Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	51434
Gene name	Anaphase promoting complex subunit 7
Gene symbol	ANAPC7
Synonyms (NCBI Gene)	APC7FERBON
Chromosome	12
Chromosome location	12q24.11
Summary	This gene encodes a tetratricopeptide repeat containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins f

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miRTarBase ID	miRNA	Experiments	Reference
MIRT022598	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT044330	hsa-miR-106b-5p	CLASH	23622248
MIRT041625	hsa-miR-484	CLASH	23622248
MIRT039011	hsa-miR-766-3p	CLASH	23622248
MIRT038814	hsa-miR-93-3p	CLASH	23622248
MIRT613530	hsa-miR-548u	HITS-CLIP	23824327
MIRT613529	hsa-miR-7161-5p	HITS-CLIP	23824327
MIRT613528	hsa-miR-4432	HITS-CLIP	23824327
MIRT613527	hsa-miR-3126-3p	HITS-CLIP	23824327
MIRT613526	hsa-miR-3155a	HITS-CLIP	23824327
MIRT613525	hsa-miR-3155b	HITS-CLIP	23824327
MIRT041625	hsa-miR-484	HITS-CLIP	23824327
MIRT613524	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT613523	hsa-miR-1266-5p	HITS-CLIP	23824327
MIRT613522	hsa-miR-4518	HITS-CLIP	23824327
MIRT613521	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT613520	hsa-miR-3176	HITS-CLIP	23824327
MIRT613519	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT613518	hsa-miR-3926	HITS-CLIP	23824327
MIRT613517	hsa-miR-548s	HITS-CLIP	23824327
MIRT613530	hsa-miR-548u	HITS-CLIP	23824327
MIRT613529	hsa-miR-7161-5p	HITS-CLIP	23824327
MIRT613528	hsa-miR-4432	HITS-CLIP	23824327
MIRT613527	hsa-miR-3126-3p	HITS-CLIP	23824327
MIRT613526	hsa-miR-3155a	HITS-CLIP	23824327
MIRT613525	hsa-miR-3155b	HITS-CLIP	23824327
MIRT041625	hsa-miR-484	HITS-CLIP	23824327
MIRT613524	hsa-miR-3664-3p	HITS-CLIP	23824327
MIRT613523	hsa-miR-1266-5p	HITS-CLIP	23824327
MIRT613522	hsa-miR-4518	HITS-CLIP	23824327
MIRT613521	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT613520	hsa-miR-3176	HITS-CLIP	23824327
MIRT613519	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT613518	hsa-miR-3926	HITS-CLIP	23824327
MIRT613517	hsa-miR-548s	HITS-CLIP	23824327
MIRT781078	hsa-miR-1206	CLIP-seq
MIRT781079	hsa-miR-1228	CLIP-seq
MIRT781080	hsa-miR-1270	CLIP-seq
MIRT781081	hsa-miR-1292	CLIP-seq
MIRT781082	hsa-miR-143	CLIP-seq
MIRT781083	hsa-miR-1909	CLIP-seq
MIRT781084	hsa-miR-1910	CLIP-seq
MIRT781085	hsa-miR-1972	CLIP-seq
MIRT781086	hsa-miR-205	CLIP-seq
MIRT781087	hsa-miR-22	CLIP-seq
MIRT781088	hsa-miR-224	CLIP-seq
MIRT781089	hsa-miR-2278	CLIP-seq
MIRT781090	hsa-miR-2392	CLIP-seq
MIRT781091	hsa-miR-24	CLIP-seq
MIRT781092	hsa-miR-302a	CLIP-seq
MIRT781093	hsa-miR-302b	CLIP-seq
MIRT781094	hsa-miR-302c	CLIP-seq
MIRT781095	hsa-miR-302d	CLIP-seq
MIRT781096	hsa-miR-302e	CLIP-seq
MIRT781097	hsa-miR-3064-5p	CLIP-seq
MIRT781098	hsa-miR-3135b	CLIP-seq
MIRT781099	hsa-miR-3136-3p	CLIP-seq
MIRT781100	hsa-miR-3155	CLIP-seq
MIRT781101	hsa-miR-3163	CLIP-seq
MIRT781102	hsa-miR-3189-5p	CLIP-seq
MIRT781103	hsa-miR-3192	CLIP-seq
MIRT781104	hsa-miR-3202	CLIP-seq
MIRT781105	hsa-miR-328	CLIP-seq
