PDE4B (phosphodiesterase 4B)

Gene

• Entrez ID: 5142
• Gene name: Phosphodiesterase 4B
• Gene symbol: PDE4B
• Synonyms (NCBI Gene): DPDE4, PDEIVB
• Chromosome: 1
• Chromosome location: 1p31.3
• Summary: This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered act

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT144178	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT726989	hsa-miR-26a-5p	HITS-CLIP	22473208
MIRT726988	hsa-miR-26b-5p	HITS-CLIP	22473208
MIRT144178	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT1220468	hsa-miR-1207-5p	CLIP-seq
MIRT1220469	hsa-miR-130a	CLIP-seq
MIRT1220470	hsa-miR-130b	CLIP-seq
MIRT1220471	hsa-miR-148a	CLIP-seq
MIRT1220472	hsa-miR-148b	CLIP-seq
MIRT1220473	hsa-miR-152	CLIP-seq
MIRT1220474	hsa-miR-2682	CLIP-seq
MIRT1220475	hsa-miR-298	CLIP-seq
MIRT1220476	hsa-miR-301a	CLIP-seq
MIRT1220477	hsa-miR-301b	CLIP-seq
MIRT1220478	hsa-miR-34a	CLIP-seq
MIRT1220479	hsa-miR-34c-5p	CLIP-seq
MIRT1220480	hsa-miR-3591-3p	CLIP-seq
MIRT1220481	hsa-miR-3666	CLIP-seq
MIRT1220482	hsa-miR-3714	CLIP-seq
MIRT1220483	hsa-miR-4295	CLIP-seq
MIRT1220484	hsa-miR-449a	CLIP-seq
MIRT1220485	hsa-miR-449b	CLIP-seq
MIRT1220486	hsa-miR-449c	CLIP-seq
MIRT1220487	hsa-miR-454	CLIP-seq
MIRT1220488	hsa-miR-4696	CLIP-seq
MIRT1220489	hsa-miR-4736	CLIP-seq
MIRT1220490	hsa-miR-4742-5p	CLIP-seq
MIRT1220491	hsa-miR-4763-3p	CLIP-seq
MIRT1220492	hsa-miR-221	CLIP-seq
MIRT1220493	hsa-miR-222	CLIP-seq
MIRT1220494	hsa-miR-23a	CLIP-seq
MIRT1220495	hsa-miR-23b	CLIP-seq
MIRT1220496	hsa-miR-23c	CLIP-seq
MIRT1220497	hsa-miR-3145-5p	CLIP-seq
MIRT1220498	hsa-miR-3160-5p	CLIP-seq
MIRT1220499	hsa-miR-3163	CLIP-seq
MIRT1220500	hsa-miR-340	CLIP-seq
MIRT1220501	hsa-miR-345	CLIP-seq
MIRT1220502	hsa-miR-3545-3p	CLIP-seq
MIRT1220503	hsa-miR-4256	CLIP-seq
MIRT1220504	hsa-miR-4277	CLIP-seq
MIRT1220505	hsa-miR-431	CLIP-seq
MIRT1220506	hsa-miR-4422	CLIP-seq
MIRT1220507	hsa-miR-4539	CLIP-seq
MIRT1220508	hsa-miR-4728-3p	CLIP-seq
MIRT1220509	hsa-miR-4762-3p	CLIP-seq
MIRT1220510	hsa-miR-4766-5p	CLIP-seq
MIRT1220511	hsa-miR-4795-3p	CLIP-seq
MIRT1220512	hsa-miR-494	CLIP-seq
MIRT1220513	hsa-miR-499-3p	CLIP-seq
MIRT1220514	hsa-miR-499a-3p	CLIP-seq
MIRT1220515	hsa-miR-548c-3p	CLIP-seq
MIRT1220516	hsa-miR-21	CLIP-seq
MIRT1220517	hsa-miR-3613-3p	CLIP-seq
MIRT1220518	hsa-miR-488	CLIP-seq
MIRT1220519	hsa-miR-505	CLIP-seq
MIRT1220520	hsa-miR-561	CLIP-seq
MIRT1220521	hsa-miR-590-5p	CLIP-seq
MIRT1220492	hsa-miR-221	CLIP-seq
MIRT1220493	hsa-miR-222	CLIP-seq
MIRT1220494	hsa-miR-23a	CLIP-seq
MIRT1220495	hsa-miR-23b	CLIP-seq
MIRT1220496	hsa-miR-23c	CLIP-seq
MIRT1220522	hsa-miR-3188	CLIP-seq
MIRT1220523	hsa-miR-361-5p	CLIP-seq
MIRT1220524	hsa-miR-548v	CLIP-seq
MIRT1220468	hsa-miR-1207-5p	CLIP-seq
MIRT2063628	hsa-miR-1278	CLIP-seq
MIRT2063629	hsa-miR-1827	CLIP-seq
MIRT2063630	hsa-miR-204	CLIP-seq
MIRT2063631	hsa-miR-211	CLIP-seq
MIRT2063632	hsa-miR-2113	CLIP-seq
MIRT2063633	hsa-miR-3124-3p	CLIP-seq
