Gene Gene information from NCBI Gene database.
Entrez ID 51379
Gene name Cytokine receptor like factor 3
Gene symbol CRLF3
Synonyms (NCBI Gene)
CREME-9CREME9CRLM9CYTOR4FRWSp48.2
Chromosome 17
Chromosome location 17q11.2
Summary This gene encodes a cytokine receptor-like factor that may negatively regulate cell cycle progression at the G0/G1 phase. Studies of the related rat protein suggest that it may regulate neuronal morphology and synaptic vesicle biogenesis. This gene is one
miRNA miRNA information provided by mirtarbase database.
551
miRTarBase ID miRNA Experiments Reference
MIRT019999 hsa-miR-375 Microarray 20215506
MIRT024952 hsa-miR-215-5p Microarray 19074876
MIRT026882 hsa-miR-192-5p Microarray 19074876
MIRT039257 hsa-miR-671-5p CLASH 23622248
MIRT489517 hsa-miR-1910-3p HITS-CLIP 23706177
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
13
GO ID Ontology Definition Evidence Reference
GO:0003677 Function DNA binding IBA
GO:0005515 Function Protein binding IPI 25416956, 26871637, 29892012, 32296183, 32814053
GO:0005634 Component Nucleus IBA
GO:0005737 Component Cytoplasm IDA 19427400
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
614853 17177 ENSG00000176390
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8IUI8
Protein name Cytokine receptor-like factor 3 (Cytokine receptor-like molecule 9) (CREME-9) (Cytokine receptor-related protein 4) (Type I cytokine receptor-like factor p48)
Protein function May play a role in the negative regulation of cell cycle progression.
Family and domains
Tissue specificity TISSUE SPECIFICITY: Expressed in several embryonic and adult tissues, including adult and fetal brain, liver, spleen and pancreas. Expressed in adult, but not fetal kidney. Expressed in skin and squamous cell carcinoma (SCC) and in several other cancer ty
Sequence
MRGAMELEPELLLQEARENVEAAQSYRRELGHRLEGLREARRQIKESASQTRDVLKQHFN
DLKGTLGKLLDERLVTLLQEVDTIEQETIKPLDDCQKLIEHGVNTAEDLVREGEIAMLGG
VGEENEKLWSFTKKASHIQLDSLPEVPLLVDVPCLSAQLDDSILNIVKDHIFKHGTVASR
PPVQIEELIEKPGGIIVRWCKVDDDFTAQDYRLQFRKCTSNHFEDVYVGSETEFIVLHID
PNVDYQFRVCARGDGRQEWSPWSVPQIGHSTLVPHEWTAGFEGYSLSSRRNIALRNDSES
SGVLYSRAPTYFCGQTLTFRVETVGQPDRRDSIGVCAEKQDGYDSLQRDQAVCISTNGAV
FVNGKEMTNQLPAVTSGSTVTFDIEAVTLGTTSNNEGGHFKLRVTISSNNREVVFDWLLD
QSCGSLYFGCSFFYPGWKVLVF
Sequence length 442
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CORONARY ARTERY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CUTANEOUS LEISHMANIASIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Alzheimer Disease Associate 33878365
★☆☆☆☆
Found in Text Mining only
Autistic Disorder Associate 34233200
★☆☆☆☆
Found in Text Mining only
Intellectual Disability Associate 11468690
★☆☆☆☆
Found in Text Mining only
Neoplasms Associate 38587197
★☆☆☆☆
Found in Text Mining only
Nerve Degeneration Associate 34233200
★☆☆☆☆
Found in Text Mining only
Neurofibroma Associate 11468690
★☆☆☆☆
Found in Text Mining only
Tangier Disease Associate 34233200
★☆☆☆☆
Found in Text Mining only