Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5142
Gene name Gene Name - the full gene name approved by the HGNC.	Phosphodiesterase 4B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PDE4B
Synonyms (NCBI Gene) Gene synonyms aliases	DPDE4, PDEIVB
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1p31.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered act

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miRTarBase ID	miRNA	Experiments	Reference
MIRT144178	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT726989	hsa-miR-26a-5p	HITS-CLIP	22473208
MIRT726988	hsa-miR-26b-5p	HITS-CLIP	22473208
MIRT144178	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT1220468	hsa-miR-1207-5p	CLIP-seq
MIRT1220469	hsa-miR-130a	CLIP-seq
MIRT1220470	hsa-miR-130b	CLIP-seq
MIRT1220471	hsa-miR-148a	CLIP-seq
MIRT1220472	hsa-miR-148b	CLIP-seq
MIRT1220473	hsa-miR-152	CLIP-seq
MIRT1220474	hsa-miR-2682	CLIP-seq
MIRT1220475	hsa-miR-298	CLIP-seq
MIRT1220476	hsa-miR-301a	CLIP-seq
MIRT1220477	hsa-miR-301b	CLIP-seq
MIRT1220478	hsa-miR-34a	CLIP-seq
MIRT1220479	hsa-miR-34c-5p	CLIP-seq
MIRT1220480	hsa-miR-3591-3p	CLIP-seq
MIRT1220481	hsa-miR-3666	CLIP-seq
MIRT1220482	hsa-miR-3714	CLIP-seq
MIRT1220483	hsa-miR-4295	CLIP-seq
MIRT1220484	hsa-miR-449a	CLIP-seq
MIRT1220485	hsa-miR-449b	CLIP-seq
MIRT1220486	hsa-miR-449c	CLIP-seq
MIRT1220487	hsa-miR-454	CLIP-seq
MIRT1220488	hsa-miR-4696	CLIP-seq
MIRT1220489	hsa-miR-4736	CLIP-seq
MIRT1220490	hsa-miR-4742-5p	CLIP-seq
MIRT1220491	hsa-miR-4763-3p	CLIP-seq
MIRT1220492	hsa-miR-221	CLIP-seq
MIRT1220493	hsa-miR-222	CLIP-seq
MIRT1220494	hsa-miR-23a	CLIP-seq
MIRT1220495	hsa-miR-23b	CLIP-seq
MIRT1220496	hsa-miR-23c	CLIP-seq
MIRT1220497	hsa-miR-3145-5p	CLIP-seq
MIRT1220498	hsa-miR-3160-5p	CLIP-seq
MIRT1220499	hsa-miR-3163	CLIP-seq
MIRT1220500	hsa-miR-340	CLIP-seq
MIRT1220501	hsa-miR-345	CLIP-seq
MIRT1220502	hsa-miR-3545-3p	CLIP-seq
MIRT1220503	hsa-miR-4256	CLIP-seq
MIRT1220504	hsa-miR-4277	CLIP-seq
MIRT1220505	hsa-miR-431	CLIP-seq
MIRT1220506	hsa-miR-4422	CLIP-seq
MIRT1220507	hsa-miR-4539	CLIP-seq
MIRT1220508	hsa-miR-4728-3p	CLIP-seq
MIRT1220509	hsa-miR-4762-3p	CLIP-seq
MIRT1220510	hsa-miR-4766-5p	CLIP-seq
MIRT1220511	hsa-miR-4795-3p	CLIP-seq
MIRT1220512	hsa-miR-494	CLIP-seq
MIRT1220513	hsa-miR-499-3p	CLIP-seq
MIRT1220514	hsa-miR-499a-3p	CLIP-seq
MIRT1220515	hsa-miR-548c-3p	CLIP-seq
MIRT1220516	hsa-miR-21	CLIP-seq
MIRT1220517	hsa-miR-3613-3p	CLIP-seq
MIRT1220518	hsa-miR-488	CLIP-seq
MIRT1220519	hsa-miR-505	CLIP-seq
MIRT1220520	hsa-miR-561	CLIP-seq
MIRT1220521	hsa-miR-590-5p	CLIP-seq
MIRT1220492	hsa-miR-221	CLIP-seq
MIRT1220493	hsa-miR-222	CLIP-seq
MIRT1220494	hsa-miR-23a	CLIP-seq
MIRT1220495	hsa-miR-23b	CLIP-seq
MIRT1220496	hsa-miR-23c	CLIP-seq
MIRT1220522	hsa-miR-3188	CLIP-seq
MIRT1220523	hsa-miR-361-5p	CLIP-seq
MIRT1220524	hsa-miR-548v	CLIP-seq
MIRT1220468	hsa-miR-1207-5p	CLIP-seq
MIRT2063628	hsa-miR-1278	CLIP-seq
MIRT2063629	hsa-miR-1827	CLIP-seq
MIRT2063630	hsa-miR-204	CLIP-seq
MIRT2063631	hsa-miR-211	CLIP-seq
MIRT2063632	hsa-miR-2113	CLIP-seq