MIRT2063634	hsa-miR-3166	CLIP-seq
MIRT1220480	hsa-miR-3591-3p	CLIP-seq
MIRT2063635	hsa-miR-3612	CLIP-seq
MIRT2063636	hsa-miR-4264	CLIP-seq
MIRT2063637	hsa-miR-4328	CLIP-seq
MIRT2063638	hsa-miR-4443	CLIP-seq
MIRT2063639	hsa-miR-4446-5p	CLIP-seq
MIRT2063640	hsa-miR-4470	CLIP-seq
MIRT2063641	hsa-miR-452	CLIP-seq
MIRT2063642	hsa-miR-4652-3p	CLIP-seq
MIRT2063643	hsa-miR-4676-3p	CLIP-seq
MIRT2063644	hsa-miR-4711-3p	CLIP-seq
MIRT2063645	hsa-miR-4719	CLIP-seq
MIRT1220489	hsa-miR-4736	CLIP-seq
MIRT1220490	hsa-miR-4742-5p	CLIP-seq
MIRT2063646	hsa-miR-4755-5p	CLIP-seq
MIRT1220491	hsa-miR-4763-3p	CLIP-seq
MIRT2063647	hsa-miR-4797-3p	CLIP-seq
MIRT2063648	hsa-miR-548k	CLIP-seq
MIRT1220520	hsa-miR-561	CLIP-seq
MIRT2063649	hsa-miR-592	CLIP-seq
MIRT2063650	hsa-miR-599	CLIP-seq
MIRT2063651	hsa-miR-623	CLIP-seq
MIRT2063652	hsa-miR-650	CLIP-seq
MIRT2063653	hsa-miR-940	CLIP-seq
MIRT2063628	hsa-miR-1278	CLIP-seq
MIRT2063629	hsa-miR-1827	CLIP-seq
MIRT2063635	hsa-miR-3612	CLIP-seq
MIRT2063638	hsa-miR-4443	CLIP-seq
MIRT2063640	hsa-miR-4470	CLIP-seq
MIRT2063641	hsa-miR-452	CLIP-seq
MIRT2063643	hsa-miR-4676-3p	CLIP-seq
MIRT1220490	hsa-miR-4742-5p	CLIP-seq
MIRT2063648	hsa-miR-548k	CLIP-seq
MIRT2063652	hsa-miR-650	CLIP-seq
MIRT2063653	hsa-miR-940	CLIP-seq
MIRT1220490	hsa-miR-4742-5p	CLIP-seq
MIRT2063628	hsa-miR-1278	CLIP-seq
MIRT2063629	hsa-miR-1827	CLIP-seq
MIRT2063635	hsa-miR-3612	CLIP-seq
MIRT2063638	hsa-miR-4443	CLIP-seq
MIRT2063640	hsa-miR-4470	CLIP-seq
MIRT2063641	hsa-miR-452	CLIP-seq
MIRT2063643	hsa-miR-4676-3p	CLIP-seq
MIRT1220490	hsa-miR-4742-5p	CLIP-seq
MIRT2063648	hsa-miR-548k	CLIP-seq
MIRT2063652	hsa-miR-650	CLIP-seq
MIRT2063653	hsa-miR-940	CLIP-seq
MIRT1220492	hsa-miR-221	CLIP-seq
MIRT1220493	hsa-miR-222	CLIP-seq
MIRT1220494	hsa-miR-23a	CLIP-seq
MIRT1220495	hsa-miR-23b	CLIP-seq
MIRT1220496	hsa-miR-23c	CLIP-seq
MIRT1220499	hsa-miR-3163	CLIP-seq
MIRT1220522	hsa-miR-3188	CLIP-seq
MIRT2431953	hsa-miR-323-3p	CLIP-seq
MIRT1220500	hsa-miR-340	CLIP-seq
MIRT1220504	hsa-miR-4277	CLIP-seq
MIRT1220511	hsa-miR-4795-3p	CLIP-seq
MIRT1220513	hsa-miR-499-3p	CLIP-seq
MIRT1220514	hsa-miR-499a-3p	CLIP-seq
MIRT1220524	hsa-miR-548v	CLIP-seq
MIRT1220518	hsa-miR-488	CLIP-seq
MIRT2589695	hsa-miR-1179	CLIP-seq
MIRT2589696	hsa-miR-1206	CLIP-seq
MIRT1220468	hsa-miR-1207-5p	CLIP-seq
MIRT2589697	hsa-miR-1227	CLIP-seq
MIRT2589698	hsa-miR-1244	CLIP-seq
MIRT2589699	hsa-miR-1269	CLIP-seq
MIRT2589700	hsa-miR-1269b	CLIP-seq
MIRT2589701	hsa-miR-1273d	CLIP-seq
MIRT2063628	hsa-miR-1278	CLIP-seq
MIRT2589702	hsa-miR-1288	CLIP-seq
MIRT2589703	hsa-miR-1291	CLIP-seq
MIRT2589704	hsa-miR-134	CLIP-seq
MIRT2589705	hsa-miR-140-3p	CLIP-seq
MIRT2589706	hsa-miR-142-3p	CLIP-seq
MIRT2589707	hsa-miR-145	CLIP-seq
MIRT2589708	hsa-miR-1587	CLIP-seq
MIRT2063629	hsa-miR-1827	CLIP-seq
MIRT2589709	hsa-miR-1914	CLIP-seq
MIRT2589710	hsa-miR-199a-3p	CLIP-seq
MIRT2589711	hsa-miR-199b-3p	CLIP-seq
MIRT2589712	hsa-miR-2054	CLIP-seq
MIRT2063632	hsa-miR-2113	CLIP-seq
