Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5144
Gene name Gene Name - the full gene name approved by the HGNC.	Phosphodiesterase 4D
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PDE4D
Synonyms (NCBI Gene) Gene synonyms aliases	ACRDYS2, DPDE3, HSPDE4D, PDE43, PDE4DN2, STRK1
Disease Acronyms (UniProt) Disease acronyms from UniProt database	ACRDYS2
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5q11.2-q12.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes one of four mammalian counterparts to the fruit fly `dunce` gene. The encoded protein has 3`,5`-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses

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SNP ID	Visualize variation	Clinical significance	Consequence
rs387906744	T>G	Pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant
rs397514464	G>T	Pathogenic	Missense variant, genic upstream transcript variant, genic downstream transcript variant, coding sequence variant, 5 prime UTR variant
rs397514465	A>C,G	Pathogenic	Missense variant, genic upstream transcript variant, genic downstream transcript variant, coding sequence variant, 5 prime UTR variant
rs397514466	A>C	Pathogenic	Genic upstream transcript variant, coding sequence variant, missense variant, 5 prime UTR variant
rs397514467	T>G	Pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant
rs397514468	G>C	Pathogenic	Missense variant, genic upstream transcript variant, genic downstream transcript variant, coding sequence variant, 5 prime UTR variant
rs397514469	C>T	Pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant
rs397515433	G>A	Pathogenic	Genic upstream transcript variant, genic downstream transcript variant, coding sequence variant, missense variant
rs587777188	A>G	Pathogenic	Coding sequence variant, missense variant, genic downstream transcript variant
rs1057520731	A>C	Pathogenic	Genic upstream transcript variant, genic downstream transcript variant, missense variant, coding sequence variant, 5 prime UTR variant
rs1554033904	T>C	Likely-pathogenic	Coding sequence variant, missense variant, genic downstream transcript variant
rs1554033934	T>C	Uncertain-significance, pathogenic	Coding sequence variant, missense variant, genic downstream transcript variant
rs1554039692	A>C	Likely-pathogenic	Coding sequence variant, missense variant, genic downstream transcript variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018254	hsa-miR-335-5p	Microarray	18185580
MIRT019645	hsa-miR-340-5p	Sequencing	20371350
MIRT025858	hsa-miR-7-5p	Microarray	17612493
MIRT027087	hsa-miR-103a-3p	Sequencing	20371350
MIRT031236	hsa-miR-19b-3p	Sequencing	20371350
MIRT031356	hsa-miR-18a-5p	Sequencing	20371350
MIRT031849	hsa-miR-16-5p	Sequencing	20371350
MIRT700987	hsa-miR-424-3p	HITS-CLIP	23313552
MIRT700986	hsa-miR-3646	HITS-CLIP	23313552
MIRT700985	hsa-miR-3120-3p	HITS-CLIP	23313552
MIRT700984	hsa-miR-6888-5p	HITS-CLIP	23313552
MIRT700983	hsa-miR-6080	HITS-CLIP	23313552
MIRT700982	hsa-miR-642a-3p	HITS-CLIP	23313552
MIRT700981	hsa-miR-642b-3p	HITS-CLIP	23313552
MIRT700980	hsa-miR-4266	HITS-CLIP	23313552
MIRT700979	hsa-miR-4325	HITS-CLIP	23313552
MIRT700978	hsa-miR-3611	HITS-CLIP	23313552
MIRT471502	hsa-miR-548ac	PAR-CLIP	21572407
MIRT471500	hsa-miR-548bb-3p	PAR-CLIP	21572407
MIRT471499	hsa-miR-548d-3p	PAR-CLIP	21572407
MIRT471498	hsa-miR-548h-3p	PAR-CLIP	21572407
MIRT471497	hsa-miR-548z	PAR-CLIP	21572407
MIRT471496	hsa-miR-6835-3p	PAR-CLIP	21572407
MIRT555726	hsa-miR-4422	PAR-CLIP	21572407
MIRT471495	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT471494	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT031849	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT471493	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT471492	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT471491	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT471490	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT471489	hsa-miR-6783-5p	PAR-CLIP	21572407
MIRT471488	hsa-miR-142-5p	PAR-CLIP	21572407
MIRT471487	hsa-miR-5590-3p	PAR-CLIP	21572407
MIRT471486	hsa-miR-4457	PAR-CLIP	21572407
MIRT471484	hsa-miR-3148	PAR-CLIP	21572407
MIRT471485	hsa-miR-4668-5p	PAR-CLIP	21572407
MIRT019645	hsa-miR-340-5p	PAR-CLIP	21572407
MIRT535444	hsa-miR-1324	PAR-CLIP	22012620
MIRT535443	hsa-miR-4682	PAR-CLIP	22012620
MIRT535442	hsa-miR-4502	PAR-CLIP	22012620
MIRT535441	hsa-miR-4513	PAR-CLIP	22012620
MIRT535440	hsa-miR-6855-3p	PAR-CLIP	22012620
MIRT535439	hsa-miR-6857-3p	PAR-CLIP	22012620
MIRT535438	hsa-miR-3136-5p	PAR-CLIP	22012620
MIRT535437	hsa-miR-4439	PAR-CLIP	22012620
MIRT471508	hsa-miR-4735-3p	PAR-CLIP	23592263
MIRT471507	hsa-miR-18b-5p	PAR-CLIP	23592263
MIRT031356	hsa-miR-18a-5p	PAR-CLIP	23592263