MIRT2063633	hsa-miR-3124-3p	CLIP-seq
MIRT2063634	hsa-miR-3166	CLIP-seq
MIRT1220480	hsa-miR-3591-3p	CLIP-seq
MIRT2063635	hsa-miR-3612	CLIP-seq
MIRT2063636	hsa-miR-4264	CLIP-seq
MIRT2063637	hsa-miR-4328	CLIP-seq
MIRT2063638	hsa-miR-4443	CLIP-seq
MIRT2063639	hsa-miR-4446-5p	CLIP-seq
MIRT2063640	hsa-miR-4470	CLIP-seq
MIRT2063641	hsa-miR-452	CLIP-seq
MIRT2063642	hsa-miR-4652-3p	CLIP-seq
MIRT2063643	hsa-miR-4676-3p	CLIP-seq
MIRT2063644	hsa-miR-4711-3p	CLIP-seq
MIRT2063645	hsa-miR-4719	CLIP-seq
MIRT1220489	hsa-miR-4736	CLIP-seq
MIRT1220490	hsa-miR-4742-5p	CLIP-seq
MIRT2063646	hsa-miR-4755-5p	CLIP-seq
MIRT1220491	hsa-miR-4763-3p	CLIP-seq
MIRT2063647	hsa-miR-4797-3p	CLIP-seq
MIRT2063648	hsa-miR-548k	CLIP-seq
MIRT1220520	hsa-miR-561	CLIP-seq
MIRT2063649	hsa-miR-592	CLIP-seq
MIRT2063650	hsa-miR-599	CLIP-seq
MIRT2063651	hsa-miR-623	CLIP-seq
MIRT2063652	hsa-miR-650	CLIP-seq
MIRT2063653	hsa-miR-940	CLIP-seq
MIRT2063628	hsa-miR-1278	CLIP-seq
MIRT2063629	hsa-miR-1827	CLIP-seq
MIRT2063635	hsa-miR-3612	CLIP-seq
MIRT2063638	hsa-miR-4443	CLIP-seq
MIRT2063640	hsa-miR-4470	CLIP-seq
MIRT2063641	hsa-miR-452	CLIP-seq
MIRT2063643	hsa-miR-4676-3p	CLIP-seq
MIRT1220490	hsa-miR-4742-5p	CLIP-seq
MIRT2063648	hsa-miR-548k	CLIP-seq
MIRT2063652	hsa-miR-650	CLIP-seq
MIRT2063653	hsa-miR-940	CLIP-seq
MIRT1220490	hsa-miR-4742-5p	CLIP-seq
MIRT2063628	hsa-miR-1278	CLIP-seq
MIRT2063629	hsa-miR-1827	CLIP-seq
MIRT2063635	hsa-miR-3612	CLIP-seq
MIRT2063638	hsa-miR-4443	CLIP-seq
MIRT2063640	hsa-miR-4470	CLIP-seq
MIRT2063641	hsa-miR-452	CLIP-seq
MIRT2063643	hsa-miR-4676-3p	CLIP-seq
MIRT1220490	hsa-miR-4742-5p	CLIP-seq
MIRT2063648	hsa-miR-548k	CLIP-seq
MIRT2063652	hsa-miR-650	CLIP-seq
MIRT2063653	hsa-miR-940	CLIP-seq
MIRT1220492	hsa-miR-221	CLIP-seq
MIRT1220493	hsa-miR-222	CLIP-seq
MIRT1220494	hsa-miR-23a	CLIP-seq
MIRT1220495	hsa-miR-23b	CLIP-seq
MIRT1220496	hsa-miR-23c	CLIP-seq
MIRT1220499	hsa-miR-3163	CLIP-seq
MIRT1220522	hsa-miR-3188	CLIP-seq
MIRT2431953	hsa-miR-323-3p	CLIP-seq
MIRT1220500	hsa-miR-340	CLIP-seq
MIRT1220504	hsa-miR-4277	CLIP-seq
MIRT1220511	hsa-miR-4795-3p	CLIP-seq
MIRT1220513	hsa-miR-499-3p	CLIP-seq
MIRT1220514	hsa-miR-499a-3p	CLIP-seq
MIRT1220524	hsa-miR-548v	CLIP-seq
MIRT1220518	hsa-miR-488	CLIP-seq
MIRT2589695	hsa-miR-1179	CLIP-seq
MIRT2589696	hsa-miR-1206	CLIP-seq
MIRT1220468	hsa-miR-1207-5p	CLIP-seq
MIRT2589697	hsa-miR-1227	CLIP-seq
MIRT2589698	hsa-miR-1244	CLIP-seq
MIRT2589699	hsa-miR-1269	CLIP-seq
MIRT2589700	hsa-miR-1269b	CLIP-seq
MIRT2589701	hsa-miR-1273d	CLIP-seq
MIRT2063628	hsa-miR-1278	CLIP-seq
MIRT2589702	hsa-miR-1288	CLIP-seq
MIRT2589703	hsa-miR-1291	CLIP-seq
MIRT2589704	hsa-miR-134	CLIP-seq
MIRT2589705	hsa-miR-140-3p	CLIP-seq
MIRT2589706	hsa-miR-142-3p	CLIP-seq
MIRT2589707	hsa-miR-145	CLIP-seq
MIRT2589708	hsa-miR-1587	CLIP-seq
MIRT2063629	hsa-miR-1827	CLIP-seq
MIRT2589709	hsa-miR-1914	CLIP-seq
MIRT2589710	hsa-miR-199a-3p	CLIP-seq
MIRT2589711	hsa-miR-199b-3p	CLIP-seq
MIRT2589712	hsa-miR-2054	CLIP-seq
MIRT2063632	hsa-miR-2113	CLIP-seq
MIRT1220492	hsa-miR-221	CLIP-seq
MIRT1220493	hsa-miR-222	CLIP-seq
