TNFRSF12A (TNF receptor superfamily member 12A)

Gene

• Entrez ID: 51330
• Gene name: TNF receptor superfamily member 12A
• Gene symbol: TNFRSF12A
• Synonyms (NCBI Gene): CD266, FN14, TWEAKR
• Chromosome: 16
• Chromosome location: 16p13.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022342	hsa-miR-124-3p	Microarray	18668037
MIRT031460	hsa-miR-16-5p	Proteomics	18668040
MIRT042306	hsa-miR-484	CLASH	23622248
MIRT665701	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT665700	hsa-miR-92a-1-5p	HITS-CLIP	23824327
MIRT665699	hsa-miR-203a-5p	HITS-CLIP	23824327
MIRT665698	hsa-miR-1273g-5p	HITS-CLIP	23824327
MIRT142988	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT142989	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT142988	hsa-miR-19a-3p	Luciferase reporter assay, qRT-PCR, Western blot	26367773
MIRT142989	hsa-miR-19b-3p	Luciferase reporter assay, Western blotting, qRT-PCR	32696503
MIRT665701	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT665700	hsa-miR-92a-1-5p	HITS-CLIP	23824327
MIRT665699	hsa-miR-203a-5p	HITS-CLIP	23824327
MIRT665698	hsa-miR-1273g-5p	HITS-CLIP	23824327
MIRT1442883	hsa-miR-105	CLIP-seq
MIRT1442884	hsa-miR-1207-3p	CLIP-seq
MIRT1442885	hsa-miR-1255a	CLIP-seq
MIRT1442886	hsa-miR-1255b	CLIP-seq
MIRT1442887	hsa-miR-1272	CLIP-seq
MIRT1442888	hsa-miR-1275	CLIP-seq
MIRT1442889	hsa-miR-1299	CLIP-seq
MIRT1442890	hsa-miR-1470	CLIP-seq
MIRT1442891	hsa-miR-149	CLIP-seq
MIRT1442892	hsa-miR-1827	CLIP-seq
MIRT1442893	hsa-miR-1913	CLIP-seq
MIRT1442894	hsa-miR-1914	CLIP-seq
MIRT1442895	hsa-miR-1915	CLIP-seq
MIRT1442896	hsa-miR-19a	CLIP-seq
MIRT1442897	hsa-miR-19b	CLIP-seq
MIRT1442898	hsa-miR-204	CLIP-seq
MIRT1442899	hsa-miR-2052	CLIP-seq
MIRT1442900	hsa-miR-211	CLIP-seq
MIRT1442901	hsa-miR-2110	CLIP-seq
MIRT1442902	hsa-miR-2467-5p	CLIP-seq
MIRT1442903	hsa-miR-3150a-3p	CLIP-seq
MIRT1442904	hsa-miR-3165	CLIP-seq
MIRT1442905	hsa-miR-3173-3p	CLIP-seq
MIRT1442906	hsa-miR-3175	CLIP-seq
MIRT1442907	hsa-miR-3188	CLIP-seq
MIRT1442908	hsa-miR-3192	CLIP-seq
MIRT1442909	hsa-miR-3200-5p	CLIP-seq
MIRT1442910	hsa-miR-3202	CLIP-seq
MIRT1442911	hsa-miR-324-3p	CLIP-seq
MIRT1442912	hsa-miR-331-3p	CLIP-seq
MIRT1442913	hsa-miR-346	CLIP-seq
MIRT1442914	hsa-miR-3612	CLIP-seq
MIRT1442915	hsa-miR-361-3p	CLIP-seq
MIRT1442916	hsa-miR-3616-3p	CLIP-seq
MIRT1442917	hsa-miR-3689a-3p	CLIP-seq
MIRT1442918	hsa-miR-3689c	CLIP-seq
MIRT1442919	hsa-miR-3691-3p	CLIP-seq
MIRT1442920	hsa-miR-3918	CLIP-seq
MIRT1442921	hsa-miR-3975	CLIP-seq
MIRT1442922	hsa-miR-4255	CLIP-seq
MIRT1442923	hsa-miR-4259	CLIP-seq
MIRT1442924	hsa-miR-4260	CLIP-seq
MIRT1442925	hsa-miR-4279	CLIP-seq
MIRT1442926	hsa-miR-4287	CLIP-seq
MIRT1442927	hsa-miR-4292	CLIP-seq
MIRT1442928	hsa-miR-4302	CLIP-seq
MIRT1442929	hsa-miR-4313	CLIP-seq
MIRT1442930	hsa-miR-4314	CLIP-seq
MIRT1442931	hsa-miR-4316	CLIP-seq
