Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
51429
Gene name Gene Name - the full gene name approved by the HGNC.
Sorting nexin 9
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SNX9
Synonyms (NCBI Gene) Gene synonyms aliases
SDP1, SH3PX1, SH3PXD3A, WISP
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6q25.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the sorting nexin family. Members of this family contain a phosphoinositide binding domain, and are involved in intracellular trafficking. The encoded protein does not contain a coiled coil region, like some family members, b
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT016587 hsa-miR-193b-3p Microarray 20304954
MIRT018610 hsa-miR-335-5p Microarray 18185580
MIRT022921 hsa-miR-124-3p Proteomics;Microarray 18668037
MIRT049111 hsa-miR-92a-3p CLASH 23622248
MIRT042698 hsa-miR-196b-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000278 Process Mitotic cell cycle IEA
GO:0000281 Process Mitotic cytokinesis IEA
GO:0000281 Process Mitotic cytokinesis IMP 22718350
GO:0001726 Component Ruffle IEA
GO:0005515 Function Protein binding IPI 10531379, 11799118, 14679214, 15703209, 16374509, 16585770, 17242350, 18353773, 18388313, 19487689, 19807924, 20129922, 20427313, 20491914, 23085988, 25107275, 25544563, 25825872, 27107012, 33961781, 35271311
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605952 14973 ENSG00000130340
Protein
UniProt ID Q9Y5X1
Protein name Sorting nexin-9 (SH3 and PX domain-containing protein 1) (Protein SDP1) (SH3 and PX domain-containing protein 3A)
Protein function Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of
PDB 2RAI , 2RAJ , 2RAK , 3DYT , 3DYU , 3LGE , 7OJ9
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00018 SH3_1 6 54 SH3 domain Domain
PF00787 PX 273 357 PX domain Domain
PF10456 BAR_3_WASP_bdg 358 593 WASP-binding domain of Sorting nexin protein Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed, with highest levels in heart and placenta, and lowest levels in thymus and peripheral blood leukocytes. {ECO:0000269|PubMed:10531379}.
Sequence
Sequence length 595
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Salmonella infection   Golgi Associated Vesicle Biogenesis
Clathrin-mediated endocytosis
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Borderline personality disorder Borderline personality disorder N/A N/A GWAS
Cholelithiasis Cholelithiasis N/A N/A GWAS
Glioblastoma Glioblastoma N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 33878706
Astrocytoma Associate 32108034
Breast Neoplasms Inhibit 27278018
Carcinoma Non Small Cell Lung Inhibit 27278018
Carcinoma Squamous Cell Associate 37746966
Colorectal Neoplasms Associate 30784076
Fatigue Associate 37915075
Neoplasm Metastasis Stimulate 27278018
Neoplasms Associate 26892443, 27278018, 30784076, 32108034
Post Acute COVID 19 Syndrome Associate 37915075