MEX3C (mex-3 RNA binding family member C)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 51320 |
| Gene name | Mex-3 RNA binding family member C |
| Gene symbol | MEX3C |
| Synonyms (NCBI Gene) |
BM-013MEX-3CRKHD2RNF194
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| Chromosome | 18 |
| Chromosome location | 18q21.2 |
| Summary | This gene encodes a member of a family of proteins with two K homology (KH) RNA-binding domains and a C-terminal RING-finger domain. The protein interacts with mRNA via the KH domains, and the protein shuttles between the nucleus and cytoplasm. Polymorphi |
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miRNA
miRNA information provided by mirtarbase database.
440
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q5U5Q3 | ||||||||||||||||||||
| Protein name | RNA-binding E3 ubiquitin-protein ligase MEX3C (EC 2.3.2.27) (RING finger and KH domain-containing protein 2) (RING finger protein 194) (RING-type E3 ubiquitin transferase MEX3C) | ||||||||||||||||||||
| Protein function | E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiqui | ||||||||||||||||||||
| PDB | 5WWW , 5WWX , 5WWZ , 5ZI6 | ||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Highest levels found in fetal brain and testis. Also expressed in thymus, salivary gland and uterus. Highly expressed in cells of the innate immune system, in particular activated NK cells. Week expression in the intestine. {ECO:000026 | ||||||||||||||||||||
| Sequence |
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| Sequence length | 659 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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