PDE6A (phosphodiesterase 6A)

Gene

• Entrez ID: 5145
• Gene name: Phosphodiesterase 6A
• Gene symbol: PDE6A
• Synonyms (NCBI Gene): CGPR-A, PDEA, RP43
• Chromosome: 5
• Chromosome location: 5q32
• Summary: This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an i

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs17711594	T>G	Conflicting-interpretations-of-pathogenicity, uncertain-significance, benign	Coding sequence variant, missense variant
rs61733363	G>C	Benign-likely-benign, likely-pathogenic, benign	Coding sequence variant, missense variant, genic upstream transcript variant
rs121909835	C>T	Pathogenic	Coding sequence variant, missense variant
rs121918576	G>C	Pathogenic	Stop gained, coding sequence variant
rs121918577	G>A,T	Pathogenic	Upstream transcript variant, missense variant, synonymous variant, 5 prime UTR variant, coding sequence variant, genic upstream transcript variant
rs121918578	C>T	Pathogenic	Stop gained, coding sequence variant
rs139444207	G>T	Conflicting-interpretations-of-pathogenicity, likely-pathogenic	Coding sequence variant, missense variant
rs141252097	G>A,T	Uncertain-significance, likely-pathogenic	Coding sequence variant, genic upstream transcript variant, missense variant
rs144484128	G>A	Likely-pathogenic	Coding sequence variant, missense variant
rs148598583	T>C	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, missense variant
rs375659222	G>A,C	Pathogenic	Coding sequence variant, synonymous variant, stop gained
rs753942596	G>A	Pathogenic	Stop gained, coding sequence variant
rs754012367	GTCA>-	Pathogenic	Frameshift variant, coding sequence variant
rs773065850	->GCATGCTCATGCTGTCGACG	Likely-pathogenic	Coding sequence variant, frameshift variant
rs781377291	C>T	Likely-pathogenic	Splice donor variant
rs781616522	C>G,T	Likely-pathogenic	Splice donor variant
rs794727139	C>T	Pathogenic	Splice donor variant
rs794727166	C>A,T	Uncertain-significance, pathogenic	Intron variant
rs976670244	T>A,C	Likely-pathogenic	Missense variant, genic upstream transcript variant, initiator codon variant
rs1060499536	T>C	Pathogenic	Splice acceptor variant
rs1064797315	A>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1161389116	G>A,C	Likely-pathogenic	Missense variant, stop gained, coding sequence variant
rs1456336365	A>-	Pathogenic	Coding sequence variant, stop gained
rs1554090012	A>T	Likely-pathogenic	Splice donor variant, upstream transcript variant, genic upstream transcript variant
rs1561671507	C>T	Pathogenic	Splice donor variant
rs1561679951	C>T	Pathogenic	Stop gained, coding sequence variant
rs1581164936	TGTTC>-	Pathogenic	Coding sequence variant, frameshift variant
rs1581164958	A>-	Pathogenic	Coding sequence variant, frameshift variant
rs1581166539	G>A	Pathogenic	Coding sequence variant, stop gained
rs1581180469	C>T	Pathogenic	Coding sequence variant, stop gained
rs1581186849	T>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1581190641	G>A	Pathogenic	Stop gained, genic upstream transcript variant, upstream transcript variant, coding sequence variant, 5 prime UTR variant
rs1581217626	C>AG	Pathogenic	Coding sequence variant, genic upstream transcript variant, frameshift variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT696302	hsa-miR-214-5p	HITS-CLIP	23313552
MIRT696301	hsa-miR-6811-3p	HITS-CLIP	23313552
MIRT696300	hsa-miR-6514-3p	HITS-CLIP	23313552
MIRT696299	hsa-miR-5587-5p	HITS-CLIP	23313552
MIRT678836	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT678835	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT680454	hsa-miR-764	HITS-CLIP	23824327
MIRT678834	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT680453	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT678833	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT678832	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT680452	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT680451	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT678830	hsa-miR-4635	HITS-CLIP	23824327
MIRT678829	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT678828	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT678827	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT680450	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT678825	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT678824	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT678823	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT678822	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT678821	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT678820	hsa-miR-640	HITS-CLIP	23824327