MIRT471506	hsa-miR-4282	PAR-CLIP	23592263
MIRT471505	hsa-miR-4760-3p	PAR-CLIP	23592263
MIRT471501	hsa-miR-7158-3p	PAR-CLIP	23592263
MIRT471508	hsa-miR-4735-3p	PAR-CLIP	23592263
MIRT471507	hsa-miR-18b-5p	PAR-CLIP	23592263
MIRT031356	hsa-miR-18a-5p	PAR-CLIP	23592263
MIRT471506	hsa-miR-4282	PAR-CLIP	23592263
MIRT471505	hsa-miR-4760-3p	PAR-CLIP	23592263
MIRT471504	hsa-miR-302f	PAR-CLIP	23592263
MIRT471503	hsa-miR-31-3p	PAR-CLIP	23592263
MIRT471501	hsa-miR-7158-3p	PAR-CLIP	23592263
MIRT471502	hsa-miR-548ac	PAR-CLIP	23592263
MIRT471500	hsa-miR-548bb-3p	PAR-CLIP	23592263
MIRT471499	hsa-miR-548d-3p	PAR-CLIP	23592263
MIRT471498	hsa-miR-548h-3p	PAR-CLIP	23592263
MIRT471497	hsa-miR-548z	PAR-CLIP	23592263
MIRT471496	hsa-miR-6835-3p	PAR-CLIP	23592263
MIRT471495	hsa-miR-15a-5p	PAR-CLIP	23592263
MIRT471494	hsa-miR-15b-5p	PAR-CLIP	23592263
MIRT031849	hsa-miR-16-5p	PAR-CLIP	23592263
MIRT471493	hsa-miR-195-5p	PAR-CLIP	23592263
MIRT471492	hsa-miR-424-5p	PAR-CLIP	23592263
MIRT471491	hsa-miR-497-5p	PAR-CLIP	23592263
MIRT471490	hsa-miR-6838-5p	PAR-CLIP	23592263
MIRT471489	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT471488	hsa-miR-142-5p	PAR-CLIP	23592263
MIRT471487	hsa-miR-5590-3p	PAR-CLIP	23592263
MIRT471486	hsa-miR-4457	PAR-CLIP	23592263
MIRT471484	hsa-miR-3148	PAR-CLIP	23592263
MIRT471485	hsa-miR-4668-5p	PAR-CLIP	23592263
MIRT756380	hsa-miR-139-5p	Immunoblot, Luciferase reporter assay, qRT-PCR	27383270
MIRT735265	hsa-miR-105-5p	Luciferase reporter assay, Western blotting, qRT-PCR	33985571
MIRT736009	hsa-miR-373-3p	Western blotting, qRT-PCR	31572429
MIRT700987	hsa-miR-424-3p	HITS-CLIP	23313552
MIRT700986	hsa-miR-3646	HITS-CLIP	23313552
MIRT700985	hsa-miR-3120-3p	HITS-CLIP	23313552
MIRT700984	hsa-miR-6888-5p	HITS-CLIP	23313552
MIRT700983	hsa-miR-6080	HITS-CLIP	23313552
MIRT700982	hsa-miR-642a-3p	HITS-CLIP	23313552
MIRT700981	hsa-miR-642b-3p	HITS-CLIP	23313552
MIRT700980	hsa-miR-4266	HITS-CLIP	23313552
MIRT700979	hsa-miR-4325	HITS-CLIP	23313552
MIRT700978	hsa-miR-3611	HITS-CLIP	23313552
MIRT471502	hsa-miR-548ac	PAR-CLIP	21572407
MIRT471500	hsa-miR-548bb-3p	PAR-CLIP	21572407
MIRT471499	hsa-miR-548d-3p	PAR-CLIP	21572407
MIRT471498	hsa-miR-548h-3p	PAR-CLIP	21572407
MIRT471497	hsa-miR-548z	PAR-CLIP	21572407
MIRT471496	hsa-miR-6835-3p	PAR-CLIP	21572407
MIRT555726	hsa-miR-4422	PAR-CLIP	21572407
MIRT471495	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT471494	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT031849	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT471493	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT471492	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT471491	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT471490	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT471489	hsa-miR-6783-5p	PAR-CLIP	21572407
MIRT471488	hsa-miR-142-5p	PAR-CLIP	21572407
MIRT471487	hsa-miR-5590-3p	PAR-CLIP	21572407
MIRT471486	hsa-miR-4457	PAR-CLIP	21572407
MIRT471484	hsa-miR-3148	PAR-CLIP	21572407
MIRT471485	hsa-miR-4668-5p	PAR-CLIP	21572407
MIRT019645	hsa-miR-340-5p	PAR-CLIP	21572407
MIRT535444	hsa-miR-1324	PAR-CLIP	22012620
MIRT535443	hsa-miR-4682	PAR-CLIP	22012620
MIRT535442	hsa-miR-4502	PAR-CLIP	22012620
MIRT535441	hsa-miR-4513	PAR-CLIP	22012620
MIRT535440	hsa-miR-6855-3p	PAR-CLIP	22012620
MIRT535439	hsa-miR-6857-3p	PAR-CLIP	22012620
MIRT535438	hsa-miR-3136-5p	PAR-CLIP	22012620
MIRT535437	hsa-miR-4439	PAR-CLIP	22012620
MIRT471508	hsa-miR-4735-3p	PAR-CLIP	23592263
MIRT471507	hsa-miR-18b-5p	PAR-CLIP	23592263
MIRT031356	hsa-miR-18a-5p	PAR-CLIP	23592263
MIRT471506	hsa-miR-4282	PAR-CLIP	23592263
MIRT471505	hsa-miR-4760-3p	PAR-CLIP	23592263
MIRT471501	hsa-miR-7158-3p	PAR-CLIP	23592263
MIRT471508	hsa-miR-4735-3p	PAR-CLIP	23592263
MIRT471507	hsa-miR-18b-5p	PAR-CLIP	23592263
MIRT031356	hsa-miR-18a-5p	PAR-CLIP	23592263
MIRT471506	hsa-miR-4282	PAR-CLIP	23592263
MIRT471505	hsa-miR-4760-3p	PAR-CLIP	23592263
MIRT471504	hsa-miR-302f	PAR-CLIP	23592263
MIRT471503	hsa-miR-31-3p	PAR-CLIP	23592263
MIRT471501	hsa-miR-7158-3p	PAR-CLIP	23592263
MIRT471502	hsa-miR-548ac	PAR-CLIP	23592263
MIRT471500	hsa-miR-548bb-3p	PAR-CLIP	23592263
MIRT471499	hsa-miR-548d-3p	PAR-CLIP	23592263
MIRT471498	hsa-miR-548h-3p	PAR-CLIP	23592263
MIRT471497	hsa-miR-548z	PAR-CLIP	23592263
MIRT471496	hsa-miR-6835-3p	PAR-CLIP	23592263
MIRT471495	hsa-miR-15a-5p	PAR-CLIP	23592263
MIRT471494	hsa-miR-15b-5p	PAR-CLIP	23592263
MIRT031849	hsa-miR-16-5p	PAR-CLIP	23592263
MIRT471493	hsa-miR-195-5p	PAR-CLIP	23592263
MIRT471492	hsa-miR-424-5p	PAR-CLIP	23592263
MIRT471491	hsa-miR-497-5p	PAR-CLIP	23592263
MIRT471490	hsa-miR-6838-5p	PAR-CLIP	23592263
MIRT471489	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT471488	hsa-miR-142-5p	PAR-CLIP	23592263
