ZNF771 (zinc finger protein 771)

Gene

• Entrez ID: 51333
• Gene name: Zinc finger protein 771
• Gene symbol: ZNF771
• Synonyms (NCBI Gene): DSC43
• Chromosome: 16
• Chromosome location: 16p11.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016930	hsa-miR-335-5p	Microarray	18185580
MIRT1538987	hsa-miR-1	CLIP-seq
MIRT1538988	hsa-miR-1245	CLIP-seq
MIRT1538989	hsa-miR-142-3p	CLIP-seq
MIRT1538990	hsa-miR-206	CLIP-seq
MIRT1538991	hsa-miR-299-3p	CLIP-seq
MIRT1538992	hsa-miR-3151	CLIP-seq
MIRT1538993	hsa-miR-342-5p	CLIP-seq
MIRT1538994	hsa-miR-4447	CLIP-seq
MIRT1538995	hsa-miR-4472	CLIP-seq
MIRT1538996	hsa-miR-4651	CLIP-seq
MIRT1538997	hsa-miR-4664-5p	CLIP-seq
MIRT1538998	hsa-miR-491-5p	CLIP-seq
MIRT1538999	hsa-miR-541	CLIP-seq
MIRT1539000	hsa-miR-602	CLIP-seq
MIRT1539001	hsa-miR-608	CLIP-seq
MIRT1539002	hsa-miR-613	CLIP-seq
MIRT1539003	hsa-miR-654-5p	CLIP-seq
MIRT1538987	hsa-miR-1	CLIP-seq
MIRT1538990	hsa-miR-206	CLIP-seq
MIRT1539000	hsa-miR-602	CLIP-seq
MIRT1539002	hsa-miR-613	CLIP-seq
MIRT2673038	hsa-miR-150	CLIP-seq
MIRT2673039	hsa-miR-339-5p	CLIP-seq
MIRT2673040	hsa-miR-4287	CLIP-seq
MIRT2673041	hsa-miR-4320	CLIP-seq
MIRT2673042	hsa-miR-4421	CLIP-seq
MIRT2673043	hsa-miR-4469	CLIP-seq
MIRT2673044	hsa-miR-4685-3p	CLIP-seq
MIRT2673045	hsa-miR-4713-5p	CLIP-seq
MIRT2673046	hsa-miR-532-3p	CLIP-seq
MIRT2673038	hsa-miR-150	CLIP-seq
MIRT2673039	hsa-miR-339-5p	CLIP-seq
MIRT2673040	hsa-miR-4287	CLIP-seq
MIRT2673041	hsa-miR-4320	CLIP-seq
MIRT2673042	hsa-miR-4421	CLIP-seq
MIRT2673043	hsa-miR-4469	CLIP-seq
MIRT2673044	hsa-miR-4685-3p	CLIP-seq
MIRT2673045	hsa-miR-4713-5p	CLIP-seq
MIRT2673046	hsa-miR-532-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q7L3S4
• Protein name: Zinc finger protein 771 (Mesenchymal stem cell protein DSC43)
• Protein function: May be involved in transcriptional regulation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00096	zf-C2H2	63 → 85	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	91 → 113	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	119 → 141	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	147 → 169	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	175 → 197	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	203 → 225	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	231 → 253	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	259 → 281	Zinc finger, C2H2 type	Domain

• Sequence:

  MPGEQQAEEEEEEEMQEEMVLLVKGEEDEGEEKYEVVKLKIPMDNKEVPGEAPAPSADPA
  RPHACPDCGRAFARRSTLAKHARTHTGERPFGCTECGRRFSQKSALTKHGRTHTGERPYE
  CPECDKRFSAASNLRQHRRRHTGEKPYACAHCGRRFAQSSNYAQHLRVHTGEKPYACPDC
  GRAFGGSSCLARHRRTHTGERPYACADCGTRFAQSSALAKHRRVHTGEKPHRCAVCGRRF
  GHRSNLAEHARTHTGERPYPCAECGRRFRLSSHFIRHRRAHMRRRLYICAGCGRDFKLPP
  GATAATATERCPECEGS

• Sequence length: 317

Pathways

Reactome:

Generic Transcription Pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Obesity	Associate	27564309	★☆☆☆☆ Found in Text Mining only