MIRT781106	hsa-miR-3605-5p	CLIP-seq
MIRT781107	hsa-miR-3646	CLIP-seq
MIRT781108	hsa-miR-3652	CLIP-seq
MIRT781109	hsa-miR-3689a-3p	CLIP-seq
MIRT781110	hsa-miR-3689c	CLIP-seq
MIRT781111	hsa-miR-370	CLIP-seq
MIRT781112	hsa-miR-372	CLIP-seq
MIRT781113	hsa-miR-373	CLIP-seq
MIRT781114	hsa-miR-410	CLIP-seq
MIRT781115	hsa-miR-4252	CLIP-seq
MIRT781116	hsa-miR-4257	CLIP-seq
MIRT781117	hsa-miR-4292	CLIP-seq
MIRT781118	hsa-miR-4300	CLIP-seq
MIRT781119	hsa-miR-4308	CLIP-seq
MIRT781120	hsa-miR-4314	CLIP-seq
MIRT781121	hsa-miR-4323	CLIP-seq
MIRT781122	hsa-miR-4330	CLIP-seq
MIRT781123	hsa-miR-4430	CLIP-seq
MIRT781124	hsa-miR-4436b-3p	CLIP-seq
MIRT781125	hsa-miR-4471	CLIP-seq
MIRT781126	hsa-miR-4505	CLIP-seq
MIRT781127	hsa-miR-4533	CLIP-seq
MIRT781128	hsa-miR-4534	CLIP-seq
MIRT781129	hsa-miR-4632	CLIP-seq
MIRT781130	hsa-miR-4633-3p	CLIP-seq
MIRT781131	hsa-miR-4646-5p	CLIP-seq
MIRT781132	hsa-miR-4661-5p	CLIP-seq
MIRT781133	hsa-miR-4683	CLIP-seq
MIRT781134	hsa-miR-4690-3p	CLIP-seq
MIRT781135	hsa-miR-4705	CLIP-seq
MIRT781136	hsa-miR-4716-5p	CLIP-seq
MIRT781137	hsa-miR-4717-3p	CLIP-seq
MIRT781138	hsa-miR-4717-5p	CLIP-seq
MIRT781139	hsa-miR-4726-3p	CLIP-seq
MIRT781140	hsa-miR-4758-3p	CLIP-seq
MIRT781141	hsa-miR-4764-3p	CLIP-seq
MIRT781142	hsa-miR-4770	CLIP-seq
MIRT781143	hsa-miR-4802-3p	CLIP-seq
MIRT781144	hsa-miR-486-3p	CLIP-seq
MIRT781145	hsa-miR-520a-3p	CLIP-seq
MIRT781146	hsa-miR-520b	CLIP-seq
MIRT781147	hsa-miR-520c-3p	CLIP-seq
MIRT781148	hsa-miR-520d-3p	CLIP-seq
MIRT781149	hsa-miR-520e	CLIP-seq
MIRT781150	hsa-miR-548k	CLIP-seq
MIRT781151	hsa-miR-548n	CLIP-seq
MIRT781152	hsa-miR-558	CLIP-seq
MIRT781153	hsa-miR-583	CLIP-seq
MIRT781154	hsa-miR-620	CLIP-seq
MIRT781155	hsa-miR-760	CLIP-seq
MIRT781156	hsa-miR-764	CLIP-seq
MIRT781157	hsa-miR-920	CLIP-seq
MIRT781078	hsa-miR-1206	CLIP-seq
MIRT781084	hsa-miR-1910	CLIP-seq
MIRT781092	hsa-miR-302a	CLIP-seq
MIRT781093	hsa-miR-302b	CLIP-seq
MIRT781094	hsa-miR-302c	CLIP-seq
MIRT781095	hsa-miR-302d	CLIP-seq
MIRT781096	hsa-miR-302e	CLIP-seq
MIRT781112	hsa-miR-372	CLIP-seq
MIRT781113	hsa-miR-373	CLIP-seq
MIRT1930539	hsa-miR-455-3p	CLIP-seq
MIRT781145	hsa-miR-520a-3p	CLIP-seq
MIRT781146	hsa-miR-520b	CLIP-seq
MIRT781147	hsa-miR-520c-3p	CLIP-seq
MIRT781148	hsa-miR-520d-3p	CLIP-seq
MIRT781149	hsa-miR-520e	CLIP-seq
MIRT781078	hsa-miR-1206	CLIP-seq
MIRT781079	hsa-miR-1228	CLIP-seq
MIRT2171179	hsa-miR-141	CLIP-seq
MIRT781084	hsa-miR-1910	CLIP-seq
MIRT2171180	hsa-miR-200a	CLIP-seq
MIRT781086	hsa-miR-205	CLIP-seq
MIRT781089	hsa-miR-2278	CLIP-seq
MIRT781091	hsa-miR-24	CLIP-seq
MIRT781100	hsa-miR-3155	CLIP-seq
MIRT781102	hsa-miR-3189-5p	CLIP-seq
MIRT2171181	hsa-miR-3655	CLIP-seq
MIRT781109	hsa-miR-3689a-3p	CLIP-seq
MIRT781110	hsa-miR-3689c	CLIP-seq
MIRT781111	hsa-miR-370	CLIP-seq
MIRT781116	hsa-miR-4257	CLIP-seq
MIRT781118	hsa-miR-4300	CLIP-seq
MIRT2171182	hsa-miR-4328	CLIP-seq
MIRT781122	hsa-miR-4330	CLIP-seq
MIRT1930539	hsa-miR-455-3p	CLIP-seq
MIRT781132	hsa-miR-4661-5p	CLIP-seq
MIRT781134	hsa-miR-4690-3p	CLIP-seq