MIRT471487	hsa-miR-5590-3p	PAR-CLIP	23592263
MIRT471486	hsa-miR-4457	PAR-CLIP	23592263
MIRT471484	hsa-miR-3148	PAR-CLIP	23592263
MIRT471485	hsa-miR-4668-5p	PAR-CLIP	23592263
MIRT756308	hsa-miR-370-5p	qRT-PCR	38247802
MIRT756380	hsa-miR-139-5p	Luciferase reporter assay, Western blotting	37794118
MIRT1220599	hsa-miR-101	CLIP-seq
MIRT1220600	hsa-miR-144	CLIP-seq
MIRT1220601	hsa-miR-2355-5p	CLIP-seq
MIRT1220602	hsa-miR-24	CLIP-seq
MIRT1220603	hsa-miR-323b-3p	CLIP-seq
MIRT1220604	hsa-miR-361-5p	CLIP-seq
MIRT1220605	hsa-miR-3679-3p	CLIP-seq
MIRT1220606	hsa-miR-4284	CLIP-seq
MIRT1220607	hsa-miR-4446-5p	CLIP-seq
MIRT1220608	hsa-miR-4452	CLIP-seq
MIRT1220609	hsa-miR-4474-3p	CLIP-seq
MIRT1220610	hsa-miR-4490	CLIP-seq
MIRT1220611	hsa-miR-4520a-3p	CLIP-seq
MIRT1220612	hsa-miR-4520b-3p	CLIP-seq
MIRT1220613	hsa-miR-4793-5p	CLIP-seq
MIRT1220614	hsa-miR-890	CLIP-seq
MIRT1220615	hsa-miR-1184	CLIP-seq
MIRT1220616	hsa-miR-1257	CLIP-seq
MIRT1220617	hsa-miR-1275	CLIP-seq
MIRT1220618	hsa-miR-1301	CLIP-seq
MIRT1220619	hsa-miR-145	CLIP-seq
MIRT1220620	hsa-miR-148a	CLIP-seq
MIRT1220621	hsa-miR-148b	CLIP-seq
MIRT1220622	hsa-miR-152	CLIP-seq
MIRT1220623	hsa-miR-15a	CLIP-seq
MIRT1220624	hsa-miR-15b	CLIP-seq
MIRT1220625	hsa-miR-16	CLIP-seq
MIRT1220626	hsa-miR-195	CLIP-seq
MIRT1220627	hsa-miR-223	CLIP-seq
MIRT1220601	hsa-miR-2355-5p	CLIP-seq
MIRT1220628	hsa-miR-2467-5p	CLIP-seq
MIRT1220629	hsa-miR-3065-5p	CLIP-seq
MIRT1220630	hsa-miR-3180-5p	CLIP-seq
MIRT1220631	hsa-miR-320a	CLIP-seq
MIRT1220632	hsa-miR-320b	CLIP-seq
MIRT1220633	hsa-miR-320c	CLIP-seq
MIRT1220634	hsa-miR-320d	CLIP-seq
MIRT1220635	hsa-miR-323-3p	CLIP-seq
MIRT1220636	hsa-miR-3668	CLIP-seq
MIRT1220637	hsa-miR-375	CLIP-seq
MIRT1220638	hsa-miR-3944-5p	CLIP-seq
MIRT1220639	hsa-miR-3974	CLIP-seq
MIRT1220640	hsa-miR-410	CLIP-seq
MIRT1220641	hsa-miR-421	CLIP-seq
MIRT1220642	hsa-miR-424	CLIP-seq
MIRT1220643	hsa-miR-4273	CLIP-seq
MIRT1220644	hsa-miR-4307	CLIP-seq
MIRT1220645	hsa-miR-4328	CLIP-seq
MIRT1220646	hsa-miR-4420	CLIP-seq
MIRT1220647	hsa-miR-4429	CLIP-seq
MIRT1220648	hsa-miR-4446-3p	CLIP-seq
MIRT1220649	hsa-miR-4448	CLIP-seq
MIRT1220650	hsa-miR-4459	CLIP-seq
MIRT1220651	hsa-miR-4525	CLIP-seq
MIRT1220652	hsa-miR-4660	CLIP-seq
MIRT1220653	hsa-miR-4665-5p	CLIP-seq
MIRT1220654	hsa-miR-4668-3p	CLIP-seq
MIRT1220655	hsa-miR-4677-5p	CLIP-seq
MIRT1220656	hsa-miR-4695-5p	CLIP-seq
MIRT1220657	hsa-miR-4697-3p	CLIP-seq
MIRT1220658	hsa-miR-4698	CLIP-seq
MIRT1220659	hsa-miR-4723-5p	CLIP-seq
MIRT1220660	hsa-miR-4724-5p	CLIP-seq
MIRT1220661	hsa-miR-4732-5p	CLIP-seq
MIRT1220662	hsa-miR-4761-5p	CLIP-seq
MIRT1220663	hsa-miR-485-3p	CLIP-seq
MIRT1220664	hsa-miR-495	CLIP-seq
MIRT1220665	hsa-miR-496	CLIP-seq
MIRT1220666	hsa-miR-497	CLIP-seq
MIRT1220667	hsa-miR-5047	CLIP-seq
MIRT1220668	hsa-miR-513a-3p	CLIP-seq
MIRT1220669	hsa-miR-548v	CLIP-seq
MIRT1220670	hsa-miR-582-5p	CLIP-seq
MIRT1220671	hsa-miR-625	CLIP-seq
MIRT1220672	hsa-miR-665	CLIP-seq
MIRT1220673	hsa-miR-944	CLIP-seq
MIRT1220644	hsa-miR-4307	CLIP-seq
MIRT2063667	hsa-miR-4635	CLIP-seq
MIRT2063668	hsa-miR-4753-3p	CLIP-seq
MIRT2063669	hsa-miR-513c	CLIP-seq
MIRT2063670	hsa-miR-514b-5p	CLIP-seq
MIRT2063671	hsa-miR-526b	CLIP-seq
MIRT2063672	hsa-miR-548c-3p	CLIP-seq
MIRT2063673	hsa-miR-578	CLIP-seq
MIRT1220599	hsa-miR-101	CLIP-seq
MIRT1220600	hsa-miR-144	CLIP-seq
MIRT2292129	hsa-miR-1470	CLIP-seq
MIRT1220629	hsa-miR-3065-5p	CLIP-seq
MIRT2292130	hsa-miR-4496	CLIP-seq
MIRT2292131	hsa-miR-4782-5p	CLIP-seq
MIRT1220664	hsa-miR-495	CLIP-seq
MIRT2292132	hsa-miR-507	CLIP-seq
MIRT2292133	hsa-miR-545	CLIP-seq
MIRT2292134	hsa-miR-548p	CLIP-seq
MIRT2292135	hsa-miR-557	CLIP-seq
MIRT2292136	hsa-miR-562	CLIP-seq
MIRT2292137	hsa-miR-607	CLIP-seq
MIRT1220670	hsa-miR-582-5p	CLIP-seq
MIRT2456102	hsa-miR-323b-5p	CLIP-seq
MIRT2456103	hsa-miR-3942-3p	CLIP-seq
MIRT2456104	hsa-miR-4257	CLIP-seq
MIRT2456105	hsa-miR-4305	CLIP-seq
MIRT2456106	hsa-miR-4330	CLIP-seq
MIRT2456107	hsa-miR-4724-3p	CLIP-seq
MIRT2589793	hsa-miR-1224-3p	CLIP-seq
MIRT2589794	hsa-miR-1236	CLIP-seq
MIRT2589795	hsa-miR-1254	CLIP-seq
MIRT2589796	hsa-miR-1265	CLIP-seq
MIRT2589797	hsa-miR-1278	CLIP-seq
MIRT2589798	hsa-miR-1285	CLIP-seq
MIRT2589799	hsa-miR-141	CLIP-seq
MIRT1220619	hsa-miR-145	CLIP-seq
MIRT2589800	hsa-miR-200a	CLIP-seq
MIRT2589801	hsa-miR-203	CLIP-seq
MIRT2589802	hsa-miR-2053	CLIP-seq
MIRT2589803	hsa-miR-2054	CLIP-seq
MIRT1220601	hsa-miR-2355-5p	CLIP-seq
MIRT1220628	hsa-miR-2467-5p	CLIP-seq
MIRT2589804	hsa-miR-2909	CLIP-seq
MIRT2589805	hsa-miR-2964a-5p	CLIP-seq
MIRT2589806	hsa-miR-299-5p	CLIP-seq
MIRT2589807	hsa-miR-3064-5p	CLIP-seq
MIRT2589808	hsa-miR-3074-5p	CLIP-seq
MIRT2589809	hsa-miR-3116	CLIP-seq
MIRT2589810	hsa-miR-3121-3p	CLIP-seq
