Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	51366
Gene name	Ubiquitin protein ligase E3 component n-recognin 5
Gene symbol	UBR5
Synonyms (NCBI Gene)	DD5EDDEDD1HYD
Chromosome	8
Chromosome location	8q22.3
Summary	This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016621	hsa-miR-484	Sequencing	20371350
MIRT024039	hsa-miR-1-3p	Proteomics	18668040
MIRT028107	hsa-miR-93-5p	Sequencing	20371350
MIRT031026	hsa-miR-21-5p	Microarray	18591254
MIRT043427	hsa-miR-331-3p	CLASH	23622248
MIRT439352	ebv-miR-BART10-3p	HITS-CLIP	22473208
MIRT439350	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT439349	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT439352	ebv-miR-BART10-3p	HITS-CLIP	22473208
MIRT439350	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT726187	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT726188	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT028107	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT726186	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT439349	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT726185	hsa-miR-27a-3p	HITS-CLIP	22473208
MIRT726184	hsa-miR-27b-3p	HITS-CLIP	22473208
MIRT1471499	hsa-miR-106a	CLIP-seq
MIRT1471500	hsa-miR-106b	CLIP-seq
MIRT1471501	hsa-miR-1178	CLIP-seq
MIRT1471502	hsa-miR-1244	CLIP-seq
MIRT1471503	hsa-miR-1245	CLIP-seq
MIRT1471504	hsa-miR-1284	CLIP-seq
MIRT1471505	hsa-miR-1301	CLIP-seq
MIRT1471506	hsa-miR-140-5p	CLIP-seq
MIRT1471507	hsa-miR-17	CLIP-seq
MIRT1471508	hsa-miR-203	CLIP-seq
MIRT1471509	hsa-miR-20a	CLIP-seq
MIRT1471510	hsa-miR-20b	CLIP-seq
MIRT1471511	hsa-miR-219-5p	CLIP-seq
MIRT1471512	hsa-miR-2277-3p	CLIP-seq
MIRT1471513	hsa-miR-300	CLIP-seq
MIRT1471514	hsa-miR-3121-5p	CLIP-seq
MIRT1471515	hsa-miR-3148	CLIP-seq
MIRT1471516	hsa-miR-3156-5p	CLIP-seq
MIRT1471517	hsa-miR-3163	CLIP-seq
MIRT1471518	hsa-miR-3182	CLIP-seq
MIRT1471519	hsa-miR-320e	CLIP-seq
MIRT1471520	hsa-miR-33a	CLIP-seq
MIRT1471521	hsa-miR-33b	CLIP-seq
MIRT1471522	hsa-miR-340	CLIP-seq
MIRT1471523	hsa-miR-3606	CLIP-seq
MIRT1471524	hsa-miR-3609	CLIP-seq
MIRT1471525	hsa-miR-361-5p	CLIP-seq
MIRT1471526	hsa-miR-3670	CLIP-seq
MIRT1471527	hsa-miR-3679-3p	CLIP-seq
MIRT1471528	hsa-miR-3688-3p	CLIP-seq
MIRT1471529	hsa-miR-3689a-5p	CLIP-seq