MIRT781135	hsa-miR-4705	CLIP-seq
MIRT781136	hsa-miR-4716-5p	CLIP-seq
MIRT781139	hsa-miR-4726-3p	CLIP-seq
MIRT781140	hsa-miR-4758-3p	CLIP-seq
MIRT2171183	hsa-miR-4796-5p	CLIP-seq
MIRT781144	hsa-miR-486-3p	CLIP-seq
MIRT781156	hsa-miR-764	CLIP-seq
MIRT781157	hsa-miR-920	CLIP-seq
MIRT781084	hsa-miR-1910	CLIP-seq
MIRT781086	hsa-miR-205	CLIP-seq
MIRT781092	hsa-miR-302a	CLIP-seq
MIRT781093	hsa-miR-302b	CLIP-seq
MIRT781094	hsa-miR-302c	CLIP-seq
MIRT781095	hsa-miR-302d	CLIP-seq
MIRT781096	hsa-miR-302e	CLIP-seq
MIRT781112	hsa-miR-372	CLIP-seq
MIRT781113	hsa-miR-373	CLIP-seq
MIRT1930539	hsa-miR-455-3p	CLIP-seq
MIRT781145	hsa-miR-520a-3p	CLIP-seq
MIRT781146	hsa-miR-520b	CLIP-seq
MIRT781147	hsa-miR-520c-3p	CLIP-seq
MIRT781148	hsa-miR-520d-3p	CLIP-seq
MIRT781149	hsa-miR-520e	CLIP-seq
MIRT781084	hsa-miR-1910	CLIP-seq
MIRT781086	hsa-miR-205	CLIP-seq
MIRT781092	hsa-miR-302a	CLIP-seq
MIRT781093	hsa-miR-302b	CLIP-seq
MIRT781094	hsa-miR-302c	CLIP-seq
MIRT781095	hsa-miR-302d	CLIP-seq
MIRT781096	hsa-miR-302e	CLIP-seq
MIRT2464842	hsa-miR-3122	CLIP-seq
MIRT781112	hsa-miR-372	CLIP-seq
MIRT781113	hsa-miR-373	CLIP-seq
MIRT2464843	hsa-miR-3913-5p	CLIP-seq
MIRT2464844	hsa-miR-4452	CLIP-seq
MIRT2464845	hsa-miR-450b-3p	CLIP-seq
MIRT1930539	hsa-miR-455-3p	CLIP-seq
MIRT2464846	hsa-miR-4735-5p	CLIP-seq
MIRT2464847	hsa-miR-4775	CLIP-seq
MIRT781145	hsa-miR-520a-3p	CLIP-seq
MIRT781146	hsa-miR-520b	CLIP-seq
MIRT781147	hsa-miR-520c-3p	CLIP-seq
MIRT781148	hsa-miR-520d-3p	CLIP-seq
MIRT781149	hsa-miR-520e	CLIP-seq
MIRT2464848	hsa-miR-590-3p	CLIP-seq
MIRT2464849	hsa-miR-769-3p	CLIP-seq
MIRT2473846	hsa-miR-1321	CLIP-seq
MIRT2473847	hsa-miR-2053	CLIP-seq
MIRT2473848	hsa-miR-2117	CLIP-seq
MIRT2473849	hsa-miR-361-3p	CLIP-seq
MIRT2473850	hsa-miR-3653	CLIP-seq
MIRT2473851	hsa-miR-3658	CLIP-seq
MIRT2473852	hsa-miR-3677-5p	CLIP-seq
MIRT2473853	hsa-miR-3679-3p	CLIP-seq
MIRT2473854	hsa-miR-409-3p	CLIP-seq
MIRT2473855	hsa-miR-4277	CLIP-seq
MIRT2473856	hsa-miR-4282	CLIP-seq
MIRT2473857	hsa-miR-4297	CLIP-seq
MIRT2473858	hsa-miR-4667-3p	CLIP-seq
MIRT2473859	hsa-miR-4684-5p	CLIP-seq
MIRT2473860	hsa-miR-4739	CLIP-seq
MIRT2473861	hsa-miR-4756-5p	CLIP-seq
MIRT2473862	hsa-miR-494	CLIP-seq
MIRT2473863	hsa-miR-569	CLIP-seq
MIRT2473864	hsa-miR-642b	CLIP-seq
MIRT2473865	hsa-miR-889	CLIP-seq
MIRT2473846	hsa-miR-1321	CLIP-seq
MIRT2473847	hsa-miR-2053	CLIP-seq
MIRT2473848	hsa-miR-2117	CLIP-seq
MIRT2473849	hsa-miR-361-3p	CLIP-seq
MIRT2473850	hsa-miR-3653	CLIP-seq
MIRT2473851	hsa-miR-3658	CLIP-seq
MIRT2473852	hsa-miR-3677-5p	CLIP-seq
MIRT2473853	hsa-miR-3679-3p	CLIP-seq
MIRT2473854	hsa-miR-409-3p	CLIP-seq
MIRT2473855	hsa-miR-4277	CLIP-seq
MIRT2473856	hsa-miR-4282	CLIP-seq
MIRT2473857	hsa-miR-4297	CLIP-seq
MIRT2473858	hsa-miR-4667-3p	CLIP-seq
MIRT2473859	hsa-miR-4684-5p	CLIP-seq
MIRT2473860	hsa-miR-4739	CLIP-seq
MIRT2473861	hsa-miR-4756-5p	CLIP-seq
MIRT2473862	hsa-miR-494	CLIP-seq
MIRT2473863	hsa-miR-569	CLIP-seq
MIRT2473864	hsa-miR-642b	CLIP-seq
MIRT2473865	hsa-miR-889	CLIP-seq