MIRT2589811	hsa-miR-3121-5p	CLIP-seq
MIRT2589812	hsa-miR-3127-3p	CLIP-seq
MIRT2589813	hsa-miR-3144-5p	CLIP-seq
MIRT2589814	hsa-miR-3152-5p	CLIP-seq
MIRT2589815	hsa-miR-3159	CLIP-seq
MIRT1220630	hsa-miR-3180-5p	CLIP-seq
MIRT2589816	hsa-miR-3187-3p	CLIP-seq
MIRT2589817	hsa-miR-3187-5p	CLIP-seq
MIRT2589818	hsa-miR-3190	CLIP-seq
MIRT2589819	hsa-miR-3191	CLIP-seq
MIRT2589820	hsa-miR-3192	CLIP-seq
MIRT2589821	hsa-miR-3198	CLIP-seq
MIRT2589822	hsa-miR-330-3p	CLIP-seq
MIRT2589823	hsa-miR-340	CLIP-seq
MIRT2589824	hsa-miR-3605-5p	CLIP-seq
MIRT2589825	hsa-miR-3647-3p	CLIP-seq
MIRT2589826	hsa-miR-3657	CLIP-seq
MIRT2589827	hsa-miR-3681	CLIP-seq
MIRT2589828	hsa-miR-3689a-3p	CLIP-seq
MIRT2589829	hsa-miR-3689c	CLIP-seq
MIRT2589830	hsa-miR-370	CLIP-seq
MIRT2589831	hsa-miR-377	CLIP-seq
MIRT2589832	hsa-miR-380	CLIP-seq
MIRT2589833	hsa-miR-3913-3p	CLIP-seq
MIRT2589834	hsa-miR-4278	CLIP-seq
MIRT2589835	hsa-miR-4291	CLIP-seq
MIRT2456105	hsa-miR-4305	CLIP-seq
MIRT1220644	hsa-miR-4307	CLIP-seq
MIRT2589836	hsa-miR-4309	CLIP-seq
MIRT2589837	hsa-miR-4310	CLIP-seq
MIRT1220648	hsa-miR-4446-3p	CLIP-seq
MIRT1220649	hsa-miR-4448	CLIP-seq
MIRT1220650	hsa-miR-4459	CLIP-seq
MIRT2589838	hsa-miR-4460	CLIP-seq
MIRT2589839	hsa-miR-4477b	CLIP-seq
MIRT2589840	hsa-miR-4492	CLIP-seq
MIRT2589841	hsa-miR-4495	CLIP-seq
MIRT2292130	hsa-miR-4496	CLIP-seq
MIRT2589842	hsa-miR-4498	CLIP-seq
MIRT2589843	hsa-miR-4505	CLIP-seq
MIRT2589844	hsa-miR-452	CLIP-seq
MIRT2589845	hsa-miR-4528	CLIP-seq
MIRT2589846	hsa-miR-4529-5p	CLIP-seq
MIRT2063667	hsa-miR-4635	CLIP-seq
MIRT2589847	hsa-miR-4639-3p	CLIP-seq
MIRT2589848	hsa-miR-4652-5p	CLIP-seq
MIRT2589849	hsa-miR-4659a-3p	CLIP-seq
MIRT2589850	hsa-miR-4659b-3p	CLIP-seq
MIRT2589851	hsa-miR-4676-3p	CLIP-seq
MIRT2589852	hsa-miR-4686	CLIP-seq
MIRT2589853	hsa-miR-4688	CLIP-seq
MIRT1220656	hsa-miR-4695-5p	CLIP-seq
MIRT2589854	hsa-miR-4699-5p	CLIP-seq
MIRT2589855	hsa-miR-4711-3p	CLIP-seq
MIRT2589856	hsa-miR-4714-5p	CLIP-seq
MIRT2456107	hsa-miR-4724-3p	CLIP-seq
MIRT2589857	hsa-miR-4727-3p	CLIP-seq
MIRT2589858	hsa-miR-4728-5p	CLIP-seq
MIRT2589859	hsa-miR-4738-3p	CLIP-seq
MIRT2589860	hsa-miR-4762-5p	CLIP-seq
MIRT2589861	hsa-miR-4766-5p	CLIP-seq
MIRT2589862	hsa-miR-4774-3p	CLIP-seq
MIRT2589863	hsa-miR-488	CLIP-seq
MIRT2589864	hsa-miR-489	CLIP-seq
MIRT2292133	hsa-miR-545	CLIP-seq
MIRT2589865	hsa-miR-548ae	CLIP-seq
MIRT2589866	hsa-miR-548aj	CLIP-seq
MIRT2589867	hsa-miR-548am	CLIP-seq
MIRT2292134	hsa-miR-548p	CLIP-seq
MIRT2589868	hsa-miR-548x	CLIP-seq
MIRT2292136	hsa-miR-562	CLIP-seq
MIRT2589869	hsa-miR-570	CLIP-seq
MIRT2589870	hsa-miR-579	CLIP-seq
MIRT2589871	hsa-miR-587	CLIP-seq
MIRT2589872	hsa-miR-590-3p	CLIP-seq
MIRT2589873	hsa-miR-606	CLIP-seq
MIRT2292137	hsa-miR-607	CLIP-seq
MIRT2589874	hsa-miR-612	CLIP-seq
MIRT2589875	hsa-miR-629	CLIP-seq
MIRT2589876	hsa-miR-642b	CLIP-seq
MIRT2589877	hsa-miR-651	CLIP-seq
MIRT2589878	hsa-miR-659	CLIP-seq
MIRT2589879	hsa-miR-661	CLIP-seq
MIRT1220672	hsa-miR-665	CLIP-seq
MIRT2589880	hsa-miR-7	CLIP-seq
MIRT2589881	hsa-miR-762	CLIP-seq
MIRT2589882	hsa-miR-885-5p	CLIP-seq
MIRT2589883	hsa-miR-888	CLIP-seq
MIRT1220614	hsa-miR-890	CLIP-seq
MIRT2589884	hsa-miR-892a	CLIP-seq
MIRT2589885	hsa-miR-935	CLIP-seq
MIRT1220673	hsa-miR-944	CLIP-seq
MIRT2589811	hsa-miR-3121-5p	CLIP-seq
MIRT2589831	hsa-miR-377	CLIP-seq
MIRT2456107	hsa-miR-4724-3p	CLIP-seq
MIRT2292133	hsa-miR-545	CLIP-seq
MIRT2292134	hsa-miR-548p	CLIP-seq
MIRT2687377	hsa-miR-103a	CLIP-seq
MIRT2687378	hsa-miR-105	CLIP-seq
MIRT2687379	hsa-miR-107	CLIP-seq
MIRT1220615	hsa-miR-1184	CLIP-seq
MIRT2687380	hsa-miR-1193	CLIP-seq
MIRT2589793	hsa-miR-1224-3p	CLIP-seq
MIRT2589794	hsa-miR-1236	CLIP-seq
MIRT2687381	hsa-miR-1238	CLIP-seq
MIRT2687382	hsa-miR-124	CLIP-seq
MIRT2589795	hsa-miR-1254	CLIP-seq
MIRT2589796	hsa-miR-1265	CLIP-seq
MIRT2589797	hsa-miR-1278	CLIP-seq
MIRT2589798	hsa-miR-1285	CLIP-seq
MIRT2687383	hsa-miR-1291	CLIP-seq
MIRT1220618	hsa-miR-1301	CLIP-seq
MIRT2589799	hsa-miR-141	CLIP-seq
MIRT1220600	hsa-miR-144	CLIP-seq
MIRT1220619	hsa-miR-145	CLIP-seq
MIRT2687384	hsa-miR-150	CLIP-seq
MIRT2687385	hsa-miR-19a	CLIP-seq
MIRT2687386	hsa-miR-19b	CLIP-seq
MIRT2589800	hsa-miR-200a	CLIP-seq
MIRT2589801	hsa-miR-203	CLIP-seq
MIRT2589802	hsa-miR-2053	CLIP-seq
MIRT2589803	hsa-miR-2054	CLIP-seq
MIRT1220601	hsa-miR-2355-5p	CLIP-seq
MIRT2687387	hsa-miR-2392	CLIP-seq
MIRT1220628	hsa-miR-2467-5p	CLIP-seq
MIRT2589804	hsa-miR-2909	CLIP-seq
MIRT2589805	hsa-miR-2964a-5p	CLIP-seq
MIRT2589806	hsa-miR-299-5p	CLIP-seq
MIRT2589807	hsa-miR-3064-5p	CLIP-seq
MIRT2589808	hsa-miR-3074-5p	CLIP-seq
MIRT2589809	hsa-miR-3116	CLIP-seq
MIRT2589810	hsa-miR-3121-3p	CLIP-seq
MIRT2589811	hsa-miR-3121-5p	CLIP-seq
MIRT2589812	hsa-miR-3127-3p	CLIP-seq
