Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5141
Gene name Gene Name - the full gene name approved by the HGNC.	Phosphodiesterase 4A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PDE4A
Synonyms (NCBI Gene) Gene synonyms aliases	DPDE2, PDE4, PDE46
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19p13.2
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular sign

Show/Hide all(272)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016809	hsa-miR-335-5p	Microarray	18185580
MIRT040823	hsa-miR-18a-3p	CLASH	23622248
MIRT037515	hsa-miR-744-5p	CLASH	23622248
MIRT709572	hsa-miR-504-5p	HITS-CLIP	19536157
MIRT709571	hsa-miR-3620-3p	HITS-CLIP	19536157
MIRT709570	hsa-miR-874-5p	HITS-CLIP	19536157
MIRT709569	hsa-miR-4313	HITS-CLIP	19536157
MIRT492804	hsa-miR-4779	PAR-CLIP	20371350
MIRT492803	hsa-miR-6760-5p	PAR-CLIP	20371350
MIRT492802	hsa-miR-4419a	PAR-CLIP	20371350
MIRT492801	hsa-miR-4510	PAR-CLIP	20371350
MIRT492800	hsa-miR-6127	PAR-CLIP	20371350
MIRT492799	hsa-miR-6129	PAR-CLIP	20371350
MIRT492798	hsa-miR-6130	PAR-CLIP	20371350
MIRT492797	hsa-miR-6133	PAR-CLIP	20371350
MIRT492793	hsa-miR-765	PAR-CLIP	20371350
MIRT492792	hsa-miR-1249-5p	PAR-CLIP	20371350
MIRT492791	hsa-miR-6797-5p	PAR-CLIP	20371350
MIRT492790	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT492789	hsa-miR-4649-5p	PAR-CLIP	20371350
MIRT492788	hsa-miR-6729-5p	PAR-CLIP	20371350
MIRT492787	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT492807	hsa-miR-1911-3p	PAR-CLIP	20371350
MIRT492806	hsa-miR-6758-5p	PAR-CLIP	20371350
MIRT492805	hsa-miR-6856-5p	PAR-CLIP	20371350
MIRT492804	hsa-miR-4779	PAR-CLIP	20371350
MIRT492803	hsa-miR-6760-5p	PAR-CLIP	20371350
MIRT569132	hsa-miR-6805-5p	PAR-CLIP	20371350
MIRT492802	hsa-miR-4419a	PAR-CLIP	20371350
MIRT492801	hsa-miR-4510	PAR-CLIP	20371350
MIRT492800	hsa-miR-6127	PAR-CLIP	20371350
MIRT492799	hsa-miR-6129	PAR-CLIP	20371350
MIRT492798	hsa-miR-6130	PAR-CLIP	20371350
MIRT492797	hsa-miR-6133	PAR-CLIP	20371350
MIRT492796	hsa-miR-185-5p	PAR-CLIP	20371350
MIRT492795	hsa-miR-4306	PAR-CLIP	20371350
MIRT492794	hsa-miR-4644	PAR-CLIP	20371350
MIRT492793	hsa-miR-765	PAR-CLIP	20371350
MIRT492792	hsa-miR-1249-5p	PAR-CLIP	20371350
MIRT492791	hsa-miR-6797-5p	PAR-CLIP	20371350
MIRT149366	hsa-miR-6731-5p	PAR-CLIP	20371350
MIRT149377	hsa-miR-8085	PAR-CLIP	20371350
MIRT492790	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT492789	hsa-miR-4649-5p	PAR-CLIP	20371350
MIRT492788	hsa-miR-6729-5p	PAR-CLIP	20371350
MIRT492787	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT149369	hsa-miR-6846-5p	PAR-CLIP	20371350
MIRT149370	hsa-miR-6848-5p	PAR-CLIP	20371350
MIRT492807	hsa-miR-1911-3p	PAR-CLIP	23592263
MIRT492806	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT492805	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT492804	hsa-miR-4779	PAR-CLIP	23592263
MIRT492803	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT492802	hsa-miR-4419a	PAR-CLIP	23592263