MIRT1220492	hsa-miR-221	CLIP-seq
MIRT1220493	hsa-miR-222	CLIP-seq
MIRT2589713	hsa-miR-2355-3p	CLIP-seq
MIRT1220494	hsa-miR-23a	CLIP-seq
MIRT1220495	hsa-miR-23b	CLIP-seq
MIRT1220496	hsa-miR-23c	CLIP-seq
MIRT2589714	hsa-miR-3074-5p	CLIP-seq
MIRT2589715	hsa-miR-3118	CLIP-seq
MIRT2589716	hsa-miR-3120-3p	CLIP-seq
MIRT2589717	hsa-miR-3129-5p	CLIP-seq
MIRT2589718	hsa-miR-3162-3p	CLIP-seq
MIRT1220499	hsa-miR-3163	CLIP-seq
MIRT1220522	hsa-miR-3188	CLIP-seq
MIRT2431953	hsa-miR-323-3p	CLIP-seq
MIRT2589719	hsa-miR-328	CLIP-seq
MIRT1220500	hsa-miR-340	CLIP-seq
MIRT1220502	hsa-miR-3545-3p	CLIP-seq
MIRT2589720	hsa-miR-3607-3p	CLIP-seq
MIRT2063635	hsa-miR-3612	CLIP-seq
MIRT1220523	hsa-miR-361-5p	CLIP-seq
MIRT2589721	hsa-miR-3622b-5p	CLIP-seq
MIRT2589722	hsa-miR-3654	CLIP-seq
MIRT2589723	hsa-miR-3658	CLIP-seq
MIRT2589724	hsa-miR-3665	CLIP-seq
MIRT2589725	hsa-miR-3686	CLIP-seq
MIRT2589726	hsa-miR-370	CLIP-seq
MIRT2589727	hsa-miR-375	CLIP-seq
MIRT2589728	hsa-miR-376a	CLIP-seq
MIRT2589729	hsa-miR-376b	CLIP-seq
MIRT2589730	hsa-miR-3913-3p	CLIP-seq
MIRT2589731	hsa-miR-3944-5p	CLIP-seq
MIRT2589732	hsa-miR-3973	CLIP-seq
MIRT2589733	hsa-miR-3975	CLIP-seq
MIRT2589734	hsa-miR-421	CLIP-seq
MIRT2589735	hsa-miR-4255	CLIP-seq
MIRT2589736	hsa-miR-4268	CLIP-seq
MIRT2589737	hsa-miR-4270	CLIP-seq
MIRT2589738	hsa-miR-4272	CLIP-seq
MIRT1220504	hsa-miR-4277	CLIP-seq
MIRT2589739	hsa-miR-4318	CLIP-seq
MIRT2589740	hsa-miR-4417	CLIP-seq
MIRT1220506	hsa-miR-4422	CLIP-seq
MIRT2589741	hsa-miR-4441	CLIP-seq
MIRT2063638	hsa-miR-4443	CLIP-seq
MIRT2589742	hsa-miR-4448	CLIP-seq
MIRT2589743	hsa-miR-4459	CLIP-seq
MIRT2063640	hsa-miR-4470	CLIP-seq
MIRT2589744	hsa-miR-4492	CLIP-seq
MIRT2589745	hsa-miR-4498	CLIP-seq
MIRT2589746	hsa-miR-4514	CLIP-seq
MIRT2589747	hsa-miR-4515	CLIP-seq
MIRT2063641	hsa-miR-452	CLIP-seq
MIRT2589748	hsa-miR-4528	CLIP-seq
MIRT2589749	hsa-miR-4529-3p	CLIP-seq
MIRT1220507	hsa-miR-4539	CLIP-seq
MIRT2589750	hsa-miR-4638-3p	CLIP-seq
MIRT2589751	hsa-miR-4640-3p	CLIP-seq
MIRT2063642	hsa-miR-4652-3p	CLIP-seq
MIRT2589752	hsa-miR-4653-3p	CLIP-seq
MIRT2589753	hsa-miR-4656	CLIP-seq
MIRT2589754	hsa-miR-4661-3p	CLIP-seq
MIRT2589755	hsa-miR-4675	CLIP-seq
MIRT2063643	hsa-miR-4676-3p	CLIP-seq
MIRT2589756	hsa-miR-4677-3p	CLIP-seq
MIRT2589757	hsa-miR-4678	CLIP-seq
MIRT2589758	hsa-miR-4679	CLIP-seq
MIRT2589759	hsa-miR-4692	CLIP-seq
MIRT2589760	hsa-miR-4695-5p	CLIP-seq
MIRT2589761	hsa-miR-4709-5p	CLIP-seq
MIRT2589762	hsa-miR-4720-3p	CLIP-seq
MIRT2589763	hsa-miR-4720-5p	CLIP-seq
MIRT2589764	hsa-miR-4722-5p	CLIP-seq
MIRT1220508	hsa-miR-4728-3p	CLIP-seq
MIRT2589765	hsa-miR-4735-5p	CLIP-seq
MIRT1220489	hsa-miR-4736	CLIP-seq
MIRT2589766	hsa-miR-4740-5p	CLIP-seq
MIRT2589767	hsa-miR-4741	CLIP-seq
MIRT1220490	hsa-miR-4742-5p	CLIP-seq
MIRT2589768	hsa-miR-4753-5p	CLIP-seq
MIRT1220491	hsa-miR-4763-3p	CLIP-seq
MIRT1220510	hsa-miR-4766-5p	CLIP-seq
MIRT2589769	hsa-miR-4778-5p	CLIP-seq
MIRT1220511	hsa-miR-4795-3p	CLIP-seq