MIRT2589813	hsa-miR-3144-5p	CLIP-seq
MIRT2589814	hsa-miR-3152-5p	CLIP-seq
MIRT2687388	hsa-miR-3156-3p	CLIP-seq
MIRT2589815	hsa-miR-3159	CLIP-seq
MIRT2687389	hsa-miR-3173-5p	CLIP-seq
MIRT1220630	hsa-miR-3180-5p	CLIP-seq
MIRT2589816	hsa-miR-3187-3p	CLIP-seq
MIRT2589817	hsa-miR-3187-5p	CLIP-seq
MIRT2589818	hsa-miR-3190	CLIP-seq
MIRT2589819	hsa-miR-3191	CLIP-seq
MIRT2589820	hsa-miR-3192	CLIP-seq
MIRT2687390	hsa-miR-3194-3p	CLIP-seq
MIRT2589821	hsa-miR-3198	CLIP-seq
MIRT2687391	hsa-miR-3200-3p	CLIP-seq
MIRT2589823	hsa-miR-340	CLIP-seq
MIRT2589824	hsa-miR-3605-5p	CLIP-seq
MIRT2589825	hsa-miR-3647-3p	CLIP-seq
MIRT2687392	hsa-miR-3649	CLIP-seq
MIRT2589826	hsa-miR-3657	CLIP-seq
MIRT2687393	hsa-miR-3664-5p	CLIP-seq
MIRT2687394	hsa-miR-3671	CLIP-seq
MIRT2589827	hsa-miR-3681	CLIP-seq
MIRT2589828	hsa-miR-3689a-3p	CLIP-seq
MIRT2589829	hsa-miR-3689c	CLIP-seq
MIRT2687395	hsa-miR-3689d	CLIP-seq
MIRT2589830	hsa-miR-370	CLIP-seq
MIRT2687396	hsa-miR-3714	CLIP-seq
MIRT2589831	hsa-miR-377	CLIP-seq
MIRT2589832	hsa-miR-380	CLIP-seq
MIRT2687397	hsa-miR-3908	CLIP-seq
MIRT2687398	hsa-miR-3910	CLIP-seq
MIRT2589833	hsa-miR-3913-3p	CLIP-seq
MIRT2687399	hsa-miR-3925-3p	CLIP-seq
MIRT2687400	hsa-miR-3942-5p	CLIP-seq
MIRT2687401	hsa-miR-3977	CLIP-seq
MIRT2687402	hsa-miR-409-5p	CLIP-seq
MIRT2687403	hsa-miR-423-3p	CLIP-seq
MIRT2589834	hsa-miR-4278	CLIP-seq
MIRT2589835	hsa-miR-4291	CLIP-seq
MIRT2687404	hsa-miR-4292	CLIP-seq
MIRT2687405	hsa-miR-4301	CLIP-seq
MIRT2456105	hsa-miR-4305	CLIP-seq
MIRT1220644	hsa-miR-4307	CLIP-seq
MIRT2589836	hsa-miR-4309	CLIP-seq
MIRT2589837	hsa-miR-4310	CLIP-seq
MIRT1220645	hsa-miR-4328	CLIP-seq
MIRT1220648	hsa-miR-4446-3p	CLIP-seq
MIRT1220649	hsa-miR-4448	CLIP-seq
MIRT1220650	hsa-miR-4459	CLIP-seq
MIRT2589838	hsa-miR-4460	CLIP-seq
MIRT2589839	hsa-miR-4477b	CLIP-seq
MIRT2589840	hsa-miR-4492	CLIP-seq
MIRT2589841	hsa-miR-4495	CLIP-seq
MIRT2292130	hsa-miR-4496	CLIP-seq
MIRT2589842	hsa-miR-4498	CLIP-seq
MIRT2687406	hsa-miR-4499	CLIP-seq
MIRT2589843	hsa-miR-4505	CLIP-seq
MIRT2589844	hsa-miR-452	CLIP-seq
MIRT2589845	hsa-miR-4528	CLIP-seq
MIRT2589846	hsa-miR-4529-5p	CLIP-seq
MIRT2063667	hsa-miR-4635	CLIP-seq
MIRT2589847	hsa-miR-4639-3p	CLIP-seq
MIRT2687407	hsa-miR-4645-5p	CLIP-seq
MIRT2589848	hsa-miR-4652-5p	CLIP-seq
MIRT1220652	hsa-miR-4660	CLIP-seq
MIRT2687408	hsa-miR-4673	CLIP-seq
MIRT2589851	hsa-miR-4676-3p	CLIP-seq
MIRT2589852	hsa-miR-4686	CLIP-seq
MIRT2589853	hsa-miR-4688	CLIP-seq
MIRT1220656	hsa-miR-4695-5p	CLIP-seq
MIRT2589854	hsa-miR-4699-5p	CLIP-seq
MIRT2687409	hsa-miR-4703-5p	CLIP-seq
MIRT2589855	hsa-miR-4711-3p	CLIP-seq
MIRT2687410	hsa-miR-4713-5p	CLIP-seq
MIRT2589856	hsa-miR-4714-5p	CLIP-seq
MIRT2456107	hsa-miR-4724-3p	CLIP-seq
MIRT2589857	hsa-miR-4727-3p	CLIP-seq
MIRT2589858	hsa-miR-4728-5p	CLIP-seq
MIRT2687411	hsa-miR-4734	CLIP-seq
MIRT2589859	hsa-miR-4738-3p	CLIP-seq
MIRT2063668	hsa-miR-4753-3p	CLIP-seq
MIRT1220662	hsa-miR-4761-5p	CLIP-seq
MIRT2589860	hsa-miR-4762-5p	CLIP-seq
MIRT2687412	hsa-miR-4766-3p	CLIP-seq
MIRT2589861	hsa-miR-4766-5p	CLIP-seq
MIRT2687413	hsa-miR-4768-5p	CLIP-seq
MIRT2589862	hsa-miR-4774-3p	CLIP-seq
MIRT2687414	hsa-miR-4802-3p	CLIP-seq
MIRT2687415	hsa-miR-4802-5p	CLIP-seq
MIRT2589864	hsa-miR-489	CLIP-seq
MIRT1220667	hsa-miR-5047	CLIP-seq
MIRT2687416	hsa-miR-506	CLIP-seq
MIRT2687417	hsa-miR-515-5p	CLIP-seq
MIRT2687418	hsa-miR-532-3p	CLIP-seq
MIRT2687419	hsa-miR-532-5p	CLIP-seq
MIRT2292133	hsa-miR-545	CLIP-seq
MIRT2687420	hsa-miR-548a-3p	CLIP-seq
MIRT2589865	hsa-miR-548ae	CLIP-seq
MIRT2589866	hsa-miR-548aj	CLIP-seq
MIRT2589867	hsa-miR-548am	CLIP-seq
MIRT2687421	hsa-miR-548e	CLIP-seq
MIRT2687422	hsa-miR-548f	CLIP-seq
MIRT2292134	hsa-miR-548p	CLIP-seq
MIRT2687423	hsa-miR-548u	CLIP-seq
MIRT2589868	hsa-miR-548x	CLIP-seq
MIRT2687424	hsa-miR-561	CLIP-seq
MIRT2292136	hsa-miR-562	CLIP-seq
MIRT2589869	hsa-miR-570	CLIP-seq
MIRT2589870	hsa-miR-579	CLIP-seq
MIRT2687425	hsa-miR-582-3p	CLIP-seq
MIRT2589871	hsa-miR-587	CLIP-seq
MIRT2589872	hsa-miR-590-3p	CLIP-seq
MIRT2687426	hsa-miR-591	CLIP-seq
MIRT2589873	hsa-miR-606	CLIP-seq
MIRT2292137	hsa-miR-607	CLIP-seq
MIRT2589874	hsa-miR-612	CLIP-seq
MIRT2687427	hsa-miR-624	CLIP-seq
MIRT2589875	hsa-miR-629	CLIP-seq
MIRT2687428	hsa-miR-630	CLIP-seq
MIRT2589876	hsa-miR-642b	CLIP-seq
MIRT2589877	hsa-miR-651	CLIP-seq
MIRT2589878	hsa-miR-659	CLIP-seq
MIRT2589879	hsa-miR-661	CLIP-seq
MIRT1220672	hsa-miR-665	CLIP-seq
MIRT2589880	hsa-miR-7	CLIP-seq
MIRT2687429	hsa-miR-760	CLIP-seq
MIRT2589881	hsa-miR-762	CLIP-seq
MIRT2687430	hsa-miR-766	CLIP-seq
MIRT2589882	hsa-miR-885-5p	CLIP-seq
MIRT2589883	hsa-miR-888	CLIP-seq
MIRT1220614	hsa-miR-890	CLIP-seq
MIRT2589884	hsa-miR-892a	CLIP-seq
MIRT2589885	hsa-miR-935	CLIP-seq
MIRT1220673	hsa-miR-944	CLIP-seq

