Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	51338
Gene name Gene Name - the full gene name approved by the HGNC.	Membrane spanning 4-domains A4A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MS4A4A
Synonyms (NCBI Gene) Gene synonyms aliases	4SPAN1, CD20-L1, CD20L1, HDCME31P, MS4A4, MS4A7
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11q12.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features, similar intron/exon splice boundaries, and display unique expression patterns in hematopoietic cell

Show/Hide all(52)

miRTarBase ID	miRNA	Experiments	Reference
MIRT025653	hsa-miR-7-5p	Microarray	17612493
MIRT509336	hsa-miR-4700-3p	PAR-CLIP	23446348
MIRT509335	hsa-miR-4433b-3p	PAR-CLIP	23446348
MIRT509334	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT509333	hsa-miR-4433a-3p	PAR-CLIP	23446348
MIRT509332	hsa-miR-1292-3p	PAR-CLIP	23446348
MIRT509331	hsa-miR-5095	PAR-CLIP	23446348
MIRT509330	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT509329	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT509336	hsa-miR-4700-3p	PAR-CLIP	23446348
MIRT509335	hsa-miR-4433b-3p	PAR-CLIP	23446348
MIRT509334	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT509333	hsa-miR-4433a-3p	PAR-CLIP	23446348
MIRT509332	hsa-miR-1292-3p	PAR-CLIP	23446348
MIRT509331	hsa-miR-5095	PAR-CLIP	23446348
MIRT509330	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT509329	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT1161028	hsa-miR-1276	CLIP-seq
MIRT1161029	hsa-miR-203	CLIP-seq
MIRT1161030	hsa-miR-4311	CLIP-seq
MIRT1161031	hsa-miR-4676-5p	CLIP-seq
MIRT1161032	hsa-miR-575	CLIP-seq
MIRT1161033	hsa-miR-583	CLIP-seq
MIRT1161034	hsa-miR-1252	CLIP-seq
MIRT1161035	hsa-miR-1272	CLIP-seq
MIRT1161036	hsa-miR-1284	CLIP-seq
MIRT1161037	hsa-miR-1322	CLIP-seq
MIRT1161038	hsa-miR-142-5p	CLIP-seq
MIRT1161039	hsa-miR-2116	CLIP-seq
MIRT1161040	hsa-miR-3153	CLIP-seq
MIRT1161041	hsa-miR-329	CLIP-seq
MIRT1161042	hsa-miR-340	CLIP-seq
MIRT1161043	hsa-miR-362-3p	CLIP-seq
MIRT1161044	hsa-miR-3675-3p	CLIP-seq
MIRT1161045	hsa-miR-3941	CLIP-seq
MIRT1161046	hsa-miR-410	CLIP-seq
MIRT1161047	hsa-miR-4434	CLIP-seq
MIRT1161048	hsa-miR-4516	CLIP-seq
MIRT1161049	hsa-miR-4722-5p	CLIP-seq
MIRT1161050	hsa-miR-4768-3p	CLIP-seq
MIRT1161051	hsa-miR-4789-5p	CLIP-seq
MIRT1161052	hsa-miR-561	CLIP-seq
MIRT1161053	hsa-miR-603	CLIP-seq
MIRT1161034	hsa-miR-1252	CLIP-seq
MIRT2275327	hsa-miR-128	CLIP-seq
MIRT2275328	hsa-miR-27a	CLIP-seq
MIRT2275329	hsa-miR-27b	CLIP-seq
MIRT2275330	hsa-miR-4310	CLIP-seq
MIRT2275331	hsa-miR-581	CLIP-seq
MIRT2275332	hsa-miR-592	CLIP-seq
MIRT2275333	hsa-miR-597	CLIP-seq
MIRT2275334	hsa-miR-599	CLIP-seq

Show/Hide all(6)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	30833792, 32296183
GO:0005783	Component	Endoplasmic reticulum	IDA	31413141
GO:0005794	Component	Golgi apparatus	IDA	31413141
GO:0005886	Component	Plasma membrane	IDA	23874341
GO:0016021	Component	Integral component of membrane	IEA
GO:0044853	Component	Plasma membrane raft	IDA	31413141

MIM	HGNC	e!Ensembl
606547	13371	ENSG00000110079

Protein

UniProt ID

Q96JQ5

Protein name

Membrane-spanning 4-domains subfamily A member 4A (CD20 antigen-like 1) (Four-span transmembrane protein 1)

Protein function

May be involved in signal transduction as a component of a multimeric receptor complex.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04103	CD20	65 → 207	CD20-like family	Family

Tissue specificity

TISSUE SPECIFICITY: Variable expression in multiple hemopoietic cell lines.

Sequence

MHQTYSRHCRPEESTFSAAMTTMQGMEQAMPGAGPGVPQLGNMAVIHSHLWKGLQEKFLK
GEPKVLGVVQILTALMSLSMGITMMCMASNTYGSNPISVYIGYTIWGSVMFIISGSLSIA
AGIRTTKGLVRGSLGMNITSSVLAASGILINTFSLAFYSFHHPYCNYYGNSNNCHGTMSI
LMGLDGMVLLLSVLEFCIAVSLSAFGCKVLCCTPGGVVLILPSHSHMAETASPTPLNEV

Sequence length

239

Interactions

View interactions

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Alzheimer disease	Familial Alzheimer Disease (FAD), Alzheimer Disease, Late Onset, Alzheimer Disease, Early Onset, Alzheimer`s Disease, Alzheimer`s Disease, Focal Onset	rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039 View all (65 more)	21460841, 21627779, 25778476, 29777097, 30617256
Arthritis	Juvenile arthritis	rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470	19565504

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Hypertrophic cardiomyopathy	Hypertrophic cardiomyopathy			GWAS

Show/Hide Text Mining Associations (12)

Disease Name	Relationship Type	References
Associations from Text Mining
Alzheimer Disease	Associate	25778476, 28199971, 30859738, 31144443, 33712570, 38172904
Arthritis Rheumatoid	Associate	32483203, 34346525
Cerebral Infarction	Associate	30859738
COVID 19	Associate	34346525
Diabetic Nephropathies	Associate	37622120
Esophageal Neoplasms	Associate	36569220
Immune System Diseases	Associate	25717186
Inflammation	Associate	36569220
Lymphoma Follicular	Associate	37373066
Mast Cell Activation Disorders	Associate	25717186
Microscopic Polyangiitis	Associate	23690996, 28569178
Ovarian Neoplasms	Associate	32444534, 35186171

MS4A4A (membrane spanning 4-domains A4A)