Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	51440
Gene name	Hippocalcin like 4
Gene symbol	HPCAL4
Synonyms (NCBI Gene)	HLP4
Chromosome	1
Chromosome location	1p34.2
Summary	The protein encoded by this gene is highly similar to human hippocalcin protein and hippocalcin like-1 protein. It also has similarity to rat neural visinin-like Ca2+-binding protein-type 1 and 2 proteins. This encoded protein may be involved in the calci

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miRTarBase ID	miRNA	Experiments	Reference
MIRT037510	hsa-miR-744-5p	CLASH	23622248
MIRT1054038	hsa-miR-1226	CLIP-seq
MIRT1054039	hsa-miR-1264	CLIP-seq
MIRT1054040	hsa-miR-1266	CLIP-seq
MIRT1054041	hsa-miR-129-3p	CLIP-seq
MIRT1054042	hsa-miR-1294	CLIP-seq
MIRT1054043	hsa-miR-1297	CLIP-seq
MIRT1054044	hsa-miR-1302	CLIP-seq
MIRT1054045	hsa-miR-141	CLIP-seq
MIRT1054046	hsa-miR-146b-3p	CLIP-seq
MIRT1054047	hsa-miR-1827	CLIP-seq
MIRT1054048	hsa-miR-1909	CLIP-seq
MIRT1054049	hsa-miR-1915	CLIP-seq
MIRT1054050	hsa-miR-197	CLIP-seq
MIRT1054051	hsa-miR-200a	CLIP-seq
MIRT1054052	hsa-miR-2114	CLIP-seq
MIRT1054053	hsa-miR-22	CLIP-seq
MIRT1054054	hsa-miR-26a	CLIP-seq
MIRT1054055	hsa-miR-26b	CLIP-seq
MIRT1054056	hsa-miR-3125	CLIP-seq
MIRT1054057	hsa-miR-3127-3p	CLIP-seq
MIRT1054058	hsa-miR-3132	CLIP-seq
MIRT1054059	hsa-miR-3134	CLIP-seq
MIRT1054060	hsa-miR-3158-3p	CLIP-seq
MIRT1054061	hsa-miR-3160-3p	CLIP-seq
MIRT1054062	hsa-miR-3202	CLIP-seq
MIRT1054063	hsa-miR-323-5p	CLIP-seq
MIRT1054064	hsa-miR-335	CLIP-seq
MIRT1054065	hsa-miR-3647-3p	CLIP-seq
MIRT1054066	hsa-miR-3664-3p	CLIP-seq
MIRT1054067	hsa-miR-3679-3p	CLIP-seq
MIRT1054068	hsa-miR-3916	CLIP-seq
MIRT1054069	hsa-miR-4281	CLIP-seq
MIRT1054070	hsa-miR-4292	CLIP-seq
MIRT1054071	hsa-miR-4298	CLIP-seq
MIRT1054072	hsa-miR-4308	CLIP-seq
MIRT1054073	hsa-miR-4436a	CLIP-seq
MIRT1054074	hsa-miR-4446-5p	CLIP-seq
MIRT1054075	hsa-miR-4465	CLIP-seq
MIRT1054076	hsa-miR-4476	CLIP-seq
MIRT1054077	hsa-miR-4487	CLIP-seq
MIRT1054078	hsa-miR-450b-5p	CLIP-seq
MIRT1054079	hsa-miR-4518	CLIP-seq
MIRT1054080	hsa-miR-4520a-3p	CLIP-seq
MIRT1054081	hsa-miR-4534	CLIP-seq
MIRT1054082	hsa-miR-4684-5p	CLIP-seq
MIRT1054083	hsa-miR-4687-5p	CLIP-seq
MIRT1054084	hsa-miR-4694-3p	CLIP-seq
MIRT1054085	hsa-miR-4699-5p	CLIP-seq
MIRT1054086	hsa-miR-4710	CLIP-seq
MIRT1054087	hsa-miR-4726-3p	CLIP-seq
MIRT1054088	hsa-miR-4729	CLIP-seq
MIRT1054089	hsa-miR-4733-3p	CLIP-seq
MIRT1054090	hsa-miR-4753-3p	CLIP-seq
MIRT1054091	hsa-miR-4755-3p	CLIP-seq
MIRT1054092	hsa-miR-4768-5p	CLIP-seq
MIRT1054093	hsa-miR-4780	CLIP-seq
MIRT1054094	hsa-miR-4802-5p	CLIP-seq
MIRT1054095	hsa-miR-507	CLIP-seq
MIRT1054096	hsa-miR-5096	CLIP-seq
MIRT1054097	hsa-miR-557	CLIP-seq
MIRT1054098	hsa-miR-558	CLIP-seq
MIRT1054099	hsa-miR-579	CLIP-seq
MIRT1054100	hsa-miR-659	CLIP-seq
MIRT1054101	hsa-miR-664	CLIP-seq
MIRT1054102	hsa-miR-665	CLIP-seq
MIRT1054103	hsa-miR-668	CLIP-seq
MIRT1054104	hsa-miR-889	CLIP-seq
MIRT2012253	hsa-miR-1200	CLIP-seq
MIRT2012254	hsa-miR-1237	CLIP-seq
MIRT2012255	hsa-miR-128	CLIP-seq
MIRT2012256	hsa-miR-138	CLIP-seq
MIRT2012257	hsa-miR-1913	CLIP-seq
MIRT1054052	hsa-miR-2114	CLIP-seq
MIRT2012258	hsa-miR-299-3p	CLIP-seq
MIRT1054057	hsa-miR-3127-3p	CLIP-seq
MIRT2012259	hsa-miR-3144-5p	CLIP-seq
MIRT2012260	hsa-miR-3151	CLIP-seq
MIRT2012261	hsa-miR-3176	CLIP-seq
MIRT2012262	hsa-miR-3191	CLIP-seq
MIRT2012263	hsa-miR-324-3p	CLIP-seq
MIRT2012264	hsa-miR-3663-3p	CLIP-seq
MIRT1054066	hsa-miR-3664-3p	CLIP-seq
MIRT2012265	hsa-miR-3922-3p	CLIP-seq
MIRT2012266	hsa-miR-4324	CLIP-seq
MIRT2012267	hsa-miR-4435	CLIP-seq
MIRT1054073	hsa-miR-4436a	CLIP-seq
MIRT2012268	hsa-miR-4447	CLIP-seq
MIRT2012269	hsa-miR-4472	CLIP-seq
MIRT2012270	hsa-miR-4652-5p	CLIP-seq
MIRT2012271	hsa-miR-4659a-3p	CLIP-seq
MIRT2012272	hsa-miR-4659b-3p	CLIP-seq
MIRT2012273	hsa-miR-4690-5p	CLIP-seq
MIRT2012274	hsa-miR-4725-5p	CLIP-seq
MIRT2012275	hsa-miR-4749-3p	CLIP-seq
MIRT2012276	hsa-miR-491-5p	CLIP-seq
MIRT2012277	hsa-miR-504	CLIP-seq
MIRT2012278	hsa-miR-544b	CLIP-seq
MIRT1054049	hsa-miR-1915	CLIP-seq
MIRT2244642	hsa-miR-2467-3p	CLIP-seq
MIRT2244643	hsa-miR-3158-5p	CLIP-seq
MIRT2244644	hsa-miR-3194-5p	CLIP-seq
MIRT2244645	hsa-miR-3622a-3p	CLIP-seq
MIRT2244646	hsa-miR-3622b-3p	CLIP-seq
MIRT1054066	hsa-miR-3664-3p	CLIP-seq
MIRT2244647	hsa-miR-3678-3p	CLIP-seq
MIRT2244648	hsa-miR-3919	CLIP-seq
MIRT2244649	hsa-miR-412	CLIP-seq
MIRT1054073	hsa-miR-4436a	CLIP-seq
MIRT2244650	hsa-miR-451b	CLIP-seq
MIRT1054080	hsa-miR-4520a-3p	CLIP-seq
MIRT2012271	hsa-miR-4659a-3p	CLIP-seq
MIRT2012272	hsa-miR-4659b-3p	CLIP-seq
MIRT1054087	hsa-miR-4726-3p	CLIP-seq
MIRT1054092	hsa-miR-4768-5p	CLIP-seq
MIRT1054096	hsa-miR-5096	CLIP-seq
MIRT2244651	hsa-miR-873	CLIP-seq
MIRT2012254	hsa-miR-1237	CLIP-seq
MIRT2389152	hsa-miR-1248	CLIP-seq
MIRT2389153	hsa-miR-4711-3p	CLIP-seq
MIRT2389154	hsa-miR-599	CLIP-seq
MIRT2389155	hsa-miR-942	CLIP-seq
MIRT1054059	hsa-miR-3134	CLIP-seq
MIRT2437640	hsa-miR-3156-5p	CLIP-seq
MIRT1054063	hsa-miR-323-5p	CLIP-seq
MIRT1054069	hsa-miR-4281	CLIP-seq
MIRT1054081	hsa-miR-4534	CLIP-seq

