Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	51347
Gene name	TAO kinase 3
Gene symbol	TAOK3
Synonyms (NCBI Gene)	DPKJIKMAP3K18hKFC-A
Chromosome	12
Chromosome location	12q24.23
Summary	The protein encoded by this gene is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. The encoded protein is a member of the GCK subfamily of STE20-like

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miRTarBase ID	miRNA	Experiments	Reference
MIRT041263	hsa-miR-193b-3p	CLASH	23622248
MIRT380147	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT380145	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616415	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT380147	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT380145	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT621882	hsa-miR-548ao-5p	HITS-CLIP	23824327
MIRT621881	hsa-miR-548ax	HITS-CLIP	23824327
MIRT616415	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT380147	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT380145	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616415	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT380147	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT380145	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616415	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT380147	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT380145	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616415	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT380147	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT380145	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616415	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT380147	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT380145	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT621882	hsa-miR-548ao-5p	HITS-CLIP	23824327
MIRT621881	hsa-miR-548ax	HITS-CLIP	23824327
MIRT621880	hsa-miR-548aj-5p	HITS-CLIP	23824327
MIRT621879	hsa-miR-548f-5p	HITS-CLIP	23824327
MIRT621878	hsa-miR-548g-5p	HITS-CLIP	23824327
MIRT621877	hsa-miR-548x-5p	HITS-CLIP	23824327
MIRT621876	hsa-miR-1468-3p	HITS-CLIP	23824327
MIRT621875	hsa-miR-548aw	HITS-CLIP	23824327
MIRT616415	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT380147	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT380145	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616415	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT380147	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT380145	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616415	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT380147	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT380145	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT621882	hsa-miR-548ao-5p	HITS-CLIP	23824327
MIRT621881	hsa-miR-548ax	HITS-CLIP	23824327
MIRT616415	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT380147	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT380145	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616415	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT380147	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT380145	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616415	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT380147	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT380145	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616415	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT380147	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT380145	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616415	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT380147	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT380145	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT621882	hsa-miR-548ao-5p	HITS-CLIP	23824327
MIRT621881	hsa-miR-548ax	HITS-CLIP	23824327
MIRT621880	hsa-miR-548aj-5p	HITS-CLIP	23824327
MIRT621879	hsa-miR-548f-5p	HITS-CLIP	23824327
MIRT621878	hsa-miR-548g-5p	HITS-CLIP	23824327
MIRT621877	hsa-miR-548x-5p	HITS-CLIP	23824327
MIRT621876	hsa-miR-1468-3p	HITS-CLIP	23824327
MIRT621875	hsa-miR-548aw	HITS-CLIP	23824327
MIRT616415	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT380147	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT380145	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616415	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT1411040	hsa-miR-106a	CLIP-seq
MIRT1411041	hsa-miR-106b	CLIP-seq
MIRT1411042	hsa-miR-1256	CLIP-seq
MIRT1411043	hsa-miR-17	CLIP-seq
MIRT1411044	hsa-miR-200b	CLIP-seq
MIRT1411045	hsa-miR-200c	CLIP-seq
MIRT1411046	hsa-miR-2052	CLIP-seq
MIRT1411047	hsa-miR-20a	CLIP-seq
MIRT1411048	hsa-miR-20b	CLIP-seq
MIRT1411049	hsa-miR-2113	CLIP-seq
MIRT1411050	hsa-miR-2116	CLIP-seq
MIRT1411051	hsa-miR-214	CLIP-seq
MIRT1411052	hsa-miR-3145-5p	CLIP-seq
MIRT1411053	hsa-miR-3148	CLIP-seq
MIRT1411054	hsa-miR-3150a-3p	CLIP-seq
MIRT1411055	hsa-miR-3175	CLIP-seq
MIRT1411056	hsa-miR-3545-3p	CLIP-seq