MIRT492801	hsa-miR-4510	PAR-CLIP	23592263
MIRT492800	hsa-miR-6127	PAR-CLIP	23592263
MIRT492799	hsa-miR-6129	PAR-CLIP	23592263
MIRT492798	hsa-miR-6130	PAR-CLIP	23592263
MIRT492797	hsa-miR-6133	PAR-CLIP	23592263
MIRT492796	hsa-miR-185-5p	PAR-CLIP	23592263
MIRT492795	hsa-miR-4306	PAR-CLIP	23592263
MIRT492794	hsa-miR-4644	PAR-CLIP	23592263
MIRT492793	hsa-miR-765	PAR-CLIP	23592263
MIRT492792	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT492791	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT149366	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT149377	hsa-miR-8085	PAR-CLIP	23592263
MIRT492790	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT492789	hsa-miR-4649-5p	PAR-CLIP	23592263
MIRT492788	hsa-miR-6729-5p	PAR-CLIP	23592263
MIRT492787	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT149369	hsa-miR-6846-5p	PAR-CLIP	23592263
MIRT149370	hsa-miR-6848-5p	PAR-CLIP	23592263
MIRT149309	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT149310	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT726988	hsa-miR-26b-5p	Luciferase reporter assay, qRT-PCR, Western blot	26493444
MIRT569132	hsa-miR-6805-5p	PAR-CLIP	26701625
MIRT709572	hsa-miR-504-5p	HITS-CLIP	19536157
MIRT709571	hsa-miR-3620-3p	HITS-CLIP	19536157
MIRT709570	hsa-miR-874-5p	HITS-CLIP	19536157
MIRT709569	hsa-miR-4313	HITS-CLIP	19536157
MIRT492804	hsa-miR-4779	PAR-CLIP	20371350
MIRT492803	hsa-miR-6760-5p	PAR-CLIP	20371350
MIRT492802	hsa-miR-4419a	PAR-CLIP	20371350
MIRT492801	hsa-miR-4510	PAR-CLIP	20371350
MIRT492800	hsa-miR-6127	PAR-CLIP	20371350
MIRT492799	hsa-miR-6129	PAR-CLIP	20371350
MIRT492798	hsa-miR-6130	PAR-CLIP	20371350
MIRT492797	hsa-miR-6133	PAR-CLIP	20371350
MIRT492793	hsa-miR-765	PAR-CLIP	20371350
MIRT492792	hsa-miR-1249-5p	PAR-CLIP	20371350
MIRT492791	hsa-miR-6797-5p	PAR-CLIP	20371350
MIRT492790	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT492789	hsa-miR-4649-5p	PAR-CLIP	20371350
MIRT492788	hsa-miR-6729-5p	PAR-CLIP	20371350
MIRT492787	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT492807	hsa-miR-1911-3p	PAR-CLIP	20371350
MIRT492806	hsa-miR-6758-5p	PAR-CLIP	20371350
MIRT492805	hsa-miR-6856-5p	PAR-CLIP	20371350
MIRT492804	hsa-miR-4779	PAR-CLIP	20371350
MIRT492803	hsa-miR-6760-5p	PAR-CLIP	20371350
MIRT569132	hsa-miR-6805-5p	PAR-CLIP	20371350
MIRT492802	hsa-miR-4419a	PAR-CLIP	20371350
MIRT492801	hsa-miR-4510	PAR-CLIP	20371350
MIRT492800	hsa-miR-6127	PAR-CLIP	20371350
MIRT492799	hsa-miR-6129	PAR-CLIP	20371350
MIRT492798	hsa-miR-6130	PAR-CLIP	20371350
MIRT492797	hsa-miR-6133	PAR-CLIP	20371350
MIRT492796	hsa-miR-185-5p	PAR-CLIP	20371350
MIRT492795	hsa-miR-4306	PAR-CLIP	20371350
MIRT492794	hsa-miR-4644	PAR-CLIP	20371350
MIRT492793	hsa-miR-765	PAR-CLIP	20371350
MIRT492792	hsa-miR-1249-5p	PAR-CLIP	20371350
MIRT492791	hsa-miR-6797-5p	PAR-CLIP	20371350
MIRT149366	hsa-miR-6731-5p	PAR-CLIP	20371350
MIRT149377	hsa-miR-8085	PAR-CLIP	20371350