MIRT2589770	hsa-miR-4799-3p	CLIP-seq
MIRT2589771	hsa-miR-4804-3p	CLIP-seq
MIRT1220518	hsa-miR-488	CLIP-seq
MIRT2589772	hsa-miR-489	CLIP-seq
MIRT1220512	hsa-miR-494	CLIP-seq
MIRT1220513	hsa-miR-499-3p	CLIP-seq
MIRT1220514	hsa-miR-499a-3p	CLIP-seq
MIRT2589773	hsa-miR-508-5p	CLIP-seq
MIRT2589774	hsa-miR-520d-5p	CLIP-seq
MIRT2589775	hsa-miR-520g	CLIP-seq
MIRT2589776	hsa-miR-520h	CLIP-seq
MIRT2589777	hsa-miR-524-5p	CLIP-seq
MIRT2589778	hsa-miR-541	CLIP-seq
MIRT2589779	hsa-miR-545	CLIP-seq
MIRT1220515	hsa-miR-548c-3p	CLIP-seq
MIRT2063648	hsa-miR-548k	CLIP-seq
MIRT2589780	hsa-miR-548n	CLIP-seq
MIRT2589781	hsa-miR-548p	CLIP-seq
MIRT2589782	hsa-miR-548t	CLIP-seq
MIRT1220524	hsa-miR-548v	CLIP-seq
MIRT2589783	hsa-miR-571	CLIP-seq
MIRT2589784	hsa-miR-590-3p	CLIP-seq
MIRT2063652	hsa-miR-650	CLIP-seq
MIRT2589785	hsa-miR-654-5p	CLIP-seq
MIRT2589786	hsa-miR-657	CLIP-seq
MIRT2589787	hsa-miR-663b	CLIP-seq
MIRT2589788	hsa-miR-676	CLIP-seq
MIRT2589789	hsa-miR-762	CLIP-seq
MIRT2589790	hsa-miR-936	CLIP-seq
MIRT2063653	hsa-miR-940	CLIP-seq
MIRT2589791	hsa-miR-943	CLIP-seq
MIRT2431953	hsa-miR-323-3p	CLIP-seq
MIRT2589792	hsa-miR-4738-3p	CLIP-seq
MIRT2589774	hsa-miR-520d-5p	CLIP-seq
MIRT2589777	hsa-miR-524-5p	CLIP-seq
MIRT2687309	hsa-miR-103a	CLIP-seq
MIRT2687310	hsa-miR-107	CLIP-seq
MIRT2589695	hsa-miR-1179	CLIP-seq
MIRT2589696	hsa-miR-1206	CLIP-seq
MIRT1220468	hsa-miR-1207-5p	CLIP-seq
MIRT2589697	hsa-miR-1227	CLIP-seq
MIRT2589698	hsa-miR-1244	CLIP-seq
MIRT2687311	hsa-miR-1252	CLIP-seq
MIRT2687312	hsa-miR-1261	CLIP-seq
MIRT2589699	hsa-miR-1269	CLIP-seq
MIRT2589700	hsa-miR-1269b	CLIP-seq
MIRT2589701	hsa-miR-1273d	CLIP-seq
MIRT2063628	hsa-miR-1278	CLIP-seq
MIRT2687313	hsa-miR-1284	CLIP-seq
MIRT2589702	hsa-miR-1288	CLIP-seq
MIRT2589703	hsa-miR-1291	CLIP-seq
MIRT2687314	hsa-miR-1305	CLIP-seq
MIRT1220469	hsa-miR-130a	CLIP-seq
MIRT1220470	hsa-miR-130b	CLIP-seq
MIRT2589704	hsa-miR-134	CLIP-seq
MIRT2589705	hsa-miR-140-3p	CLIP-seq
MIRT2589706	hsa-miR-142-3p	CLIP-seq
MIRT2589707	hsa-miR-145	CLIP-seq
MIRT1220471	hsa-miR-148a	CLIP-seq
MIRT1220472	hsa-miR-148b	CLIP-seq
MIRT1220473	hsa-miR-152	CLIP-seq
MIRT2589708	hsa-miR-1587	CLIP-seq
MIRT2063629	hsa-miR-1827	CLIP-seq
MIRT2687315	hsa-miR-1913	CLIP-seq
MIRT2589709	hsa-miR-1914	CLIP-seq
MIRT2589710	hsa-miR-199a-3p	CLIP-seq
MIRT2589711	hsa-miR-199b-3p	CLIP-seq
MIRT2589712	hsa-miR-2054	CLIP-seq
MIRT2063632	hsa-miR-2113	CLIP-seq
MIRT1220492	hsa-miR-221	CLIP-seq
MIRT1220493	hsa-miR-222	CLIP-seq
MIRT2589713	hsa-miR-2355-3p	CLIP-seq
MIRT1220494	hsa-miR-23a	CLIP-seq
MIRT1220495	hsa-miR-23b	CLIP-seq
MIRT1220496	hsa-miR-23c	CLIP-seq
MIRT1220474	hsa-miR-2682	CLIP-seq
MIRT1220475	hsa-miR-298	CLIP-seq
MIRT2687316	hsa-miR-300	CLIP-seq
MIRT1220476	hsa-miR-301a	CLIP-seq
MIRT1220477	hsa-miR-301b	CLIP-seq
MIRT2589714	hsa-miR-3074-5p	CLIP-seq
MIRT2589715	hsa-miR-3118	CLIP-seq
MIRT2589716	hsa-miR-3120-3p	CLIP-seq
MIRT2589717	hsa-miR-3129-5p	CLIP-seq
MIRT2687317	hsa-miR-3152-3p	CLIP-seq