MIRT678819	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT678836	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT678835	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT678834	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT678833	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT678832	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT678831	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT678830	hsa-miR-4635	HITS-CLIP	23824327
MIRT678829	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT678828	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT678827	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT678826	hsa-miR-6131	HITS-CLIP	23824327
MIRT678825	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT678824	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT678823	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT678822	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT678821	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT678820	hsa-miR-640	HITS-CLIP	23824327
MIRT678819	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT664912	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT664911	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT664910	hsa-miR-1281	HITS-CLIP	23824327
MIRT664909	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT664908	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT664907	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT664906	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT696302	hsa-miR-214-5p	HITS-CLIP	23313552
MIRT696301	hsa-miR-6811-3p	HITS-CLIP	23313552
MIRT696300	hsa-miR-6514-3p	HITS-CLIP	23313552
MIRT696299	hsa-miR-5587-5p	HITS-CLIP	23313552
MIRT678836	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT678835	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT680454	hsa-miR-764	HITS-CLIP	23824327
MIRT678834	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT680453	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT678833	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT678832	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT680452	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT680451	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT678830	hsa-miR-4635	HITS-CLIP	23824327
MIRT678829	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT678828	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT678827	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT680450	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT678825	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT678824	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT678823	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT678822	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT678821	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT678820	hsa-miR-640	HITS-CLIP	23824327
MIRT678819	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT678836	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT678835	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT678834	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT678833	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT678832	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT678831	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT678830	hsa-miR-4635	HITS-CLIP	23824327
MIRT678829	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT678828	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT678827	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT678826	hsa-miR-6131	HITS-CLIP	23824327
MIRT678825	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT678824	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT678823	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT678822	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT678821	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT678820	hsa-miR-640	HITS-CLIP	23824327
MIRT678819	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT664912	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT664911	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT664910	hsa-miR-1281	HITS-CLIP	23824327
MIRT664909	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT664908	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT664907	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT664906	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT1220740	hsa-miR-1200	CLIP-seq
MIRT1220741	hsa-miR-122	CLIP-seq
MIRT1220742	hsa-miR-1225-3p	CLIP-seq
MIRT1220743	hsa-miR-1233	CLIP-seq
MIRT1220744	hsa-miR-1252	CLIP-seq
MIRT1220745	hsa-miR-1273e	CLIP-seq
MIRT1220746	hsa-miR-1305	CLIP-seq
MIRT1220747	hsa-miR-1343	CLIP-seq
MIRT1220748	hsa-miR-1827	CLIP-seq
MIRT1220749	hsa-miR-1915	CLIP-seq
MIRT1220750	hsa-miR-197	CLIP-seq
MIRT1220751	hsa-miR-1976	CLIP-seq
MIRT1220752	hsa-miR-2110	CLIP-seq
MIRT1220753	hsa-miR-2964a-5p	CLIP-seq
MIRT1220754	hsa-miR-299-5p	CLIP-seq
MIRT1220755	hsa-miR-3122	CLIP-seq
