SFMBT1 (Scm like with four mbt domains 1)

Gene

• Entrez ID: 51460
• Gene name: Scm like with four mbt domains 1
• Gene symbol: SFMBT1
• Synonyms (NCBI Gene): RU1, SFMBT, hSFMBT
• Chromosome: 3
• Chromosome location: 3p21.1
• Summary: This gene shares high similarity with the Drosophila Scm (sex comb on midleg) gene. It encodes a protein which contains four malignant brain tumor repeat (mbt) domains and may be involved in antigen recognition. [provided by RefSeq, Jun 2012]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029891	hsa-miR-26b-5p	Microarray	19088304
MIRT052054	hsa-let-7b-5p	CLASH	23622248
MIRT050135	hsa-miR-26a-5p	CLASH	23622248
MIRT1341601	hsa-miR-1252	CLIP-seq
MIRT1341602	hsa-miR-142-5p	CLIP-seq
MIRT1341603	hsa-miR-340	CLIP-seq
MIRT1341604	hsa-miR-3616-3p	CLIP-seq
MIRT1341605	hsa-miR-4252	CLIP-seq
MIRT1341606	hsa-miR-4264	CLIP-seq
MIRT1341607	hsa-miR-4422	CLIP-seq
MIRT1341608	hsa-miR-4476	CLIP-seq
MIRT1341609	hsa-miR-4722-3p	CLIP-seq
MIRT1341610	hsa-miR-4797-3p	CLIP-seq
MIRT1341611	hsa-miR-619	CLIP-seq
MIRT1341612	hsa-miR-875-3p	CLIP-seq
MIRT1341613	hsa-let-7a	CLIP-seq
MIRT1341614	hsa-let-7b	CLIP-seq
MIRT1341615	hsa-let-7c	CLIP-seq
MIRT1341616	hsa-let-7d	CLIP-seq
MIRT1341617	hsa-let-7e	CLIP-seq
MIRT1341618	hsa-let-7f	CLIP-seq
MIRT1341619	hsa-let-7g	CLIP-seq
MIRT1341620	hsa-let-7i	CLIP-seq
MIRT1341621	hsa-miR-1205	CLIP-seq
MIRT1341622	hsa-miR-1225-3p	CLIP-seq
MIRT1341623	hsa-miR-1238	CLIP-seq
MIRT1341624	hsa-miR-1264	CLIP-seq
MIRT1341625	hsa-miR-1283	CLIP-seq
MIRT1341626	hsa-miR-196a	CLIP-seq
MIRT1341627	hsa-miR-196b	CLIP-seq
MIRT1341628	hsa-miR-30a	CLIP-seq
MIRT1341629	hsa-miR-30b	CLIP-seq
MIRT1341630	hsa-miR-30c	CLIP-seq
MIRT1341631	hsa-miR-30d	CLIP-seq
MIRT1341632	hsa-miR-30e	CLIP-seq
MIRT1341633	hsa-miR-3689a-3p	CLIP-seq
MIRT1341634	hsa-miR-3689c	CLIP-seq
MIRT1341635	hsa-miR-421	CLIP-seq
MIRT1341636	hsa-miR-4257	CLIP-seq
MIRT1341637	hsa-miR-4323	CLIP-seq
MIRT1341638	hsa-miR-4458	CLIP-seq
MIRT1341639	hsa-miR-4500	CLIP-seq
MIRT1341640	hsa-miR-4709-5p	CLIP-seq
MIRT1341641	hsa-miR-4728-5p	CLIP-seq
MIRT1341642	hsa-miR-4759	CLIP-seq
MIRT1341643	hsa-miR-98	CLIP-seq
MIRT1341644	hsa-miR-125a-3p	CLIP-seq
MIRT1341645	hsa-miR-3665	CLIP-seq
MIRT1341646	hsa-miR-651	CLIP-seq
MIRT1341647	hsa-miR-657	CLIP-seq
MIRT2101146	hsa-miR-190	CLIP-seq
MIRT2101147	hsa-miR-190b	CLIP-seq
MIRT1341635	hsa-miR-421	CLIP-seq
MIRT2101148	hsa-miR-4633-5p	CLIP-seq
MIRT2101149	hsa-miR-4677-3p	CLIP-seq
MIRT1341640	hsa-miR-4709-5p	CLIP-seq
MIRT2101150	hsa-miR-532-5p	CLIP-seq
MIRT2101151	hsa-miR-595	CLIP-seq
MIRT1341613	hsa-let-7a	CLIP-seq
MIRT1341614	hsa-let-7b	CLIP-seq
MIRT1341615	hsa-let-7c	CLIP-seq
MIRT1341616	hsa-let-7d	CLIP-seq
MIRT1341617	hsa-let-7e	CLIP-seq
MIRT1341618	hsa-let-7f	CLIP-seq
MIRT1341619	hsa-let-7g	CLIP-seq
MIRT1341620	hsa-let-7i	CLIP-seq
MIRT1341636	hsa-miR-4257	CLIP-seq
MIRT1341638	hsa-miR-4458	CLIP-seq
MIRT1341639	hsa-miR-4500	CLIP-seq
MIRT2325556	hsa-miR-628-5p	CLIP-seq
MIRT1341643	hsa-miR-98	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003682	Function	Chromatin binding	IBA
GO:0003714	Function	Transcription corepressor activity	IEA
GO:0003714	Function	Transcription corepressor activity	TAS	23592795
GO:0005515	Function	Protein binding	IPI	16189514, 17599839, 23592795, 25416956, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	17599839
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0006325	Process	Chromatin organization	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0042393	Function	Histone binding	IBA
GO:0042393	Function	Histone binding	IDA	17599839, 23592795
GO:0042393	Function	Histone binding	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IBA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IDA	23592795
GO:0045892	Process	Negative regulation of DNA-templated transcription	IMP	17599839, 23349461
GO:0048635	Process	Negative regulation of muscle organ development	IMP	23349461

