Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	51350
Gene name Gene Name - the full gene name approved by the HGNC.	Keratin 76
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	KRT76
Synonyms (NCBI Gene) Gene synonyms aliases	HUMCYT2A, KRT2B, KRT2P
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q13.13
Summary Summary of gene provided in NCBI Entrez Gene.	Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq

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miRTarBase ID	miRNA	Experiments
MIRT1101491	hsa-miR-1270	CLIP-seq
MIRT1101492	hsa-miR-1973	CLIP-seq
MIRT1101493	hsa-miR-4274	CLIP-seq
MIRT1101494	hsa-miR-4683	CLIP-seq
MIRT1101495	hsa-miR-516b	CLIP-seq
MIRT1101496	hsa-miR-620	CLIP-seq
MIRT1101497	hsa-miR-622	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005882	Component	Intermediate filament	IEA
GO:0005882	Component	Intermediate filament	NAS	1282112
GO:0007010	Process	Cytoskeleton organization	NAS	1282112
GO:0008544	Process	Epidermis development	IEA
GO:0030280	Function	Structural constituent of skin epidermis	IBA
GO:0031424	Process	Keratinization	IBA
GO:0043473	Process	Pigmentation	IEA
GO:0045095	Component	Keratin filament	IBA
GO:0045095	Component	Keratin filament	IEA
GO:0045109	Process	Intermediate filament organization	IBA
GO:0048733	Process	Sebaceous gland development	IEA
GO:0070062	Component	Extracellular exosome	HDA	23533145

MIM	HGNC	e!Ensembl
616671	24430	ENSG00000185069

Protein

UniProt ID

Q01546

Protein name

Keratin, type II cytoskeletal 2 oral (Cytokeratin-2P) (CK-2P) (K2P) (Keratin-76) (K76) (Type-II keratin Kb9)

Protein function

Probably contributes to terminal cornification.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16208	Keratin_2_head	16 → 179	Keratin type II head	Family
PF00038	Filament	182 → 495	Intermediate filament protein	Coiled-coil

Sequence

MNRQVCKKSFSGRSQGFSGRSAVVSGSSRMSCVARSGGAGGGACGFRSGAGSFGSRSLYN
LGSNKSISISVAAGSSRAGGFGGGRSSCGFAGGYGGGFGGSYGGGFGGGRGVGSGFGGAG
GFGGAGGFGGPGVFGGPGSFGGPGGFGPGGFPGGIQEVIVNQSLLQPLNVEIDPQIGQVK
AQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWELLQQQTTGSGPSSLEPCFESYISF
LCKQLDSLLGERGNLEGELKSMQDLVEDFKKKYEDEINKRTAAENEFVGLKKDVDAAFMN
KVELQAKVDSLTDEVSFLRTLYEMELSQMQSHASDTSVVLSMDNNRCLDLGSIIAEVRAQ
YEEIAQRSKSEAEALYQTKLGELQTTAGRHGDDLRNTKSEIMELNRMIQRLRAEIENVKK
QNANLQTAIAEAEQRGEMALKDANAKLQDLQTALQKAKDDLARLLRDYQELMNVKLALDV
EIATYRKLLEGEECRMSGECQSAVCISVVSNVTSTSGSSGSSRGVFGGVSGSGSGGYKGG
SSSSSSSGYGVSGGSGSGYGGVSSGSTGGRGSSGSYQSSSSGSRLGGAGSISVSHSGMGS
SSGSIQTSGGSGYKSGGGGSTSIRFSQTTSSSQHSSTK

Sequence length

638

Interactions

View interactions

	Reactome
			Keratinization Formation of the cornified envelope

KRT76 (keratin 76)