MIRT1220756	hsa-miR-3135b	CLIP-seq
MIRT1220757	hsa-miR-3136-3p	CLIP-seq
MIRT1220758	hsa-miR-3148	CLIP-seq
MIRT1220759	hsa-miR-3150a-3p	CLIP-seq
MIRT1220760	hsa-miR-3170	CLIP-seq
MIRT1220761	hsa-miR-3187-3p	CLIP-seq
MIRT1220762	hsa-miR-3202	CLIP-seq
MIRT1220763	hsa-miR-335	CLIP-seq
MIRT1220764	hsa-miR-3545-3p	CLIP-seq
MIRT1220765	hsa-miR-3622b-5p	CLIP-seq
MIRT1220766	hsa-miR-3652	CLIP-seq
MIRT1220767	hsa-miR-3688-3p	CLIP-seq
MIRT1220768	hsa-miR-3689a-3p	CLIP-seq
MIRT1220769	hsa-miR-3689c	CLIP-seq
MIRT1220770	hsa-miR-3913-5p	CLIP-seq
MIRT1220771	hsa-miR-3929	CLIP-seq
MIRT1220772	hsa-miR-3934	CLIP-seq
MIRT1220773	hsa-miR-3940-3p	CLIP-seq
MIRT1220774	hsa-miR-4271	CLIP-seq
MIRT1220775	hsa-miR-4279	CLIP-seq
MIRT1220776	hsa-miR-4294	CLIP-seq
MIRT1220777	hsa-miR-431	CLIP-seq
MIRT1220778	hsa-miR-4324	CLIP-seq
MIRT1220779	hsa-miR-4419b	CLIP-seq
MIRT1220780	hsa-miR-4423-5p	CLIP-seq
MIRT1220781	hsa-miR-4430	CLIP-seq
MIRT1220782	hsa-miR-4435	CLIP-seq
MIRT1220783	hsa-miR-4459	CLIP-seq
MIRT1220784	hsa-miR-4478	CLIP-seq
MIRT1220785	hsa-miR-4533	CLIP-seq
MIRT1220786	hsa-miR-4649-3p	CLIP-seq
MIRT1220787	hsa-miR-4659a-5p	CLIP-seq
MIRT1220788	hsa-miR-4659b-5p	CLIP-seq
MIRT1220789	hsa-miR-4701-5p	CLIP-seq
MIRT1220790	hsa-miR-4716-5p	CLIP-seq
MIRT1220791	hsa-miR-4719	CLIP-seq
MIRT1220792	hsa-miR-4722-3p	CLIP-seq
MIRT1220793	hsa-miR-4722-5p	CLIP-seq
MIRT1220794	hsa-miR-4725-3p	CLIP-seq
MIRT1220795	hsa-miR-4726-3p	CLIP-seq
MIRT1220796	hsa-miR-4728-5p	CLIP-seq
MIRT1220797	hsa-miR-4733-5p	CLIP-seq
MIRT1220798	hsa-miR-4747-5p	CLIP-seq
MIRT1220799	hsa-miR-4755-3p	CLIP-seq
MIRT1220800	hsa-miR-4760-3p	CLIP-seq
MIRT1220801	hsa-miR-4761-5p	CLIP-seq
MIRT1220802	hsa-miR-4776-3p	CLIP-seq
MIRT1220803	hsa-miR-4781-3p	CLIP-seq
MIRT1220804	hsa-miR-4786-3p	CLIP-seq
MIRT1220805	hsa-miR-4796-5p	CLIP-seq
MIRT1220806	hsa-miR-4802-5p	CLIP-seq
MIRT1220807	hsa-miR-485-5p	CLIP-seq
MIRT1220808	hsa-miR-498	CLIP-seq
MIRT1220809	hsa-miR-5095	CLIP-seq
MIRT1220810	hsa-miR-5096	CLIP-seq
MIRT1220811	hsa-miR-544b	CLIP-seq
MIRT1220812	hsa-miR-548s	CLIP-seq
MIRT1220813	hsa-miR-552	CLIP-seq
MIRT1220814	hsa-miR-588	CLIP-seq
MIRT1220815	hsa-miR-663b	CLIP-seq
MIRT1220816	hsa-miR-671-5p	CLIP-seq
MIRT1220817	hsa-miR-718	CLIP-seq
MIRT1220818	hsa-miR-765	CLIP-seq
MIRT1220819	hsa-miR-891b	CLIP-seq
MIRT1220820	hsa-miR-924	CLIP-seq
MIRT1220821	hsa-miR-940	CLIP-seq
MIRT1220753	hsa-miR-2964a-5p	CLIP-seq
MIRT1220805	hsa-miR-4796-5p	CLIP-seq
MIRT1220750	hsa-miR-197	CLIP-seq
MIRT1220760	hsa-miR-3170	CLIP-seq
MIRT1220761	hsa-miR-3187-3p	CLIP-seq
MIRT1220764	hsa-miR-3545-3p	CLIP-seq
MIRT1220772	hsa-miR-3934	CLIP-seq
MIRT1220782	hsa-miR-4435	CLIP-seq
MIRT1220789	hsa-miR-4701-5p	CLIP-seq
MIRT1220790	hsa-miR-4716-5p	CLIP-seq
MIRT1220799	hsa-miR-4755-3p	CLIP-seq
MIRT1220803	hsa-miR-4781-3p	CLIP-seq
MIRT1220810	hsa-miR-5096	CLIP-seq
MIRT1220812	hsa-miR-548s	CLIP-seq
MIRT1220814	hsa-miR-588	CLIP-seq
MIRT1922310	hsa-miR-1273f	CLIP-seq
MIRT1220750	hsa-miR-197	CLIP-seq
MIRT1922311	hsa-miR-3149	CLIP-seq
MIRT1220760	hsa-miR-3170	CLIP-seq
MIRT1220761	hsa-miR-3187-3p	CLIP-seq
MIRT1220764	hsa-miR-3545-3p	CLIP-seq
MIRT1220772	hsa-miR-3934	CLIP-seq
MIRT1922312	hsa-miR-411	CLIP-seq
MIRT1220782	hsa-miR-4435	CLIP-seq
MIRT1220789	hsa-miR-4701-5p	CLIP-seq
MIRT1220790	hsa-miR-4716-5p	CLIP-seq
MIRT1220799	hsa-miR-4755-3p	CLIP-seq
MIRT1220803	hsa-miR-4781-3p	CLIP-seq
MIRT1220810	hsa-miR-5096	CLIP-seq
MIRT1220812	hsa-miR-548s	CLIP-seq
MIRT1220814	hsa-miR-588	CLIP-seq
MIRT1922310	hsa-miR-1273f	CLIP-seq
MIRT1220750	hsa-miR-197	CLIP-seq
MIRT1220760	hsa-miR-3170	CLIP-seq
MIRT1220761	hsa-miR-3187-3p	CLIP-seq
MIRT1220764	hsa-miR-3545-3p	CLIP-seq
MIRT1220772	hsa-miR-3934	CLIP-seq
MIRT1922312	hsa-miR-411	CLIP-seq
MIRT1220782	hsa-miR-4435	CLIP-seq
MIRT1220789	hsa-miR-4701-5p	CLIP-seq
MIRT1220790	hsa-miR-4716-5p	CLIP-seq
MIRT1220799	hsa-miR-4755-3p	CLIP-seq
MIRT1220803	hsa-miR-4781-3p	CLIP-seq
MIRT1220810	hsa-miR-5096	CLIP-seq
MIRT1220812	hsa-miR-548s	CLIP-seq
MIRT1220814	hsa-miR-588	CLIP-seq
MIRT2063677	hsa-miR-106a	CLIP-seq
MIRT2063678	hsa-miR-106b	CLIP-seq
MIRT1220740	hsa-miR-1200	CLIP-seq
MIRT2063679	hsa-miR-1273	CLIP-seq
MIRT1922310	hsa-miR-1273f	CLIP-seq
MIRT2063680	hsa-miR-1285	CLIP-seq
MIRT2063681	hsa-miR-1294	CLIP-seq
MIRT2063682	hsa-miR-1304	CLIP-seq
MIRT2063683	hsa-miR-150	CLIP-seq
MIRT2063684	hsa-miR-17	CLIP-seq
MIRT1220749	hsa-miR-1915	CLIP-seq
MIRT1220750	hsa-miR-197	CLIP-seq
MIRT1220751	hsa-miR-1976	CLIP-seq
MIRT2063685	hsa-miR-20a	CLIP-seq
MIRT2063686	hsa-miR-20b	CLIP-seq
MIRT1220753	hsa-miR-2964a-5p	CLIP-seq
MIRT2063687	hsa-miR-302a	CLIP-seq
MIRT2063688	hsa-miR-302b	CLIP-seq
MIRT2063689	hsa-miR-302c	CLIP-seq
MIRT2063690	hsa-miR-302d	CLIP-seq
MIRT2063691	hsa-miR-302e	CLIP-seq
MIRT2063692	hsa-miR-3134	CLIP-seq
MIRT1220757	hsa-miR-3136-3p	CLIP-seq
