Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	51330
Gene name Gene Name - the full gene name approved by the HGNC.	TNF receptor superfamily member 12A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TNFRSF12A
Synonyms (NCBI Gene) Gene synonyms aliases	CD266, FN14, TWEAKR
Chromosome Chromosome number	16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	16p13.3

Show/Hide all(221)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022342	hsa-miR-124-3p	Microarray	18668037
MIRT031460	hsa-miR-16-5p	Proteomics	18668040
MIRT042306	hsa-miR-484	CLASH	23622248
MIRT665701	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT665700	hsa-miR-92a-1-5p	HITS-CLIP	23824327
MIRT665699	hsa-miR-203a-5p	HITS-CLIP	23824327
MIRT665698	hsa-miR-1273g-5p	HITS-CLIP	23824327
MIRT142988	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT142989	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT142988	hsa-miR-19a-3p	Luciferase reporter assay, qRT-PCR, Western blot	26367773
MIRT142989	hsa-miR-19b-3p	Luciferase reporter assay, Western blotting, qRT-PCR	32696503
MIRT665701	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT665700	hsa-miR-92a-1-5p	HITS-CLIP	23824327
MIRT665699	hsa-miR-203a-5p	HITS-CLIP	23824327
MIRT665698	hsa-miR-1273g-5p	HITS-CLIP	23824327
MIRT1442883	hsa-miR-105	CLIP-seq
MIRT1442884	hsa-miR-1207-3p	CLIP-seq
MIRT1442885	hsa-miR-1255a	CLIP-seq
MIRT1442886	hsa-miR-1255b	CLIP-seq
MIRT1442887	hsa-miR-1272	CLIP-seq
MIRT1442888	hsa-miR-1275	CLIP-seq
MIRT1442889	hsa-miR-1299	CLIP-seq
MIRT1442890	hsa-miR-1470	CLIP-seq
MIRT1442891	hsa-miR-149	CLIP-seq
MIRT1442892	hsa-miR-1827	CLIP-seq
MIRT1442893	hsa-miR-1913	CLIP-seq
MIRT1442894	hsa-miR-1914	CLIP-seq
MIRT1442895	hsa-miR-1915	CLIP-seq
MIRT1442896	hsa-miR-19a	CLIP-seq
MIRT1442897	hsa-miR-19b	CLIP-seq
MIRT1442898	hsa-miR-204	CLIP-seq
MIRT1442899	hsa-miR-2052	CLIP-seq
MIRT1442900	hsa-miR-211	CLIP-seq
MIRT1442901	hsa-miR-2110	CLIP-seq
MIRT1442902	hsa-miR-2467-5p	CLIP-seq
MIRT1442903	hsa-miR-3150a-3p	CLIP-seq
MIRT1442904	hsa-miR-3165	CLIP-seq
MIRT1442905	hsa-miR-3173-3p	CLIP-seq
MIRT1442906	hsa-miR-3175	CLIP-seq
MIRT1442907	hsa-miR-3188	CLIP-seq
MIRT1442908	hsa-miR-3192	CLIP-seq
MIRT1442909	hsa-miR-3200-5p	CLIP-seq
MIRT1442910	hsa-miR-3202	CLIP-seq
MIRT1442911	hsa-miR-324-3p	CLIP-seq
MIRT1442912	hsa-miR-331-3p	CLIP-seq
MIRT1442913	hsa-miR-346	CLIP-seq
MIRT1442914	hsa-miR-3612	CLIP-seq
MIRT1442915	hsa-miR-361-3p	CLIP-seq
MIRT1442916	hsa-miR-3616-3p	CLIP-seq
MIRT1442917	hsa-miR-3689a-3p	CLIP-seq
MIRT1442918	hsa-miR-3689c	CLIP-seq
MIRT1442919	hsa-miR-3691-3p	CLIP-seq
MIRT1442920	hsa-miR-3918	CLIP-seq
MIRT1442921	hsa-miR-3975	CLIP-seq
MIRT1442922	hsa-miR-4255	CLIP-seq
MIRT1442923	hsa-miR-4259	CLIP-seq
MIRT1442924	hsa-miR-4260	CLIP-seq
MIRT1442925	hsa-miR-4279	CLIP-seq
MIRT1442926	hsa-miR-4287	CLIP-seq
MIRT1442927	hsa-miR-4292	CLIP-seq
MIRT1442928	hsa-miR-4302	CLIP-seq
MIRT1442929	hsa-miR-4313	CLIP-seq
MIRT1442930	hsa-miR-4314	CLIP-seq
MIRT1442931	hsa-miR-4316	CLIP-seq
MIRT1442932	hsa-miR-4436a	CLIP-seq
MIRT1442933	hsa-miR-4463	CLIP-seq
MIRT1442934	hsa-miR-4469	CLIP-seq
MIRT1442935	hsa-miR-4476	CLIP-seq
MIRT1442936	hsa-miR-4512	CLIP-seq
MIRT1442937	hsa-miR-4533	CLIP-seq
MIRT1442938	hsa-miR-4646-5p	CLIP-seq
MIRT1442939	hsa-miR-4652-3p	CLIP-seq
MIRT1442940	hsa-miR-4665-5p	CLIP-seq
MIRT1442941	hsa-miR-4667-3p	CLIP-seq
MIRT1442942	hsa-miR-4682	CLIP-seq
MIRT1442943	hsa-miR-4685-3p	CLIP-seq
MIRT1442944	hsa-miR-4685-5p	CLIP-seq
MIRT1442945	hsa-miR-4697-3p	CLIP-seq
MIRT1442946	hsa-miR-4713-5p	CLIP-seq
MIRT1442947	hsa-miR-4728-5p	CLIP-seq
MIRT1442948	hsa-miR-4742-3p	CLIP-seq
MIRT1442949	hsa-miR-4757-5p	CLIP-seq
MIRT1442950	hsa-miR-4779	CLIP-seq
MIRT1442951	hsa-miR-4782-5p	CLIP-seq
MIRT1442952	hsa-miR-485-5p	CLIP-seq
MIRT1442953	hsa-miR-516b	CLIP-seq
MIRT1442954	hsa-miR-548c-3p	CLIP-seq
MIRT1442955	hsa-miR-571	CLIP-seq
MIRT1442956	hsa-miR-650	CLIP-seq
MIRT1442957	hsa-miR-760	CLIP-seq
MIRT1442958	hsa-miR-892b	CLIP-seq
MIRT1442959	hsa-miR-939	CLIP-seq
MIRT1442883	hsa-miR-105	CLIP-seq
MIRT1442894	hsa-miR-1914	CLIP-seq
MIRT1442896	hsa-miR-19a	CLIP-seq
MIRT1442897	hsa-miR-19b	CLIP-seq
MIRT1442912	hsa-miR-331-3p	CLIP-seq
MIRT1442883	hsa-miR-105	CLIP-seq
MIRT1442884	hsa-miR-1207-3p	CLIP-seq
MIRT2132545	hsa-miR-1207-5p	CLIP-seq
MIRT2132546	hsa-miR-1225-3p	CLIP-seq
MIRT1442885	hsa-miR-1255a	CLIP-seq
MIRT1442886	hsa-miR-1255b	CLIP-seq
MIRT1442887	hsa-miR-1272	CLIP-seq
MIRT1442888	hsa-miR-1275	CLIP-seq
MIRT2132547	hsa-miR-147	CLIP-seq
MIRT1442891	hsa-miR-149	CLIP-seq
MIRT1442892	hsa-miR-1827	CLIP-seq
MIRT2132548	hsa-miR-1909	CLIP-seq
MIRT1442894	hsa-miR-1914	CLIP-seq
MIRT1442896	hsa-miR-19a	CLIP-seq
MIRT1442897	hsa-miR-19b	CLIP-seq
MIRT1442898	hsa-miR-204	CLIP-seq
MIRT1442899	hsa-miR-2052	CLIP-seq
MIRT1442900	hsa-miR-211	CLIP-seq
MIRT1442901	hsa-miR-2110	CLIP-seq
MIRT2132549	hsa-miR-2113	CLIP-seq
MIRT1442902	hsa-miR-2467-5p	CLIP-seq
MIRT1442903	hsa-miR-3150a-3p	CLIP-seq
MIRT1442905	hsa-miR-3173-3p	CLIP-seq
MIRT1442906	hsa-miR-3175	CLIP-seq
MIRT1442907	hsa-miR-3188	CLIP-seq
MIRT1442912	hsa-miR-331-3p	CLIP-seq
MIRT1442916	hsa-miR-3616-3p	CLIP-seq
MIRT1442921	hsa-miR-3975	CLIP-seq
MIRT1442923	hsa-miR-4259	CLIP-seq
MIRT1442924	hsa-miR-4260	CLIP-seq
MIRT1442926	hsa-miR-4287	CLIP-seq
MIRT1442928	hsa-miR-4302	CLIP-seq
MIRT1442929	hsa-miR-4313	CLIP-seq
MIRT1442931	hsa-miR-4316	CLIP-seq
MIRT1442935	hsa-miR-4476	CLIP-seq
MIRT2132550	hsa-miR-4481	CLIP-seq
MIRT1442937	hsa-miR-4533	CLIP-seq
MIRT2132551	hsa-miR-4640-5p	CLIP-seq
MIRT2132552	hsa-miR-4649-5p	CLIP-seq
MIRT1442939	hsa-miR-4652-3p	CLIP-seq
MIRT1442940	hsa-miR-4665-5p	CLIP-seq
MIRT1442941	hsa-miR-4667-3p	CLIP-seq
MIRT1442943	hsa-miR-4685-3p	CLIP-seq
MIRT1442945	hsa-miR-4697-3p	CLIP-seq
MIRT2132553	hsa-miR-4707-5p	CLIP-seq
MIRT2132554	hsa-miR-4726-5p	CLIP-seq
MIRT2132555	hsa-miR-4736	CLIP-seq
MIRT1442948	hsa-miR-4742-3p	CLIP-seq
MIRT2132556	hsa-miR-4745-5p	CLIP-seq
MIRT2132557	hsa-miR-4758-5p	CLIP-seq
MIRT2132558	hsa-miR-4763-3p	CLIP-seq
MIRT1442950	hsa-miR-4779	CLIP-seq
MIRT1442952	hsa-miR-485-5p	CLIP-seq
MIRT1442955	hsa-miR-571	CLIP-seq
MIRT2132559	hsa-miR-599	CLIP-seq
MIRT1442957	hsa-miR-760	CLIP-seq
MIRT1442958	hsa-miR-892b	CLIP-seq
MIRT1442959	hsa-miR-939	CLIP-seq
MIRT2132560	hsa-miR-940	CLIP-seq
MIRT1442883	hsa-miR-105	CLIP-seq
MIRT1442884	hsa-miR-1207-3p	CLIP-seq
MIRT2132545	hsa-miR-1207-5p	CLIP-seq
MIRT1442887	hsa-miR-1272	CLIP-seq
MIRT1442888	hsa-miR-1275	CLIP-seq
MIRT1442892	hsa-miR-1827	CLIP-seq
MIRT1442893	hsa-miR-1913	CLIP-seq
MIRT1442894	hsa-miR-1914	CLIP-seq
MIRT1442895	hsa-miR-1915	CLIP-seq
MIRT1442896	hsa-miR-19a	CLIP-seq
MIRT1442897	hsa-miR-19b	CLIP-seq
MIRT1442899	hsa-miR-2052	CLIP-seq
MIRT1442901	hsa-miR-2110	CLIP-seq
MIRT2132549	hsa-miR-2113	CLIP-seq
MIRT2353506	hsa-miR-296-5p	CLIP-seq
MIRT1442903	hsa-miR-3150a-3p	CLIP-seq
MIRT2353507	hsa-miR-3151	CLIP-seq
MIRT1442905	hsa-miR-3173-3p	CLIP-seq
MIRT2353508	hsa-miR-3174	CLIP-seq
MIRT1442906	hsa-miR-3175	CLIP-seq
MIRT1442909	hsa-miR-3200-5p	CLIP-seq
MIRT1442911	hsa-miR-324-3p	CLIP-seq
MIRT1442912	hsa-miR-331-3p	CLIP-seq
MIRT1442913	hsa-miR-346	CLIP-seq
MIRT1442915	hsa-miR-361-3p	CLIP-seq
MIRT1442916	hsa-miR-3616-3p	CLIP-seq
MIRT1442919	hsa-miR-3691-3p	CLIP-seq
MIRT1442920	hsa-miR-3918	CLIP-seq
MIRT2353509	hsa-miR-4257	CLIP-seq
MIRT1442923	hsa-miR-4259	CLIP-seq
MIRT1442924	hsa-miR-4260	CLIP-seq
MIRT1442927	hsa-miR-4292	CLIP-seq
MIRT1442928	hsa-miR-4302	CLIP-seq
MIRT1442929	hsa-miR-4313	CLIP-seq
MIRT1442935	hsa-miR-4476	CLIP-seq
MIRT2132550	hsa-miR-4481	CLIP-seq
MIRT1442936	hsa-miR-4512	CLIP-seq
MIRT1442937	hsa-miR-4533	CLIP-seq
MIRT2132551	hsa-miR-4640-5p	CLIP-seq
MIRT2353510	hsa-miR-4650-5p	CLIP-seq
MIRT1442940	hsa-miR-4665-5p	CLIP-seq
MIRT1442942	hsa-miR-4682	CLIP-seq
MIRT1442944	hsa-miR-4685-5p	CLIP-seq
MIRT1442945	hsa-miR-4697-3p	CLIP-seq
MIRT2132554	hsa-miR-4726-5p	CLIP-seq
MIRT1442948	hsa-miR-4742-3p	CLIP-seq
MIRT2132556	hsa-miR-4745-5p	CLIP-seq
MIRT1442949	hsa-miR-4757-5p	CLIP-seq
MIRT2132557	hsa-miR-4758-5p	CLIP-seq
MIRT2132558	hsa-miR-4763-3p	CLIP-seq
MIRT2353511	hsa-miR-4765	CLIP-seq
MIRT1442950	hsa-miR-4779	CLIP-seq
MIRT1442955	hsa-miR-571	CLIP-seq
MIRT2132559	hsa-miR-599	CLIP-seq
MIRT1442959	hsa-miR-939	CLIP-seq
MIRT2132560	hsa-miR-940	CLIP-seq
MIRT1442883	hsa-miR-105	CLIP-seq
MIRT1442896	hsa-miR-19a	CLIP-seq
MIRT1442897	hsa-miR-19b	CLIP-seq
MIRT1442904	hsa-miR-3165	CLIP-seq
MIRT1442909	hsa-miR-3200-5p	CLIP-seq
MIRT1442932	hsa-miR-4436a	CLIP-seq
MIRT2132550	hsa-miR-4481	CLIP-seq
MIRT2132556	hsa-miR-4745-5p	CLIP-seq
MIRT2132557	hsa-miR-4758-5p	CLIP-seq

Transcription factors

Show/Hide all(2)

Transcription factor	Regulation	Reference
MAML1	Repression	18503747
NR1I2	Activation	21072196

Show/Hide all(13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	IEA
GO:0005515	Function	Protein binding	IPI	11728344, 21525013, 23438059, 25416956, 31515488, 32296183
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0006915	Process	Apoptotic process	IEA
GO:0007155	Process	Cell adhesion	IEA
GO:0016021	Component	Integral component of membrane	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0033209	Process	Tumor necrosis factor-mediated signaling pathway	TAS
GO:0043065	Process	Positive regulation of apoptotic process	IDA	21525013
GO:0061041	Process	Regulation of wound healing	IDA	11728344
GO:2001238	Process	Positive regulation of extrinsic apoptotic signaling pathway	IBA	21873635
GO:2001238	Process	Positive regulation of extrinsic apoptotic signaling pathway	IMP	21525013

MIM	HGNC	e!Ensembl
605914	18152	ENSG00000006327

Protein

UniProt ID

Q9NP84

Protein name

Tumor necrosis factor receptor superfamily member 12A (Fibroblast growth factor-inducible immediate-early response protein 14) (FGF-inducible 14) (Tweak-receptor) (TweakR) (CD antigen CD266)

Protein function

Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.

PDB

2EQP , 2KMZ , 2RPJ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12191	stn_TNFRSF12A	1 → 129	Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas.

Sequence

MARGSLRRLLRLLVLGLWLALLRSVAGEQAPGTAPCSRGSSWSADLDKCMDCASCRARPH
SDFCLGCAAAPPAPFRLLWPILGGALSLTFVLGLLSGFLVWRRCRRREKFTTPIEETGGE
GCPAVALIQ

Sequence length

129

Interactions

View interactions

	KEGG		Reactome
	Cytokine-cytokine receptor interaction		TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Myocardial infarction	Myocardial Infarction		20082609	ClinVar

Show/Hide Text Mining Associations (73)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma	Stimulate	23077618
Alzheimer Disease	Associate	38256230, 40595248
Arthritis	Associate	19147618
Arthritis Psoriatic	Associate	19147618
Arthritis Rheumatoid	Associate	19147618, 21435232
Asthma	Associate	35606385
Atrophy	Associate	21852085
Autoimmune Diseases	Associate	24056367
Brain Neoplasms	Associate	15611130, 29453678
Brain Neoplasms	Stimulate	33991013
Breast Neoplasms	Associate	18505918, 25375638, 30142200
Calcinosis	Associate	27441657
Carcinoma Hepatocellular	Associate	23886137, 28138696
Carcinoma Non Small Cell Lung	Associate	24469836
Carcinoma Renal Cell	Associate	21483105
Carcinoma Squamous Cell	Associate	22438963, 30414907
Cerebral Infarction	Associate	38277520
Chronic Disease	Associate	23750247, 26931128
Chronobiology Disorders	Associate	35163208
COVID 19	Associate	37657050
Deglutition Disorders	Associate	24467773
Dermatomyositis	Stimulate	24467773
Diabetes Mellitus Type 2	Associate	32846846
Dupuytren Contracture	Associate	34274346
Endometrial Hyperplasia	Associate	34517088
Fatty Liver	Associate	37657050
Fibrosis	Associate	26931128, 27050952, 32881622
Glioblastoma	Stimulate	12651623, 29453678
Glioblastoma	Associate	15611130, 19861406, 29724813, 40595248
Glioma	Associate	12651623, 15611130, 23775076, 26764186, 29453678, 29741404, 33991013, 35592520, 40595248
Hypoxia	Associate	20382683
Idiopathic Pulmonary Fibrosis	Associate	34948231
Inflammation	Associate	20382683, 20844036, 21435232, 22438963, 24056367, 26931128, 27050952, 30009538, 30576385
Kininogen Deficiency High Molecular Weight and Low Molecular Weight	Associate	35327656
Lung Neoplasms	Associate	24469836
Lymphoma Non Hodgkin	Associate	33991013
MASS syndrome	Associate	30009538
Monckeberg Medial Calcific Sclerosis	Associate	27441657
Multiple Sclerosis	Associate	35561450
Muscle Neoplasms	Associate	26931128
Muscular Atrophy	Associate	32624006, 32881622
Muscular Diseases	Associate	24467773
Mycobacterium Infections Nontuberculous	Inhibit	36321903
Necrosis	Stimulate	33991013
Neoplasm Metastasis	Associate	21708117, 28138696, 30301189
Neoplasms	Stimulate	12651623, 23886137
Neoplasms	Associate	21072196, 23469193, 23750247, 24056367, 24469836, 27544999, 28138696, 29453678, 29741404, 30414611, 30414907, 32846846, 33991013, 34517088, 35327656, 35592520, 37545514 View all (2 more)
Neoplasms	Inhibit	40595248
Neoplasms Squamous Cell	Associate	35327656
Neuroinflammatory Diseases	Associate	23320797
Neurologic Manifestations	Associate	30009538
Obesity	Associate	20382683
Osteosarcoma	Associate	30014744, 40383808
Ovarian Neoplasms	Associate	23469193
Pemphigoid Bullous	Associate	28351660
Periodontal Diseases	Associate	17100776
Plaque Atherosclerotic	Associate	15056843, 27441657
Polycystic Ovary Syndrome	Associate	38256230
Polymyositis	Associate	24467773
Prostatic Neoplasms	Associate	31500625
Psoriasis	Stimulate	22438963
Retinal Vein Occlusion	Associate	23886137
Skin Diseases	Associate	22438963
Spinal Cord Injuries	Stimulate	26931128
Squamous Cell Carcinoma of Head and Neck	Associate	32719094
Thyroid Cancer Papillary	Associate	30414611, 34767591, 35515000
Thyroid Neoplasms	Associate	32846846
Tooth Erosion	Associate	21435232
Tuberculosis	Stimulate	36321903
Urinary Bladder Neoplasms	Associate	38216619
Uterine Cervical Neoplasms	Associate	39224598
Vascular Calcification	Associate	27441657
Vasculitis Leukocytoclastic Cutaneous	Stimulate	32461624

TNFRSF12A (TNF receptor superfamily member 12A)