Other IDs

• MIM: 607319
• HGNC: 20255
• e!Ensembl: ENSG00000163935

Protein

• UniProt ID: Q9UHJ3
• Protein name: Scm-like with four MBT domains protein 1 (hSFMBT) (Renal ubiquitous protein 1)
• Protein function: Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a role during myogenesis: require
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02820	MBT	54 → 124	mbt repeat	Domain
  PF02820	MBT	167 → 236	mbt repeat	Domain
  PF02820	MBT	279 → 352	mbt repeat	Domain
  PF02820	MBT	388 → 457	mbt repeat	Domain
  PF12140	SLED	502 → 617	SLED domain	Domain
  PF00536	SAM_1	794 → 857	SAM domain (Sterile alpha motif)	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in all cell lines and normal tissues tested, including the thymus. {ECO:0000269|PubMed:10661410}.
• Sequence:

  MNGEQQLDADAGSGMEEVELSWEDYLEETGSTAVPYGSFKHVDTRLQNGFAPGMKLEVAV
  RTDPETYWVATVITTCEQLLLLRYDGYGEDRRADFWCDIRKADLYPIGWCEQNKKTLEAP
  EGIRDKVSDWDEFLRQTLIGACSPPVPLLEGLRNGRNPLDLIAPGSRLECQAFQDSLSTW
  IVTVVENIGGRLKLRYEGLESSDNYEHWLYYLDPFLHHVGWAAQQGYELQPPSAIRHLKN
  EAEWQEILAKVKEEEEEPLPSYLFKDKQVIGIHTFSVNMKLEAVDPWSPFGISPATVVKV
  FDEKYFLVEMDDLRPENHARRSFVCHADSPGIFPVQWSLKNGLHISPPPGYPSQDFDWAD
  YLKQCGAEAAPQRCFPPLISEHEFKENMKLEAVNPILPEEVCVATITAVRGSYLWLQLEG
  SKKPIPECIVSVESMDIFPLGWCETNGHPLSTPRRARVYKQRKIAVVQPEKQVPSSRTVH
  EGLRNQELNSTESVMINGKYCCPKIYFNHRCFSGPYLNKGRIAELPQCVGPGNCVLVLRE
  VLTLLINAAYKPSRVLRELQLDKDSVWHGCGEVLKAKYKGKSYRATVEIVKTADRVTEFC
  RQTCIKLECCPNLFGPRMVLDKCSENCSVLTKTKYTHYYGKKKNKRIGRPPGGHSNLACA
  LKKASKRRKRRKNVFVHKKKRSSASVDNTPAGSPQGSGGEDEDDPDEGDDDSLSEGSTSE
  QQDELQEESEMSEKKSCSSSPTQSEISTSLPPDRQRRKRELRTFSFSDDENKPPSPKEIR
  IEVAERLHLDSNPLKWSVADVVRFIRSTDCAPLARIFLDQEIDGQALLLLTLPTVQECMD
  LKLGPAIKLCHHIERIKFAFYEQFAN

• Sequence length: 866

Pathways

KEGG:

Polycomb repressive complex