MIRT1411057	hsa-miR-3609	CLIP-seq
MIRT1411058	hsa-miR-3619-5p	CLIP-seq
MIRT1411059	hsa-miR-383	CLIP-seq
MIRT1411060	hsa-miR-3919	CLIP-seq
MIRT1411061	hsa-miR-3928	CLIP-seq
MIRT1411062	hsa-miR-4282	CLIP-seq
MIRT1411063	hsa-miR-429	CLIP-seq
MIRT1411064	hsa-miR-4318	CLIP-seq
MIRT1411065	hsa-miR-4457	CLIP-seq
MIRT1411066	hsa-miR-4459	CLIP-seq
MIRT1411067	hsa-miR-4461	CLIP-seq
MIRT1411068	hsa-miR-4539	CLIP-seq
MIRT1411069	hsa-miR-4642	CLIP-seq
MIRT1411070	hsa-miR-4680-5p	CLIP-seq
MIRT1411071	hsa-miR-4693-5p	CLIP-seq
MIRT1411072	hsa-miR-4711-3p	CLIP-seq
MIRT1411073	hsa-miR-4724-5p	CLIP-seq
MIRT1411074	hsa-miR-4756-3p	CLIP-seq
MIRT1411075	hsa-miR-4772-5p	CLIP-seq
MIRT1411076	hsa-miR-4776-3p	CLIP-seq
MIRT1411077	hsa-miR-4796-3p	CLIP-seq
MIRT1411078	hsa-miR-491-5p	CLIP-seq
MIRT1411079	hsa-miR-513b	CLIP-seq
MIRT1411080	hsa-miR-519a	CLIP-seq
MIRT1411081	hsa-miR-519b-3p	CLIP-seq
MIRT1411082	hsa-miR-519c-3p	CLIP-seq
MIRT1411083	hsa-miR-519d	CLIP-seq
MIRT1411084	hsa-miR-548ah	CLIP-seq
MIRT1411085	hsa-miR-548c-3p	CLIP-seq
MIRT1411086	hsa-miR-592	CLIP-seq
MIRT1411087	hsa-miR-593	CLIP-seq
MIRT1411088	hsa-miR-599	CLIP-seq
MIRT1411089	hsa-miR-653	CLIP-seq
MIRT1411090	hsa-miR-657	CLIP-seq
MIRT1411091	hsa-miR-761	CLIP-seq
MIRT1411092	hsa-miR-765	CLIP-seq
MIRT1411093	hsa-miR-875-3p	CLIP-seq
MIRT1411094	hsa-miR-892a	CLIP-seq
MIRT1411095	hsa-miR-93	CLIP-seq
MIRT1411096	hsa-miR-939	CLIP-seq
MIRT2123427	hsa-miR-190	CLIP-seq
MIRT2123428	hsa-miR-190b	CLIP-seq
MIRT2123429	hsa-miR-197	CLIP-seq
MIRT1411044	hsa-miR-200b	CLIP-seq
MIRT1411045	hsa-miR-200c	CLIP-seq
MIRT2123430	hsa-miR-223	CLIP-seq
MIRT2123431	hsa-miR-299-5p	CLIP-seq
MIRT2123432	hsa-miR-3662	CLIP-seq
MIRT2123433	hsa-miR-4269	CLIP-seq
MIRT1411063	hsa-miR-429	CLIP-seq
MIRT2123434	hsa-miR-4517	CLIP-seq
MIRT2123435	hsa-miR-4693-3p	CLIP-seq
MIRT2123436	hsa-miR-4697-3p	CLIP-seq
MIRT2123437	hsa-miR-499-3p	CLIP-seq
MIRT2123438	hsa-miR-499a-3p	CLIP-seq
MIRT2123439	hsa-miR-554	CLIP-seq
MIRT2123440	hsa-miR-595	CLIP-seq
MIRT2123441	hsa-miR-604	CLIP-seq
MIRT2345477	hsa-miR-1236	CLIP-seq
MIRT2345478	hsa-miR-1257	CLIP-seq
MIRT2123427	hsa-miR-190	CLIP-seq
MIRT2123428	hsa-miR-190b	CLIP-seq
MIRT2123429	hsa-miR-197	CLIP-seq
MIRT1411044	hsa-miR-200b	CLIP-seq
MIRT1411045	hsa-miR-200c	CLIP-seq
MIRT2123430	hsa-miR-223	CLIP-seq
MIRT1411052	hsa-miR-3145-5p	CLIP-seq
MIRT1411053	hsa-miR-3148	CLIP-seq
MIRT2345479	hsa-miR-3173-3p	CLIP-seq
MIRT1411056	hsa-miR-3545-3p	CLIP-seq
MIRT2123432	hsa-miR-3662	CLIP-seq
MIRT2123433	hsa-miR-4269	CLIP-seq
MIRT1411063	hsa-miR-429	CLIP-seq
MIRT1411067	hsa-miR-4461	CLIP-seq
MIRT2345480	hsa-miR-4476	CLIP-seq
MIRT2123434	hsa-miR-4517	CLIP-seq
MIRT1411068	hsa-miR-4539	CLIP-seq
MIRT2345481	hsa-miR-4666-3p	CLIP-seq
MIRT2345482	hsa-miR-4672	CLIP-seq
MIRT1411070	hsa-miR-4680-5p	CLIP-seq
MIRT2123436	hsa-miR-4697-3p	CLIP-seq
MIRT1411073	hsa-miR-4724-5p	CLIP-seq
MIRT2345483	hsa-miR-4779	CLIP-seq
MIRT2345484	hsa-miR-488	CLIP-seq
MIRT2123437	hsa-miR-499-3p	CLIP-seq
MIRT2123438	hsa-miR-499a-3p	CLIP-seq
MIRT1411085	hsa-miR-548c-3p	CLIP-seq
MIRT2123439	hsa-miR-554	CLIP-seq
MIRT2123440	hsa-miR-595	CLIP-seq
MIRT1411089	hsa-miR-653	CLIP-seq
MIRT1411093	hsa-miR-875-3p	CLIP-seq
MIRT2345485	hsa-miR-922	CLIP-seq
MIRT2395515	hsa-miR-1	CLIP-seq
MIRT2395516	hsa-miR-1273g	CLIP-seq
MIRT2395517	hsa-miR-206	CLIP-seq
MIRT2395518	hsa-miR-613	CLIP-seq
MIRT2345477	hsa-miR-1236	CLIP-seq
MIRT1411044	hsa-miR-200b	CLIP-seq
MIRT1411045	hsa-miR-200c	CLIP-seq
MIRT2123430	hsa-miR-223	CLIP-seq
MIRT2638456	hsa-miR-2681	CLIP-seq
MIRT2638457	hsa-miR-296-5p	CLIP-seq
MIRT2638458	hsa-miR-3134	CLIP-seq
MIRT2638459	hsa-miR-3179	CLIP-seq
MIRT2638460	hsa-miR-3189-3p	CLIP-seq
MIRT2638461	hsa-miR-3202	CLIP-seq
MIRT2123432	hsa-miR-3662	CLIP-seq
MIRT2123433	hsa-miR-4269	CLIP-seq
MIRT1411063	hsa-miR-429	CLIP-seq
MIRT1411064	hsa-miR-4318	CLIP-seq
MIRT2638462	hsa-miR-4462	CLIP-seq
MIRT2345480	hsa-miR-4476	CLIP-seq
MIRT2638463	hsa-miR-4534	CLIP-seq
MIRT1411071	hsa-miR-4693-5p	CLIP-seq
MIRT2123436	hsa-miR-4697-3p	CLIP-seq
MIRT2638464	hsa-miR-4723-5p	CLIP-seq
MIRT2638465	hsa-miR-494	CLIP-seq
MIRT2638466	hsa-miR-502-5p	CLIP-seq
MIRT2123439	hsa-miR-554	CLIP-seq
MIRT2638467	hsa-miR-602	CLIP-seq
MIRT1411094	hsa-miR-892a	CLIP-seq
MIRT2123427	hsa-miR-190	CLIP-seq
MIRT2123428	hsa-miR-190b	CLIP-seq
MIRT2123430	hsa-miR-223	CLIP-seq
MIRT2638457	hsa-miR-296-5p	CLIP-seq
MIRT2638458	hsa-miR-3134	CLIP-seq
MIRT2638459	hsa-miR-3179	CLIP-seq
MIRT2638461	hsa-miR-3202	CLIP-seq
MIRT2692635	hsa-miR-3607-3p	CLIP-seq
MIRT2123432	hsa-miR-3662	CLIP-seq
MIRT2692636	hsa-miR-3686	CLIP-seq
MIRT2123433	hsa-miR-4269	CLIP-seq
MIRT2638462	hsa-miR-4462	CLIP-seq
MIRT2345480	hsa-miR-4476	CLIP-seq
MIRT2638463	hsa-miR-4534	CLIP-seq
MIRT2123436	hsa-miR-4697-3p	CLIP-seq
MIRT2638464	hsa-miR-4723-5p	CLIP-seq
MIRT2123437	hsa-miR-499-3p	CLIP-seq
MIRT2123438	hsa-miR-499a-3p	CLIP-seq
MIRT2123439	hsa-miR-554	CLIP-seq
MIRT2638467	hsa-miR-602	CLIP-seq