MIRT1471530	hsa-miR-3689b	CLIP-seq
MIRT1471531	hsa-miR-3689e	CLIP-seq
MIRT1471532	hsa-miR-3689f	CLIP-seq
MIRT1471533	hsa-miR-3692	CLIP-seq
MIRT1471534	hsa-miR-3714	CLIP-seq
MIRT1471535	hsa-miR-371b-3p	CLIP-seq
MIRT1471536	hsa-miR-381	CLIP-seq
MIRT1471537	hsa-miR-3929	CLIP-seq
MIRT1471538	hsa-miR-3934	CLIP-seq
MIRT1471539	hsa-miR-3938	CLIP-seq
MIRT1471540	hsa-miR-3942-3p	CLIP-seq
MIRT1471541	hsa-miR-410	CLIP-seq
MIRT1471542	hsa-miR-425	CLIP-seq
MIRT1471543	hsa-miR-4310	CLIP-seq
MIRT1471544	hsa-miR-433	CLIP-seq
MIRT1471545	hsa-miR-4419b	CLIP-seq
MIRT1471546	hsa-miR-4445	CLIP-seq
MIRT1471547	hsa-miR-4446-5p	CLIP-seq
MIRT1471548	hsa-miR-4477b	CLIP-seq
MIRT1471549	hsa-miR-4478	CLIP-seq
MIRT1471550	hsa-miR-4499	CLIP-seq
MIRT1471551	hsa-miR-4513	CLIP-seq
MIRT1471552	hsa-miR-4519	CLIP-seq
MIRT1471553	hsa-miR-4652-3p	CLIP-seq
MIRT1471554	hsa-miR-4659a-3p	CLIP-seq
MIRT1471555	hsa-miR-4659b-3p	CLIP-seq
MIRT1471556	hsa-miR-4666-3p	CLIP-seq
MIRT1471557	hsa-miR-4666-5p	CLIP-seq
MIRT1471558	hsa-miR-4672	CLIP-seq
MIRT1471559	hsa-miR-4682	CLIP-seq
MIRT1471560	hsa-miR-4694-3p	CLIP-seq
MIRT1471561	hsa-miR-4719	CLIP-seq
MIRT1471562	hsa-miR-4729	CLIP-seq
MIRT1471563	hsa-miR-4733-3p	CLIP-seq
MIRT1471564	hsa-miR-4753-3p	CLIP-seq
MIRT1471565	hsa-miR-4782-3p	CLIP-seq
MIRT1471566	hsa-miR-4795-3p	CLIP-seq
MIRT1471567	hsa-miR-4796-3p	CLIP-seq
MIRT1471568	hsa-miR-494	CLIP-seq
MIRT1471569	hsa-miR-5047	CLIP-seq
MIRT1471570	hsa-miR-508-3p	CLIP-seq
MIRT1471571	hsa-miR-519d	CLIP-seq
MIRT1471572	hsa-miR-520d-5p	CLIP-seq
MIRT1471573	hsa-miR-524-5p	CLIP-seq
MIRT1471574	hsa-miR-545	CLIP-seq
MIRT1471575	hsa-miR-548ac	CLIP-seq
MIRT1471576	hsa-miR-548ae	CLIP-seq
MIRT1471577	hsa-miR-548ag	CLIP-seq
MIRT1471578	hsa-miR-548ah	CLIP-seq
MIRT1471579	hsa-miR-548ai	CLIP-seq
MIRT1471580	hsa-miR-548aj	CLIP-seq
MIRT1471581	hsa-miR-548am	CLIP-seq
MIRT1471582	hsa-miR-548an	CLIP-seq
MIRT1471583	hsa-miR-548b-3p	CLIP-seq
MIRT1471584	hsa-miR-548c-3p	CLIP-seq
MIRT1471585	hsa-miR-548d-3p	CLIP-seq
MIRT1471586	hsa-miR-548l	CLIP-seq
MIRT1471587	hsa-miR-548n	CLIP-seq
MIRT1471588	hsa-miR-548p	CLIP-seq
MIRT1471589	hsa-miR-548t	CLIP-seq
MIRT1471590	hsa-miR-548x	CLIP-seq
MIRT1471591	hsa-miR-548z	CLIP-seq
MIRT1471592	hsa-miR-582-5p	CLIP-seq