MIRT2687318	hsa-miR-3157-5p	CLIP-seq
MIRT2589718	hsa-miR-3162-3p	CLIP-seq
MIRT1220499	hsa-miR-3163	CLIP-seq
MIRT1220522	hsa-miR-3188	CLIP-seq
MIRT2431953	hsa-miR-323-3p	CLIP-seq
MIRT2687319	hsa-miR-324-3p	CLIP-seq
MIRT2589719	hsa-miR-328	CLIP-seq
MIRT1220500	hsa-miR-340	CLIP-seq
MIRT1220478	hsa-miR-34a	CLIP-seq
MIRT1220479	hsa-miR-34c-5p	CLIP-seq
MIRT1220502	hsa-miR-3545-3p	CLIP-seq
MIRT2589720	hsa-miR-3607-3p	CLIP-seq
MIRT2063635	hsa-miR-3612	CLIP-seq
MIRT2687320	hsa-miR-361-3p	CLIP-seq
MIRT1220523	hsa-miR-361-5p	CLIP-seq
MIRT2687321	hsa-miR-3617	CLIP-seq
MIRT2589721	hsa-miR-3622b-5p	CLIP-seq
MIRT2687322	hsa-miR-3647-3p	CLIP-seq
MIRT2589722	hsa-miR-3654	CLIP-seq
MIRT2589723	hsa-miR-3658	CLIP-seq
MIRT2589724	hsa-miR-3665	CLIP-seq
MIRT1220481	hsa-miR-3666	CLIP-seq
MIRT2589725	hsa-miR-3686	CLIP-seq
MIRT2687323	hsa-miR-3689d	CLIP-seq
MIRT2589726	hsa-miR-370	CLIP-seq
MIRT1220482	hsa-miR-3714	CLIP-seq
MIRT2589727	hsa-miR-375	CLIP-seq
MIRT2589728	hsa-miR-376a	CLIP-seq
MIRT2589729	hsa-miR-376b	CLIP-seq
MIRT2687324	hsa-miR-376c	CLIP-seq
MIRT2687325	hsa-miR-381	CLIP-seq
MIRT2687326	hsa-miR-383	CLIP-seq
MIRT2589730	hsa-miR-3913-3p	CLIP-seq
MIRT2687327	hsa-miR-3922-5p	CLIP-seq
MIRT2589731	hsa-miR-3944-5p	CLIP-seq
MIRT2589732	hsa-miR-3973	CLIP-seq
MIRT2589733	hsa-miR-3975	CLIP-seq
MIRT2589734	hsa-miR-421	CLIP-seq
MIRT2589735	hsa-miR-4255	CLIP-seq
MIRT2063636	hsa-miR-4264	CLIP-seq
MIRT2589736	hsa-miR-4268	CLIP-seq
MIRT2589737	hsa-miR-4270	CLIP-seq
MIRT2687328	hsa-miR-4271	CLIP-seq
MIRT2589738	hsa-miR-4272	CLIP-seq
MIRT1220504	hsa-miR-4277	CLIP-seq
MIRT1220483	hsa-miR-4295	CLIP-seq
MIRT2687329	hsa-miR-4307	CLIP-seq
MIRT1220505	hsa-miR-431	CLIP-seq
MIRT2687330	hsa-miR-4310	CLIP-seq
MIRT2687331	hsa-miR-4313	CLIP-seq
MIRT2687332	hsa-miR-4317	CLIP-seq
MIRT2589739	hsa-miR-4318	CLIP-seq
MIRT2063637	hsa-miR-4328	CLIP-seq
MIRT2589740	hsa-miR-4417	CLIP-seq
MIRT1220506	hsa-miR-4422	CLIP-seq
MIRT2589741	hsa-miR-4441	CLIP-seq
MIRT2063638	hsa-miR-4443	CLIP-seq
MIRT2589742	hsa-miR-4448	CLIP-seq
MIRT2589743	hsa-miR-4459	CLIP-seq
MIRT2063640	hsa-miR-4470	CLIP-seq
MIRT2687333	hsa-miR-4473	CLIP-seq
MIRT2589744	hsa-miR-4492	CLIP-seq
MIRT2589745	hsa-miR-4498	CLIP-seq
MIRT1220484	hsa-miR-449a	CLIP-seq
MIRT1220485	hsa-miR-449b	CLIP-seq
MIRT1220486	hsa-miR-449c	CLIP-seq
MIRT2589746	hsa-miR-4514	CLIP-seq
MIRT2589747	hsa-miR-4515	CLIP-seq
MIRT2063641	hsa-miR-452	CLIP-seq
MIRT2589748	hsa-miR-4528	CLIP-seq
MIRT2589749	hsa-miR-4529-3p	CLIP-seq
MIRT2687334	hsa-miR-4533	CLIP-seq
MIRT1220507	hsa-miR-4539	CLIP-seq
MIRT1220487	hsa-miR-454	CLIP-seq
MIRT2589750	hsa-miR-4638-3p	CLIP-seq
MIRT2589751	hsa-miR-4640-3p	CLIP-seq
MIRT2063642	hsa-miR-4652-3p	CLIP-seq
MIRT2589752	hsa-miR-4653-3p	CLIP-seq
MIRT2589753	hsa-miR-4656	CLIP-seq
MIRT2687335	hsa-miR-4659a-5p	CLIP-seq
MIRT2687336	hsa-miR-4659b-5p	CLIP-seq
MIRT2589754	hsa-miR-4661-3p	CLIP-seq
MIRT2687337	hsa-miR-4666-3p	CLIP-seq
MIRT2687338	hsa-miR-4671-3p	CLIP-seq
