Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	51378
Gene name	Angiopoietin 4
Gene symbol	ANGPT4
Synonyms (NCBI Gene)	ANG3ANG4
Chromosome	20
Chromosome location	20p13
Summary	Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis

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Show/Hide all (182)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016991	hsa-miR-335-5p	Microarray	18185580
MIRT709498	hsa-miR-6716-5p	HITS-CLIP	19536157
MIRT709497	hsa-miR-5587-5p	HITS-CLIP	19536157
MIRT709496	hsa-miR-133a-3p	HITS-CLIP	19536157
MIRT709495	hsa-miR-133b	HITS-CLIP	19536157
MIRT709498	hsa-miR-6716-5p	HITS-CLIP	19536157
MIRT709497	hsa-miR-5587-5p	HITS-CLIP	19536157
MIRT709496	hsa-miR-133a-3p	HITS-CLIP	19536157
MIRT709495	hsa-miR-133b	HITS-CLIP	19536157
MIRT709498	hsa-miR-6716-5p	HITS-CLIP	19536157
MIRT709497	hsa-miR-5587-5p	HITS-CLIP	19536157
MIRT709496	hsa-miR-133a-3p	HITS-CLIP	19536157
MIRT709495	hsa-miR-133b	HITS-CLIP	19536157
MIRT709498	hsa-miR-6716-5p	HITS-CLIP	19536157
MIRT709497	hsa-miR-5587-5p	HITS-CLIP	19536157
MIRT709496	hsa-miR-133a-3p	HITS-CLIP	19536157
MIRT709495	hsa-miR-133b	HITS-CLIP	19536157
MIRT662519	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT662518	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT662517	hsa-miR-940	HITS-CLIP	23824327
MIRT662516	hsa-miR-3929	HITS-CLIP	23824327
MIRT662515	hsa-miR-4419b	HITS-CLIP	23824327
MIRT662514	hsa-miR-4478	HITS-CLIP	23824327
MIRT662513	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT662512	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT662511	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT662510	hsa-miR-1827	HITS-CLIP	23824327
MIRT662509	hsa-miR-5008-5p	HITS-CLIP	23824327
MIRT662508	hsa-miR-6089	HITS-CLIP	23824327
MIRT662507	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT662506	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT662505	hsa-miR-3665	HITS-CLIP	23824327
MIRT662504	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT662503	hsa-miR-4736	HITS-CLIP	23824327
MIRT662502	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT662501	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT662500	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT662499	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT662498	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT662497	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT662496	hsa-miR-3165	HITS-CLIP	23824327
MIRT662495	hsa-miR-7977	HITS-CLIP	23824327
MIRT662494	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT662493	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT662492	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT662491	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT662490	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT662489	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT662488	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT662487	hsa-miR-3689c	HITS-CLIP	23824327
MIRT662486	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT662485	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT662484	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT662483	hsa-miR-3122	HITS-CLIP	23824327
MIRT662482	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT662481	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT662480	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT662479	hsa-miR-665	HITS-CLIP	23824327
MIRT607762	hsa-miR-4797-5p	HITS-CLIP	24906430
MIRT607761	hsa-miR-508-5p	HITS-CLIP	24906430
MIRT607760	hsa-miR-3664-5p	HITS-CLIP	24906430
MIRT607759	hsa-miR-5586-3p	HITS-CLIP	24906430
MIRT607758	hsa-miR-759	HITS-CLIP	24906430
MIRT607757	hsa-miR-1273g-3p	HITS-CLIP	24906430
MIRT607756	hsa-miR-6849-3p	HITS-CLIP	24906430
MIRT607755	hsa-miR-6742-3p	HITS-CLIP	24906430
MIRT607754	hsa-miR-371b-5p	HITS-CLIP	24906430
MIRT607753	hsa-miR-373-5p	HITS-CLIP	24906430
MIRT607752	hsa-miR-616-5p	HITS-CLIP	24906430
MIRT607751	hsa-miR-371a-5p	HITS-CLIP	24906430
MIRT607750	hsa-miR-372-5p	HITS-CLIP	24906430
MIRT607749	hsa-miR-766-3p	HITS-CLIP	24906430
MIRT607748	hsa-miR-4793-3p	HITS-CLIP	24906430
MIRT607747	hsa-miR-6776-5p	HITS-CLIP	24906430
MIRT607746	hsa-miR-3120-5p	HITS-CLIP	24906430
MIRT607745	hsa-miR-4522	HITS-CLIP	24906430
MIRT607744	hsa-miR-873-3p	HITS-CLIP	24906430
MIRT607743	hsa-miR-4252	HITS-CLIP	24906430
MIRT607742	hsa-miR-661	HITS-CLIP	24906430
MIRT607741	hsa-miR-542-3p	HITS-CLIP	24906430
MIRT607740	hsa-miR-6512-3p	HITS-CLIP	24906430
MIRT607739	hsa-miR-6720-5p	HITS-CLIP	24906430
MIRT607738	hsa-miR-6888-3p	HITS-CLIP	24906430
MIRT607737	hsa-miR-3672	HITS-CLIP	24906430
MIRT607736	hsa-miR-6864-3p	HITS-CLIP	24906430
MIRT607735	hsa-miR-7703	HITS-CLIP	24906430