MIRT1471593	hsa-miR-628-5p	CLIP-seq
MIRT1471594	hsa-miR-642a	CLIP-seq
MIRT1471595	hsa-miR-767-3p	CLIP-seq
MIRT1471596	hsa-miR-889	CLIP-seq
MIRT1471597	hsa-miR-921	CLIP-seq
MIRT1471598	hsa-miR-93	CLIP-seq
MIRT2141905	hsa-miR-128	CLIP-seq
MIRT2141906	hsa-miR-1825	CLIP-seq
MIRT2141907	hsa-miR-1912	CLIP-seq
MIRT2141908	hsa-miR-1972	CLIP-seq
MIRT1471512	hsa-miR-2277-3p	CLIP-seq
MIRT2141909	hsa-miR-27a	CLIP-seq
MIRT2141910	hsa-miR-27b	CLIP-seq
MIRT1471514	hsa-miR-3121-5p	CLIP-seq
MIRT2141911	hsa-miR-3159	CLIP-seq
MIRT2141912	hsa-miR-3170	CLIP-seq
MIRT2141913	hsa-miR-3646	CLIP-seq
MIRT2141914	hsa-miR-3652	CLIP-seq
MIRT2141915	hsa-miR-3662	CLIP-seq
MIRT1471527	hsa-miR-3679-3p	CLIP-seq
MIRT2141916	hsa-miR-3684	CLIP-seq
MIRT1471533	hsa-miR-3692	CLIP-seq
MIRT1471534	hsa-miR-3714	CLIP-seq
MIRT2141917	hsa-miR-3941	CLIP-seq
MIRT1471540	hsa-miR-3942-3p	CLIP-seq
MIRT1471543	hsa-miR-4310	CLIP-seq
MIRT2141918	hsa-miR-4320	CLIP-seq
MIRT2141919	hsa-miR-4430	CLIP-seq
MIRT2141920	hsa-miR-4435	CLIP-seq
MIRT1471547	hsa-miR-4446-5p	CLIP-seq
MIRT2141921	hsa-miR-4505	CLIP-seq
MIRT1471552	hsa-miR-4519	CLIP-seq
MIRT1471558	hsa-miR-4672	CLIP-seq
MIRT2141922	hsa-miR-4731-5p	CLIP-seq
MIRT2141923	hsa-miR-4755-3p	CLIP-seq
MIRT2141924	hsa-miR-4775	CLIP-seq
MIRT2141925	hsa-miR-4781-3p	CLIP-seq
MIRT1471568	hsa-miR-494	CLIP-seq
MIRT1471574	hsa-miR-545	CLIP-seq
MIRT1471582	hsa-miR-548an	CLIP-seq
MIRT1471588	hsa-miR-548p	CLIP-seq
MIRT2141926	hsa-miR-570	CLIP-seq
MIRT2141927	hsa-miR-577	CLIP-seq
MIRT1471592	hsa-miR-582-5p	CLIP-seq
MIRT2141928	hsa-miR-587	CLIP-seq
MIRT2141929	hsa-miR-590-3p	CLIP-seq
MIRT2141930	hsa-miR-626	CLIP-seq
MIRT1471593	hsa-miR-628-5p	CLIP-seq
MIRT2141931	hsa-miR-647	CLIP-seq
MIRT2141932	hsa-miR-651	CLIP-seq
MIRT2141933	hsa-miR-9	CLIP-seq
MIRT1471512	hsa-miR-2277-3p	CLIP-seq
MIRT1471524	hsa-miR-3609	CLIP-seq
MIRT1471527	hsa-miR-3679-3p	CLIP-seq
MIRT1471533	hsa-miR-3692	CLIP-seq
MIRT1471534	hsa-miR-3714	CLIP-seq
MIRT2141917	hsa-miR-3941	CLIP-seq
MIRT1471540	hsa-miR-3942-3p	CLIP-seq
MIRT1471542	hsa-miR-425	CLIP-seq
MIRT1471543	hsa-miR-4310	CLIP-seq
MIRT1471547	hsa-miR-4446-5p	CLIP-seq
MIRT1471548	hsa-miR-4477b	CLIP-seq
MIRT1471552	hsa-miR-4519	CLIP-seq
MIRT1471558	hsa-miR-4672	CLIP-seq
MIRT1471563	hsa-miR-4733-3p	CLIP-seq
MIRT1471577	hsa-miR-548ag	CLIP-seq
MIRT1471578	hsa-miR-548ah	CLIP-seq
MIRT1471579	hsa-miR-548ai	CLIP-seq
MIRT1471582	hsa-miR-548an	CLIP-seq
MIRT1471587	hsa-miR-548n	CLIP-seq
MIRT1471589	hsa-miR-548t	CLIP-seq
MIRT1471592	hsa-miR-582-5p	CLIP-seq
MIRT2141928	hsa-miR-587	CLIP-seq
MIRT1471595	hsa-miR-767-3p	CLIP-seq
MIRT1471558	hsa-miR-4672	CLIP-seq
MIRT1471533	hsa-miR-3692	CLIP-seq
MIRT1471534	hsa-miR-3714	CLIP-seq
MIRT1471540	hsa-miR-3942-3p	CLIP-seq
MIRT1471552	hsa-miR-4519	CLIP-seq
MIRT1471568	hsa-miR-494	CLIP-seq
MIRT1471582	hsa-miR-548an	CLIP-seq
MIRT1471515	hsa-miR-3148	CLIP-seq
MIRT2462825	hsa-miR-3591-3p	CLIP-seq
MIRT2141913	hsa-miR-3646	CLIP-seq
MIRT2141915	hsa-miR-3662	CLIP-seq
MIRT1471528	hsa-miR-3688-3p	CLIP-seq
MIRT1471560	hsa-miR-4694-3p	CLIP-seq
MIRT1471584	hsa-miR-548c-3p	CLIP-seq
MIRT2656489	hsa-miR-105	CLIP-seq
MIRT1471499	hsa-miR-106a	CLIP-seq
MIRT1471500	hsa-miR-106b	CLIP-seq
MIRT2656490	hsa-miR-1179	CLIP-seq
MIRT2141905	hsa-miR-128	CLIP-seq
MIRT1471507	hsa-miR-17	CLIP-seq
MIRT1471508	hsa-miR-203	CLIP-seq
MIRT1471509	hsa-miR-20a	CLIP-seq
MIRT1471510	hsa-miR-20b	CLIP-seq
MIRT1471511	hsa-miR-219-5p	CLIP-seq
MIRT1471512	hsa-miR-2277-3p	CLIP-seq
MIRT2141909	hsa-miR-27a	CLIP-seq
MIRT2141910	hsa-miR-27b	CLIP-seq
MIRT1471515	hsa-miR-3148	CLIP-seq
MIRT2141911	hsa-miR-3159	CLIP-seq
MIRT2656491	hsa-miR-3189-5p	CLIP-seq
MIRT2656492	hsa-miR-328	CLIP-seq
MIRT1471520	hsa-miR-33a	CLIP-seq
MIRT1471521	hsa-miR-33b	CLIP-seq
MIRT2656493	hsa-miR-3613-3p	CLIP-seq
MIRT1471527	hsa-miR-3679-3p	CLIP-seq
MIRT1471528	hsa-miR-3688-3p	CLIP-seq
MIRT1471529	hsa-miR-3689a-5p	CLIP-seq
MIRT1471530	hsa-miR-3689b	CLIP-seq
MIRT1471531	hsa-miR-3689e	CLIP-seq
MIRT1471532	hsa-miR-3689f	CLIP-seq
MIRT1471533	hsa-miR-3692	CLIP-seq
MIRT1471534	hsa-miR-3714	CLIP-seq
MIRT1471535	hsa-miR-371b-3p	CLIP-seq
MIRT1471540	hsa-miR-3942-3p	CLIP-seq
MIRT2656494	hsa-miR-4273	CLIP-seq
MIRT2656495	hsa-miR-4290	CLIP-seq
MIRT1471543	hsa-miR-4310	CLIP-seq
MIRT2141918	hsa-miR-4320	CLIP-seq
MIRT1471546	hsa-miR-4445	CLIP-seq
MIRT1471547	hsa-miR-4446-5p	CLIP-seq
MIRT1471552	hsa-miR-4519	CLIP-seq
MIRT1471557	hsa-miR-4666-5p	CLIP-seq
MIRT2656496	hsa-miR-4677-5p	CLIP-seq
MIRT1471560	hsa-miR-4694-3p	CLIP-seq
MIRT1471562	hsa-miR-4729	CLIP-seq