MIRT2589713	hsa-miR-2355-3p	CLIP-seq
MIRT1220494	hsa-miR-23a	CLIP-seq
MIRT1220495	hsa-miR-23b	CLIP-seq
MIRT1220496	hsa-miR-23c	CLIP-seq
MIRT2589714	hsa-miR-3074-5p	CLIP-seq
MIRT2589715	hsa-miR-3118	CLIP-seq
MIRT2589716	hsa-miR-3120-3p	CLIP-seq
MIRT2589717	hsa-miR-3129-5p	CLIP-seq
MIRT2589718	hsa-miR-3162-3p	CLIP-seq
MIRT1220499	hsa-miR-3163	CLIP-seq
MIRT1220522	hsa-miR-3188	CLIP-seq
MIRT2431953	hsa-miR-323-3p	CLIP-seq
MIRT2589719	hsa-miR-328	CLIP-seq
MIRT1220500	hsa-miR-340	CLIP-seq
MIRT1220502	hsa-miR-3545-3p	CLIP-seq
MIRT2589720	hsa-miR-3607-3p	CLIP-seq
MIRT2063635	hsa-miR-3612	CLIP-seq
MIRT1220523	hsa-miR-361-5p	CLIP-seq
MIRT2589721	hsa-miR-3622b-5p	CLIP-seq
MIRT2589722	hsa-miR-3654	CLIP-seq
MIRT2589723	hsa-miR-3658	CLIP-seq
MIRT2589724	hsa-miR-3665	CLIP-seq
MIRT2589725	hsa-miR-3686	CLIP-seq
MIRT2589726	hsa-miR-370	CLIP-seq
MIRT2589727	hsa-miR-375	CLIP-seq
MIRT2589728	hsa-miR-376a	CLIP-seq
MIRT2589729	hsa-miR-376b	CLIP-seq
MIRT2589730	hsa-miR-3913-3p	CLIP-seq
MIRT2589731	hsa-miR-3944-5p	CLIP-seq
MIRT2589732	hsa-miR-3973	CLIP-seq
MIRT2589733	hsa-miR-3975	CLIP-seq
MIRT2589734	hsa-miR-421	CLIP-seq
MIRT2589735	hsa-miR-4255	CLIP-seq
MIRT2589736	hsa-miR-4268	CLIP-seq
MIRT2589737	hsa-miR-4270	CLIP-seq
MIRT2589738	hsa-miR-4272	CLIP-seq
MIRT1220504	hsa-miR-4277	CLIP-seq
MIRT2589739	hsa-miR-4318	CLIP-seq
MIRT2589740	hsa-miR-4417	CLIP-seq
MIRT1220506	hsa-miR-4422	CLIP-seq
MIRT2589741	hsa-miR-4441	CLIP-seq
MIRT2063638	hsa-miR-4443	CLIP-seq
MIRT2589742	hsa-miR-4448	CLIP-seq
MIRT2589743	hsa-miR-4459	CLIP-seq
MIRT2063640	hsa-miR-4470	CLIP-seq
MIRT2589744	hsa-miR-4492	CLIP-seq
MIRT2589745	hsa-miR-4498	CLIP-seq
MIRT2589746	hsa-miR-4514	CLIP-seq
MIRT2589747	hsa-miR-4515	CLIP-seq
MIRT2063641	hsa-miR-452	CLIP-seq
MIRT2589748	hsa-miR-4528	CLIP-seq
MIRT2589749	hsa-miR-4529-3p	CLIP-seq
MIRT1220507	hsa-miR-4539	CLIP-seq
MIRT2589750	hsa-miR-4638-3p	CLIP-seq
MIRT2589751	hsa-miR-4640-3p	CLIP-seq
MIRT2063642	hsa-miR-4652-3p	CLIP-seq
MIRT2589752	hsa-miR-4653-3p	CLIP-seq
MIRT2589753	hsa-miR-4656	CLIP-seq
MIRT2589754	hsa-miR-4661-3p	CLIP-seq
MIRT2589755	hsa-miR-4675	CLIP-seq
MIRT2063643	hsa-miR-4676-3p	CLIP-seq
MIRT2589756	hsa-miR-4677-3p	CLIP-seq
MIRT2589757	hsa-miR-4678	CLIP-seq
MIRT2589758	hsa-miR-4679	CLIP-seq
MIRT2589759	hsa-miR-4692	CLIP-seq
MIRT2589760	hsa-miR-4695-5p	CLIP-seq
MIRT2589761	hsa-miR-4709-5p	CLIP-seq
MIRT2589762	hsa-miR-4720-3p	CLIP-seq
MIRT2589763	hsa-miR-4720-5p	CLIP-seq
MIRT2589764	hsa-miR-4722-5p	CLIP-seq
MIRT1220508	hsa-miR-4728-3p	CLIP-seq
MIRT2589765	hsa-miR-4735-5p	CLIP-seq
MIRT1220489	hsa-miR-4736	CLIP-seq
MIRT2589766	hsa-miR-4740-5p	CLIP-seq
MIRT2589767	hsa-miR-4741	CLIP-seq
MIRT1220490	hsa-miR-4742-5p	CLIP-seq
MIRT2589768	hsa-miR-4753-5p	CLIP-seq
MIRT1220491	hsa-miR-4763-3p	CLIP-seq
MIRT1220510	hsa-miR-4766-5p	CLIP-seq
MIRT2589769	hsa-miR-4778-5p	CLIP-seq
MIRT1220511	hsa-miR-4795-3p	CLIP-seq
MIRT2589770	hsa-miR-4799-3p	CLIP-seq
MIRT2589771	hsa-miR-4804-3p	CLIP-seq
MIRT1220518	hsa-miR-488	CLIP-seq
MIRT2589772	hsa-miR-489	CLIP-seq
MIRT1220512	hsa-miR-494	CLIP-seq
