Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	51455
Gene name	REV1 DNA directed polymerase
Gene symbol	REV1
Synonyms (NCBI Gene)	AIBP80REV1L
Chromosome	2
Chromosome location	2q11.2
Summary	This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that

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miRTarBase ID	miRNA	Experiments	Reference
MIRT006779	hsa-miR-96-5p	ImmunofluorescenceLuciferase reporter assayqRT-PCRWestern blot	22761336
MIRT030984	hsa-miR-21-5p	Microarray	18591254
MIRT296871	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT439784	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT296868	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT296871	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT439784	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT296867	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT296872	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT296869	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT296874	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT296868	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT734471	hsa-miR-30c-5p	ImmunofluorescenceImmunohistochemistry (IHC)Immunoprecipitaion (IP)In situ hybridizationin vitro cullelar assaysLuciferase reporter assayqRT-PCRWestern blotting	31511498
MIRT1301114	hsa-miR-1271	CLIP-seq
MIRT1301115	hsa-miR-182	CLIP-seq
MIRT1301116	hsa-miR-183	CLIP-seq
MIRT1301117	hsa-miR-200b	CLIP-seq
MIRT1301118	hsa-miR-200c	CLIP-seq
MIRT1301119	hsa-miR-3143	CLIP-seq
MIRT1301120	hsa-miR-3185	CLIP-seq
MIRT1301121	hsa-miR-3668	CLIP-seq
MIRT1301122	hsa-miR-3935	CLIP-seq
MIRT1301123	hsa-miR-4268	CLIP-seq
MIRT1301124	hsa-miR-429	CLIP-seq
MIRT1301125	hsa-miR-4448	CLIP-seq
MIRT1301126	hsa-miR-4457	CLIP-seq
MIRT1301127	hsa-miR-4666-5p	CLIP-seq
MIRT1301128	hsa-miR-4699-3p	CLIP-seq
MIRT1301129	hsa-miR-4777-3p	CLIP-seq
MIRT1301130	hsa-miR-513b	CLIP-seq
MIRT1301131	hsa-miR-7	CLIP-seq
MIRT1301132	hsa-miR-875-5p	CLIP-seq
MIRT1301133	hsa-miR-944	CLIP-seq
MIRT1301134	hsa-miR-96	CLIP-seq
MIRT2314318	hsa-miR-1208	CLIP-seq
MIRT2314319	hsa-miR-1254	CLIP-seq
MIRT1301114	hsa-miR-1271	CLIP-seq
MIRT2314320	hsa-miR-1294	CLIP-seq
MIRT2314321	hsa-miR-1297	CLIP-seq
MIRT1301115	hsa-miR-182	CLIP-seq
MIRT1301116	hsa-miR-183	CLIP-seq
MIRT1301117	hsa-miR-200b	CLIP-seq
MIRT1301118	hsa-miR-200c	CLIP-seq
MIRT2314322	hsa-miR-26a	CLIP-seq
MIRT2314323	hsa-miR-26b	CLIP-seq
MIRT2314324	hsa-miR-30a	CLIP-seq
MIRT2314325	hsa-miR-30b	CLIP-seq
MIRT2314326	hsa-miR-30c	CLIP-seq
MIRT2314327	hsa-miR-30d	CLIP-seq
MIRT2314328	hsa-miR-30e	CLIP-seq
MIRT2314329	hsa-miR-3116	CLIP-seq
MIRT2314330	hsa-miR-3155	CLIP-seq
MIRT2314331	hsa-miR-3155b	CLIP-seq
MIRT2314332	hsa-miR-3176	CLIP-seq
MIRT2314333	hsa-miR-326	CLIP-seq
MIRT2314334	hsa-miR-330-5p	CLIP-seq
MIRT2314335	hsa-miR-3607-3p	CLIP-seq
MIRT2314336	hsa-miR-361-5p	CLIP-seq
MIRT2314337	hsa-miR-3689d	CLIP-seq
MIRT2314338	hsa-miR-3919	CLIP-seq
MIRT2314339	hsa-miR-3922-3p	CLIP-seq
MIRT2314340	hsa-miR-4254	CLIP-seq
MIRT1301124	hsa-miR-429	CLIP-seq
MIRT2314341	hsa-miR-4316	CLIP-seq
MIRT2314342	hsa-miR-4420	CLIP-seq
MIRT2314343	hsa-miR-4455	CLIP-seq
MIRT1301126	hsa-miR-4457	CLIP-seq
MIRT2314344	hsa-miR-4465	CLIP-seq
MIRT2314345	hsa-miR-4490	CLIP-seq
MIRT1301127	hsa-miR-4666-5p	CLIP-seq
MIRT1301128	hsa-miR-4699-3p	CLIP-seq
MIRT2314346	hsa-miR-4711-5p	CLIP-seq
MIRT2314347	hsa-miR-4756-3p	CLIP-seq
MIRT2314348	hsa-miR-4774-5p	CLIP-seq
MIRT1301129	hsa-miR-4777-3p	CLIP-seq
MIRT2314349	hsa-miR-484	CLIP-seq
MIRT1301130	hsa-miR-513b	CLIP-seq
MIRT2314350	hsa-miR-548c-3p	CLIP-seq
MIRT2314351	hsa-miR-609	CLIP-seq
MIRT2314352	hsa-miR-622	CLIP-seq
MIRT1301132	hsa-miR-875-5p	CLIP-seq
MIRT1301133	hsa-miR-944	CLIP-seq
MIRT1301134	hsa-miR-96	CLIP-seq
MIRT2314319	hsa-miR-1254	CLIP-seq
MIRT2610789	hsa-miR-1266	CLIP-seq
MIRT1301114	hsa-miR-1271	CLIP-seq
MIRT1301115	hsa-miR-182	CLIP-seq
MIRT2610790	hsa-miR-219-1-3p	CLIP-seq
MIRT2314329	hsa-miR-3116	CLIP-seq
MIRT2610791	hsa-miR-3157-5p	CLIP-seq
MIRT2314332	hsa-miR-3176	CLIP-seq
MIRT2610792	hsa-miR-3664-3p	CLIP-seq
MIRT2314337	hsa-miR-3689d	CLIP-seq
MIRT2314339	hsa-miR-3922-3p	CLIP-seq
MIRT2610793	hsa-miR-3942-3p	CLIP-seq
MIRT2314340	hsa-miR-4254	CLIP-seq
MIRT2610794	hsa-miR-4274	CLIP-seq
MIRT2610795	hsa-miR-4477b	CLIP-seq
MIRT2610796	hsa-miR-4518	CLIP-seq
MIRT2610797	hsa-miR-4519	CLIP-seq
MIRT2610798	hsa-miR-4524	CLIP-seq
MIRT2610799	hsa-miR-4719	CLIP-seq
MIRT2610800	hsa-miR-4786-5p	CLIP-seq
MIRT1301130	hsa-miR-513b	CLIP-seq
MIRT2314352	hsa-miR-622	CLIP-seq
MIRT2610801	hsa-miR-769-5p	CLIP-seq
MIRT2610802	hsa-miR-873	CLIP-seq
MIRT1301134	hsa-miR-96	CLIP-seq

Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IEA
GO:0003684	Function	Damaged DNA binding	IEA
GO:0003684	Function	Damaged DNA binding	TAS	10536157
GO:0003887	Function	DNA-directed DNA polymerase activity	IBA
GO:0003887	Function	DNA-directed DNA polymerase activity	IEA
GO:0005515	Function	Protein binding	IPI	11485998, 22266823, 26318859
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006259	Process	DNA metabolic process	IEA
GO:0006260	Process	DNA replication	TAS	10536157
GO:0006281	Process	DNA repair	IEA
GO:0006974	Process	DNA damage response	IEA
GO:0009411	Process	Response to UV	IDA	11485998
GO:0016740	Function	Transferase activity	IEA
GO:0016779	Function	Nucleotidyltransferase activity	IEA
GO:0017125	Function	Deoxycytidyl transferase activity	IBA
GO:0017125	Function	Deoxycytidyl transferase activity	IEA
GO:0017125	Function	Deoxycytidyl transferase activity	TAS
GO:0042276	Process	Error-prone translesion synthesis	IBA
GO:0042276	Process	Error-prone translesion synthesis	IEA
GO:0042276	Process	Error-prone translesion synthesis	IEA
GO:0042276	Process	Error-prone translesion synthesis	TAS	11485998
GO:0046872	Function	Metal ion binding	IEA
GO:0070987	Process	Error-free translesion synthesis	IBA
GO:0071897	Process	DNA biosynthetic process	IEA

MIM	HGNC	e!Ensembl
606134	14060	ENSG00000135945

Q9UBZ9

Protein name

DNA repair protein REV1 (EC 2.7.7.-) (Alpha integrin-binding protein 80) (AIBP80) (Rev1-like terminal deoxycytidyl transferase)

Protein function

Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opp

PDB

2EBW , 2LSI , 2LSK , 2LSY , 2N1G , 3GQC , 3VU7 , 4BA9 , 4EXT , 4GK0 , 4GK5 , 5VZM , 6ASR , 6AXD , 6WS0 , 6WS5

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16589	BRCT_2	45 → 130	BRCT domain, a BRCA1 C-terminus domain	Family
PF00817	IMS	422 → 622	impB/mucB/samB family	Family
PF11799	IMS_C	702 → 830	impB/mucB/samB family C-terminal domain	Domain
PF14377	UBM	931 → 957	Ubiquitin binding region	Repeat
PF14377	UBM	1009 → 1042	Ubiquitin binding region	Repeat
PF16727	REV1_C	1167 → 1248	DNA repair protein REV1 C-terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:10536157, ECO:0000269|PubMed:11278384, ECO:0000269|PubMed:11485998}.

