Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
51361
Gene name Gene Name - the full gene name approved by the HGNC.
Hook microtubule tethering protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
HOOK1
Synonyms (NCBI Gene) Gene synonyms aliases
HK1
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p32.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interac
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT017608 hsa-miR-335-5p Microarray 18185580
MIRT023735 hsa-miR-1-3p Microarray 18668037
MIRT028032 hsa-miR-93-5p Sequencing 20371350
MIRT557194 hsa-miR-4453 HITS-CLIP 21572407
MIRT557193 hsa-miR-4538 HITS-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003779 Function Actin binding IEA
GO:0005515 Function Protein binding IPI 15471887, 17043677, 18799622, 25416956, 25910212, 28514442, 29423001, 31413325, 31515488, 32296183, 32814053
GO:0005737 Component Cytoplasm IBA 21873635
GO:0005737 Component Cytoplasm IDA 15471887
GO:0005813 Component Centrosome IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
607820 19884 ENSG00000134709
Protein
UniProt ID Q9UJC3
Protein name Protein Hook homolog 1 (h-hook1) (hHK1)
Protein function Component of the FTS/Hook/FHIP complex (FHF complex) (PubMed:18799622, PubMed:32073997). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (PubMed:187
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF19047 HOOK_N 13 163 HOOK domain Domain
PF05622 HOOK 186 719 HOOK protein coiled-coil region Coiled-coil
Sequence
Sequence length 728
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 32819122
Carcinoma Hepatocellular Inhibit 28718370
Carcinoma Non Small Cell Lung Associate 32819122
Endometriosis Associate 37817158
Esophageal Neoplasms Associate 38101299
Neoplasm Metastasis Associate 25331952
Neoplasms Associate 25331952, 28718370