Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	51466
Gene name	Enah/Vasp-like
Gene symbol	EVL
Synonyms (NCBI Gene)	RNB6
Chromosome	14
Chromosome location	14q32.2

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Show/Hide all (111)

miRTarBase ID	miRNA	Experiments	Reference
MIRT046908	hsa-miR-221-3p	CLASH	23622248
MIRT972348	hsa-miR-1251	CLIP-seq
MIRT972349	hsa-miR-125a-3p	CLIP-seq
MIRT972350	hsa-miR-3164	CLIP-seq
MIRT972351	hsa-miR-3665	CLIP-seq
MIRT972352	hsa-miR-4278	CLIP-seq
MIRT972353	hsa-miR-4688	CLIP-seq
MIRT1988051	hsa-miR-147	CLIP-seq
MIRT1988052	hsa-miR-1537	CLIP-seq
MIRT1988053	hsa-miR-184	CLIP-seq
MIRT1988054	hsa-miR-1914	CLIP-seq
MIRT1988055	hsa-miR-210	CLIP-seq
MIRT1988056	hsa-miR-27a	CLIP-seq
MIRT1988057	hsa-miR-27b	CLIP-seq
MIRT1988058	hsa-miR-3144-5p	CLIP-seq
MIRT1988059	hsa-miR-3155	CLIP-seq
MIRT1988060	hsa-miR-3155b	CLIP-seq
MIRT1988061	hsa-miR-3191	CLIP-seq
MIRT1988062	hsa-miR-3192	CLIP-seq
MIRT1988063	hsa-miR-3194-3p	CLIP-seq
MIRT1988064	hsa-miR-3197	CLIP-seq
MIRT1988065	hsa-miR-339-3p	CLIP-seq
MIRT1988066	hsa-miR-3591-3p	CLIP-seq
MIRT1988067	hsa-miR-3622a-3p	CLIP-seq
MIRT1988068	hsa-miR-3622b-3p	CLIP-seq
MIRT1988069	hsa-miR-3911	CLIP-seq
MIRT1988070	hsa-miR-4261	CLIP-seq
MIRT1988071	hsa-miR-4299	CLIP-seq
MIRT1988072	hsa-miR-4436a	CLIP-seq
MIRT1988073	hsa-miR-4456	CLIP-seq
MIRT1988074	hsa-miR-4649-3p	CLIP-seq
MIRT1988075	hsa-miR-4652-5p	CLIP-seq
MIRT1988076	hsa-miR-4667-5p	CLIP-seq
MIRT1988077	hsa-miR-4700-5p	CLIP-seq
MIRT1988078	hsa-miR-4731-5p	CLIP-seq
MIRT1988079	hsa-miR-4783-5p	CLIP-seq
MIRT1988080	hsa-miR-484	CLIP-seq
MIRT1988081	hsa-miR-490-3p	CLIP-seq
MIRT1988082	hsa-miR-503	CLIP-seq
MIRT1988083	hsa-miR-513a-5p	CLIP-seq
MIRT1988084	hsa-miR-548q	CLIP-seq
MIRT1988085	hsa-miR-619	CLIP-seq
MIRT1988086	hsa-miR-644	CLIP-seq
MIRT1988087	hsa-miR-875-3p	CLIP-seq
MIRT1988054	hsa-miR-1914	CLIP-seq
MIRT1988055	hsa-miR-210	CLIP-seq
MIRT2222554	hsa-miR-3064-5p	CLIP-seq
MIRT2222555	hsa-miR-3652	CLIP-seq
MIRT2222556	hsa-miR-4430	CLIP-seq
MIRT2222557	hsa-miR-4505	CLIP-seq
MIRT2526087	hsa-miR-1254	CLIP-seq
MIRT2526088	hsa-miR-1305	CLIP-seq
MIRT1988051	hsa-miR-147	CLIP-seq
MIRT1988053	hsa-miR-184	CLIP-seq
MIRT2526089	hsa-miR-3116	CLIP-seq
MIRT1988058	hsa-miR-3144-5p	CLIP-seq
MIRT1988061	hsa-miR-3191	CLIP-seq
MIRT1988062	hsa-miR-3192	CLIP-seq
MIRT1988063	hsa-miR-3194-3p	CLIP-seq
MIRT1988064	hsa-miR-3197	CLIP-seq
MIRT1988065	hsa-miR-339-3p	CLIP-seq
MIRT1988066	hsa-miR-3591-3p	CLIP-seq
MIRT1988067	hsa-miR-3622a-3p	CLIP-seq
MIRT1988068	hsa-miR-3622b-3p	CLIP-seq
MIRT2526090	hsa-miR-3650	CLIP-seq
MIRT2526091	hsa-miR-3690	CLIP-seq
MIRT1988069	hsa-miR-3911	CLIP-seq
MIRT2526092	hsa-miR-421	CLIP-seq
MIRT2526093	hsa-miR-4520a-3p	CLIP-seq
MIRT2526094	hsa-miR-4638-3p	CLIP-seq
MIRT1988074	hsa-miR-4649-3p	CLIP-seq
MIRT1988075	hsa-miR-4652-5p	CLIP-seq
MIRT1988076	hsa-miR-4667-5p	CLIP-seq
MIRT1988077	hsa-miR-4700-5p	CLIP-seq
MIRT1988078	hsa-miR-4731-5p	CLIP-seq
MIRT2526095	hsa-miR-4734	CLIP-seq
MIRT2526096	hsa-miR-4746-3p	CLIP-seq
MIRT2526097	hsa-miR-550a	CLIP-seq
MIRT2526098	hsa-miR-566	CLIP-seq
MIRT1988086	hsa-miR-644	CLIP-seq
MIRT2526099	hsa-miR-661	CLIP-seq
MIRT2526087	hsa-miR-1254	CLIP-seq
MIRT2526088	hsa-miR-1305	CLIP-seq
MIRT1988051	hsa-miR-147	CLIP-seq
MIRT1988053	hsa-miR-184	CLIP-seq
MIRT2526089	hsa-miR-3116	CLIP-seq
MIRT1988058	hsa-miR-3144-5p	CLIP-seq
MIRT1988061	hsa-miR-3191	CLIP-seq
MIRT1988063	hsa-miR-3194-3p	CLIP-seq
MIRT1988064	hsa-miR-3197	CLIP-seq
MIRT1988065	hsa-miR-339-3p	CLIP-seq
MIRT1988066	hsa-miR-3591-3p	CLIP-seq
MIRT1988067	hsa-miR-3622a-3p	CLIP-seq
MIRT1988068	hsa-miR-3622b-3p	CLIP-seq
MIRT2526090	hsa-miR-3650	CLIP-seq
MIRT2526091	hsa-miR-3690	CLIP-seq
MIRT1988069	hsa-miR-3911	CLIP-seq
MIRT2526092	hsa-miR-421	CLIP-seq
MIRT2526093	hsa-miR-4520a-3p	CLIP-seq
MIRT2526094	hsa-miR-4638-3p	CLIP-seq
MIRT1988074	hsa-miR-4649-3p	CLIP-seq
MIRT1988075	hsa-miR-4652-5p	CLIP-seq
MIRT1988076	hsa-miR-4667-5p	CLIP-seq
MIRT1988077	hsa-miR-4700-5p	CLIP-seq
MIRT1988078	hsa-miR-4731-5p	CLIP-seq
MIRT2526095	hsa-miR-4734	CLIP-seq
MIRT2526096	hsa-miR-4746-3p	CLIP-seq
MIRT2526097	hsa-miR-550a	CLIP-seq
MIRT2526098	hsa-miR-566	CLIP-seq
MIRT1988086	hsa-miR-644	CLIP-seq
MIRT2526099	hsa-miR-661	CLIP-seq