Show/Hide all(51)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002027	Process	Regulation of heart rate	ISS	16213210
GO:0004114	Function	3',5'-cyclic-nucleotide phosphodiesterase activity	IBA	21873635
GO:0004114	Function	3',5'-cyclic-nucleotide phosphodiesterase activity	NAS	10913353
GO:0004115	Function	3',5'-cyclic-AMP phosphodiesterase activity	IBA	21873635
GO:0004115	Function	3',5'-cyclic-AMP phosphodiesterase activity	IDA	9371713, 17404263
GO:0004115	Function	3',5'-cyclic-AMP phosphodiesterase activity	IGI	8413254
GO:0005515	Function	Protein binding	IPI	17620599, 19955404, 25416956
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005815	Component	Microtubule organizing center	IEA
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0005891	Component	Voltage-gated calcium channel complex	ISS
GO:0006198	Process	CAMP catabolic process	IBA	21873635
GO:0006198	Process	CAMP catabolic process	IEA
GO:0007165	Process	Signal transduction	IBA	21873635
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0010469	Process	Regulation of signaling receptor activity	ISS
GO:0010880	Process	Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	ISS	16213210
GO:0016324	Component	Apical plasma membrane	IEA
GO:0019899	Function	Enzyme binding	ISS	22975349
GO:0019933	Process	CAMP-mediated signaling	NAS	16177794
GO:0030552	Function	CAMP binding	IDA	9371713, 15938621
GO:0031698	Function	Beta-2 adrenergic receptor binding	ISS
GO:0032729	Process	Positive regulation of interferon-gamma production	IMP	17404263
GO:0032743	Process	Positive regulation of interleukin-2 production	IMP	17404263
GO:0032754	Process	Positive regulation of interleukin-5 production	IMP	17404263
GO:0033137	Process	Negative regulation of peptidyl-serine phosphorylation	ISS	16213210
GO:0034704	Component	Calcium channel complex	IDA	16213210
GO:0043951	Process	Negative regulation of cAMP-mediated signaling	IBA	21873635
GO:0043951	Process	Negative regulation of cAMP-mediated signaling	IMP	19252089
GO:0044325	Function	Ion channel binding	IBA	21873635
GO:0044325	Function	Ion channel binding	IPI	16213210
GO:0044325	Function	Ion channel binding	ISS
GO:0045822	Process	Negative regulation of heart contraction	ISS	21903937
GO:0046872	Function	Metal ion binding	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IBA	21873635
GO:0050852	Process	T cell receptor signaling pathway	IMP	17404263
GO:0051117	Function	ATPase binding	IBA	21873635
GO:0051117	Function	ATPase binding	IPI	21903937
GO:0060314	Process	Regulation of ryanodine-sensitive calcium-release channel activity	ISS	16213210
GO:0061028	Process	Establishment of endothelial barrier	ISS
GO:0071875	Process	Adrenergic receptor signaling pathway	ISS
GO:0086004	Process	Regulation of cardiac muscle cell contraction	IBA	21873635
GO:0086004	Process	Regulation of cardiac muscle cell contraction	ISS	21903937
GO:0086024	Process	Adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate	IC
GO:0097110	Function	Scaffold protein binding	IPI	15182229
GO:1901363	Function	Heterocyclic compound binding	IPI	9371713
GO:1901844	Process	Regulation of cell communication by electrical coupling involved in cardiac conduction	IC	16213210
GO:1901898	Process	Negative regulation of relaxation of cardiac muscle	ISS