MIRT1220513	hsa-miR-499-3p	CLIP-seq
MIRT1220514	hsa-miR-499a-3p	CLIP-seq
MIRT2589773	hsa-miR-508-5p	CLIP-seq
MIRT2589774	hsa-miR-520d-5p	CLIP-seq
MIRT2589775	hsa-miR-520g	CLIP-seq
MIRT2589776	hsa-miR-520h	CLIP-seq
MIRT2589777	hsa-miR-524-5p	CLIP-seq
MIRT2589778	hsa-miR-541	CLIP-seq
MIRT2589779	hsa-miR-545	CLIP-seq
MIRT1220515	hsa-miR-548c-3p	CLIP-seq
MIRT2063648	hsa-miR-548k	CLIP-seq
MIRT2589780	hsa-miR-548n	CLIP-seq
MIRT2589781	hsa-miR-548p	CLIP-seq
MIRT2589782	hsa-miR-548t	CLIP-seq
MIRT1220524	hsa-miR-548v	CLIP-seq
MIRT2589783	hsa-miR-571	CLIP-seq
MIRT2589784	hsa-miR-590-3p	CLIP-seq
MIRT2063652	hsa-miR-650	CLIP-seq
MIRT2589785	hsa-miR-654-5p	CLIP-seq
MIRT2589786	hsa-miR-657	CLIP-seq
MIRT2589787	hsa-miR-663b	CLIP-seq
MIRT2589788	hsa-miR-676	CLIP-seq
MIRT2589789	hsa-miR-762	CLIP-seq
MIRT2589790	hsa-miR-936	CLIP-seq
MIRT2063653	hsa-miR-940	CLIP-seq
MIRT2589791	hsa-miR-943	CLIP-seq
MIRT2431953	hsa-miR-323-3p	CLIP-seq
MIRT2589792	hsa-miR-4738-3p	CLIP-seq
MIRT2589774	hsa-miR-520d-5p	CLIP-seq
MIRT2589777	hsa-miR-524-5p	CLIP-seq
MIRT2687309	hsa-miR-103a	CLIP-seq
MIRT2687310	hsa-miR-107	CLIP-seq
MIRT2589695	hsa-miR-1179	CLIP-seq
MIRT2589696	hsa-miR-1206	CLIP-seq
MIRT1220468	hsa-miR-1207-5p	CLIP-seq
MIRT2589697	hsa-miR-1227	CLIP-seq
MIRT2589698	hsa-miR-1244	CLIP-seq
MIRT2687311	hsa-miR-1252	CLIP-seq
MIRT2687312	hsa-miR-1261	CLIP-seq
MIRT2589699	hsa-miR-1269	CLIP-seq
MIRT2589700	hsa-miR-1269b	CLIP-seq
MIRT2589701	hsa-miR-1273d	CLIP-seq
MIRT2063628	hsa-miR-1278	CLIP-seq
MIRT2687313	hsa-miR-1284	CLIP-seq
MIRT2589702	hsa-miR-1288	CLIP-seq
MIRT2589703	hsa-miR-1291	CLIP-seq
MIRT2687314	hsa-miR-1305	CLIP-seq
MIRT1220469	hsa-miR-130a	CLIP-seq
MIRT1220470	hsa-miR-130b	CLIP-seq
MIRT2589704	hsa-miR-134	CLIP-seq
MIRT2589705	hsa-miR-140-3p	CLIP-seq
MIRT2589706	hsa-miR-142-3p	CLIP-seq
MIRT2589707	hsa-miR-145	CLIP-seq
MIRT1220471	hsa-miR-148a	CLIP-seq
MIRT1220472	hsa-miR-148b	CLIP-seq
MIRT1220473	hsa-miR-152	CLIP-seq
MIRT2589708	hsa-miR-1587	CLIP-seq
MIRT2063629	hsa-miR-1827	CLIP-seq
MIRT2687315	hsa-miR-1913	CLIP-seq
MIRT2589709	hsa-miR-1914	CLIP-seq
MIRT2589710	hsa-miR-199a-3p	CLIP-seq
MIRT2589711	hsa-miR-199b-3p	CLIP-seq
MIRT2589712	hsa-miR-2054	CLIP-seq
MIRT2063632	hsa-miR-2113	CLIP-seq
MIRT1220492	hsa-miR-221	CLIP-seq
MIRT1220493	hsa-miR-222	CLIP-seq
MIRT2589713	hsa-miR-2355-3p	CLIP-seq
MIRT1220494	hsa-miR-23a	CLIP-seq
MIRT1220495	hsa-miR-23b	CLIP-seq
MIRT1220496	hsa-miR-23c	CLIP-seq
MIRT1220474	hsa-miR-2682	CLIP-seq
MIRT1220475	hsa-miR-298	CLIP-seq
MIRT2687316	hsa-miR-300	CLIP-seq
MIRT1220476	hsa-miR-301a	CLIP-seq
MIRT1220477	hsa-miR-301b	CLIP-seq
MIRT2589714	hsa-miR-3074-5p	CLIP-seq
MIRT2589715	hsa-miR-3118	CLIP-seq
MIRT2589716	hsa-miR-3120-3p	CLIP-seq
MIRT2589717	hsa-miR-3129-5p	CLIP-seq
MIRT2687317	hsa-miR-3152-3p	CLIP-seq
MIRT2687318	hsa-miR-3157-5p	CLIP-seq
MIRT2589718	hsa-miR-3162-3p	CLIP-seq
MIRT1220499	hsa-miR-3163	CLIP-seq
MIRT1220522	hsa-miR-3188	CLIP-seq
MIRT2431953	hsa-miR-323-3p	CLIP-seq
MIRT2687319	hsa-miR-324-3p	CLIP-seq
MIRT2589719	hsa-miR-328	CLIP-seq
MIRT1220500	hsa-miR-340	CLIP-seq
MIRT1220478	hsa-miR-34a	CLIP-seq
MIRT1220479	hsa-miR-34c-5p	CLIP-seq
MIRT1220502	hsa-miR-3545-3p	CLIP-seq
MIRT2589720	hsa-miR-3607-3p	CLIP-seq
MIRT2063635	hsa-miR-3612	CLIP-seq
MIRT2687320	hsa-miR-361-3p	CLIP-seq
MIRT1220523	hsa-miR-361-5p	CLIP-seq
MIRT2687321	hsa-miR-3617	CLIP-seq
MIRT2589721	hsa-miR-3622b-5p	CLIP-seq
MIRT2687322	hsa-miR-3647-3p	CLIP-seq
MIRT2589722	hsa-miR-3654	CLIP-seq
MIRT2589723	hsa-miR-3658	CLIP-seq
MIRT2589724	hsa-miR-3665	CLIP-seq
MIRT1220481	hsa-miR-3666	CLIP-seq
MIRT2589725	hsa-miR-3686	CLIP-seq
MIRT2687323	hsa-miR-3689d	CLIP-seq
MIRT2589726	hsa-miR-370	CLIP-seq
MIRT1220482	hsa-miR-3714	CLIP-seq
MIRT2589727	hsa-miR-375	CLIP-seq
MIRT2589728	hsa-miR-376a	CLIP-seq
MIRT2589729	hsa-miR-376b	CLIP-seq
MIRT2687324	hsa-miR-376c	CLIP-seq
MIRT2687325	hsa-miR-381	CLIP-seq
MIRT2687326	hsa-miR-383	CLIP-seq
MIRT2589730	hsa-miR-3913-3p	CLIP-seq
MIRT2687327	hsa-miR-3922-5p	CLIP-seq
MIRT2589731	hsa-miR-3944-5p	CLIP-seq
MIRT2589732	hsa-miR-3973	CLIP-seq
MIRT2589733	hsa-miR-3975	CLIP-seq
MIRT2589734	hsa-miR-421	CLIP-seq
MIRT2589735	hsa-miR-4255	CLIP-seq
MIRT2063636	hsa-miR-4264	CLIP-seq
MIRT2589736	hsa-miR-4268	CLIP-seq
MIRT2589737	hsa-miR-4270	CLIP-seq
MIRT2687328	hsa-miR-4271	CLIP-seq
MIRT2589738	hsa-miR-4272	CLIP-seq
MIRT1220504	hsa-miR-4277	CLIP-seq
MIRT1220483	hsa-miR-4295	CLIP-seq
MIRT2687329	hsa-miR-4307	CLIP-seq
MIRT1220505	hsa-miR-431	CLIP-seq
MIRT2687330	hsa-miR-4310	CLIP-seq
MIRT2687331	hsa-miR-4313	CLIP-seq
MIRT2687332	hsa-miR-4317	CLIP-seq
MIRT2589739	hsa-miR-4318	CLIP-seq
MIRT2063637	hsa-miR-4328	CLIP-seq
MIRT2589740	hsa-miR-4417	CLIP-seq
MIRT1220506	hsa-miR-4422	CLIP-seq
MIRT2589741	hsa-miR-4441	CLIP-seq
MIRT2063638	hsa-miR-4443	CLIP-seq
MIRT2589742	hsa-miR-4448	CLIP-seq
MIRT2589743	hsa-miR-4459	CLIP-seq
MIRT2063640	hsa-miR-4470	CLIP-seq
MIRT2687333	hsa-miR-4473	CLIP-seq
MIRT2589744	hsa-miR-4492	CLIP-seq
MIRT2589745	hsa-miR-4498	CLIP-seq
MIRT1220484	hsa-miR-449a	CLIP-seq
MIRT1220485	hsa-miR-449b	CLIP-seq
MIRT1220486	hsa-miR-449c	CLIP-seq
MIRT2589746	hsa-miR-4514	CLIP-seq
MIRT2589747	hsa-miR-4515	CLIP-seq
MIRT2063641	hsa-miR-452	CLIP-seq
MIRT2589748	hsa-miR-4528	CLIP-seq
MIRT2589749	hsa-miR-4529-3p	CLIP-seq
MIRT2687334	hsa-miR-4533	CLIP-seq
MIRT1220507	hsa-miR-4539	CLIP-seq
MIRT1220487	hsa-miR-454	CLIP-seq
MIRT2589750	hsa-miR-4638-3p	CLIP-seq
MIRT2589751	hsa-miR-4640-3p	CLIP-seq
MIRT2063642	hsa-miR-4652-3p	CLIP-seq
MIRT2589752	hsa-miR-4653-3p	CLIP-seq
MIRT2589753	hsa-miR-4656	CLIP-seq
MIRT2687335	hsa-miR-4659a-5p	CLIP-seq
MIRT2687336	hsa-miR-4659b-5p	CLIP-seq
MIRT2589754	hsa-miR-4661-3p	CLIP-seq
MIRT2687337	hsa-miR-4666-3p	CLIP-seq
MIRT2687338	hsa-miR-4671-3p	CLIP-seq
MIRT2589755	hsa-miR-4675	CLIP-seq
MIRT2063643	hsa-miR-4676-3p	CLIP-seq
MIRT2589756	hsa-miR-4677-3p	CLIP-seq
MIRT2589757	hsa-miR-4678	CLIP-seq
MIRT2589758	hsa-miR-4679	CLIP-seq
MIRT2687339	hsa-miR-4687-5p	CLIP-seq
MIRT2687340	hsa-miR-4690-3p	CLIP-seq
MIRT2589759	hsa-miR-4692	CLIP-seq
MIRT2687341	hsa-miR-4694-5p	CLIP-seq
MIRT2687342	hsa-miR-4695-3p	CLIP-seq
MIRT2589760	hsa-miR-4695-5p	CLIP-seq
MIRT1220488	hsa-miR-4696	CLIP-seq
MIRT2589761	hsa-miR-4709-5p	CLIP-seq
MIRT2063644	hsa-miR-4711-3p	CLIP-seq
MIRT2687343	hsa-miR-4716-3p	CLIP-seq
MIRT2589762	hsa-miR-4720-3p	CLIP-seq
MIRT2589763	hsa-miR-4720-5p	CLIP-seq
MIRT2589764	hsa-miR-4722-5p	CLIP-seq
MIRT2687344	hsa-miR-4725-3p	CLIP-seq
MIRT1220508	hsa-miR-4728-3p	CLIP-seq
MIRT2589765	hsa-miR-4735-5p	CLIP-seq
MIRT1220489	hsa-miR-4736	CLIP-seq
MIRT2589792	hsa-miR-4738-3p	CLIP-seq
MIRT2589766	hsa-miR-4740-5p	CLIP-seq
MIRT2589767	hsa-miR-4741	CLIP-seq
MIRT1220490	hsa-miR-4742-5p	CLIP-seq
MIRT2687345	hsa-miR-4747-5p	CLIP-seq
MIRT2687346	hsa-miR-4749-3p	CLIP-seq
MIRT2589768	hsa-miR-4753-5p	CLIP-seq
MIRT1220491	hsa-miR-4763-3p	CLIP-seq
MIRT1220510	hsa-miR-4766-5p	CLIP-seq
MIRT2687347	hsa-miR-4772-5p	CLIP-seq
MIRT2687348	hsa-miR-4776-3p	CLIP-seq
MIRT2589769	hsa-miR-4778-5p	CLIP-seq
MIRT1220511	hsa-miR-4795-3p	CLIP-seq
MIRT2063647	hsa-miR-4797-3p	CLIP-seq
MIRT2589770	hsa-miR-4799-3p	CLIP-seq
MIRT2687349	hsa-miR-4802-5p	CLIP-seq
MIRT2589771	hsa-miR-4804-3p	CLIP-seq
MIRT1220518	hsa-miR-488	CLIP-seq
MIRT2589772	hsa-miR-489	CLIP-seq
MIRT2687350	hsa-miR-490-3p	CLIP-seq
MIRT1220512	hsa-miR-494	CLIP-seq
MIRT2687351	hsa-miR-498	CLIP-seq
MIRT1220513	hsa-miR-499-3p	CLIP-seq
MIRT1220514	hsa-miR-499a-3p	CLIP-seq
MIRT2589773	hsa-miR-508-5p	CLIP-seq
MIRT2589774	hsa-miR-520d-5p	CLIP-seq
MIRT2589775	hsa-miR-520g	CLIP-seq
MIRT2589776	hsa-miR-520h	CLIP-seq
MIRT2589777	hsa-miR-524-5p	CLIP-seq
MIRT2589778	hsa-miR-541	CLIP-seq
MIRT2589779	hsa-miR-545	CLIP-seq
MIRT2687352	hsa-miR-548a-5p	CLIP-seq
MIRT2687353	hsa-miR-548ab	CLIP-seq
MIRT2687354	hsa-miR-548ac	CLIP-seq
MIRT2687355	hsa-miR-548ae	CLIP-seq
MIRT2687356	hsa-miR-548aj	CLIP-seq
MIRT2687357	hsa-miR-548ak	CLIP-seq
MIRT2687358	hsa-miR-548am	CLIP-seq
MIRT2687359	hsa-miR-548b-5p	CLIP-seq
MIRT1220515	hsa-miR-548c-3p	CLIP-seq
MIRT2687360	hsa-miR-548c-5p	CLIP-seq
MIRT2687361	hsa-miR-548d-3p	CLIP-seq
MIRT2687362	hsa-miR-548d-5p	CLIP-seq
MIRT2687363	hsa-miR-548h	CLIP-seq
MIRT2687364	hsa-miR-548i	CLIP-seq
MIRT2687365	hsa-miR-548j	CLIP-seq
MIRT2063648	hsa-miR-548k	CLIP-seq
MIRT2589780	hsa-miR-548n	CLIP-seq
MIRT2589781	hsa-miR-548p	CLIP-seq
MIRT2589782	hsa-miR-548t	CLIP-seq
MIRT2687366	hsa-miR-548u	CLIP-seq
MIRT1220524	hsa-miR-548v	CLIP-seq
MIRT2687367	hsa-miR-548w	CLIP-seq
MIRT2687368	hsa-miR-548x	CLIP-seq
MIRT2687369	hsa-miR-548y	CLIP-seq
MIRT2687370	hsa-miR-548z	CLIP-seq
MIRT2687371	hsa-miR-555	CLIP-seq
MIRT2687372	hsa-miR-559	CLIP-seq
MIRT2687373	hsa-miR-570	CLIP-seq
MIRT2589783	hsa-miR-571	CLIP-seq
MIRT2687374	hsa-miR-580	CLIP-seq
MIRT2589784	hsa-miR-590-3p	CLIP-seq
MIRT2063649	hsa-miR-592	CLIP-seq
MIRT2063650	hsa-miR-599	CLIP-seq
MIRT2687375	hsa-miR-602	CLIP-seq
MIRT2687376	hsa-miR-641	CLIP-seq
MIRT2063652	hsa-miR-650	CLIP-seq
MIRT2589785	hsa-miR-654-5p	CLIP-seq
MIRT2589786	hsa-miR-657	CLIP-seq
MIRT2589787	hsa-miR-663b	CLIP-seq
MIRT2589788	hsa-miR-676	CLIP-seq
MIRT2589789	hsa-miR-762	CLIP-seq
MIRT2589790	hsa-miR-936	CLIP-seq
MIRT2063653	hsa-miR-940	CLIP-seq
MIRT2589791	hsa-miR-943	CLIP-seq

Show/Hide all(38)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000930	Component	Gamma-tubulin complex	IEA
GO:0001780	Process	Neutrophil homeostasis	ISS
GO:0004114	Function	3',5'-cyclic-nucleotide phosphodiesterase activity	IBA	21873635
GO:0004115	Function	3',5'-cyclic-AMP phosphodiesterase activity	IBA	21873635
GO:0004115	Function	3',5'-cyclic-AMP phosphodiesterase activity	IDA	17404263
GO:0004115	Function	3',5'-cyclic-AMP phosphodiesterase activity	IGI	8413254
GO:0004115	Function	3',5'-cyclic-AMP phosphodiesterase activity	ISS
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005813	Component	Centrosome	IEA
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0005891	Component	Voltage-gated calcium channel complex	ISS
GO:0006198	Process	CAMP catabolic process	IEA
GO:0007165	Process	Signal transduction	IBA	21873635
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0008021	Component	Synaptic vesicle	IEA
GO:0014069	Component	Postsynaptic density	IEA
GO:0030018	Component	Z disc	ISS
GO:0030552	Function	CAMP binding	IGI	8413254
GO:0030593	Process	Neutrophil chemotaxis	ISS
GO:0032729	Process	Positive regulation of interferon-gamma production	IMP	17404263
GO:0032743	Process	Positive regulation of interleukin-2 production	IMP	17404263
GO:0035690	Process	Cellular response to drug	ISS
GO:0043015	Function	Gamma-tubulin binding	IEA
GO:0043197	Component	Dendritic spine	IEA
GO:0044325	Function	Ion channel binding	IBA	21873635
GO:0044325	Function	Ion channel binding	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IBA	21873635
GO:0050852	Process	T cell receptor signaling pathway	IMP	17404263
GO:0050900	Process	Leukocyte migration	ISS
GO:0060076	Component	Excitatory synapse	IEA
GO:0071222	Process	Cellular response to lipopolysaccharide	ISS
GO:0071872	Process	Cellular response to epinephrine stimulus	ISS
GO:0086004	Process	Regulation of cardiac muscle cell contraction	ISS
GO:0140199	Process	Negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process	IEA
GO:1901841	Process	Regulation of high voltage-gated calcium channel activity	ISS
GO:1901898	Process	Negative regulation of relaxation of cardiac muscle	ISS

MIM	HGNC	e!Ensembl
600127	8781	ENSG00000184588

Protein

UniProt ID

Q07343

Protein name

3',5'-cyclic-AMP phosphodiesterase 4B (EC 3.1.4.53) (DPDE4) (PDE32) (cAMP-specific phosphodiesterase 4B)

Protein function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:15260978). May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiast

PDB

1F0J , 1RO6 , 1RO9 , 1ROR , 1TB5 , 1XLX , 1XLZ , 1XM4 , 1XM6 , 1XMU , 1XMY , 1XN0 , 1XOS , 1XOT , 1Y2H , 1Y2J , 2CHM , 2QYL , 3D3P , 3FRG , 3G45 , 3GWT , 3HC8 , 3HDZ , 3HMV , 3KKT , 3LY2 , 3O0J , 3O56 , 3O57 , 3W5E , 3WD9 , 4KP6 , 4MYQ , 4NW7 , 4WZI , 4X0F , 5K6J , 5LAQ , 5OHJ , 6BOJ , 8OEG

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF18100	PDE4_UCR	166 → 281	Phosphodiesterase 4 upstream conserved regions (UCR)	Domain
PF00233	PDEase_I	405 → 646		Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in brain, heart, lung and skeletal muscle (PubMed:17519386). Expressed in white blood cells (PubMed:8392015). {ECO:0000269|PubMed:17519386, ECO:0000269|PubMed:8392015}.; TISSUE SPECIFICITY: [Isoform PDE4B5]: Brain-specific is

Sequence

MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQS
ERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVL
HATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVR
NNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYR
SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKK
KQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSH
NRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHV
LLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHL
AVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTS
SGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEI
SPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSP
SPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLG
ETDIDIATEDKSPVDT

Sequence length

736

Interactions

View interactions

	KEGG		Reactome
	Purine metabolism Metabolic pathways cAMP signaling pathway Parathyroid hormone synthesis, secretion and action Morphine addiction		DARPP-32 events

Show/Hide Causal Diseases (4)

Disease term	Disease name	dbSNP ID	References
Causal
Autism	Autistic Disorder	rs121964908, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699 View all (8 more)	18090323
Leukemia	Leukemia, Myelocytic, Acute, Acute Myeloid Leukemia (AML-M2)	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297	17330099
Narcolepsy	Narcolepsy	rs104894574, rs387906655	19629137
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	26198764, 16293762, 28991256, 30285260, 18394866

Show/Hide Unknown Diseases (9)

Disease term	Disease name	Evidence	References	Source
Unknown
Asthma	Asthma		21912604	ClinVar
Mental depression	Mental Depression, Depressive disorder		21458469, 17823207, 18090323, 21184794, 21376063	ClinVar
Gastroesophageal Reflux Disease	Gastroesophageal Reflux Disease			GWAS
Metabolic Syndrome	Metabolic Syndrome			GWAS
Cervical Cancer	Cervical Cancer	Our screens identified 10 miRNAs that enhance fitness of HeLa cells and have been reported to be up-regulated in cervical cancer (Table2).		GWAS, CBGDA
Anxiety Disorder	Anxiety Disorder			GWAS
Multiple Sclerosis	Multiple Sclerosis			GWAS
Insomnia	Insomnia			GWAS
Heart Failure	Heart Failure			GWAS

Show/Hide Text Mining Associations (46)

Disease Name	Relationship Type	References
Associations from Text Mining
Arthritis Psoriatic	Associate	30181004
Breast Neoplasms	Associate	29061142
Cardiac Output Low	Associate	34788622
Colitis	Associate	31730855
Colorectal Neoplasms	Stimulate	22830422
Colorectal Neoplasms	Associate	27927168, 39202484
Cryptorchidism	Inhibit	25546171
Cryptorchidism	Associate	25546171
Depressive Disorder	Associate	19300510
Dermatitis Atopic	Associate	36142206
Diabetes Mellitus Type 1	Associate	18599519
Diabetes Mellitus Type 2	Associate	35046895
Disease	Associate	21853134
Down Syndrome	Associate	25546171
Dysmenorrhea	Inhibit	17264103
Epilepsy rolandic with paroxysmal exercise induced dystonia and writer's cramp	Associate	40646440
Esophageal Squamous Cell Carcinoma	Associate	34294701
Heart Diseases	Associate	35899614
Hypertension	Associate	35446883
Infarction	Associate	35899614
Inflammation	Associate	21854221, 30181004, 35266293
Inflammatory Bowel Diseases	Associate	31730855
Latent Autoimmune Diabetes in Adults	Associate	18599519
Learning Disabilities	Associate	25546171
Leukemia	Associate	29061142
Liver Diseases	Associate	27210814
Lymphoma B Cell	Associate	15331441
Lymphoma Follicular	Associate	23451206
Lymphoma Large B Cell Diffuse	Associate	15331441, 26869285
Measles	Associate	17538120
Mental Disorders	Associate	25546171, 27468165
MINOCA	Stimulate	35899614
Mood Disorders	Associate	25546171, 30116032
Myocardial Infarction	Associate	33354250, 35899614
Neoplasms	Associate	22830422, 23451206, 25979379, 26869285, 27927168, 29061142, 34788622, 35266293
Neoplasms Connective Tissue	Associate	31176952
Neurologic Manifestations	Associate	25546171
Parkinson Disease	Associate	33522352
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	35266293
Prostatic Neoplasms	Associate	25979379
Psoriasis	Stimulate	26806620
Psychotic Disorders	Associate	19300510
Reperfusion Injury	Associate	35899614
Respiratory Hypersensitivity	Associate	21784969
Schizophrenia	Associate	19251251, 21876540, 25546171, 29142105, 31176952
Testicular Diseases	Associate	25546171

PDE4B (phosphodiesterase 4B)