Show/Hide all (34)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	IBA
GO:0000165	Process	MAPK cascade	IMP	10924369
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	10559204
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004860	Function	Protein kinase inhibitor activity	TAS	10559204
GO:0005515	Function	Protein binding	IPI	11278723, 32814053
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005811	Component	Lipid droplet	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0006281	Process	DNA repair	IEA
GO:0006468	Process	Protein phosphorylation	IMP	11278723
GO:0006974	Process	DNA damage response	IDA	17396146
GO:0006974	Process	DNA damage response	IEA
GO:0007095	Process	Mitotic G2 DNA damage checkpoint signaling	IEA
GO:0007095	Process	Mitotic G2 DNA damage checkpoint signaling	IMP	17396146
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IDA	10559204
GO:0016740	Function	Transferase activity	IEA
GO:0032874	Process	Positive regulation of stress-activated MAPK cascade	IEA
GO:0032874	Process	Positive regulation of stress-activated MAPK cascade	IMP	17396146
GO:0043408	Process	Regulation of MAPK cascade	IBA
GO:0043507	Process	Positive regulation of JUN kinase activity	IMP	11278723
GO:0045121	Component	Membrane raft	IEA
GO:0046329	Process	Negative regulation of JNK cascade	IDA	10559204
GO:0046330	Process	Positive regulation of JNK cascade	IEA
GO:0046330	Process	Positive regulation of JNK cascade	IMP	10924369
GO:0048812	Process	Neuron projection morphogenesis	IBA
GO:0106310	Function	Protein serine kinase activity	IEA