Show/Hide all (10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005246	Function	Calcium channel regulator activity	IEA
GO:0005509	Function	Calcium ion binding	IBA
GO:0005509	Function	Calcium ion binding	IEA
GO:0005509	Function	Calcium ion binding	TAS	10520747
GO:0005515	Function	Protein binding	IPI	16189514, 25416956, 25519916, 28514442, 32296183, 32814053, 33961781
GO:0007417	Process	Central nervous system development	TAS	10520747
GO:0009408	Process	Response to heat	IEA
GO:0009966	Process	Regulation of signal transduction	IBA
GO:0019904	Function	Protein domain specific binding	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
619211	18212	ENSG00000116983

Q9UM19

Protein name

Hippocalcin-like protein 4 (HLP4)

Protein function

May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00036	EF-hand_1	64 → 92	EF hand	Domain
PF13499	EF-hand_7	98 → 176	EF-hand domain pair	Domain

Sequence

MGKTNSKLAPEVLEDLVQNTEFSEQELKQWYKGFLKDCPSGILNLEEFQQLYIKFFPYGD
ASKFAQHAFRTFDKNGDGTIDFREFICALSVTSRGSFEQKLNWAFEMYDLDGDGRITRLE
MLEIIEAIYKMVGTVIMMRMNQDGLTPQQRVDKIFKKMDQDKDDQITLEEFKEAAKSDPS
IVLLLQCDMQK

Sequence length

191

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE ABUSE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Lymphoma Large B Cell Diffuse	Associate	31485671	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	23825647	★★★★★ ★☆☆☆☆ Found in Text Mining only

HPCAL4 (hippocalcin like 4)