MIRT492790	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT492789	hsa-miR-4649-5p	PAR-CLIP	20371350
MIRT492788	hsa-miR-6729-5p	PAR-CLIP	20371350
MIRT492787	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT149369	hsa-miR-6846-5p	PAR-CLIP	20371350
MIRT149370	hsa-miR-6848-5p	PAR-CLIP	20371350
MIRT492807	hsa-miR-1911-3p	PAR-CLIP	23592263
MIRT492806	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT492805	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT492804	hsa-miR-4779	PAR-CLIP	23592263
MIRT492803	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT492802	hsa-miR-4419a	PAR-CLIP	23592263
MIRT492801	hsa-miR-4510	PAR-CLIP	23592263
MIRT492800	hsa-miR-6127	PAR-CLIP	23592263
MIRT492799	hsa-miR-6129	PAR-CLIP	23592263
MIRT492798	hsa-miR-6130	PAR-CLIP	23592263
MIRT492797	hsa-miR-6133	PAR-CLIP	23592263
MIRT492796	hsa-miR-185-5p	PAR-CLIP	23592263
MIRT492795	hsa-miR-4306	PAR-CLIP	23592263
MIRT492794	hsa-miR-4644	PAR-CLIP	23592263
MIRT492793	hsa-miR-765	PAR-CLIP	23592263
MIRT492792	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT492791	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT149366	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT149377	hsa-miR-8085	PAR-CLIP	23592263
MIRT492790	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT492789	hsa-miR-4649-5p	PAR-CLIP	23592263
MIRT492788	hsa-miR-6729-5p	PAR-CLIP	23592263
MIRT492787	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT149369	hsa-miR-6846-5p	PAR-CLIP	23592263
MIRT149370	hsa-miR-6848-5p	PAR-CLIP	23592263
MIRT1220378	hsa-miR-1254	CLIP-seq
MIRT1220379	hsa-miR-3116	CLIP-seq
MIRT1220380	hsa-miR-3652	CLIP-seq
MIRT1220381	hsa-miR-3937	CLIP-seq
MIRT1220382	hsa-miR-4430	CLIP-seq
MIRT1220383	hsa-miR-4499	CLIP-seq
MIRT1220384	hsa-miR-4731-3p	CLIP-seq
MIRT1220385	hsa-miR-4797-5p	CLIP-seq
MIRT1220386	hsa-miR-4801	CLIP-seq
MIRT1220387	hsa-miR-600	CLIP-seq
MIRT1220388	hsa-miR-646	CLIP-seq
MIRT1220389	hsa-miR-7	CLIP-seq
MIRT1220390	hsa-miR-1228	CLIP-seq
MIRT1220391	hsa-miR-1303	CLIP-seq
MIRT1220392	hsa-miR-19a	CLIP-seq
MIRT1220393	hsa-miR-19b	CLIP-seq
MIRT1220394	hsa-miR-204	CLIP-seq
MIRT1220395	hsa-miR-211	CLIP-seq
MIRT1220396	hsa-miR-3157-5p	CLIP-seq
MIRT1220397	hsa-miR-3173-3p	CLIP-seq
MIRT1220398	hsa-miR-3175	CLIP-seq
MIRT1220399	hsa-miR-3202	CLIP-seq
MIRT1220400	hsa-miR-3978	CLIP-seq
MIRT1220401	hsa-miR-4433	CLIP-seq
MIRT1220402	hsa-miR-4446-5p	CLIP-seq
MIRT1220403	hsa-miR-4691-3p	CLIP-seq
MIRT1220404	hsa-miR-4695-5p	CLIP-seq
MIRT1220405	hsa-miR-4747-5p	CLIP-seq
MIRT1220406	hsa-miR-4755-5p	CLIP-seq
MIRT1220407	hsa-miR-4758-3p	CLIP-seq
MIRT1220408	hsa-miR-4795-5p	CLIP-seq
MIRT1220409	hsa-miR-623	CLIP-seq
MIRT1220410	hsa-miR-665	CLIP-seq
MIRT1220389	hsa-miR-7	CLIP-seq
MIRT1220411	hsa-miR-877	CLIP-seq
MIRT1220378	hsa-miR-1254	CLIP-seq
MIRT1220412	hsa-miR-1270	CLIP-seq
MIRT1220413	hsa-miR-1275	CLIP-seq
MIRT1220414	hsa-miR-132	CLIP-seq
MIRT1220415	hsa-miR-135a	CLIP-seq
MIRT1220416	hsa-miR-135b	CLIP-seq