Show/Hide all (33)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000792	Component	Heterochromatin	IMP	34942119
GO:0005634	Component	Nucleus	IDA	18445686, 21241890
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005680	Component	Anaphase-promoting complex	IBA
GO:0005680	Component	Anaphase-promoting complex	IDA	16364912, 21926987, 34942119
GO:0005680	Component	Anaphase-promoting complex	IPI	27120157
GO:0005680	Component	Anaphase-promoting complex	NAS	27120157
GO:0005737	Component	Cytoplasm	IEA
GO:0005819	Component	Spindle	IDA	18445686
GO:0005819	Component	Spindle	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0007346	Process	Regulation of mitotic cell cycle	NAS	15678131
GO:0007420	Process	Brain development	IMP	34942119
GO:0015630	Component	Microtubule cytoskeleton	IDA	18445686
GO:0016567	Process	Protein ubiquitination	IBA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016567	Process	Protein ubiquitination	IMP	34942119
GO:0019903	Function	Protein phosphatase binding	IPI	21241890
GO:0031145	Process	Anaphase-promoting complex-dependent catabolic process	IDA	29033132
GO:0031145	Process	Anaphase-promoting complex-dependent catabolic process	NAS	15678131
GO:0045171	Component	Intercellular bridge	IDA
GO:0045842	Process	Positive regulation of mitotic metaphase/anaphase transition	IBA
GO:0051301	Process	Cell division	IBA
GO:0051301	Process	Cell division	IEA
GO:0051445	Process	Regulation of meiotic cell cycle	NAS	15678131
GO:0070936	Process	Protein K48-linked ubiquitination	IDA	29033132
GO:0070979	Process	Protein K11-linked ubiquitination	IDA	18485873, 29033132
GO:0072686	Component	Mitotic spindle	IDA
GO:0140767	Function	Enzyme-substrate adaptor activity	IDA	34942119
GO:0141198	Process	Protein branched polyubiquitination	IDA	29033132