MIM	HGNC	e!Ensembl
600129	8783	ENSG00000113448

Protein

UniProt ID

Q08499

Protein name

3',5'-cyclic-AMP phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) (cAMP-specific phosphodiesterase 4D)

Protein function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.

PDB

1E9K , 1MKD , 1OYN , 1PTW , 1Q9M , 1TB7 , 1TBB , 1XOM , 1XON , 1XOQ , 1XOR , 1Y2B , 1Y2C , 1Y2D , 1Y2E , 1Y2K , 1ZKN , 2FM0 , 2FM5 , 2PW3 , 2QYN , 3G4G , 3G4I , 3G4K , 3G4L , 3G58 , 3IAD , 3IAK , 3K4S , 3SL3 , 3SL4 , 3SL5 , 3SL6 , 3SL8 , 3V9B , 4OGB , 4W1O , 4WCU , 5K1I , 5K32 , 5LBO , 5TKB , 5WH5 , 5WH6 , 5WQA , 6AKR , 6BOJ , 6F6U , 6F8R , 6F8T , 6F8U

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF18100	PDE4_UCR	223 → 339	Phosphodiesterase 4 upstream conserved regions (UCR)	Domain
PF00233	PDEase_I	461 → 702		Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in colonic epithelial cells (at protein level). Widespread; most abundant in skeletal muscle. {ECO:0000269|PubMed:12834813, ECO:0000269|PubMed:17244609}.; TISSUE SPECIFICITY: [Isoform 6]: Detected in brain. {ECO:0000269|PubMe

Sequence

MEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPP
PPPSPQPQPQCPLQPPPPPPLPPPPPPPGAARGRYASSGATGRVRHRGYSDTERYLYCRA
MDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQA
NFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNF
AALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSV
SEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRP
MSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPL
TVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLST
PALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGF
KLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVL
LLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMC
DKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAP
DDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPL
DEQVEEEAVGEEEESQPEACVIDDRSPDT

Sequence length

809

Interactions

View interactions

	KEGG		Reactome
	Purine metabolism Metabolic pathways cAMP signaling pathway Parathyroid hormone synthesis, secretion and action Morphine addiction		DARPP-32 events G alpha (s) signalling events

Show/Hide Causal Diseases (19)