MIRT2141925	hsa-miR-4781-3p	CLIP-seq
MIRT1471565	hsa-miR-4782-3p	CLIP-seq
MIRT1471568	hsa-miR-494	CLIP-seq
MIRT1471570	hsa-miR-508-3p	CLIP-seq
MIRT1471571	hsa-miR-519d	CLIP-seq
MIRT1471572	hsa-miR-520d-5p	CLIP-seq
MIRT1471573	hsa-miR-524-5p	CLIP-seq
MIRT1471574	hsa-miR-545	CLIP-seq
MIRT1471582	hsa-miR-548an	CLIP-seq
MIRT1471584	hsa-miR-548c-3p	CLIP-seq
MIRT1471586	hsa-miR-548l	CLIP-seq
MIRT1471587	hsa-miR-548n	CLIP-seq
MIRT1471588	hsa-miR-548p	CLIP-seq
MIRT1471589	hsa-miR-548t	CLIP-seq
MIRT2141927	hsa-miR-577	CLIP-seq
MIRT2141928	hsa-miR-587	CLIP-seq
MIRT2141932	hsa-miR-651	CLIP-seq
MIRT1471595	hsa-miR-767-3p	CLIP-seq
MIRT2656497	hsa-miR-888	CLIP-seq
MIRT1471598	hsa-miR-93	CLIP-seq
MIRT2656490	hsa-miR-1179	CLIP-seq
MIRT2141905	hsa-miR-128	CLIP-seq
MIRT1471508	hsa-miR-203	CLIP-seq
MIRT1471511	hsa-miR-219-5p	CLIP-seq
MIRT1471512	hsa-miR-2277-3p	CLIP-seq
MIRT2141909	hsa-miR-27a	CLIP-seq
MIRT2141910	hsa-miR-27b	CLIP-seq
MIRT1471515	hsa-miR-3148	CLIP-seq
MIRT2141911	hsa-miR-3159	CLIP-seq
MIRT2656491	hsa-miR-3189-5p	CLIP-seq
MIRT2656492	hsa-miR-328	CLIP-seq
MIRT1471520	hsa-miR-33a	CLIP-seq
MIRT1471521	hsa-miR-33b	CLIP-seq
MIRT1471527	hsa-miR-3679-3p	CLIP-seq
MIRT1471528	hsa-miR-3688-3p	CLIP-seq
MIRT1471529	hsa-miR-3689a-5p	CLIP-seq
MIRT1471530	hsa-miR-3689b	CLIP-seq
MIRT1471531	hsa-miR-3689e	CLIP-seq
MIRT1471532	hsa-miR-3689f	CLIP-seq
MIRT1471533	hsa-miR-3692	CLIP-seq
MIRT1471534	hsa-miR-3714	CLIP-seq
MIRT1471540	hsa-miR-3942-3p	CLIP-seq
MIRT1471543	hsa-miR-4310	CLIP-seq
MIRT2141918	hsa-miR-4320	CLIP-seq
MIRT1471546	hsa-miR-4445	CLIP-seq
MIRT1471547	hsa-miR-4446-5p	CLIP-seq
MIRT1471552	hsa-miR-4519	CLIP-seq
MIRT1471560	hsa-miR-4694-3p	CLIP-seq
MIRT1471562	hsa-miR-4729	CLIP-seq
MIRT1471565	hsa-miR-4782-3p	CLIP-seq
MIRT1471568	hsa-miR-494	CLIP-seq
MIRT1471570	hsa-miR-508-3p	CLIP-seq
MIRT1471572	hsa-miR-520d-5p	CLIP-seq
MIRT1471573	hsa-miR-524-5p	CLIP-seq
MIRT1471574	hsa-miR-545	CLIP-seq
MIRT1471582	hsa-miR-548an	CLIP-seq
MIRT1471586	hsa-miR-548l	CLIP-seq
MIRT1471587	hsa-miR-548n	CLIP-seq
MIRT1471588	hsa-miR-548p	CLIP-seq
MIRT1471589	hsa-miR-548t	CLIP-seq
MIRT2141927	hsa-miR-577	CLIP-seq
MIRT2141928	hsa-miR-587	CLIP-seq
MIRT2141932	hsa-miR-651	CLIP-seq
MIRT1471595	hsa-miR-767-3p	CLIP-seq