MIM	HGNC	e!Ensembl
606949	17380	ENSG00000196510

Q9UJX3

Protein name

Anaphase-promoting complex subunit 7 (APC7) (Cyclosome subunit 7)

Protein function

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquit

PDB

3FFL , 4UI9 , 5A31 , 5G04 , 5G05 , 5KHR , 5KHU , 5L9T , 5L9U , 5LCW , 6Q6G , 6Q6H , 6TLJ , 6TM5 , 6TNT , 8PKP , 8TAR , 8TAU , 9GAW

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13181	TPR_8	373 → 404	Tetratricopeptide repeat	Repeat
PF13432	TPR_16	480 → 543		Family

Sequence

MDPGDAAILESSLRILYRLFESVLPPLPAALQSRMNVIDHVRDMAAAGLHSNVRLLSSLL
LTMSNNNPELFSPPQKYQLLVYHADSLFHDKEYRNAVSKYTMALQQKKALSKTSKVRPST
GNSASTPQSQCLPSEIEVKYKMAECYTMLKQDKDAIAILDGIPSRQRTPKINMMLANLYK
KAGQERPSVTSYKEVLRQCPLALDAILGLLSLSVKGAEVASMTMNVIQTVPNLDWLSVWI
KAYAFVHTGDNSRAISTICSLEKKSLLRDNVDLLGSLADLYFRAGDNKNSVLKFEQAQML
DPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALY
LGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLAS
NSIREAMVMANNVYKTLGANAQTLTLLATVCLEDPVTQEKAKTLLDKALTQRPDYIKAVV
KKAELLSREQKYEDGIALLRNALANQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLDP
NDQKSLEGMQKMEKEESPTDATQEEDVDDMEGSGEEGDLEGSDSEAAQWADQEQWFGMQ

Sequence length

599

Interactions

View interactions

	KEGG		Reactome
	Cell cycle Oocyte meiosis Ubiquitin mediated proteolysis Progesterone-mediated oocyte maturation Human T-cell leukemia virus 1 infection		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Antigen processing: Ubiquitination & Proteasome degradation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BIPOLAR DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ferguson-Bonni neurodevelopmental syndrome	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Inhibit	15743504	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Associate	15743504	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Ductal Breast	Inhibit	15743504	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Stimulate	29969755	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	29969755	★★★★★ ★☆☆☆☆ Found in Text Mining only

ANAPC7 (anaphase promoting complex subunit 7)