MIRT1442932	hsa-miR-4436a	CLIP-seq
MIRT1442933	hsa-miR-4463	CLIP-seq
MIRT1442934	hsa-miR-4469	CLIP-seq
MIRT1442935	hsa-miR-4476	CLIP-seq
MIRT1442936	hsa-miR-4512	CLIP-seq
MIRT1442937	hsa-miR-4533	CLIP-seq
MIRT1442938	hsa-miR-4646-5p	CLIP-seq
MIRT1442939	hsa-miR-4652-3p	CLIP-seq
MIRT1442940	hsa-miR-4665-5p	CLIP-seq
MIRT1442941	hsa-miR-4667-3p	CLIP-seq
MIRT1442942	hsa-miR-4682	CLIP-seq
MIRT1442943	hsa-miR-4685-3p	CLIP-seq
MIRT1442944	hsa-miR-4685-5p	CLIP-seq
MIRT1442945	hsa-miR-4697-3p	CLIP-seq
MIRT1442946	hsa-miR-4713-5p	CLIP-seq
MIRT1442947	hsa-miR-4728-5p	CLIP-seq
MIRT1442948	hsa-miR-4742-3p	CLIP-seq
MIRT1442949	hsa-miR-4757-5p	CLIP-seq
MIRT1442950	hsa-miR-4779	CLIP-seq
MIRT1442951	hsa-miR-4782-5p	CLIP-seq
MIRT1442952	hsa-miR-485-5p	CLIP-seq
MIRT1442953	hsa-miR-516b	CLIP-seq
MIRT1442954	hsa-miR-548c-3p	CLIP-seq
MIRT1442955	hsa-miR-571	CLIP-seq
MIRT1442956	hsa-miR-650	CLIP-seq
MIRT1442957	hsa-miR-760	CLIP-seq
MIRT1442958	hsa-miR-892b	CLIP-seq
MIRT1442959	hsa-miR-939	CLIP-seq
MIRT1442883	hsa-miR-105	CLIP-seq
MIRT1442894	hsa-miR-1914	CLIP-seq
MIRT1442896	hsa-miR-19a	CLIP-seq
MIRT1442897	hsa-miR-19b	CLIP-seq
MIRT1442912	hsa-miR-331-3p	CLIP-seq
MIRT1442883	hsa-miR-105	CLIP-seq
MIRT1442884	hsa-miR-1207-3p	CLIP-seq
MIRT2132545	hsa-miR-1207-5p	CLIP-seq
MIRT2132546	hsa-miR-1225-3p	CLIP-seq
MIRT1442885	hsa-miR-1255a	CLIP-seq
MIRT1442886	hsa-miR-1255b	CLIP-seq
MIRT1442887	hsa-miR-1272	CLIP-seq
MIRT1442888	hsa-miR-1275	CLIP-seq
MIRT2132547	hsa-miR-147	CLIP-seq
MIRT1442891	hsa-miR-149	CLIP-seq
MIRT1442892	hsa-miR-1827	CLIP-seq
MIRT2132548	hsa-miR-1909	CLIP-seq
MIRT1442894	hsa-miR-1914	CLIP-seq
MIRT1442896	hsa-miR-19a	CLIP-seq
MIRT1442897	hsa-miR-19b	CLIP-seq
MIRT1442898	hsa-miR-204	CLIP-seq
MIRT1442899	hsa-miR-2052	CLIP-seq
MIRT1442900	hsa-miR-211	CLIP-seq
MIRT1442901	hsa-miR-2110	CLIP-seq
MIRT2132549	hsa-miR-2113	CLIP-seq
MIRT1442902	hsa-miR-2467-5p	CLIP-seq
MIRT1442903	hsa-miR-3150a-3p	CLIP-seq
MIRT1442905	hsa-miR-3173-3p	CLIP-seq
MIRT1442906	hsa-miR-3175	CLIP-seq
MIRT1442907	hsa-miR-3188	CLIP-seq
MIRT1442912	hsa-miR-331-3p	CLIP-seq
MIRT1442916	hsa-miR-3616-3p	CLIP-seq
MIRT1442921	hsa-miR-3975	CLIP-seq
MIRT1442923	hsa-miR-4259	CLIP-seq
MIRT1442924	hsa-miR-4260	CLIP-seq
MIRT1442926	hsa-miR-4287	CLIP-seq
MIRT1442928	hsa-miR-4302	CLIP-seq
MIRT1442929	hsa-miR-4313	CLIP-seq
MIRT1442931	hsa-miR-4316	CLIP-seq
MIRT1442935	hsa-miR-4476	CLIP-seq
MIRT2132550	hsa-miR-4481	CLIP-seq
MIRT1442937	hsa-miR-4533	CLIP-seq
MIRT2132551	hsa-miR-4640-5p	CLIP-seq
MIRT2132552	hsa-miR-4649-5p	CLIP-seq
MIRT1442939	hsa-miR-4652-3p	CLIP-seq
MIRT1442940	hsa-miR-4665-5p	CLIP-seq
MIRT1442941	hsa-miR-4667-3p	CLIP-seq
MIRT1442943	hsa-miR-4685-3p	CLIP-seq
MIRT1442945	hsa-miR-4697-3p	CLIP-seq
MIRT2132553	hsa-miR-4707-5p	CLIP-seq
MIRT2132554	hsa-miR-4726-5p	CLIP-seq
MIRT2132555	hsa-miR-4736	CLIP-seq