MIRT2589755	hsa-miR-4675	CLIP-seq
MIRT2063643	hsa-miR-4676-3p	CLIP-seq
MIRT2589756	hsa-miR-4677-3p	CLIP-seq
MIRT2589757	hsa-miR-4678	CLIP-seq
MIRT2589758	hsa-miR-4679	CLIP-seq
MIRT2687339	hsa-miR-4687-5p	CLIP-seq
MIRT2687340	hsa-miR-4690-3p	CLIP-seq
MIRT2589759	hsa-miR-4692	CLIP-seq
MIRT2687341	hsa-miR-4694-5p	CLIP-seq
MIRT2687342	hsa-miR-4695-3p	CLIP-seq
MIRT2589760	hsa-miR-4695-5p	CLIP-seq
MIRT1220488	hsa-miR-4696	CLIP-seq
MIRT2589761	hsa-miR-4709-5p	CLIP-seq
MIRT2063644	hsa-miR-4711-3p	CLIP-seq
MIRT2687343	hsa-miR-4716-3p	CLIP-seq
MIRT2589762	hsa-miR-4720-3p	CLIP-seq
MIRT2589763	hsa-miR-4720-5p	CLIP-seq
MIRT2589764	hsa-miR-4722-5p	CLIP-seq
MIRT2687344	hsa-miR-4725-3p	CLIP-seq
MIRT1220508	hsa-miR-4728-3p	CLIP-seq
MIRT2589765	hsa-miR-4735-5p	CLIP-seq
MIRT1220489	hsa-miR-4736	CLIP-seq
MIRT2589792	hsa-miR-4738-3p	CLIP-seq
MIRT2589766	hsa-miR-4740-5p	CLIP-seq
MIRT2589767	hsa-miR-4741	CLIP-seq
MIRT1220490	hsa-miR-4742-5p	CLIP-seq
MIRT2687345	hsa-miR-4747-5p	CLIP-seq
MIRT2687346	hsa-miR-4749-3p	CLIP-seq
MIRT2589768	hsa-miR-4753-5p	CLIP-seq
MIRT1220491	hsa-miR-4763-3p	CLIP-seq
MIRT1220510	hsa-miR-4766-5p	CLIP-seq
MIRT2687347	hsa-miR-4772-5p	CLIP-seq
MIRT2687348	hsa-miR-4776-3p	CLIP-seq
MIRT2589769	hsa-miR-4778-5p	CLIP-seq
MIRT1220511	hsa-miR-4795-3p	CLIP-seq
MIRT2063647	hsa-miR-4797-3p	CLIP-seq
MIRT2589770	hsa-miR-4799-3p	CLIP-seq
MIRT2687349	hsa-miR-4802-5p	CLIP-seq
MIRT2589771	hsa-miR-4804-3p	CLIP-seq
MIRT1220518	hsa-miR-488	CLIP-seq
MIRT2589772	hsa-miR-489	CLIP-seq
MIRT2687350	hsa-miR-490-3p	CLIP-seq
MIRT1220512	hsa-miR-494	CLIP-seq
MIRT2687351	hsa-miR-498	CLIP-seq
MIRT1220513	hsa-miR-499-3p	CLIP-seq
MIRT1220514	hsa-miR-499a-3p	CLIP-seq
MIRT2589773	hsa-miR-508-5p	CLIP-seq
MIRT2589774	hsa-miR-520d-5p	CLIP-seq
MIRT2589775	hsa-miR-520g	CLIP-seq
MIRT2589776	hsa-miR-520h	CLIP-seq
MIRT2589777	hsa-miR-524-5p	CLIP-seq
MIRT2589778	hsa-miR-541	CLIP-seq
MIRT2589779	hsa-miR-545	CLIP-seq
MIRT2687352	hsa-miR-548a-5p	CLIP-seq
MIRT2687353	hsa-miR-548ab	CLIP-seq
MIRT2687354	hsa-miR-548ac	CLIP-seq
MIRT2687355	hsa-miR-548ae	CLIP-seq
MIRT2687356	hsa-miR-548aj	CLIP-seq
MIRT2687357	hsa-miR-548ak	CLIP-seq
MIRT2687358	hsa-miR-548am	CLIP-seq
MIRT2687359	hsa-miR-548b-5p	CLIP-seq
MIRT1220515	hsa-miR-548c-3p	CLIP-seq
MIRT2687360	hsa-miR-548c-5p	CLIP-seq
MIRT2687361	hsa-miR-548d-3p	CLIP-seq
MIRT2687362	hsa-miR-548d-5p	CLIP-seq
MIRT2687363	hsa-miR-548h	CLIP-seq
MIRT2687364	hsa-miR-548i	CLIP-seq
MIRT2687365	hsa-miR-548j	CLIP-seq
MIRT2063648	hsa-miR-548k	CLIP-seq
MIRT2589780	hsa-miR-548n	CLIP-seq
MIRT2589781	hsa-miR-548p	CLIP-seq
MIRT2589782	hsa-miR-548t	CLIP-seq
MIRT2687366	hsa-miR-548u	CLIP-seq
MIRT1220524	hsa-miR-548v	CLIP-seq
MIRT2687367	hsa-miR-548w	CLIP-seq
MIRT2687368	hsa-miR-548x	CLIP-seq
MIRT2687369	hsa-miR-548y	CLIP-seq
MIRT2687370	hsa-miR-548z	CLIP-seq
MIRT2687371	hsa-miR-555	CLIP-seq
MIRT2687372	hsa-miR-559	CLIP-seq
MIRT2687373	hsa-miR-570	CLIP-seq
MIRT2589783	hsa-miR-571	CLIP-seq