MIRT1220760	hsa-miR-3170	CLIP-seq
MIRT2063693	hsa-miR-3187-5p	CLIP-seq
MIRT2063694	hsa-miR-3194-5p	CLIP-seq
MIRT1220764	hsa-miR-3545-3p	CLIP-seq
MIRT2063695	hsa-miR-3616-5p	CLIP-seq
MIRT2063696	hsa-miR-3647-5p	CLIP-seq
MIRT2063697	hsa-miR-372	CLIP-seq
MIRT2063698	hsa-miR-373	CLIP-seq
MIRT1220772	hsa-miR-3934	CLIP-seq
MIRT1922312	hsa-miR-411	CLIP-seq
MIRT1220775	hsa-miR-4279	CLIP-seq
MIRT2063699	hsa-miR-4316	CLIP-seq
MIRT1220778	hsa-miR-4324	CLIP-seq
MIRT2063700	hsa-miR-4433	CLIP-seq
MIRT1220783	hsa-miR-4459	CLIP-seq
MIRT2063701	hsa-miR-4486	CLIP-seq
MIRT2063702	hsa-miR-4501	CLIP-seq
MIRT2063703	hsa-miR-4534	CLIP-seq
MIRT2063704	hsa-miR-4640-5p	CLIP-seq
MIRT2063705	hsa-miR-4649-5p	CLIP-seq
MIRT2063706	hsa-miR-4666-5p	CLIP-seq
MIRT2063707	hsa-miR-4690-3p	CLIP-seq
MIRT1220790	hsa-miR-4716-5p	CLIP-seq
MIRT1220792	hsa-miR-4722-3p	CLIP-seq
MIRT1220795	hsa-miR-4726-3p	CLIP-seq
MIRT2063708	hsa-miR-4726-5p	CLIP-seq
MIRT1220799	hsa-miR-4755-3p	CLIP-seq
MIRT2063709	hsa-miR-4768-3p	CLIP-seq
MIRT1220803	hsa-miR-4781-3p	CLIP-seq
MIRT1220804	hsa-miR-4786-3p	CLIP-seq
MIRT2063710	hsa-miR-4786-5p	CLIP-seq
MIRT1220805	hsa-miR-4796-5p	CLIP-seq
MIRT2063711	hsa-miR-4797-5p	CLIP-seq
MIRT1220808	hsa-miR-498	CLIP-seq
MIRT2063712	hsa-miR-508-5p	CLIP-seq
MIRT1220809	hsa-miR-5095	CLIP-seq
MIRT1220810	hsa-miR-5096	CLIP-seq
MIRT2063713	hsa-miR-512-3p	CLIP-seq
MIRT2063714	hsa-miR-519d	CLIP-seq
MIRT2063715	hsa-miR-520a-3p	CLIP-seq
MIRT2063716	hsa-miR-520b	CLIP-seq
MIRT2063717	hsa-miR-520c-3p	CLIP-seq
MIRT2063718	hsa-miR-520d-3p	CLIP-seq
MIRT2063719	hsa-miR-520e	CLIP-seq
MIRT2063720	hsa-miR-520g	CLIP-seq
MIRT2063721	hsa-miR-520h	CLIP-seq
MIRT1220811	hsa-miR-544b	CLIP-seq
MIRT1220813	hsa-miR-552	CLIP-seq
MIRT2063722	hsa-miR-573	CLIP-seq
MIRT2063723	hsa-miR-612	CLIP-seq
MIRT2063724	hsa-miR-661	CLIP-seq
MIRT1220815	hsa-miR-663b	CLIP-seq
MIRT1220816	hsa-miR-671-5p	CLIP-seq
MIRT2063725	hsa-miR-759	CLIP-seq
MIRT2063726	hsa-miR-766	CLIP-seq
MIRT2063727	hsa-miR-769-5p	CLIP-seq
MIRT2063728	hsa-miR-93	CLIP-seq
MIRT1220740	hsa-miR-1200	CLIP-seq
MIRT1220741	hsa-miR-122	CLIP-seq
MIRT1220742	hsa-miR-1225-3p	CLIP-seq
MIRT1220743	hsa-miR-1233	CLIP-seq
MIRT2063679	hsa-miR-1273	CLIP-seq
MIRT1220745	hsa-miR-1273e	CLIP-seq
MIRT1922310	hsa-miR-1273f	CLIP-seq
MIRT2063680	hsa-miR-1285	CLIP-seq
MIRT2063681	hsa-miR-1294	CLIP-seq
MIRT2292147	hsa-miR-129-5p	CLIP-seq
MIRT2063682	hsa-miR-1304	CLIP-seq
MIRT1220747	hsa-miR-1343	CLIP-seq
MIRT1220748	hsa-miR-1827	CLIP-seq
MIRT1220749	hsa-miR-1915	CLIP-seq
MIRT1220751	hsa-miR-1976	CLIP-seq
MIRT2292148	hsa-miR-24	CLIP-seq
MIRT2063687	hsa-miR-302a	CLIP-seq
MIRT2063688	hsa-miR-302b	CLIP-seq
MIRT2063689	hsa-miR-302c	CLIP-seq
MIRT2063690	hsa-miR-302d	CLIP-seq
MIRT2063691	hsa-miR-302e	CLIP-seq
MIRT1220755	hsa-miR-3122	CLIP-seq
MIRT2063692	hsa-miR-3134	CLIP-seq
MIRT1220756	hsa-miR-3135b	CLIP-seq
MIRT1220757	hsa-miR-3136-3p	CLIP-seq
MIRT2292149	hsa-miR-3140-5p	CLIP-seq
MIRT1922311	hsa-miR-3149	CLIP-seq
MIRT2292150	hsa-miR-3157-5p	CLIP-seq
MIRT2063693	hsa-miR-3187-5p	CLIP-seq
MIRT2063694	hsa-miR-3194-5p	CLIP-seq
MIRT2292151	hsa-miR-320e	CLIP-seq
MIRT2063695	hsa-miR-3616-5p	CLIP-seq
MIRT1220765	hsa-miR-3622b-5p	CLIP-seq
MIRT2063696	hsa-miR-3647-5p	CLIP-seq
MIRT1220766	hsa-miR-3652	CLIP-seq
MIRT2292152	hsa-miR-3672	CLIP-seq
MIRT1220768	hsa-miR-3689a-3p	CLIP-seq
MIRT1220769	hsa-miR-3689c	CLIP-seq
MIRT2063697	hsa-miR-372	CLIP-seq
MIRT2063698	hsa-miR-373	CLIP-seq
MIRT1220770	hsa-miR-3913-5p	CLIP-seq
MIRT1220771	hsa-miR-3929	CLIP-seq
MIRT1220772	hsa-miR-3934	CLIP-seq
MIRT1220773	hsa-miR-3940-3p	CLIP-seq
MIRT1220775	hsa-miR-4279	CLIP-seq
MIRT2292153	hsa-miR-4284	CLIP-seq
MIRT2063699	hsa-miR-4316	CLIP-seq
MIRT1220778	hsa-miR-4324	CLIP-seq
MIRT1220779	hsa-miR-4419b	CLIP-seq
MIRT1220780	hsa-miR-4423-5p	CLIP-seq
MIRT1220781	hsa-miR-4430	CLIP-seq
MIRT2063700	hsa-miR-4433	CLIP-seq
MIRT1220782	hsa-miR-4435	CLIP-seq
MIRT1220783	hsa-miR-4459	CLIP-seq
MIRT1220784	hsa-miR-4478	CLIP-seq
MIRT2063701	hsa-miR-4486	CLIP-seq
MIRT2063702	hsa-miR-4501	CLIP-seq
MIRT2063703	hsa-miR-4534	CLIP-seq
MIRT1220786	hsa-miR-4649-3p	CLIP-seq
MIRT2063705	hsa-miR-4649-5p	CLIP-seq
MIRT2292154	hsa-miR-4691-3p	CLIP-seq
MIRT1220792	hsa-miR-4722-3p	CLIP-seq
MIRT1220793	hsa-miR-4722-5p	CLIP-seq
MIRT1220795	hsa-miR-4726-3p	CLIP-seq
MIRT1220796	hsa-miR-4728-5p	CLIP-seq
MIRT2292155	hsa-miR-4731-5p	CLIP-seq
MIRT1220797	hsa-miR-4733-5p	CLIP-seq
MIRT2292156	hsa-miR-4735-5p	CLIP-seq
MIRT2063709	hsa-miR-4768-3p	CLIP-seq
MIRT2292157	hsa-miR-4775	CLIP-seq
MIRT2292158	hsa-miR-4793-3p	CLIP-seq
MIRT2292159	hsa-miR-4795-5p	CLIP-seq
MIRT1220806	hsa-miR-4802-5p	CLIP-seq
MIRT1220807	hsa-miR-485-5p	CLIP-seq
MIRT1220808	hsa-miR-498	CLIP-seq
MIRT2063712	hsa-miR-508-5p	CLIP-seq
MIRT1220809	hsa-miR-5095	CLIP-seq
MIRT2063713	hsa-miR-512-3p	CLIP-seq
