Gene Gene information from NCBI Gene database.
Entrez ID 51385
Gene name Zinc finger protein 589
Gene symbol ZNF589
Synonyms (NCBI Gene)
SZF1
Chromosome 3
Chromosome location 3p21.31
miRNA miRNA information provided by mirtarbase database.
414
miRTarBase ID miRNA Experiments Reference
MIRT046155 hsa-miR-30b-5p CLASH 23622248
MIRT453205 hsa-miR-302f HITS-CLIP 23313552
MIRT453204 hsa-miR-1910-3p HITS-CLIP 23313552
MIRT453203 hsa-miR-6511a-5p HITS-CLIP 23313552
MIRT690791 hsa-miR-3929 HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
14
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 12097288
GO:0000977 Function RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP 12097288
GO:0001227 Function DNA-binding transcription repressor activity, RNA polymerase II-specific IDA 12097288
GO:0001227 Function DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
GO:0001227 Function DNA-binding transcription repressor activity, RNA polymerase II-specific IMP 12097288
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
616702 16747 ENSG00000164048
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q86UQ0
Protein name Zinc finger protein 589 (Stem cell zinc finger protein 1)
Protein function May play a role in hematopoietic stem/progenitor cell differentiation. May play a role as a DNA binding-dependent transcriptional repressor.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01352 KRAB 34 74 KRAB box Family
PF00096 zf-C2H2 248 270 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 276 298 Zinc finger, C2H2 type Domain
PF13894 zf-C2H2_4 304 327 Domain
PF00096 zf-C2H2 332 354 Zinc finger, C2H2 type Domain
Tissue specificity TISSUE SPECIFICITY: Isoform 2 is widely expressed. Isoform 3 is only expressed in CD34(+) cells. {ECO:0000269|PubMed:10029171}.
Sequence
MWAPREQLLGWTAEALPAKDSAWPWEEKPRYLGPVTFEDVAVLFTEAEWKRLSLEQRNLY
KEVMLENLRNLVSL
AESKPEVHTCPSCPLAFGSQQFLSQDELHNHPIPGFHAGNQLHPGN
PCPEDQPQSQHPSDKNHRGAEAEDQRVEGGVRPLFWSTNERGALVGFSSLFQRPPISSWG
GNRILEIQLSPAQNASSEEVDRISKRAETPGFGAVTFGECALAFNQKSNLFRQKAVTAEK
SSDKRQSQVCRECGRGFSRKSQLIIHQRTHTGEKPYVCGECGRGFIVESVLRNHLSTHSG
EKPYVCSHCGRGFSCKPYLIRHQRTHTREKSFMCTVCGRGFREKSELIKHQRIHTGDKPY
VCRD
Sequence length 364
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Generic Transcription Pathway
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
COMPLEX NEURODEVELOPMENTAL DISORDER GenCC
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
NON-SPECIFIC SYNDROMIC INTELLECTUAL DISABILITY Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ZNF589-related disorder Uncertain significance; Benign; Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Autistic Disorder Associate 36150388
★☆☆☆☆
Found in Text Mining only