MIRT2687374	hsa-miR-580	CLIP-seq
MIRT2589784	hsa-miR-590-3p	CLIP-seq
MIRT2063649	hsa-miR-592	CLIP-seq
MIRT2063650	hsa-miR-599	CLIP-seq
MIRT2687375	hsa-miR-602	CLIP-seq
MIRT2687376	hsa-miR-641	CLIP-seq
MIRT2063652	hsa-miR-650	CLIP-seq
MIRT2589785	hsa-miR-654-5p	CLIP-seq
MIRT2589786	hsa-miR-657	CLIP-seq
MIRT2589787	hsa-miR-663b	CLIP-seq
MIRT2589788	hsa-miR-676	CLIP-seq
MIRT2589789	hsa-miR-762	CLIP-seq
MIRT2589790	hsa-miR-936	CLIP-seq
MIRT2063653	hsa-miR-940	CLIP-seq
MIRT2589791	hsa-miR-943	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000930	Component	Gamma-tubulin complex	IEA
GO:0001780	Process	Neutrophil homeostasis	IEA
GO:0001780	Process	Neutrophil homeostasis	ISS
GO:0004114	Function	3',5'-cyclic-nucleotide phosphodiesterase activity	IEA
GO:0004115	Function	3',5'-cyclic-AMP phosphodiesterase activity	IBA
GO:0004115	Function	3',5'-cyclic-AMP phosphodiesterase activity	IDA	17404263
GO:0004115	Function	3',5'-cyclic-AMP phosphodiesterase activity	IEA
GO:0004115	Function	3',5'-cyclic-AMP phosphodiesterase activity	IGI	8413254
GO:0004115	Function	3',5'-cyclic-AMP phosphodiesterase activity	ISS
GO:0004115	Function	3',5'-cyclic-AMP phosphodiesterase activity	TAS	9371714
GO:0005246	Function	Calcium channel regulator activity	IEA
GO:0005246	Function	Calcium channel regulator activity	ISS
GO:0005515	Function	Protein binding	IPI	33961781, 37207277
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IEA
GO:0005891	Component	Voltage-gated calcium channel complex	IEA
GO:0005891	Component	Voltage-gated calcium channel complex	ISS
GO:0006198	Process	CAMP catabolic process	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0008021	Component	Synaptic vesicle	IEA
GO:0008081	Function	Phosphoric diester hydrolase activity	IEA
GO:0014069	Component	Postsynaptic density	IEA
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030018	Component	Z disc	IEA
GO:0030018	Component	Z disc	ISS
GO:0030552	Function	CAMP binding	IGI	8413254
GO:0030593	Process	Neutrophil chemotaxis	IEA
GO:0030593	Process	Neutrophil chemotaxis	ISS
GO:0032729	Process	Positive regulation of type II interferon production	IMP	17404263
GO:0032743	Process	Positive regulation of interleukin-2 production	IMP	17404263
GO:0043015	Function	Gamma-tubulin binding	IEA
GO:0043197	Component	Dendritic spine	IEA
GO:0044325	Function	Transmembrane transporter binding	IEA
GO:0044325	Function	Transmembrane transporter binding	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0047555	Function	3',5'-cyclic-GMP phosphodiesterase activity	IBA
GO:0050852	Process	T cell receptor signaling pathway	IMP	17404263
GO:0050900	Process	Leukocyte migration	IEA
GO:0050900	Process	Leukocyte migration	ISS
GO:0060076	Component	Excitatory synapse	IEA
GO:0071222	Process	Cellular response to lipopolysaccharide	IEA
GO:0071222	Process	Cellular response to lipopolysaccharide	ISS
GO:0071466	Process	Cellular response to xenobiotic stimulus	IEA
