Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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51517
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
NCK interacting protein with SH3 domain |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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NCKIPSD |
Synonyms (NCBI Gene)
Gene synonyms aliases
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AF3P21, DIP, DIP1, ORF1, SPIN90, VIP54, WASLBP, WISH |
Chromosome
Chromosome number
|
3 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
3p21.31 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene contains a nuclear localization signal. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress |
UniProt ID |
Q9NZQ3
|
Protein name |
NCK-interacting protein with SH3 domain (54 kDa VacA-interacting protein) (54 kDa vimentin-interacting protein) (VIP54) (90 kDa SH3 protein interacting with Nck) (AF3p21) (Dia-interacting protein 1) (DIP-1) (Diaphanous protein-interacting protein) (SH3 ad |
Protein function |
Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 ( |
PDB |
6DEC
,
6DED
,
6DEE
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00018
|
SH3_1 |
3 → 50 |
SH3 domain |
Domain |
PF09431
|
DUF2013 |
547 → 683 |
Protein of unknown function (DUF2013) |
Family |
|
Tissue specificity |
TISSUE SPECIFICITY: Highest expression in heart, brain, skeletal muscle, kidney and liver. Lower levels in placenta, lung, small intestine and leukocytes. Weak expression in colon, thymus and spleen. {ECO:0000269|PubMed:10619843}. |
Sequence |
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Sequence length |
722 |
Interactions |
View interactions
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