MIRT1220417	hsa-miR-185	CLIP-seq
MIRT1220418	hsa-miR-1913	CLIP-seq
MIRT1220392	hsa-miR-19a	CLIP-seq
MIRT1220393	hsa-miR-19b	CLIP-seq
MIRT1220419	hsa-miR-212	CLIP-seq
MIRT1220420	hsa-miR-298	CLIP-seq
MIRT1220379	hsa-miR-3116	CLIP-seq
MIRT1220421	hsa-miR-3124-3p	CLIP-seq
MIRT1220422	hsa-miR-3138	CLIP-seq
MIRT1220423	hsa-miR-3153	CLIP-seq
MIRT1220424	hsa-miR-3158-5p	CLIP-seq
MIRT1220425	hsa-miR-3163	CLIP-seq
MIRT1220426	hsa-miR-3184	CLIP-seq
MIRT1220427	hsa-miR-3189-5p	CLIP-seq
MIRT1220428	hsa-miR-3190	CLIP-seq
MIRT1220399	hsa-miR-3202	CLIP-seq
MIRT1220429	hsa-miR-324-3p	CLIP-seq
MIRT1220430	hsa-miR-34a	CLIP-seq
MIRT1220431	hsa-miR-34c-5p	CLIP-seq
MIRT1220432	hsa-miR-3609	CLIP-seq
MIRT1220433	hsa-miR-3613-3p	CLIP-seq
MIRT1220434	hsa-miR-361-3p	CLIP-seq
MIRT1220435	hsa-miR-3647-3p	CLIP-seq
MIRT1220380	hsa-miR-3652	CLIP-seq
MIRT1220436	hsa-miR-3667-3p	CLIP-seq
MIRT1220381	hsa-miR-3937	CLIP-seq
MIRT1220437	hsa-miR-3973	CLIP-seq
MIRT1220400	hsa-miR-3978	CLIP-seq
MIRT1220438	hsa-miR-423-5p	CLIP-seq
MIRT1220439	hsa-miR-4252	CLIP-seq
MIRT1220440	hsa-miR-4267	CLIP-seq
MIRT1220441	hsa-miR-4271	CLIP-seq
MIRT1220442	hsa-miR-4278	CLIP-seq
MIRT1220443	hsa-miR-4282	CLIP-seq
MIRT1220444	hsa-miR-432	CLIP-seq
MIRT1220382	hsa-miR-4430	CLIP-seq
MIRT1220401	hsa-miR-4433	CLIP-seq
MIRT1220445	hsa-miR-4447	CLIP-seq
MIRT1220446	hsa-miR-4472	CLIP-seq
MIRT1220383	hsa-miR-4499	CLIP-seq
MIRT1220447	hsa-miR-449a	CLIP-seq
MIRT1220448	hsa-miR-449b	CLIP-seq
MIRT1220449	hsa-miR-4525	CLIP-seq
MIRT1220450	hsa-miR-4531	CLIP-seq
MIRT1220451	hsa-miR-4533	CLIP-seq
MIRT1220452	hsa-miR-4665-5p	CLIP-seq
MIRT1220453	hsa-miR-4668-3p	CLIP-seq
MIRT1220454	hsa-miR-4710	CLIP-seq
MIRT1220455	hsa-miR-4716-3p	CLIP-seq
MIRT1220456	hsa-miR-4723-5p	CLIP-seq
MIRT1220457	hsa-miR-4725-3p	CLIP-seq
MIRT1220458	hsa-miR-4728-5p	CLIP-seq
MIRT1220384	hsa-miR-4731-3p	CLIP-seq
MIRT1220459	hsa-miR-4746-5p	CLIP-seq
MIRT1220405	hsa-miR-4747-5p	CLIP-seq
MIRT1220407	hsa-miR-4758-3p	CLIP-seq
MIRT1220408	hsa-miR-4795-5p	CLIP-seq
MIRT1220460	hsa-miR-4796-3p	CLIP-seq
MIRT1220385	hsa-miR-4797-5p	CLIP-seq
MIRT1220386	hsa-miR-4801	CLIP-seq
MIRT1220461	hsa-miR-486-3p	CLIP-seq
MIRT1220462	hsa-miR-520g	CLIP-seq
MIRT1220463	hsa-miR-520h	CLIP-seq
MIRT1220464	hsa-miR-548ah	CLIP-seq
MIRT1220387	hsa-miR-600	CLIP-seq
MIRT1220465	hsa-miR-605	CLIP-seq
MIRT1220466	hsa-miR-620	CLIP-seq
MIRT1220467	hsa-miR-625	CLIP-seq
MIRT1220388	hsa-miR-646	CLIP-seq
MIRT1220410	hsa-miR-665	CLIP-seq
MIRT1220389	hsa-miR-7	CLIP-seq
MIRT1220402	hsa-miR-4446-5p	CLIP-seq
MIRT2292098	hsa-miR-3135b	CLIP-seq
MIRT1220399	hsa-miR-3202	CLIP-seq
MIRT1220380	hsa-miR-3652	CLIP-seq
MIRT1220382	hsa-miR-4430	CLIP-seq
MIRT2292099	hsa-miR-4487	CLIP-seq
MIRT2292100	hsa-miR-4633-3p	CLIP-seq
MIRT1220422	hsa-miR-3138	CLIP-seq
MIRT2456079	hsa-miR-122	CLIP-seq
MIRT2456080	hsa-miR-1324	CLIP-seq
MIRT2456081	hsa-miR-3159	CLIP-seq
MIRT2456082	hsa-miR-486-5p	CLIP-seq
MIRT2456083	hsa-miR-95	CLIP-seq

Show/Hide all(23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004114	Function	3',5'-cyclic-nucleotide phosphodiesterase activity	IBA	21873635
GO:0004115	Function	3',5'-cyclic-AMP phosphodiesterase activity	IBA	21873635
GO:0004115	Function	3',5'-cyclic-AMP phosphodiesterase activity	IDA	17404263
GO:0004115	Function	3',5'-cyclic-AMP phosphodiesterase activity	IGI	8413254
GO:0005515	Function	Protein binding	IPI	11306681
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0006198	Process	CAMP catabolic process	IEA
GO:0007165	Process	Signal transduction	IBA	21873635
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007608	Process	Sensory perception of smell	IEA
GO:0010738	Process	Regulation of protein kinase A signaling	IEA
GO:0016020	Component	Membrane	TAS	9677330
GO:0030552	Function	CAMP binding	IGI	8413254
GO:0032587	Component	Ruffle membrane	IEA
GO:0035690	Process	Cellular response to drug	IEA
GO:0043949	Process	Regulation of cAMP-mediated signaling	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IBA	21873635
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	11306681

MIM	HGNC	e!Ensembl
600126	8780	ENSG00000065989

Protein

UniProt ID

P27815

Protein name

3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A)

Protein function

Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. ; [Isoform 1]: Efficiently hydrolyzes cAMP. {ECO:000

PDB

2QYK , 3I8V , 3TVX

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF18100	PDE4_UCR	178 → 293	Phosphodiesterase 4 upstream conserved regions (UCR)	Domain
PF00233	PDEase_I	432 → 673		Domain

Tissue specificity

TISSUE SPECIFICITY: [Isoform 1]: Expressed in lymphoid cell subsets including CD8-positive T cells and T-helper 2 cells. Expressed in dendritic cells. {ECO:0000269|PubMed:15738310}.; TISSUE SPECIFICITY: [Isoform 2]: Highly expressed in liver, stomach, tes