Sequence

MRRGGWRKRAENDGWETWGGYMAAKVQKLEEQFRSDAAMQKDGTSSTIFSGVAIYVNGYT
DPSAEELRKLMMLHGGQYHVYYSRSKTTHIIATNLPNAKIKELKGEKVIRPEWIVESIKA
GRLLSYIPYQLYTKQSSVQKGLSFNPVCRPEDPLPGPSNIAKQLNNRVNHIVKKIETENE
VKVNGMNSWNEEDENNDFSFVDLEQTSPGRKQNGIPHPRGSTAIFNGHTPSSNGALKTQD
CLVPMVNSVASRLSPAFSQEEDKAEKSSTDFRDCTLQQLQQSTRNTDALRNPHRTNSFSL
SPLHSNTKINGAHHSTVQGPSSTKSTSSVSTFSKAAPSVPSKPSDCNFISNFYSHSRLHH
ISMWKCELTEFVNTLQRQSNGIFPGREKLKKMKTGRSALVVTDTGDMSVLNSPRHQSCIM
HVDMDCFFVSVGIRNRPDLKGKPVAVTSNRGTGRAPLRPGANPQLEWQYYQNKILKGKAA
DIPDSSLWENPDSAQANGIDSVLSRAEIASCSYEARQLGIKNGMFFGHAKQLCPNLQAVP
YDFHAYKEVAQTLYETLASYTHNIEAVSCDEALVDITEILAETKLTPDEFANAVRMEIKD
QTKCAASVGIGSNILLARMATRKAKPDGQYHLKPEEVDDFIRGQLVTNLPGVGHSMESKL
ASLGIKTCGDLQYMTMAKLQKEFGPKTGQMLYRFCRGLDDRPVRTEKERKSVSAEINYGI
RFTQPKEAEAFLLSLSEEIQRRLEATGMKGKRLTLKIMVRKPGAPVETAKFGGHGICDNI
ARTVTLDQATDNAKIIGKAMLNMFHTMKLNISDMRGVGIHVNQLVPTNLNPSTCPSRPSV
QSSHFPSGSYSVRDVFQVQKAKKSTEEEHKEVFRAAVDLEISSASRTCTFLPPFPAHLPT
SPDTNKAESSGKWNGLHTPVSVQSRLNLSIEVPSPSQLDQSVLEALPPDLREQVEQVCAV
QQAESHGDKKKEPVNGCNTGILPQPVGTVLLQIPEPQESNSDAGINLIALPAFSQVDPEV
FAALPAELQRELKAAYDQRQRQGENSTHQQSASASVPKNPLLHLKAAVKEKKRNKKKKTI
GSPKRIQSPLNNKLLNSPAKTLPGACGSPQKLIDGFLKHEGPPAEKPLEELSASTSGVPG
LSSLQSDPAGCVRPPAPNLAGAVEFNDVKTLLREWITTISDPMEEDILQVVKYCTDLIEE
KDLEKLDLVIKYMKRLMQQSVESVWNMAFDFILDNVQVVLQQTYGSTLKVT

Sequence length

1251

Interactions

View interactions

	KEGG		Reactome
	Fanconi anemia pathway		Translesion synthesis by REV1 Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Colon adenocarcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (11)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Carcinogenesis	Associate	26914252, 35115490	★★★★★ ★☆☆☆☆ Found in Text Mining only
Chromosome Aberrations	Inhibit	18448394	★★★★★ ★☆☆☆☆ Found in Text Mining only
Chromosome Aberrations	Associate	20028736	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Associate	35880088	★★★★★ ★☆☆☆☆ Found in Text Mining only
Fanconi Anemia	Associate	18448394	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammation	Associate	23454887	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Associate	24012694	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Stimulate	35115490	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	21690293, 24167294, 37532520	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Associate	25748439	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Associate	26914252	★★★★★ ★☆☆☆☆ Found in Text Mining only

REV1 (REV1 DNA directed polymerase)