MIRT607734	hsa-miR-1262	HITS-CLIP	24906430
MIRT607733	hsa-miR-4701-3p	HITS-CLIP	24906430
MIRT607732	hsa-miR-6736-5p	HITS-CLIP	24906430
MIRT607731	hsa-miR-6510-3p	HITS-CLIP	24906430
MIRT607734	hsa-miR-1262	PAR-CLIP	27292025
MIRT607757	hsa-miR-1273g-3p	PAR-CLIP	27292025
MIRT607746	hsa-miR-3120-5p	PAR-CLIP	27292025
MIRT607760	hsa-miR-3664-5p	PAR-CLIP	27292025
MIRT607737	hsa-miR-3672	PAR-CLIP	27292025
MIRT607743	hsa-miR-4252	PAR-CLIP	27292025
MIRT607745	hsa-miR-4522	PAR-CLIP	27292025
MIRT607733	hsa-miR-4701-3p	PAR-CLIP	27292025
MIRT607748	hsa-miR-4793-3p	PAR-CLIP	27292025
MIRT607762	hsa-miR-4797-5p	PAR-CLIP	27292025
MIRT607761	hsa-miR-508-5p	PAR-CLIP	27292025
MIRT607741	hsa-miR-542-3p	PAR-CLIP	27292025
MIRT607759	hsa-miR-5586-3p	PAR-CLIP	27292025
MIRT607731	hsa-miR-6510-3p	PAR-CLIP	27292025
MIRT607740	hsa-miR-6512-3p	PAR-CLIP	27292025
MIRT607742	hsa-miR-661	PAR-CLIP	27292025
MIRT607739	hsa-miR-6720-5p	PAR-CLIP	27292025
MIRT607732	hsa-miR-6736-5p	PAR-CLIP	27292025
MIRT607755	hsa-miR-6742-3p	PAR-CLIP	27292025
MIRT607747	hsa-miR-6776-5p	PAR-CLIP	27292025
MIRT607756	hsa-miR-6849-3p	PAR-CLIP	27292025
MIRT607736	hsa-miR-6864-3p	PAR-CLIP	27292025
MIRT607738	hsa-miR-6888-3p	PAR-CLIP	27292025
MIRT607758	hsa-miR-759	PAR-CLIP	27292025
MIRT607749	hsa-miR-766-3p	PAR-CLIP	27292025
MIRT607735	hsa-miR-7703	PAR-CLIP	27292025
MIRT607744	hsa-miR-873-3p	PAR-CLIP	27292025
MIRT709498	hsa-miR-6716-5p	HITS-CLIP	19536157
MIRT709497	hsa-miR-5587-5p	HITS-CLIP	19536157
MIRT709496	hsa-miR-133a-3p	HITS-CLIP	19536157
MIRT709495	hsa-miR-133b	HITS-CLIP	19536157
MIRT709498	hsa-miR-6716-5p	HITS-CLIP	19536157
MIRT709497	hsa-miR-5587-5p	HITS-CLIP	19536157
MIRT709496	hsa-miR-133a-3p	HITS-CLIP	19536157
MIRT709495	hsa-miR-133b	HITS-CLIP	19536157
MIRT709498	hsa-miR-6716-5p	HITS-CLIP	19536157
MIRT709497	hsa-miR-5587-5p	HITS-CLIP	19536157
MIRT709496	hsa-miR-133a-3p	HITS-CLIP	19536157
MIRT709495	hsa-miR-133b	HITS-CLIP	19536157
MIRT709498	hsa-miR-6716-5p	HITS-CLIP	19536157
MIRT709497	hsa-miR-5587-5p	HITS-CLIP	19536157
MIRT709496	hsa-miR-133a-3p	HITS-CLIP	19536157
MIRT709495	hsa-miR-133b	HITS-CLIP	19536157
MIRT662519	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT662518	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT662517	hsa-miR-940	HITS-CLIP	23824327
MIRT662516	hsa-miR-3929	HITS-CLIP	23824327
MIRT662515	hsa-miR-4419b	HITS-CLIP	23824327
MIRT662514	hsa-miR-4478	HITS-CLIP	23824327
MIRT662513	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT662512	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT662511	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT662510	hsa-miR-1827	HITS-CLIP	23824327
MIRT662509	hsa-miR-5008-5p	HITS-CLIP	23824327
MIRT662508	hsa-miR-6089	HITS-CLIP	23824327
MIRT662507	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT662506	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT662505	hsa-miR-3665	HITS-CLIP	23824327
MIRT662504	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT662503	hsa-miR-4736	HITS-CLIP	23824327
MIRT662502	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT662501	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT662500	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT662499	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT662498	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT662497	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT662496	hsa-miR-3165	HITS-CLIP	23824327
MIRT662495	hsa-miR-7977	HITS-CLIP	23824327
MIRT662494	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT662493	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT662492	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT662491	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT662490	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT662489	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT662488	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT662487	hsa-miR-3689c	HITS-CLIP	23824327
MIRT662486	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT662485	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT662484	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT662483	hsa-miR-3122	HITS-CLIP	23824327
MIRT662482	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT662481	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT662480	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT662479	hsa-miR-665	HITS-CLIP	23824327
MIRT1930656	hsa-miR-149	CLIP-seq
MIRT1930657	hsa-miR-1915	CLIP-seq
MIRT1930658	hsa-miR-24	CLIP-seq
MIRT1930659	hsa-miR-3664-3p	CLIP-seq
MIRT1930660	hsa-miR-4284	CLIP-seq
MIRT1930661	hsa-miR-4716-5p	CLIP-seq
MIRT1930662	hsa-miR-671-5p	CLIP-seq
MIRT1930663	hsa-miR-873	CLIP-seq

Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	IEA
GO:0001935	Process	Endothelial cell proliferation	IDA	10025962
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	10025962
GO:0007165	Process	Signal transduction	IBA
GO:0007219	Process	Notch signaling pathway	IEA
GO:0007596	Process	Blood coagulation	IEA
GO:0010595	Process	Positive regulation of endothelial cell migration	IDA	12958144
GO:0016525	Process	Negative regulation of angiogenesis	IDA	16790085
GO:0030297	Function	Transmembrane receptor protein tyrosine kinase activator activity	IDA	10051567, 15851516
GO:0030971	Function	Receptor tyrosine kinase binding	IBA
GO:0030971	Function	Receptor tyrosine kinase binding	IDA	10051567
GO:0031012	Component	Extracellular matrix	IBA
GO:0043066	Process	Negative regulation of apoptotic process	IDA	12958144, 15284220
GO:0043536	Process	Positive regulation of blood vessel endothelial cell migration	IDA	15284220
GO:0043537	Process	Negative regulation of blood vessel endothelial cell migration	IDA	16790085
GO:0045766	Process	Positive regulation of angiogenesis	IDA	15284220
GO:0050731	Process	Positive regulation of peptidyl-tyrosine phosphorylation	IDA	15851516
GO:0071456	Process	Cellular response to hypoxia	IEP	12958144