MIRT2063715	hsa-miR-520a-3p	CLIP-seq
MIRT2063716	hsa-miR-520b	CLIP-seq
MIRT2063717	hsa-miR-520c-3p	CLIP-seq
MIRT2063718	hsa-miR-520d-3p	CLIP-seq
MIRT2063719	hsa-miR-520e	CLIP-seq
MIRT1220811	hsa-miR-544b	CLIP-seq
MIRT1220813	hsa-miR-552	CLIP-seq
MIRT2063722	hsa-miR-573	CLIP-seq
MIRT2292160	hsa-miR-590-3p	CLIP-seq
MIRT2063723	hsa-miR-612	CLIP-seq
MIRT2063724	hsa-miR-661	CLIP-seq
MIRT1220817	hsa-miR-718	CLIP-seq
MIRT1220818	hsa-miR-765	CLIP-seq
MIRT2063726	hsa-miR-766	CLIP-seq
MIRT1220819	hsa-miR-891b	CLIP-seq
MIRT1220821	hsa-miR-940	CLIP-seq
MIRT1220741	hsa-miR-122	CLIP-seq
MIRT1220749	hsa-miR-1915	CLIP-seq
MIRT1220753	hsa-miR-2964a-5p	CLIP-seq
MIRT1220755	hsa-miR-3122	CLIP-seq
MIRT1220756	hsa-miR-3135b	CLIP-seq
MIRT2292151	hsa-miR-320e	CLIP-seq
MIRT1220765	hsa-miR-3622b-5p	CLIP-seq
MIRT1220770	hsa-miR-3913-5p	CLIP-seq
MIRT1220792	hsa-miR-4722-3p	CLIP-seq
MIRT1220797	hsa-miR-4733-5p	CLIP-seq
MIRT2292158	hsa-miR-4793-3p	CLIP-seq
MIRT1220805	hsa-miR-4796-5p	CLIP-seq
MIRT2063712	hsa-miR-508-5p	CLIP-seq
MIRT1220809	hsa-miR-5095	CLIP-seq
MIRT1220813	hsa-miR-552	CLIP-seq
MIRT2063726	hsa-miR-766	CLIP-seq
MIRT1220740	hsa-miR-1200	CLIP-seq
MIRT1922310	hsa-miR-1273f	CLIP-seq
MIRT2063680	hsa-miR-1285	CLIP-seq
MIRT2456115	hsa-miR-139-3p	CLIP-seq
MIRT1220748	hsa-miR-1827	CLIP-seq
MIRT1220749	hsa-miR-1915	CLIP-seq
MIRT1220751	hsa-miR-1976	CLIP-seq
MIRT1220755	hsa-miR-3122	CLIP-seq
MIRT1220756	hsa-miR-3135b	CLIP-seq
MIRT1922311	hsa-miR-3149	CLIP-seq
MIRT1220760	hsa-miR-3170	CLIP-seq
MIRT2063693	hsa-miR-3187-5p	CLIP-seq
MIRT2063694	hsa-miR-3194-5p	CLIP-seq
MIRT1220766	hsa-miR-3652	CLIP-seq
MIRT1220768	hsa-miR-3689a-3p	CLIP-seq
MIRT1220769	hsa-miR-3689c	CLIP-seq
MIRT1220770	hsa-miR-3913-5p	CLIP-seq
MIRT1220771	hsa-miR-3929	CLIP-seq
MIRT1922312	hsa-miR-411	CLIP-seq
MIRT2456116	hsa-miR-423-3p	CLIP-seq
MIRT1220775	hsa-miR-4279	CLIP-seq
MIRT1220776	hsa-miR-4294	CLIP-seq
MIRT1220777	hsa-miR-431	CLIP-seq
MIRT1220778	hsa-miR-4324	CLIP-seq
MIRT1220779	hsa-miR-4419b	CLIP-seq
MIRT1220780	hsa-miR-4423-5p	CLIP-seq
MIRT1220781	hsa-miR-4430	CLIP-seq
MIRT1220783	hsa-miR-4459	CLIP-seq
MIRT1220784	hsa-miR-4478	CLIP-seq
MIRT1220786	hsa-miR-4649-3p	CLIP-seq
MIRT1220792	hsa-miR-4722-3p	CLIP-seq
MIRT1220793	hsa-miR-4722-5p	CLIP-seq
MIRT1220795	hsa-miR-4726-3p	CLIP-seq
MIRT1220796	hsa-miR-4728-5p	CLIP-seq
MIRT1220797	hsa-miR-4733-5p	CLIP-seq
MIRT2292156	hsa-miR-4735-5p	CLIP-seq
MIRT2292157	hsa-miR-4775	CLIP-seq
MIRT2063710	hsa-miR-4786-5p	CLIP-seq
MIRT1220807	hsa-miR-485-5p	CLIP-seq
MIRT1220808	hsa-miR-498	CLIP-seq
MIRT1220811	hsa-miR-544b	CLIP-seq
MIRT2292160	hsa-miR-590-3p	CLIP-seq
MIRT2063723	hsa-miR-612	CLIP-seq
MIRT2063724	hsa-miR-661	CLIP-seq
MIRT2456117	hsa-miR-720	CLIP-seq
MIRT2063725	hsa-miR-759	CLIP-seq
MIRT2063727	hsa-miR-769-5p	CLIP-seq
MIRT1220820	hsa-miR-924	CLIP-seq
MIRT1220821	hsa-miR-940	CLIP-seq
MIRT1922310	hsa-miR-1273f	CLIP-seq
MIRT1922311	hsa-miR-3149	CLIP-seq
MIRT1220760	hsa-miR-3170	CLIP-seq
MIRT1922312	hsa-miR-411	CLIP-seq
MIRT2456116	hsa-miR-423-3p	CLIP-seq
MIRT2292156	hsa-miR-4735-5p	CLIP-seq
MIRT2292157	hsa-miR-4775	CLIP-seq
MIRT2292160	hsa-miR-590-3p	CLIP-seq
MIRT2456117	hsa-miR-720	CLIP-seq
MIRT2063725	hsa-miR-759	CLIP-seq
MIRT2063677	hsa-miR-106a	CLIP-seq
MIRT2063678	hsa-miR-106b	CLIP-seq
MIRT2589918	hsa-miR-1178	CLIP-seq
MIRT1220740	hsa-miR-1200	CLIP-seq
MIRT1220741	hsa-miR-122	CLIP-seq
MIRT1220745	hsa-miR-1273e	CLIP-seq
MIRT1922310	hsa-miR-1273f	CLIP-seq
MIRT2589919	hsa-miR-1287	CLIP-seq
MIRT1220747	hsa-miR-1343	CLIP-seq
MIRT2456115	hsa-miR-139-3p	CLIP-seq
MIRT2063683	hsa-miR-150	CLIP-seq
MIRT2063684	hsa-miR-17	CLIP-seq
MIRT1220748	hsa-miR-1827	CLIP-seq
MIRT1220749	hsa-miR-1915	CLIP-seq
MIRT1220750	hsa-miR-197	CLIP-seq
MIRT1220751	hsa-miR-1976	CLIP-seq
MIRT2063685	hsa-miR-20a	CLIP-seq
MIRT2063686	hsa-miR-20b	CLIP-seq
MIRT2063687	hsa-miR-302a	CLIP-seq
MIRT2063688	hsa-miR-302b	CLIP-seq
MIRT2063689	hsa-miR-302c	CLIP-seq
MIRT2063690	hsa-miR-302d	CLIP-seq
MIRT2063691	hsa-miR-302e	CLIP-seq
MIRT1220755	hsa-miR-3122	CLIP-seq
MIRT1220756	hsa-miR-3135b	CLIP-seq
MIRT1220757	hsa-miR-3136-3p	CLIP-seq
MIRT1922311	hsa-miR-3149	CLIP-seq
MIRT1220760	hsa-miR-3170	CLIP-seq
MIRT1220761	hsa-miR-3187-3p	CLIP-seq
MIRT1220763	hsa-miR-335	CLIP-seq
MIRT1220765	hsa-miR-3622b-5p	CLIP-seq
MIRT1220766	hsa-miR-3652	CLIP-seq
MIRT1220768	hsa-miR-3689a-3p	CLIP-seq
MIRT1220769	hsa-miR-3689c	CLIP-seq
MIRT2063697	hsa-miR-372	CLIP-seq
MIRT2063698	hsa-miR-373	CLIP-seq
MIRT1220770	hsa-miR-3913-5p	CLIP-seq
MIRT1220771	hsa-miR-3929	CLIP-seq
MIRT1922312	hsa-miR-411	CLIP-seq
MIRT1220775	hsa-miR-4279	CLIP-seq
MIRT1220776	hsa-miR-4294	CLIP-seq
MIRT1220777	hsa-miR-431	CLIP-seq
MIRT1220778	hsa-miR-4324	CLIP-seq
MIRT2589920	hsa-miR-4330	CLIP-seq
MIRT1220779	hsa-miR-4419b	CLIP-seq
MIRT1220780	hsa-miR-4423-5p	CLIP-seq