MIRT1442948	hsa-miR-4742-3p	CLIP-seq
MIRT2132556	hsa-miR-4745-5p	CLIP-seq
MIRT2132557	hsa-miR-4758-5p	CLIP-seq
MIRT2132558	hsa-miR-4763-3p	CLIP-seq
MIRT1442950	hsa-miR-4779	CLIP-seq
MIRT1442952	hsa-miR-485-5p	CLIP-seq
MIRT1442955	hsa-miR-571	CLIP-seq
MIRT2132559	hsa-miR-599	CLIP-seq
MIRT1442957	hsa-miR-760	CLIP-seq
MIRT1442958	hsa-miR-892b	CLIP-seq
MIRT1442959	hsa-miR-939	CLIP-seq
MIRT2132560	hsa-miR-940	CLIP-seq
MIRT1442883	hsa-miR-105	CLIP-seq
MIRT1442884	hsa-miR-1207-3p	CLIP-seq
MIRT2132545	hsa-miR-1207-5p	CLIP-seq
MIRT1442887	hsa-miR-1272	CLIP-seq
MIRT1442888	hsa-miR-1275	CLIP-seq
MIRT1442892	hsa-miR-1827	CLIP-seq
MIRT1442893	hsa-miR-1913	CLIP-seq
MIRT1442894	hsa-miR-1914	CLIP-seq
MIRT1442895	hsa-miR-1915	CLIP-seq
MIRT1442896	hsa-miR-19a	CLIP-seq
MIRT1442897	hsa-miR-19b	CLIP-seq
MIRT1442899	hsa-miR-2052	CLIP-seq
MIRT1442901	hsa-miR-2110	CLIP-seq
MIRT2132549	hsa-miR-2113	CLIP-seq
MIRT2353506	hsa-miR-296-5p	CLIP-seq
MIRT1442903	hsa-miR-3150a-3p	CLIP-seq
MIRT2353507	hsa-miR-3151	CLIP-seq
MIRT1442905	hsa-miR-3173-3p	CLIP-seq
MIRT2353508	hsa-miR-3174	CLIP-seq
MIRT1442906	hsa-miR-3175	CLIP-seq
MIRT1442909	hsa-miR-3200-5p	CLIP-seq
MIRT1442911	hsa-miR-324-3p	CLIP-seq
MIRT1442912	hsa-miR-331-3p	CLIP-seq
MIRT1442913	hsa-miR-346	CLIP-seq
MIRT1442915	hsa-miR-361-3p	CLIP-seq
MIRT1442916	hsa-miR-3616-3p	CLIP-seq
MIRT1442919	hsa-miR-3691-3p	CLIP-seq
MIRT1442920	hsa-miR-3918	CLIP-seq
MIRT2353509	hsa-miR-4257	CLIP-seq
MIRT1442923	hsa-miR-4259	CLIP-seq
MIRT1442924	hsa-miR-4260	CLIP-seq
MIRT1442927	hsa-miR-4292	CLIP-seq
MIRT1442928	hsa-miR-4302	CLIP-seq
MIRT1442929	hsa-miR-4313	CLIP-seq
MIRT1442935	hsa-miR-4476	CLIP-seq
MIRT2132550	hsa-miR-4481	CLIP-seq
MIRT1442936	hsa-miR-4512	CLIP-seq
MIRT1442937	hsa-miR-4533	CLIP-seq
MIRT2132551	hsa-miR-4640-5p	CLIP-seq
MIRT2353510	hsa-miR-4650-5p	CLIP-seq
MIRT1442940	hsa-miR-4665-5p	CLIP-seq
MIRT1442942	hsa-miR-4682	CLIP-seq
MIRT1442944	hsa-miR-4685-5p	CLIP-seq
MIRT1442945	hsa-miR-4697-3p	CLIP-seq
MIRT2132554	hsa-miR-4726-5p	CLIP-seq
MIRT1442948	hsa-miR-4742-3p	CLIP-seq
MIRT2132556	hsa-miR-4745-5p	CLIP-seq
MIRT1442949	hsa-miR-4757-5p	CLIP-seq
MIRT2132557	hsa-miR-4758-5p	CLIP-seq
MIRT2132558	hsa-miR-4763-3p	CLIP-seq
MIRT2353511	hsa-miR-4765	CLIP-seq
MIRT1442950	hsa-miR-4779	CLIP-seq
MIRT1442955	hsa-miR-571	CLIP-seq
MIRT2132559	hsa-miR-599	CLIP-seq
MIRT1442959	hsa-miR-939	CLIP-seq
MIRT2132560	hsa-miR-940	CLIP-seq
MIRT1442883	hsa-miR-105	CLIP-seq
MIRT1442896	hsa-miR-19a	CLIP-seq
MIRT1442897	hsa-miR-19b	CLIP-seq
MIRT1442904	hsa-miR-3165	CLIP-seq
MIRT1442909	hsa-miR-3200-5p	CLIP-seq
MIRT1442932	hsa-miR-4436a	CLIP-seq
MIRT2132550	hsa-miR-4481	CLIP-seq
MIRT2132556	hsa-miR-4745-5p	CLIP-seq
MIRT2132557	hsa-miR-4758-5p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
MAML1	Repression	18503747
NR1I2	Activation	21072196