Sequence

MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQ
PHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGR
SPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTP
FAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDW
CLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEI
PSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTD
QEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYML
TLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGV
SNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDM
VLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLE
LYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADL
VHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEE
ISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLT
QQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLP
STAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT

Sequence length

886

Interactions

View interactions

	KEGG		Reactome
	Purine metabolism Metabolic pathways cAMP signaling pathway Parathyroid hormone synthesis, secretion and action Morphine addiction		DARPP-32 events G alpha (s) signalling events

Show/Hide Causal Diseases (4)

Disease term	Disease name	dbSNP ID	References
Causal
Autism	Autistic Disorder	rs121964908, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699 View all (8 more)	18090323
Hypercholesterolemia	Hypercholesterolemia, Familial	rs28942111, rs28942112, rs137852912, rs121908025, rs28942082, rs28942083, rs121908028, rs121908030, rs28942079, rs28942084, rs121908032, rs387906302, rs387906303, rs121908033, rs121908034 View all (1161 more)	22968135
Psoriasis	Psoriasis	rs281875215, rs587777763, rs281875213, rs281875212	25574825
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	21898905, 18060387

Show/Hide Unknown Diseases (3)

Disease term	Disease name	References	Source
Unknown
Mental depression	Mental Depression, Depressive disorder	17700644, 22487514, 17481393, 18060387, 18090323, 23003922	ClinVar
Multiple Sclerosis	Multiple Sclerosis		GWAS
Inflammatory Bowel Disease	Inflammatory Bowel Disease		GWAS

Show/Hide Text Mining Associations (40)

Disease Name	Relationship Type	References
Associations from Text Mining
Alopecia Areata	Associate	33099386
Alzheimer Disease	Associate	18591513, 35229272
Arthritis Psoriatic	Associate	30181004
Asthma	Associate	15681504, 32447834
Bone Diseases	Associate	17900349
Breast Neoplasms	Associate	28755423, 28971320
Bronchitis Chronic	Associate	32197620, 33295083
Cardiovascular Diseases	Associate	18591513
Colorectal Neoplasms	Associate	22830422
Coronary Aneurysm	Associate	35899614
COVID 19	Associate	36571271
Dermatitis Atopic	Associate	37156706
Disorders of Excessive Somnolence	Associate	30824285
Esophageal Neoplasms	Associate	28771997
Esophageal Squamous Cell Carcinoma	Associate	34190001
Fibrous Dysplasia of Bone	Associate	32284396
Fibrous Dysplasia Polyostotic	Associate	32284396
Inflammation	Associate	16807266, 21784969, 32197620, 33295083, 34771000
Leukemia	Associate	12531792
Leukemia Lymphocytic Chronic B Cell	Associate	12531792, 17699872, 19033455, 19380787, 28867658
Leukemia Myeloid Acute	Associate	36436494
Liver Diseases	Associate	27210814
Lung Injury	Associate	34771000
Lymphoma B Cell	Associate	15331441
Lymphoma Large B Cell Diffuse	Associate	15331441
Mental Disorders	Associate	32284396
Mucus Inspissation of Respiratory Tract	Associate	15681504
Multiple Sclerosis	Associate	36571271
Myocardial Infarction	Associate	35899614
Neoplasms	Associate	27927168, 28971320, 30809467, 37427586
Osteoarthritis	Associate	17900349
Pancreatic Neoplasms	Associate	37427586
Parkinson Disease	Associate	29475134, 30824285
Pneumonia	Associate	21784969
Postoperative Nausea and Vomiting	Inhibit	29475134
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	11964308
Pulmonary Disease Chronic Obstructive	Associate	11522597, 15681504, 16807266, 23043089, 32021151, 32197620, 33295083, 34771000, 37192443
Rectal Neoplasms	Associate	30809467
Shock Septic	Associate	19091080
Status Asthmaticus	Associate	21611147

PDE4A (phosphodiesterase 4A)