GO:0071466	Process	Cellular response to xenobiotic stimulus	ISS
GO:0071872	Process	Cellular response to epinephrine stimulus	IEA
GO:0071872	Process	Cellular response to epinephrine stimulus	ISS
GO:0071878	Process	Negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway	IEA
GO:0071878	Process	Negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway	ISS
GO:0071944	Component	Cell periphery	IEA
GO:0086004	Process	Regulation of cardiac muscle cell contraction	IEA
GO:0086004	Process	Regulation of cardiac muscle cell contraction	ISS
GO:0141162	Process	Negative regulation of cAMP/PKA signal transduction	IBA
GO:1901898	Process	Negative regulation of relaxation of cardiac muscle	IEA
GO:1901898	Process	Negative regulation of relaxation of cardiac muscle	ISS
GO:1902514	Process	Regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	IEA
GO:1902514	Process	Regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	ISS

Other IDs

• MIM: 600127
• HGNC: 8781
• e!Ensembl: ENSG00000184588

Protein

• UniProt ID: Q07343
• Protein name: 3',5'-cyclic-AMP phosphodiesterase 4B (EC 3.1.4.53) (DPDE4) (PDE32) (cAMP-specific phosphodiesterase 4B)
• Protein function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:15260978). May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiast
• PDB: 1F0J, 1RO6, 1RO9, 1ROR, 1TB5, 1XLX, 1XLZ, 1XM4, 1XM6, 1XMU, 1XMY, 1XN0, 1XOS, 1XOT, 1Y2H, 1Y2J, 2CHM, 2QYL, 3D3P, 3FRG, 3G45, 3GWT, 3HC8, 3HDZ, 3HMV, 3KKT, 3LY2, 3O0J, 3O56, 3O57, 3W5E, 3WD9, 4KP6, 4MYQ, 4NW7, 4WZI, 4X0F, 5K6J, 5LAQ, 5OHJ, 6BOJ, 8OEG
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF18100	PDE4_UCR	166 → 281	Phosphodiesterase 4 upstream conserved regions (UCR)	Domain
  PF00233	PDEase_I	405 → 646		Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in brain, heart, lung and skeletal muscle (PubMed:17519386). Expressed in white blood cells (PubMed:8392015). {ECO:0000269|PubMed:17519386, ECO:0000269|PubMed:8392015}.; TISSUE SPECIFICITY: [Isoform PDE4B5]: Brain-specific is
• Sequence:

  MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQS
  ERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVL
  HATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVR
  NNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYR
  SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKK
  KQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSH
  NRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHV
  LLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHL
  AVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTS
  SGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEI
  SPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSP
  SPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLG
  ETDIDIATEDKSPVDT

• Sequence length: 736

Pathways

KEGG:

Purine metabolism
Metabolic pathways
cAMP signaling pathway
Parathyroid hormone synthesis, secretion and action
Morphine addiction

Reactome:

DARPP-32 events