Show/Hide all (56)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000209	Process	Protein polyubiquitination	IBA
GO:0000209	Process	Protein polyubiquitination	IDA	21118991, 28689657
GO:0000785	Component	Chromatin	IDA	37478846
GO:0003723	Function	RNA binding	IEA
GO:0004842	Function	Ubiquitin-protein transferase activity	IEA
GO:0005515	Function	Protein binding	IPI	12011095, 16601676, 21118991, 24417819, 33122718
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	37478846
GO:0005634	Component	Nucleus	IDA	12011095, 21118991, 28689657
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	29033132
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0006281	Process	DNA repair	IEA
GO:0006974	Process	DNA damage response	IDA	12011095
GO:0006974	Process	DNA damage response	IEA
GO:0006979	Process	Response to oxidative stress	IDA	17603038
GO:0008270	Function	Zinc ion binding	IEA
GO:0010498	Process	Proteasomal protein catabolic process	IDA	34711951
GO:0010628	Process	Positive regulation of gene expression	IDA	18076571
GO:0016020	Component	Membrane	HDA	19946888
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030520	Process	Estrogen receptor signaling pathway	IDA	7481822, 9338790, 15831516
GO:0032991	Component	Protein-containing complex	IDA	18076571
GO:0033696	Process	Heterochromatin boundary formation	IMP	22884692
GO:0034450	Function	Ubiquitin-ubiquitin ligase activity	IBA
GO:0034450	Function	Ubiquitin-ubiquitin ligase activity	IDA	21118991, 29378950
GO:0035519	Process	Protein K29-linked ubiquitination	IDA	21118991
GO:0042307	Process	Positive regulation of protein import into nucleus	IMP	21118991
GO:0043130	Function	Ubiquitin binding	IDA	17897937, 37620400
GO:0043130	Function	Ubiquitin binding	IEA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IDA	29378950
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IEA
GO:0045879	Process	Negative regulation of smoothened signaling pathway	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0048384	Process	Retinoic acid receptor signaling pathway	IDA	9267036, 19917671
GO:0048384	Process	Retinoic acid receptor signaling pathway	IMP	28698609
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	18076571
GO:0050847	Process	Progesterone receptor signaling pathway	IDA	9620806, 10757795
GO:0050847	Process	Progesterone receptor signaling pathway	IDA	12011095
GO:0050847	Process	Progesterone receptor signaling pathway	IMP	10757795
GO:0061630	Function	Ubiquitin protein ligase activity	IDA	28689657, 29033132, 29378950, 33208877, 35217622, 37040767, 37409633, 37478846, 37478862, 37620400
GO:0061630	Function	Ubiquitin protein ligase activity	IEA
GO:0070561	Process	Vitamin D receptor signaling pathway	IDA	9267036
GO:0070936	Process	Protein K48-linked ubiquitination	IDA	28689657, 29033132, 29378950, 37620400
GO:0070979	Process	Protein K11-linked ubiquitination	IDA	21118991
GO:0071629	Process	Cytoplasm protein quality control by the ubiquitin-proteasome system	IDA	29033132
GO:0071630	Process	Nuclear protein quality control by the ubiquitin-proteasome system	IDA	37478846, 37478862
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	IBA
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	IMP	21118991, 28689657
GO:0140455	Process	Cytoplasm protein quality control	IDA	29033132
GO:0140861	Process	DNA repair-dependent chromatin remodeling	IMP	22884692
GO:0141198	Process	Protein branched polyubiquitination	IDA	29033132, 29378950