Disease term	Disease name	dbSNP ID	References
Causal
Acrodysostosis with or without hormone resistance	ACRODYSOSTOSIS 1 WITH OR WITHOUT HORMONE RESISTANCE, ACRODYSOSTOSIS 2 WITH OR WITHOUT HORMONE RESISTANCE	rs387906692, rs387906694, rs387906695, rs397514464, rs397514465, rs397514466, rs397514467, rs397514468, rs387906744, rs397514469, rs397515433, rs587777188, rs886041228, rs1555815121, rs1600486197	23033274, 22464252, 22464250, 23043190
Autism	Autistic Disorder	rs121964908, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699 View all (8 more)
Brachydactyly	Brachydactyly	rs121908949, rs28937580, rs121909082, rs104894122, rs863223289, rs863223290, rs104894121, rs1587657302, rs863223292, rs74315386, rs74315387, rs28936397, rs753691079, rs121909348, rs121917852 View all (22 more)
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158 View all (309 more)	23535729
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451 View all (71 more)	23535729, 25751625, 29059683
Congenital hypothyroidism	Congenital Hypothyroidism	rs121909180, rs121912646, rs121912648, rs1587178555, rs530719719, rs189261858, rs567500345, rs560702757, rs374620255, rs774517670
Cryptorchidism	Cryptorchidism	rs121912555, rs104894697, rs104894698, rs398122886
Developmental delay	Global developmental delay	rs28941770, rs199469464, rs281865469, rs143747297, rs398123009, rs587777428, rs786205133, rs606231459, rs797044854, rs797045027, rs864309504, rs878853160, rs886039902, rs886042046, rs886041291 View all (32 more)
Diabetes mellitus	Diabetes Mellitus	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237 View all (293 more)
Esophagus neoplasm	Esophageal Neoplasms, Squamous cell carcinoma of esophagus, Malignant neoplasm of esophagus	rs28934578, rs121918714, rs1567556006, rs1575166666	22960999, 21642993, 25129146
Isolated somatotropin deficiency	Isolated somatotropin deficiency	rs797044450, rs71640277, rs863223306, rs2144738731, rs863223307, rs2144739370, rs863223309, rs863223310, rs137853223, rs2144739380, rs2144739391
Kidney disease	Chronic Kidney Diseases	rs74315342, rs749740335, rs757649673, rs112417755, rs35138315	21931561
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297	27903959
Mental retardation	Intellectual Disability	rs5742905, rs267607136, rs267607137, rs2131714307, rs267607038, rs267607042, rs80338685, rs137853127, rs80338815, rs28940893, rs387906309, rs121908096, rs121908099, rs587784365, rs121918315 View all (1024 more)
Obesity	Obesity	rs74315349, rs1474810899, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562 View all (27 more)
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	16740699, 29662167
Pseudohypoparathyroidism	Pseudohypoparathyroidism	rs137854530, rs1601164378, rs1601163749, rs137854531, rs137854532, rs11554273, rs121913495, rs587776829, rs137854534, rs2145916749, rs137854537, rs137854538, rs2146271310, rs2146178462, rs2145916486 View all (16 more)
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	21926974, 19251251
Scoliosis	Scoliosis, unspecified	rs1057518828, rs147296805, rs758163506, rs1555613564, rs1596852902, rs1596853067, rs1596853085

Show/Hide Unknown Diseases (9)

Disease term	Disease name	References	Source
Unknown
Acrodysostosis	Acrodysostosis, acrodysostosis	22464252, 22464250	ClinVar, GenCC
Asthma	Asthma	19426955, 21907864, 21611147, 20698975	ClinVar, GWAS
Mental depression	Mental Depression, Depressive disorder	12377395, 22487514, 23003922	ClinVar
Specific learning disorder	Specific learning disability		ClinVar
Acrodysostosis With Multiple Hormone Resistance	acrodysostosis with multiple hormone resistance		GenCC
Neuroticism	Neuroticism		GWAS
Obsessive-Compulsive Disorder	Obsessive-Compulsive Disorder		GWAS
Metabolic Syndrome	Metabolic Syndrome		GWAS
Dyslexia	Dyslexia		GWAS

Show/Hide Text Mining Associations (69)

Disease Name	Relationship Type	References
Associations from Text Mining
Acrodysostosis	Associate	22464250, 22464252, 25075981, 26763073, 28515031, 30006632, 31041856, 32783359, 33858404
Alport Syndrome Mental Retardation Midface Hypoplasia and Elliptocytosis	Associate	30006632
Alzheimer Disease	Associate	33157432
Arterial Occlusive Diseases	Associate	28225001
Asthma	Associate	19426955, 21876611
Asthma	Inhibit	26181301
Atherosclerosis	Associate	14517540, 20540798, 22045424, 23863764, 24485247, 28225001
Atrial Fibrillation	Associate	34289528
Autism Spectrum Disorder	Associate	37407249
Brachydactyly	Associate	28515031
Brachydactyly Type E	Associate	29499646
Breast Neoplasms	Associate	22362584, 27267999, 27859137
Carcinoma Endometrioid	Associate	29633253
Cardiomyopathy Dilated	Associate	34289528
Carotid Artery Diseases	Associate	20540798
Cerebral Infarction	Associate	14517540, 16130105, 16595789, 16835261, 22045424, 23466835, 23799094, 23863764, 24090469, 24485247, 28225001, 31653176
Cognition Disorders	Associate	23863764, 33157432
Colorectal Neoplasms	Associate	39202484
Coronary Artery Disease	Associate	38272484
Coronary Disease	Associate	22388798
Depressive Disorder	Associate	19300510
Diabetes Mellitus Type 2	Associate	32041280
Disorders of Sex Development	Associate	37413951
Emphysema	Associate	24926854
Endometrial Neoplasms	Associate	23536305
Esophageal Squamous Cell Carcinoma	Associate	22865593
Glioblastoma	Associate	24358143
Glioma	Associate	24358143
Growth Disorders	Associate	23536305
Heart Block	Associate	34289528
Heart Diseases	Associate	38272484
HEM dysplasia	Associate	30006632
Hereditary Breast and Ovarian Cancer Syndrome	Associate	23536305
Hypoxia	Associate	34630853
Infections	Associate	30006632
Inflammation	Associate	23076369, 23863764, 24142618, 24485247
Intellectual Disability	Associate	22464250, 30006632
Jackson Weiss syndrome	Associate	33858404
Melanoma	Associate	23536305
Mental Disorders	Associate	29880880
Metaphyseal acroscyphodysplasia	Associate	30006632
Multiple Myeloma	Associate	37775746
Muscular dystrophy congenital with central nervous system involvement	Associate	33858404
Nasal Polyps	Associate	24142618
Neoplasm Metastasis	Associate	27683107
Neoplasms	Associate	23536305, 26639561
Neoplastic Syndromes Hereditary	Associate	26763073
Norrie disease	Associate	32041280
Nose Diseases	Associate	22464250, 24142618, 30006632
Ovarian Neoplasms	Associate	23536305
Pancreatic Neoplasms	Stimulate	37427586
Precancerous Conditions	Associate	30598579
Prostatic Neoplasms	Associate	27683107
Pseudohypoparathyroidism	Associate	26763073, 29499646
Psoriasis	Stimulate	26806620
Psychotic Disorders	Associate	19300510
Pulmonary Disease Chronic Obstructive	Associate	24926854
Renal Artery Obstruction	Associate	35259553
Respiratory Hypersensitivity	Stimulate	26181301
Respiratory Tract Diseases	Associate	37925496
Schizophrenia	Associate	19251251, 29142105
Status Asthmaticus	Associate	21611147, 26181301
Stroke	Associate	14517540, 16595789, 16835261, 19417766, 20540798, 23076369, 23799094, 23863764, 24090469, 28225001
Stroke Lacunar	Associate	23799094
Syncope	Associate	14517540
Thromboembolism	Associate	30006632
Thyroid Diseases	Associate	30485936
Thyroid Hormone Resistance Syndrome	Associate	32783359
Thyroid Neoplasms	Associate	29178884

PDE4D (phosphodiesterase 4D)