CWC15 (CWC15 spliceosome associated protein)

Gene

• Entrez ID: 51503
• Gene name: CWC15 spliceosome associated protein
• Gene symbol: CWC15
• Synonyms (NCBI Gene): AD002, C11orf5, Cwf15, HSPC148, ORF5
• Chromosome: 11
• Chromosome location: 11q21

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT051685	hsa-let-7e-5p	CLASH	23622248
MIRT917377	hsa-miR-1270	CLIP-seq
MIRT917378	hsa-miR-4434	CLIP-seq
MIRT917379	hsa-miR-4516	CLIP-seq
MIRT917380	hsa-miR-4531	CLIP-seq
MIRT917381	hsa-miR-494	CLIP-seq
MIRT917382	hsa-miR-620	CLIP-seq
MIRT2207683	hsa-miR-4668-5p	CLIP-seq
MIRT2207684	hsa-miR-4716-3p	CLIP-seq
MIRT2207685	hsa-miR-625	CLIP-seq
MIRT2510954	hsa-miR-150	CLIP-seq
MIRT2510955	hsa-miR-3117-5p	CLIP-seq
MIRT2510956	hsa-miR-3121-3p	CLIP-seq
MIRT2510957	hsa-miR-342-5p	CLIP-seq
MIRT2510958	hsa-miR-425	CLIP-seq
MIRT2510959	hsa-miR-4651	CLIP-seq
MIRT2510960	hsa-miR-4664-5p	CLIP-seq
MIRT2510961	hsa-miR-4691-5p	CLIP-seq
MIRT2510962	hsa-miR-4693-5p	CLIP-seq
MIRT2510963	hsa-miR-4713-5p	CLIP-seq
MIRT2510964	hsa-miR-483-3p	CLIP-seq
MIRT2510965	hsa-miR-532-3p	CLIP-seq
MIRT2510966	hsa-miR-608	CLIP-seq
MIRT2510967	hsa-miR-642a	CLIP-seq
MIRT2510968	hsa-miR-661	CLIP-seq
MIRT2510955	hsa-miR-3117-5p	CLIP-seq
MIRT2510956	hsa-miR-3121-3p	CLIP-seq
MIRT2510961	hsa-miR-4691-5p	CLIP-seq
MIRT2510964	hsa-miR-483-3p	CLIP-seq
MIRT2510967	hsa-miR-642a	CLIP-seq
MIRT2678825	hsa-miR-885-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000398	Process	MRNA splicing, via spliceosome	IC	11991638
GO:0000398	Process	MRNA splicing, via spliceosome	IDA	28076346
GO:0000398	Process	MRNA splicing, via spliceosome	IEA
GO:0000398	Process	MRNA splicing, via spliceosome	ISS
GO:0000398	Process	MRNA splicing, via spliceosome	NAS	23742842
GO:0000974	Component	Prp19 complex	IPI	20176811
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	ISS
GO:0005515	Function	Protein binding	IPI	20176811, 22365833, 33961781, 35271311
GO:0005634	Component	Nucleus	IDA	20176811, 28076346
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IDA	20176811
GO:0005681	Component	Spliceosomal complex	IEA
GO:0005739	Component	Mitochondrion	IDA
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0016607	Component	Nuclear speck	IDA
GO:0045292	Process	MRNA cis splicing, via spliceosome	IBA
GO:0071007	Component	U2-type catalytic step 2 spliceosome	IDA	28076346
GO:0071013	Component	Catalytic step 2 spliceosome	IBA
GO:0071013	Component	Catalytic step 2 spliceosome	IDA	11991638

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q9P013
• Protein name: Spliceosome-associated protein CWC15 homolog
• Protein function: Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28076346, PubMed:28502770). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. As a componen
• PDB: 5MQF, 5XJC, 5YZG, 5Z56, 5Z57, 5Z58, 6FF4, 6FF7, 6ICZ, 6ID0, 6ID1, 6QDV, 6ZYM, 7AAV, 7ABF, 7ABG, 7ABI, 7DVQ, 7QTT, 7W59, 7W5A, 7W5B, 8C6J, 8CH6, 8I0P, 8I0R, 8I0S, 8I0T, 8I0U, 8I0V, 8I0W, 8RO2, 9FMD
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04889	Cwf_Cwc_15	1 → 229	Cwf15/Cwc15 cell cycle control protein	Family

• Sequence:

  MTTAARPTFEPARGGRGKGEGDLSQLSKQYSSRDLPSHTKIKYRQTTQDAPEEVRNRDFR
  RELEERERAAAREKNRDRPTREHTTSSSVSKKPRLDQIPAANLDADDPLTDEEDEDFEEE
  SDDDDTAALLAELEKIKKERAEEQARKEQEQKAEEERIRMENILSGNPLLNLTGPSQPQA
  NFKVKRRWDDDVVFKNCAKGVDDQKKDKRFVNDTLRSEFHKKFMEKYIK

• Sequence length: 229

Pathways

KEGG:

Spliceosome

Reactome:

mRNA Splicing - Major Pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONDUCT DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
COVID 19	Associate	37990144	★☆☆☆☆ Found in Text Mining only
Vitiligo	Associate	33463119	★☆☆☆☆ Found in Text Mining only