MIM	HGNC	e!Ensembl
616711	18133	ENSG00000135090

Q9H2K8

Protein name

Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Cutaneous T-cell lymphoma-associated antigen HD-CL-09) (CTCL-associated antigen HD-CL-09) (Dendritic cell-derived protein kinase) (JNK/SAPK-inhibitory kinase) (Jun kinase-inhibitory kinase) (Kinase from

Protein function

Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14

PDB

6BDN

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	24 → 277	Protein kinase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver. {ECO:0000269|PubMed:10924369, ECO:0000269|PubMed:13679851}.

Sequence

MRKGVLKDPEIADLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGK
QTHEKWQDILKEVKFLRQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQ
EVEIAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVG
TPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPT
LQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVRRDRPLRVLIDLIQRTKDAVREL
DNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPSMSVSTGSQ
SSSVNSMQEVMDESSSELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDPRPEPRPTQ
SVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQKQLIALEN
KLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQQILAQ
QKKDLTTFLESQKKQYKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAEEEAHL
LTQQRLYYDKNCRFFKRKIMIKRHEVEQQNIREELNKKRTQKEMEHAMLIRHDESTRELE
YRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIK
KQFQDTCKVQTKQYKALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMM
ASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRA
HLEQKIEEELAALQKERSERIKNLLERQEREIETFDMESLRMGFGNLVTLDFPKEDYR

Sequence length

898

Interactions

View interactions

	KEGG
	MAPK signaling pathway

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Likely benign	rs77139493	RCV005913342
Familial cancer of breast	Likely benign	rs77139493	RCV005913341
Lung cancer	Likely benign	rs77139493	RCV005913343
Neurodevelopmental disorder	Uncertain significance	rs2139244484	RCV001780028
Prostate cancer	Uncertain significance	rs864622030	RCV000204825

Show/Hide Text Mining Associations (9)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Cholangiocarcinoma	Associate	36144640
Colorectal Neoplasms	Associate	22095101
Esophageal Squamous Cell Carcinoma	Stimulate	37705061
Fatty Liver	Associate	34634521
Inflammation	Associate	34634521
Neoplasms	Associate	40095483
Non alcoholic Fatty Liver Disease	Associate	34634521
Obesity	Associate	26646899
Uterine Cervical Neoplasms	Associate	34526665

TAOK3 (TAO kinase 3)