADLSPGDKLRMEY
LSLMHAIVRTTPYLQHRHRLPDL
QAILRRILNEEETSPQCQMDRMIVREMCKEFLVLGEA
PS
Sequence length 722
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Regulation of actin dynamics for phagocytic cup formation
RHO GTPases Activate WASPs and WAVEs
FCGR3A-mediated phagocytosis
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Anorexia Anorexia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Anorexia Nervosa Associate 35470453
Anxiety Associate 39681175
Leprosy Associate 28842327
Leukemia Associate 10648423
Stroke Associate 39681175