KRT76 (keratin 76)

Gene

• Entrez ID: 51350
• Gene name: Keratin 76
• Gene symbol: KRT76
• Synonyms (NCBI Gene): HUMCYT2A, KRT2B, KRT2P
• Chromosome: 12
• Chromosome location: 12q13.13
• Summary: Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1101491	hsa-miR-1270	CLIP-seq
MIRT1101492	hsa-miR-1973	CLIP-seq
MIRT1101493	hsa-miR-4274	CLIP-seq
MIRT1101494	hsa-miR-4683	CLIP-seq
MIRT1101495	hsa-miR-516b	CLIP-seq
MIRT1101496	hsa-miR-620	CLIP-seq
MIRT1101497	hsa-miR-622	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005882	Component	Intermediate filament	IEA
GO:0005882	Component	Intermediate filament	NAS	1282112
GO:0007010	Process	Cytoskeleton organization	NAS	1282112
GO:0008544	Process	Epidermis development	IEA
GO:0030280	Function	Structural constituent of skin epidermis	IBA
GO:0031424	Process	Keratinization	IBA
GO:0043473	Process	Pigmentation	IEA
GO:0045095	Component	Keratin filament	IBA
GO:0045095	Component	Keratin filament	IEA
GO:0045109	Process	Intermediate filament organization	IBA
GO:0048733	Process	Sebaceous gland development	IEA
GO:0070062	Component	Extracellular exosome	HDA	23533145

Other IDs

• MIM: 616671
• HGNC: 24430
• e!Ensembl: ENSG00000185069

Protein

• UniProt ID: Q01546
• Protein name: Keratin, type II cytoskeletal 2 oral (Cytokeratin-2P) (CK-2P) (K2P) (Keratin-76) (K76) (Type-II keratin Kb9)
• Protein function: Probably contributes to terminal cornification.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF16208	Keratin_2_head	16 → 179	Keratin type II head	Family
  PF00038	Filament	182 → 495	Intermediate filament protein	Coiled-coil

• Sequence:

  MNRQVCKKSFSGRSQGFSGRSAVVSGSSRMSCVARSGGAGGGACGFRSGAGSFGSRSLYN
  LGSNKSISISVAAGSSRAGGFGGGRSSCGFAGGYGGGFGGSYGGGFGGGRGVGSGFGGAG
  GFGGAGGFGGPGVFGGPGSFGGPGGFGPGGFPGGIQEVIVNQSLLQPLNVEIDPQIGQVK
  AQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWELLQQQTTGSGPSSLEPCFESYISF
  LCKQLDSLLGERGNLEGELKSMQDLVEDFKKKYEDEINKRTAAENEFVGLKKDVDAAFMN
  KVELQAKVDSLTDEVSFLRTLYEMELSQMQSHASDTSVVLSMDNNRCLDLGSIIAEVRAQ
  YEEIAQRSKSEAEALYQTKLGELQTTAGRHGDDLRNTKSEIMELNRMIQRLRAEIENVKK
  QNANLQTAIAEAEQRGEMALKDANAKLQDLQTALQKAKDDLARLLRDYQELMNVKLALDV
  EIATYRKLLEGEECRMSGECQSAVCISVVSNVTSTSGSSGSSRGVFGGVSGSGSGGYKGG
  SSSSSSSGYGVSGGSGSGYGGVSSGSTGGRGSSGSYQSSSSGSRLGGAGSISVSHSGMGS
  SSGSIQTSGGSGYKSGGGGSTSIRFSQTTSSSQHSSTK

• Sequence length: 638

Pathways

Reactome:

Keratinization
Formation of the cornified envelope