MIRT1220781	hsa-miR-4430	CLIP-seq
MIRT1220782	hsa-miR-4435	CLIP-seq
MIRT1220783	hsa-miR-4459	CLIP-seq
MIRT1220784	hsa-miR-4478	CLIP-seq
MIRT2589921	hsa-miR-4494	CLIP-seq
MIRT1220786	hsa-miR-4649-3p	CLIP-seq
MIRT2063706	hsa-miR-4666-5p	CLIP-seq
MIRT1220789	hsa-miR-4701-5p	CLIP-seq
MIRT1220790	hsa-miR-4716-5p	CLIP-seq
MIRT1220792	hsa-miR-4722-3p	CLIP-seq
MIRT1220793	hsa-miR-4722-5p	CLIP-seq
MIRT1220795	hsa-miR-4726-3p	CLIP-seq
MIRT1220796	hsa-miR-4728-5p	CLIP-seq
MIRT1220797	hsa-miR-4733-5p	CLIP-seq
MIRT2292156	hsa-miR-4735-5p	CLIP-seq
MIRT1220799	hsa-miR-4755-3p	CLIP-seq
MIRT2292157	hsa-miR-4775	CLIP-seq
MIRT1220803	hsa-miR-4781-3p	CLIP-seq
MIRT1220804	hsa-miR-4786-3p	CLIP-seq
MIRT1220807	hsa-miR-485-5p	CLIP-seq
MIRT1220808	hsa-miR-498	CLIP-seq
MIRT2589922	hsa-miR-499a-5p	CLIP-seq
MIRT1220809	hsa-miR-5095	CLIP-seq
MIRT1220810	hsa-miR-5096	CLIP-seq
MIRT2063713	hsa-miR-512-3p	CLIP-seq
MIRT2063714	hsa-miR-519d	CLIP-seq
MIRT2063715	hsa-miR-520a-3p	CLIP-seq
MIRT2063716	hsa-miR-520b	CLIP-seq
MIRT2063717	hsa-miR-520c-3p	CLIP-seq
MIRT2063718	hsa-miR-520d-3p	CLIP-seq
MIRT2063719	hsa-miR-520e	CLIP-seq
MIRT2063720	hsa-miR-520g	CLIP-seq
MIRT2063721	hsa-miR-520h	CLIP-seq
MIRT1220811	hsa-miR-544b	CLIP-seq
MIRT1220812	hsa-miR-548s	CLIP-seq
MIRT1220813	hsa-miR-552	CLIP-seq
MIRT1220814	hsa-miR-588	CLIP-seq
MIRT2292160	hsa-miR-590-3p	CLIP-seq
MIRT1220815	hsa-miR-663b	CLIP-seq
MIRT1220816	hsa-miR-671-5p	CLIP-seq
MIRT1220817	hsa-miR-718	CLIP-seq
MIRT1220819	hsa-miR-891b	CLIP-seq
MIRT1220820	hsa-miR-924	CLIP-seq
MIRT2063728	hsa-miR-93	CLIP-seq
MIRT1220821	hsa-miR-940	CLIP-seq
MIRT2063677	hsa-miR-106a	CLIP-seq
MIRT2063678	hsa-miR-106b	CLIP-seq
MIRT2589918	hsa-miR-1178	CLIP-seq
MIRT1220740	hsa-miR-1200	CLIP-seq
MIRT1220741	hsa-miR-122	CLIP-seq
MIRT1220745	hsa-miR-1273e	CLIP-seq
MIRT1922310	hsa-miR-1273f	CLIP-seq
MIRT1220747	hsa-miR-1343	CLIP-seq
MIRT2063683	hsa-miR-150	CLIP-seq
MIRT2063684	hsa-miR-17	CLIP-seq
MIRT1220748	hsa-miR-1827	CLIP-seq
MIRT1220749	hsa-miR-1915	CLIP-seq
MIRT1220750	hsa-miR-197	CLIP-seq
MIRT1220751	hsa-miR-1976	CLIP-seq
MIRT2063685	hsa-miR-20a	CLIP-seq
MIRT2063686	hsa-miR-20b	CLIP-seq
MIRT2063687	hsa-miR-302a	CLIP-seq
MIRT2063688	hsa-miR-302b	CLIP-seq
MIRT2063689	hsa-miR-302c	CLIP-seq
MIRT2063690	hsa-miR-302d	CLIP-seq
MIRT2063691	hsa-miR-302e	CLIP-seq
MIRT1220755	hsa-miR-3122	CLIP-seq
MIRT1220756	hsa-miR-3135b	CLIP-seq
MIRT1220757	hsa-miR-3136-3p	CLIP-seq
MIRT1922311	hsa-miR-3149	CLIP-seq
MIRT1220760	hsa-miR-3170	CLIP-seq
MIRT1220761	hsa-miR-3187-3p	CLIP-seq
MIRT1220763	hsa-miR-335	CLIP-seq
MIRT1220765	hsa-miR-3622b-5p	CLIP-seq
MIRT1220766	hsa-miR-3652	CLIP-seq
MIRT1220768	hsa-miR-3689a-3p	CLIP-seq
MIRT1220769	hsa-miR-3689c	CLIP-seq
MIRT2063697	hsa-miR-372	CLIP-seq
MIRT2063698	hsa-miR-373	CLIP-seq
MIRT1220770	hsa-miR-3913-5p	CLIP-seq
MIRT1220771	hsa-miR-3929	CLIP-seq
MIRT1922312	hsa-miR-411	CLIP-seq
MIRT1220775	hsa-miR-4279	CLIP-seq
MIRT1220776	hsa-miR-4294	CLIP-seq
MIRT1220777	hsa-miR-431	CLIP-seq
MIRT1220778	hsa-miR-4324	CLIP-seq
MIRT2589920	hsa-miR-4330	CLIP-seq
MIRT1220779	hsa-miR-4419b	CLIP-seq
MIRT1220780	hsa-miR-4423-5p	CLIP-seq
MIRT1220781	hsa-miR-4430	CLIP-seq
MIRT1220782	hsa-miR-4435	CLIP-seq
MIRT1220783	hsa-miR-4459	CLIP-seq
MIRT1220784	hsa-miR-4478	CLIP-seq
MIRT2589921	hsa-miR-4494	CLIP-seq
MIRT1220786	hsa-miR-4649-3p	CLIP-seq
MIRT2063706	hsa-miR-4666-5p	CLIP-seq
MIRT1220789	hsa-miR-4701-5p	CLIP-seq
MIRT1220790	hsa-miR-4716-5p	CLIP-seq
MIRT1220792	hsa-miR-4722-3p	CLIP-seq
MIRT1220793	hsa-miR-4722-5p	CLIP-seq
MIRT1220795	hsa-miR-4726-3p	CLIP-seq
MIRT1220796	hsa-miR-4728-5p	CLIP-seq
MIRT1220797	hsa-miR-4733-5p	CLIP-seq
MIRT2292156	hsa-miR-4735-5p	CLIP-seq
MIRT1220799	hsa-miR-4755-3p	CLIP-seq
MIRT2292157	hsa-miR-4775	CLIP-seq
MIRT1220803	hsa-miR-4781-3p	CLIP-seq
MIRT1220804	hsa-miR-4786-3p	CLIP-seq
MIRT1220807	hsa-miR-485-5p	CLIP-seq
MIRT1220808	hsa-miR-498	CLIP-seq
MIRT2589922	hsa-miR-499a-5p	CLIP-seq
MIRT1220809	hsa-miR-5095	CLIP-seq
MIRT1220810	hsa-miR-5096	CLIP-seq
MIRT2063713	hsa-miR-512-3p	CLIP-seq
MIRT2063714	hsa-miR-519d	CLIP-seq
MIRT2063715	hsa-miR-520a-3p	CLIP-seq
MIRT2063716	hsa-miR-520b	CLIP-seq
MIRT2063717	hsa-miR-520c-3p	CLIP-seq
MIRT2063718	hsa-miR-520d-3p	CLIP-seq
MIRT2063719	hsa-miR-520e	CLIP-seq
MIRT2063720	hsa-miR-520g	CLIP-seq
MIRT2063721	hsa-miR-520h	CLIP-seq
MIRT1220811	hsa-miR-544b	CLIP-seq
MIRT1220812	hsa-miR-548s	CLIP-seq
MIRT1220813	hsa-miR-552	CLIP-seq
MIRT1220814	hsa-miR-588	CLIP-seq
MIRT2292160	hsa-miR-590-3p	CLIP-seq
MIRT1220815	hsa-miR-663b	CLIP-seq
MIRT1220816	hsa-miR-671-5p	CLIP-seq
MIRT1220817	hsa-miR-718	CLIP-seq
MIRT1220819	hsa-miR-891b	CLIP-seq
MIRT1220820	hsa-miR-924	CLIP-seq
MIRT2063728	hsa-miR-93	CLIP-seq
MIRT1220821	hsa-miR-940	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
SP1	Unknown	9770645