MIM	HGNC	e!Ensembl
608413	16806	ENSG00000104517

O95071

Protein name

E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)

Protein function

E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm and nucleus (PubMed:29033132, PubMed:33208877, PubMed:37478846, PubMed:37478862). Mainly acts as a ubiquitin chain elongator that extends pre-ubi

PDB

1I2T , 2QHO , 3PT3 , 8BJA , 8C06 , 8C07 , 8D4X , 8E0Q , 8EWI , 8P82 , 8P83

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF11547	E3_UbLigase_EDD	179 → 230	E3 ubiquitin ligase EDD	Domain
PF00658	PABP	2385 → 2449	Poly-adenylate binding protein, unique domain	Family
PF00632	HECT	2498 → 2799	HECT-domain (ubiquitin-transferase)	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney. {ECO:0000269|PubMed:10030672}.

Sequence

MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVLEQATIKQCVVGPNHAAF
LLEDGRVCRIGFSVQPDRLELGKPDNNDGSKLNSNSGAGRTSRPGRTSDSPWFLSGSETL
GRLAGNTLGSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVI
PASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASE
SYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLP
LERDSELLRERESVLRLRERRWLDGASFDNERGSTSKEGEPNLDKKNTPVQSPVSLGEDL
QWWPDKDGTKFICIGALYSELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLT
NEKIVLLSANSIRATVATENNKVATWVDETLSSVASKLEHTAQTYSELQGERIVSLHCCA
LYTCAQLENSLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNP
LYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQ
EPVKTEMGPPPSPASTCSDASSIASSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVE
DVKNVPVGKVLKVDGAYVAVKFPGTSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVK
TGGTPKVPDCFQRTPKKLCIPEKTEILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQ
ENNFPTSSIAFLGQNERNVAIFTAGQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPP
ISSLGMGVHSLINLPANSTIKKKAAVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQAVV
LEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVE
AIANAISVVSSNGPGNRAGSSSSRSLRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPP
IAPPSWVPDPPAMDPDGDIDFILAPAVGSLTTAATGTGQGPSTSTIPGPSTEPSVVESKD
RKANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIA
KAEISSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCG
LLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLT
ATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLE
PPRFAQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRL
DCFTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILS
VEMASSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLA
STSIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEE
QDDIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAA
ETESDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQ
SDDIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNTQHQRAASTAPSSTSTPAAS
SAGLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSASSLARAYSIVIRQISDLMG
LIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALA
SAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRATLLSARQGMMSARGDFLNY
ALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTREL
LELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPF
EVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPT
KMSYAANLKNVMNMQNRQKKEGEEQPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTE
SEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEV
KESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVT
FKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNANKGTHTSLMQRLRNRGERDRER
EREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGER
LYPRVQAMQPAFASKITGMLLELSPAQLLLLLASEDSLRARVDEAMELIIAHGRENGADS
ILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGK
NTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLR
QLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAE
HRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDES
GENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQ
HLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV

Sequence length

2799

Interactions

View interactions

	KEGG
	Ubiquitin mediated proteolysis

Show/Hide Unknown Diseases (23)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
-	no classification for the single variant	rs796052149, rs755753791	-
Acute myeloid leukemia	Benign	rs34739767, rs16869320	RCV005923519 RCV005935149
Adrenocortical carcinoma, hereditary	Benign	rs34739767	RCV005923521
Cervical cancer	Benign	rs16869320	RCV005935151
Cholangiocarcinoma	Benign	rs16869320	RCV005935156
Chronic lymphocytic leukemia/small lymphocytic lymphoma	Benign	rs34739767, rs16869320	RCV005923528 RCV005935158
Colon adenocarcinoma	Benign	rs34739767	RCV005923518
Colorectal cancer	Benign	rs34739767	RCV005923525
Familial pancreatic carcinoma	Benign	rs34739767	RCV005923523
Gastric cancer	Benign	rs16869320	RCV005935153
Hepatocellular carcinoma	Benign	rs34739767	RCV005923520
Long QT syndrome	Uncertain significance	rs754562275	RCV000190238
Lung cancer	Benign	rs16869320	RCV005935157
Malignant lymphoma, large B-cell, diffuse	Benign	rs34739767	RCV005923524
Malignant tumor of esophagus	Benign	rs16869320	RCV005935150
Neurodevelopmental disorder	Uncertain significance	rs1815507275	RCV004586492
Ovarian cancer	Benign	rs34739767	RCV005923522
Ovarian serous cystadenocarcinoma	Benign	rs16869320	RCV005935154
Sarcoma	Benign	rs34739767, rs16869320	RCV005923526 RCV005935152
Thymoma	Benign	rs16869320	RCV005935155
UBR5-associated neurodevelopmental condition	Uncertain significance	rs2489111207	RCV005430866
UBR5-related disorder	Uncertain significance; Likely benign; Benign	rs750665102, rs2489111207, rs751155901, rs2489174554, rs1271742852, rs149793011, rs149412815, rs148105163, rs2489036630, rs1814542301, rs750454150, rs2489609279, rs61752302, rs756520520, rs35794419 View all (16 more)	RCV004548466 RCV003333448 RCV004548667 RCV004554176 RCV004552450 RCV004554216 RCV004554217 RCV004554218 RCV004548793 RCV004550821 RCV004550866 RCV004550867 RCV004550961 RCV004548758 RCV004550849 RCV004548834 RCV004550847 RCV004554561 RCV004548951 RCV004554460 RCV004554469 RCV004551021 RCV004552853 RCV004552731 RCV004552829 RCV004552874 RCV004554545 RCV004548945 RCV004554359 RCV004554439 RCV004554480
Uterine corpus endometrial carcinoma	Benign	rs34739767	RCV005923527

Show/Hide Text Mining Associations (34)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenomatous Polyposis Coli	Stimulate	18076571
Alzheimer Disease	Associate	22833209
Autism Spectrum Disorder	Associate	31413120
Breast Neoplasms	Associate	21383020, 24441042, 32363114, 35551175, 40004017
Breast Neoplasms	Stimulate	21949371
Carcinogenesis	Associate	22884692
Carcinoma Hepatocellular	Associate	36388433
Carcinoma Ovarian Epithelial	Associate	18349819
Carcinoma Renal Cell	Associate	33710368
Carcinoma Small Cell	Associate	35662501
Cognitive Dysfunction	Associate	22833209
Colitis	Associate	33122718
Colorectal Neoplasms	Inhibit	18076571
Colorectal Neoplasms	Associate	30804124
Coronavirus Infections	Inhibit	35980206
Death	Stimulate	18349819
Disease	Stimulate	18349819
Immunologic Deficiency Syndromes	Associate	33122718
Inflammatory Bowel Disease 25 Autosomal Recessive	Associate	33122718
Inflammatory Bowel Diseases	Associate	33122718
Laryngeal Neoplasms	Associate	32468011
Lymphatic Metastasis	Stimulate	36388433
Lymphoma Mantle Cell	Associate	23407552
Neoplasm Metastasis	Stimulate	32363114
Neoplasms	Associate	12011095, 21949371, 29742019, 30508113, 32363114, 33208877, 33710368, 34897998, 35551175, 36388433
Neoplasms	Inhibit	18076571
Ovarian Neoplasms	Associate	18349819, 27721409, 36528667
Peritonitis	Associate	30804124
Prostatic Neoplasms	Associate	34897998
Pulmonary Arterial Hypertension	Associate	30699358
Squamous Cell Carcinoma of Head and Neck	Associate	38577917
Tay Sachs Disease	Associate	22833209
Triple Negative Breast Neoplasms	Associate	35551175
Williams Syndrome	Associate	31413120

UBR5 (ubiquitin protein ligase E3 component n-recognin 5)