MIM	HGNC	e!Ensembl
603705	487	ENSG00000101280

Q9Y264

Protein name

Angiopoietin-4 (ANG-4) (Angiopoietin-3) (ANG-3)

Protein function

Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00147	Fibrinogen_C	287 → 501	Fibrinogen beta and gamma chains, C-terminal globular domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in the lung with much lower levels found in other tissues.

Sequence

MLSQLAMLQGSLLLVVATMSVAQQTRQEADRGCETLVVQHGHCSYTFLLPKSEPCPPGPE
VSRDSNTLQRESLANPLHLGKLPTQQVKQLEQALQNNTQWLKKLERAIKTILRSKLEQVQ
QQMAQNQTAPMLELGTSLLNQTTAQIRKLTDMEAQLLNQTSRMDAQMPETFLSTNKLENQ
LLLQRQKLQQLQGQNSALEKRLQALETKQQEELASILSKKAKLLNTLSRQSAALTNIERG
LRGVRHNSSLLQDQQHSLRQLLVLLRHLVQERANASAPAFIMAGEQVFQDCAEIQRSGAS
ASGVYTIQVSNATKPRKVFCDLQSSGGRWTLIQRRENGTVNFQRNWKDYKQGFGDPAGEH
WLGNEVVHQLTRRAAYSLRVELQDWEGHEAYAQYEHFHLGSENQLYRLSVVGYSGSAGRQ
SSLVLQNTSFSTLDSDNDHCLCKCAQVMSGGWWFDACGLSNLNGVYYHAPDNKYKMDGIR
WHYFKGPSYSLRASRMMIRPLDI

Sequence length

503

Interactions

View interactions

	KEGG		Reactome
	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway HIF-1 signaling pathway PI3K-Akt signaling pathway		Tie2 Signaling

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BRAIN ANEURYSM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PERIPHERAL NEUROPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
POSTERIOR CORTICAL ATROPHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TREATMENT-RESISTANT HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (23)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Inhibit	22048948	★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Associate	26277786	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Associate	31642813, 34685578	★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Disease	Associate	27773939	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Inhibit	35932065	★★★★★ ★☆☆☆☆ Found in Text Mining only
Fibrosis	Inhibit	32582222	★★★★★ ★☆☆☆☆ Found in Text Mining only
Gastrointestinal Stromal Tumors	Associate	17724803	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Stimulate	20823154	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hemangiosarcoma	Associate	10854238	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia	Stimulate	15198927	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammation	Inhibit	32582222	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leiomyoma	Associate	17724803	★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Inhibit	26277786	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	17724803, 21603628, 31642813	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Stimulate	20823154	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurilemmoma	Associate	17724803	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Associate	27773939	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Associate	37884970	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pre Eclampsia	Associate	17616861, 36088594	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Associate	30361641	★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcoma Kaposi	Associate	10854238	★★★★★ ★☆☆☆☆ Found in Text Mining only
Small Cell Lung Carcinoma	Inhibit	26277786	★★★★★ ★☆☆☆☆ Found in Text Mining only
Vascular Remodeling	Inhibit	32582222	★★★★★ ★☆☆☆☆ Found in Text Mining only

ANGPT4 (angiopoietin 4)