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001750	Component	Photoreceptor outer segment	IEA
GO:0004114	Function	3',5'-cyclic-nucleotide phosphodiesterase activity	IEA
GO:0004115	Function	3',5'-cyclic-AMP phosphodiesterase activity	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0007601	Process	Visual perception	IEA
GO:0007601	Process	Visual perception	TAS	7493036
GO:0008081	Function	Phosphoric diester hydrolase activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0042622	Component	Photoreceptor outer segment membrane	IBA
GO:0042995	Component	Cell projection	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0047555	Function	3',5'-cyclic-GMP phosphodiesterase activity	IBA
GO:0047555	Function	3',5'-cyclic-GMP phosphodiesterase activity	IEA
GO:0060041	Process	Retina development in camera-type eye	IBA
GO:0097381	Component	Photoreceptor disc membrane	IEA
GO:0097381	Component	Photoreceptor disc membrane	TAS
GO:0141162	Process	Negative regulation of cAMP/PKA signal transduction	IBA

Other IDs

• MIM: 180071
• HGNC: 8785
• e!Ensembl: ENSG00000132915

Protein

• UniProt ID: P16499
• Protein name: Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (GMP-PDE alpha) (EC 3.1.4.35) (PDE V-B1)
• Protein function: Rod-specific cGMP phosphodiesterase that catalyzes the hydrolysis of 3',5'-cyclic GMP (PubMed:20940301). This protein participates in processes of transmission and amplification of the visual signal.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01590	GAF	73 → 222	GAF domain	Domain
  PF01590	GAF	254 → 431	GAF domain	Domain
  PF00233	PDEase_I	558 → 803		Domain

• Sequence:

  MGEVTAEEVEKFLDSNIGFAKQYYNLHYRAKLISDLLGAKEAAVDFSNYHSPSSMEESEI
  IFDLLRDFQENLQTEKCIFNVMKKLCFLLQADRMSLFMYRTRNGIAELATRLFNVHKDAV
  LEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILAS
  PIMNGKDVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIMKVYHLSYLHNCETRRGQI
  LLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEVP
  PYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPAYVAQNGLICNIM
  NAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLM
  ESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKILKTREVYGKEPW
  ECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQE
  ALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHD
  IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIH
  MMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEIVMAMMMTACD
  LSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFV
  CTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYDAKMKVQEEKKQKQQSAKSAAAGN
  QPGGNPSPGGATTSKSCCIQ

• Sequence length: 860

Pathways

KEGG:

Purine metabolism
Metabolic pathways
Phototransduction

Reactome:

Activation of the phototransduction cascade
Inactivation, recovery and regulation of the phototransduction cascade
Ca2+ pathway

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Autosomal recessive retinitis pigmentosa	Likely pathogenic	rs1752838447	RCV001257851
Leber congenital amaurosis	Pathogenic	rs794727166	RCV000515673
PDE6A-related disorder	Likely pathogenic	rs2480577993	RCV003397254
Retinal dystrophy	Likely pathogenic; Pathogenic	rs759589388, rs794727139, rs754012367, rs121909835, rs773065850, rs753942596, rs144484128, rs146591309, rs781377291, rs1581211727, rs748946491, rs759563967, rs1754021035, rs1383907349, rs781616522, rs369896113, rs1753232409, rs750539462	RCV003888315 RCV004816264 RCV004816276 RCV001074616 RCV001075107 RCV004817725 RCV001075345 RCV001073963 RCV001073345 RCV004818008 RCV004813663 RCV001073639 RCV001075135 RCV001074262 RCV001073714 RCV001073962 RCV001073306 RCV004814010
Retinitis pigmentosa	Likely pathogenic; Pathogenic	rs759589388, rs794727139, rs754012367, rs2480433988, rs121918576, rs1761074706, rs753942596, rs144484128, rs146591309, rs1161389116, rs1554090012, rs1581180469, rs1581190641, rs1265680220, rs976670244, rs781377291, rs781616522, rs1581211727, rs1581164958, rs375659222, rs1581164936, rs1581166539, rs1581217626, rs1561671507, rs1761073125, rs1752838269, rs1754418004, rs141252097, rs748946491	RCV001724800 RCV001199499 RCV000787640 RCV003324705 RCV000987614 RCV004560363 RCV000504732 RCV000505062 RCV000504959 RCV001199495 RCV001199500 RCV000787636 RCV000787635 RCV000787641 RCV000787639 RCV000787638 RCV000787637 RCV000787642 RCV000987613 RCV000987615 RCV001003110 RCV001003111 RCV001003113 RCV001003109 RCV001199494 RCV001199492 RCV001199497 RCV001724216 RCV001724223
Retinitis pigmentosa 43	Likely pathogenic; Pathogenic	rs943943635, rs1450419928, rs2113595869, rs2113586537, rs770529851, rs561600163, rs759589388, rs1390479623, rs2113558095, rs1406110455, rs794727139, rs754012367, rs1060499536, rs2480610173, rs121918576, rs121918577, rs121918578, rs1366137772, rs121909835, rs773065850, rs753942596, rs144484128, rs146591309, rs1428612396, rs1581211727, rs1581166539, rs1581186849, rs759537984, rs748946491, rs759563967, rs1383907349, rs781616522, rs1753232409, rs1259637349, rs373537826, rs750539462, rs1752838447	RCV005038097 RCV001376484 RCV001591813 RCV001591814 RCV001591815 RCV001591816 RCV002503172 RCV002246599 RCV002250182 RCV005034604 RCV001376192 RCV001376193 RCV000210743 RCV003155525 RCV000013989 RCV000013990 RCV000013991 RCV005038594 RCV000022755 RCV001782973 RCV005252934 RCV005034046 RCV001376482 RCV004808875 RCV006271658 RCV002272384 RCV001376452 RCV005056832 RCV003225740 RCV001784630 RCV005036389 RCV002497487 RCV002505661 RCV001196671 RCV003323829 RCV005038008 RCV004798901

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Cervical cancer	Benign; Likely benign; Conflicting classifications of pathogenicity	rs10057110, rs78775072	RCV005898946 RCV005886230
Lymphoma	Conflicting classifications of pathogenicity	rs78775072	RCV005886233
Malignant tumor of esophagus	Conflicting classifications of pathogenicity	rs78775072	RCV005886229
Melanoma	Conflicting classifications of pathogenicity	rs78775072	RCV005886234
Ovarian cancer	Conflicting classifications of pathogenicity	rs78775072	RCV005886231
Ovarian serous cystadenocarcinoma	Uncertain significance	rs755174137	RCV005925476
PDE6A-related retinopathy	Conflicting classifications of pathogenicity	rs201527437	RCV005355675
Retinitis Pigmentosa, Recessive	Uncertain significance; Benign; Likely benign	rs886060207, rs764134058, rs57328066, rs886060208, rs886060213, rs36043437, rs886060218, rs569137634, rs886060209, rs886060214	RCV000348036 RCV000339879 RCV000407776 RCV000407753 RCV000342672 RCV000403420 RCV000349810 RCV000369532 RCV000353107 RCV000284896 RCV000299496
Sarcoma	Conflicting classifications of pathogenicity	rs78775072	RCV005886232
Usher syndrome	Conflicting classifications of pathogenicity	rs199924410, rs199738915	RCV003389471 RCV003389470
Uterine corpus endometrial carcinoma	Conflicting classifications of pathogenicity	rs78775072	RCV005886235

Associations from Text Mining
Disease Name	Relationship Type	References
Atrophy	Associate	33057649
Carcinoma Hepatocellular	Associate	36714595
Cone Rod Dystrophies	Associate	30998820, 39596324
Diabetes Gestational	Associate	30185669
Diabetic Retinopathy	Associate	37318461
Hypertensive Retinopathy	Associate	39218074
Leber Congenital Amaurosis	Associate	36140798
Macular Edema	Associate	33057649
Neoplasms Adipose Tissue	Associate	38190589
Night Blindness	Associate	30998820, 36140798
Obesity	Associate	36714595, 38190589
Retinal Dystrophies	Associate	25943428, 36140798, 39218074
Retinitis Pigmentosa	Associate	17110911, 18723146, 22128245, 26321862, 30685614, 33057649, 34057927, 35033039, 35533076, 36140798, 37322672, 37578425, 39218074, 7479749
Specific Granule Deficiency	Associate	35033039
Vision Disorders	Associate	33057649
X Linked Combined Immunodeficiency Diseases	Associate	18723146