Show/Hide all (36)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001725	Component	Stress fiber	IEA
GO:0003779	Function	Actin binding	IEA
GO:0005515	Function	Protein binding	IPI	10993894, 16336193, 23275563, 24705354, 25416956, 28514442, 29892012, 32296183, 32814053
GO:0005522	Function	Profilin binding	IBA
GO:0005522	Function	Profilin binding	ISS
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005925	Component	Focal adhesion	IBA
GO:0005925	Component	Focal adhesion	ISS
GO:0007015	Process	Actin filament organization	IEA
GO:0007015	Process	Actin filament organization	TAS	9268706
GO:0007166	Process	Cell surface receptor signaling pathway	NAS	10993894
GO:0007399	Process	Nervous system development	NAS	10993894
GO:0007411	Process	Axon guidance	IBA
GO:0008154	Process	Actin polymerization or depolymerization	IBA
GO:0008154	Process	Actin polymerization or depolymerization	IEA
GO:0008154	Process	Actin polymerization or depolymerization	ISS
GO:0009887	Process	Animal organ morphogenesis	NAS	10993894
GO:0010633	Process	Negative regulation of epithelial cell migration	IMP	23153535
GO:0016020	Component	Membrane	HDA	19946888
GO:0017124	Function	SH3 domain binding	IEA
GO:0017124	Function	SH3 domain binding	ISS
GO:0030027	Component	Lamellipodium	IEA
GO:0030027	Component	Lamellipodium	ISS
GO:0030838	Process	Positive regulation of actin filament polymerization	IBA
GO:0042995	Component	Cell projection	IEA
GO:0044089	Process	Positive regulation of cellular component biogenesis	IEA
GO:0051289	Process	Protein homotetramerization	IEA
GO:0051495	Process	Positive regulation of cytoskeleton organization	IEA
GO:0051496	Process	Positive regulation of stress fiber assembly	IMP	23153535
GO:0110053	Process	Regulation of actin filament organization	IEA
GO:1900028	Process	Negative regulation of ruffle assembly	IMP	23153535
GO:1902905	Process	Positive regulation of supramolecular fiber organization	IEA

MIM	HGNC	e!Ensembl
616912	20234	ENSG00000196405

Q9UI08

Protein name

Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like)

Protein function

Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nuclea

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00568	WH1	1 → 109	WH1 domain	Domain
PF08776	VASP_tetra	377 → 413	VASP tetramerisation domain	Coiled-coil

Sequence

MSEQSICQARASVMVYDDTSKKWVPIKPGQQGFSRINIYHNTASNTFRVVGVKLQDQQVV
INYSIVKGLKYNQATPTFHQWRDARQVYGLNFASKEEATTFSNAMLFALNIMNSQEGGPS
SQRQVQNGPSPDEMDIQRRQVMEQHQQQRQESLERRTSATGPILPPGHPSSAASAPVSCS
GPPPPPPPPVPPPPTGATPPPPPPLPAGGAQGSSHDESSMSGLAAAIAGAKLRRVQRPED
ASGGSSPSGTSKSDANRASSGGGGGGLMEEMNKLLAKRRKAASQSDKPAEKKEDESQMED
PSTSPSPGTRAASQPPNSSEAGRKPWERSNSVEKPVSSILSRTPSVAKSPEAKSPLQSQP
HSRMKPAGSVNDMALDAFDLDRMKQEILEEVVRELHKVKEEIIDAIRQELSGISTT

Sequence length

416

Interactions

View interactions

	KEGG		Reactome
	Rap1 signaling pathway		Signaling by ROBO receptors RHO GTPases Activate Formins

EVL (Enah/Vasp-like)