MEX3C (mex-3 RNA binding family member C)
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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51320 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Mex-3 RNA binding family member C |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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MEX3C |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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BM-013, MEX-3C, RKHD2, RNF194 |
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Chromosome
Chromosome number
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18 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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18q21.2 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a member of a family of proteins with two K homology (KH) RNA-binding domains and a C-terminal RING-finger domain. The protein interacts with mRNA via the KH domains, and the protein shuttles between the nucleus and cytoplasm. Polymorphi |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||||||||||||
| UniProt ID | Q5U5Q3 | ||||||||||||||||||||
| Protein name | RNA-binding E3 ubiquitin-protein ligase MEX3C (EC 2.3.2.27) (RING finger and KH domain-containing protein 2) (RING finger protein 194) (RING-type E3 ubiquitin transferase MEX3C) | ||||||||||||||||||||
| Protein function | E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiqui | ||||||||||||||||||||
| PDB | 5WWW , 5WWX , 5WWZ , 5ZI6 | ||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Highest levels found in fetal brain and testis. Also expressed in thymus, salivary gland and uterus. Highly expressed in cells of the innate immune system, in particular activated NK cells. Week expression in the intestine. {ECO:000026 | ||||||||||||||||||||
| Sequence |
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| Sequence length | 659 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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