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	IEA
GO:0001726	Component	Ruffle	IEA
GO:0005515	Function	Protein binding	IPI	11728344, 21525013, 23438059, 25416956, 31515488, 32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006915	Process	Apoptotic process	IEA
GO:0006931	Process	Substrate-dependent cell migration, cell attachment to substrate	IEA
GO:0007155	Process	Cell adhesion	IEA
GO:0007155	Process	Cell adhesion	IEA
GO:0009986	Component	Cell surface	IEA
GO:0016020	Component	Membrane	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IDA	21525013
GO:0043065	Process	Positive regulation of apoptotic process	IEA
GO:0045765	Process	Regulation of angiogenesis	IEA
GO:0045773	Process	Positive regulation of axon extension	IEA
GO:0061041	Process	Regulation of wound healing	IDA	11728344
GO:0097191	Process	Extrinsic apoptotic signaling pathway	IEA
GO:2001238	Process	Positive regulation of extrinsic apoptotic signaling pathway	IBA
GO:2001238	Process	Positive regulation of extrinsic apoptotic signaling pathway	IMP	21525013

Other IDs

• MIM: 605914
• HGNC: 18152
• e!Ensembl: ENSG00000006327

Protein

• UniProt ID: Q9NP84
• Protein name: Tumor necrosis factor receptor superfamily member 12A (Fibroblast growth factor-inducible immediate-early response protein 14) (FGF-inducible 14) (Tweak-receptor) (TweakR) (CD antigen CD266)
• Protein function: Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.
• PDB: 2EQP, 2KMZ, 2RPJ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12191	stn_TNFRSF12A	1 → 129	Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas.
• Sequence:

  MARGSLRRLLRLLVLGLWLALLRSVAGEQAPGTAPCSRGSSWSADLDKCMDCASCRARPH
  SDFCLGCAAAPPAPFRLLWPILGGALSLTFVLGLLSGFLVWRRCRRREKFTTPIEETGGE
  GCPAVALIQ

• Sequence length: 129

Pathways

KEGG:

Cytokine-cytokine receptor interaction

Reactome:

TNFR2 non-canonical NF-kB pathway
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway