PLAC8 (placenta associated 8)

Gene

• Entrez ID: 51316
• Gene name: Placenta associated 8
• Gene symbol: PLAC8
• Synonyms (NCBI Gene): C15, DGIC, PNAS-144, onzin
• Chromosome: 4
• Chromosome location: 4q21.22

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT694987	hsa-miR-1285-5p	HITS-CLIP	23313552
MIRT694986	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT694985	hsa-miR-1285-3p	HITS-CLIP	23313552
MIRT694984	hsa-miR-3187-5p	HITS-CLIP	23313552
MIRT694983	hsa-miR-5189-5p	HITS-CLIP	23313552
MIRT694982	hsa-miR-612	HITS-CLIP	23313552
MIRT694981	hsa-miR-6860	HITS-CLIP	23313552
MIRT694980	hsa-miR-661	HITS-CLIP	23313552
MIRT694979	hsa-miR-196a-3p	HITS-CLIP	23313552
MIRT694978	hsa-miR-4797-5p	HITS-CLIP	23313552
MIRT694977	hsa-miR-6513-3p	HITS-CLIP	23313552
MIRT694976	hsa-miR-759	HITS-CLIP	23313552
MIRT694975	hsa-miR-598-5p	HITS-CLIP	23313552
MIRT694974	hsa-miR-3920	HITS-CLIP	23313552
MIRT694973	hsa-miR-29a-5p	HITS-CLIP	23313552
MIRT694972	hsa-miR-4481	HITS-CLIP	23313552
MIRT694971	hsa-miR-4745-5p	HITS-CLIP	23313552
MIRT694970	hsa-miR-509-3p	HITS-CLIP	23313552
MIRT694969	hsa-miR-6772-5p	HITS-CLIP	23313552
MIRT694968	hsa-miR-4455	HITS-CLIP	23313552
MIRT694967	hsa-miR-609	HITS-CLIP	23313552
MIRT694966	hsa-miR-542-3p	HITS-CLIP	23313552
MIRT694965	hsa-miR-6748-5p	HITS-CLIP	23313552
MIRT694964	hsa-miR-1297	HITS-CLIP	23313552
MIRT694963	hsa-miR-26a-5p	HITS-CLIP	23313552
MIRT694962	hsa-miR-26b-5p	HITS-CLIP	23313552
MIRT694961	hsa-miR-4465	HITS-CLIP	23313552
MIRT694960	hsa-miR-1261	HITS-CLIP	23313552
MIRT694959	hsa-miR-498	HITS-CLIP	23313552
MIRT694987	hsa-miR-1285-5p	HITS-CLIP	23313552
MIRT694986	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT694985	hsa-miR-1285-3p	HITS-CLIP	23313552
MIRT694984	hsa-miR-3187-5p	HITS-CLIP	23313552
MIRT694983	hsa-miR-5189-5p	HITS-CLIP	23313552
MIRT694982	hsa-miR-612	HITS-CLIP	23313552
MIRT694981	hsa-miR-6860	HITS-CLIP	23313552
MIRT694980	hsa-miR-661	HITS-CLIP	23313552
MIRT694979	hsa-miR-196a-3p	HITS-CLIP	23313552
MIRT694978	hsa-miR-4797-5p	HITS-CLIP	23313552
MIRT694977	hsa-miR-6513-3p	HITS-CLIP	23313552
MIRT694976	hsa-miR-759	HITS-CLIP	23313552
MIRT694975	hsa-miR-598-5p	HITS-CLIP	23313552
MIRT694974	hsa-miR-3920	HITS-CLIP	23313552
MIRT694973	hsa-miR-29a-5p	HITS-CLIP	23313552
MIRT694972	hsa-miR-4481	HITS-CLIP	23313552
MIRT694971	hsa-miR-4745-5p	HITS-CLIP	23313552
MIRT694970	hsa-miR-509-3p	HITS-CLIP	23313552
MIRT694969	hsa-miR-6772-5p	HITS-CLIP	23313552
MIRT694968	hsa-miR-4455	HITS-CLIP	23313552
MIRT694967	hsa-miR-609	HITS-CLIP	23313552
MIRT694966	hsa-miR-542-3p	HITS-CLIP	23313552
MIRT694965	hsa-miR-6748-5p	HITS-CLIP	23313552
MIRT694964	hsa-miR-1297	HITS-CLIP	23313552
MIRT694963	hsa-miR-26a-5p	HITS-CLIP	23313552
MIRT694962	hsa-miR-26b-5p	HITS-CLIP	23313552
MIRT694961	hsa-miR-4465	HITS-CLIP	23313552
MIRT694960	hsa-miR-1261	HITS-CLIP	23313552
MIRT694959	hsa-miR-498	HITS-CLIP	23313552
MIRT1238970	hsa-miR-1273f	CLIP-seq
MIRT1238971	hsa-miR-1285	CLIP-seq
MIRT1238972	hsa-miR-143	CLIP-seq
MIRT1238973	hsa-miR-1908	CLIP-seq
MIRT1238974	hsa-miR-3160-3p	CLIP-seq
MIRT1238975	hsa-miR-3173-3p	CLIP-seq
MIRT1238976	hsa-miR-3188	CLIP-seq
MIRT1238977	hsa-miR-3189-3p	CLIP-seq
MIRT1238978	hsa-miR-3613-3p	CLIP-seq
MIRT1238979	hsa-miR-3617	CLIP-seq
MIRT1238980	hsa-miR-3622b-5p	CLIP-seq
MIRT1238981	hsa-miR-3689a-3p	CLIP-seq
MIRT1238982	hsa-miR-3689c	CLIP-seq
MIRT1238983	hsa-miR-3689d	CLIP-seq
MIRT1238984	hsa-miR-3713	CLIP-seq
MIRT1238985	hsa-miR-371-5p	CLIP-seq
MIRT1238986	hsa-miR-371b-5p	CLIP-seq
MIRT1238987	hsa-miR-3929	CLIP-seq
MIRT1238988	hsa-miR-3945	CLIP-seq
MIRT1238989	hsa-miR-4252	CLIP-seq
MIRT1238990	hsa-miR-4253	CLIP-seq
MIRT1238991	hsa-miR-4419b	CLIP-seq
MIRT1238992	hsa-miR-4428	CLIP-seq
MIRT1238993	hsa-miR-4459	CLIP-seq
MIRT1238994	hsa-miR-4477b	CLIP-seq
MIRT1238995	hsa-miR-4478	CLIP-seq
MIRT1238996	hsa-miR-4487	CLIP-seq
MIRT1238997	hsa-miR-4499	CLIP-seq
MIRT1238998	hsa-miR-4684-5p	CLIP-seq
MIRT1238999	hsa-miR-4708-5p	CLIP-seq
MIRT1239000	hsa-miR-4712-3p	CLIP-seq
MIRT1239001	hsa-miR-4728-5p	CLIP-seq
MIRT1239002	hsa-miR-4770	CLIP-seq
MIRT1239003	hsa-miR-4793-3p	CLIP-seq
MIRT1239004	hsa-miR-485-5p	CLIP-seq
MIRT1239005	hsa-miR-508-5p	CLIP-seq
MIRT1239006	hsa-miR-548c-3p	CLIP-seq
MIRT1239007	hsa-miR-558	CLIP-seq
MIRT1239008	hsa-miR-641	CLIP-seq
MIRT1239009	hsa-miR-643	CLIP-seq
MIRT1239010	hsa-miR-649	CLIP-seq
MIRT1239011	hsa-miR-663	CLIP-seq
MIRT1239012	hsa-miR-665	CLIP-seq
MIRT1239013	hsa-miR-766	CLIP-seq
MIRT1238971	hsa-miR-1285	CLIP-seq
MIRT1238973	hsa-miR-1908	CLIP-seq
MIRT1239014	hsa-miR-197	CLIP-seq
MIRT1238980	hsa-miR-3622b-5p	CLIP-seq
MIRT1238988	hsa-miR-3945	CLIP-seq
MIRT1238990	hsa-miR-4253	CLIP-seq
MIRT1239015	hsa-miR-4328	CLIP-seq
MIRT1238998	hsa-miR-4684-5p	CLIP-seq
MIRT1239016	hsa-miR-5096	CLIP-seq
MIRT1239006	hsa-miR-548c-3p	CLIP-seq
MIRT1239011	hsa-miR-663	CLIP-seq
MIRT2070305	hsa-miR-361-5p	CLIP-seq
MIRT2070306	hsa-miR-579	CLIP-seq
MIRT2297552	hsa-miR-607	CLIP-seq
MIRT2392594	hsa-miR-1228	CLIP-seq
MIRT2392595	hsa-miR-24	CLIP-seq
MIRT2392596	hsa-miR-3065-3p	CLIP-seq
MIRT1238975	hsa-miR-3173-3p	CLIP-seq
MIRT2392597	hsa-miR-338-3p	CLIP-seq
MIRT2392598	hsa-miR-342-3p	CLIP-seq
MIRT2392599	hsa-miR-3606	CLIP-seq
MIRT1238979	hsa-miR-3617	CLIP-seq
MIRT2392600	hsa-miR-4284	CLIP-seq
MIRT1238992	hsa-miR-4428	CLIP-seq
MIRT1238994	hsa-miR-4477b	CLIP-seq
MIRT2392601	hsa-miR-4530	CLIP-seq
MIRT2392602	hsa-miR-4637	CLIP-seq
MIRT2392603	hsa-miR-4725-5p	CLIP-seq
MIRT2392604	hsa-miR-504	CLIP-seq
MIRT1239008	hsa-miR-641	CLIP-seq
MIRT1238971	hsa-miR-1285	CLIP-seq
MIRT1238973	hsa-miR-1908	CLIP-seq
MIRT1238980	hsa-miR-3622b-5p	CLIP-seq
MIRT1238988	hsa-miR-3945	CLIP-seq
MIRT1238990	hsa-miR-4253	CLIP-seq
MIRT1238998	hsa-miR-4684-5p	CLIP-seq
MIRT1239006	hsa-miR-548c-3p	CLIP-seq
MIRT1239011	hsa-miR-663	CLIP-seq
MIRT2392594	hsa-miR-1228	CLIP-seq
MIRT1238971	hsa-miR-1285	CLIP-seq
MIRT2594925	hsa-miR-1827	CLIP-seq
MIRT1238973	hsa-miR-1908	CLIP-seq
MIRT2392596	hsa-miR-3065-3p	CLIP-seq
MIRT2594926	hsa-miR-3165	CLIP-seq
MIRT1238977	hsa-miR-3189-3p	CLIP-seq
MIRT2392597	hsa-miR-338-3p	CLIP-seq
MIRT1238978	hsa-miR-3613-3p	CLIP-seq
MIRT1238980	hsa-miR-3622b-5p	CLIP-seq
MIRT2594927	hsa-miR-3665	CLIP-seq
MIRT1238981	hsa-miR-3689a-3p	CLIP-seq
MIRT1238982	hsa-miR-3689c	CLIP-seq
MIRT1238985	hsa-miR-371-5p	CLIP-seq
MIRT1238986	hsa-miR-371b-5p	CLIP-seq
MIRT1238987	hsa-miR-3929	CLIP-seq
MIRT1238988	hsa-miR-3945	CLIP-seq
MIRT1238989	hsa-miR-4252	CLIP-seq
MIRT1238990	hsa-miR-4253	CLIP-seq
MIRT2594928	hsa-miR-4293	CLIP-seq
MIRT1238991	hsa-miR-4419b	CLIP-seq
MIRT2594929	hsa-miR-4433	CLIP-seq
MIRT1238993	hsa-miR-4459	CLIP-seq
MIRT1238995	hsa-miR-4478	CLIP-seq
MIRT2392601	hsa-miR-4530	CLIP-seq
MIRT1238998	hsa-miR-4684-5p	CLIP-seq
MIRT1239001	hsa-miR-4728-5p	CLIP-seq
MIRT2594930	hsa-miR-4736	CLIP-seq
MIRT2594931	hsa-miR-4768-3p	CLIP-seq
MIRT2594932	hsa-miR-4786-5p	CLIP-seq
MIRT1239003	hsa-miR-4793-3p	CLIP-seq
MIRT1239004	hsa-miR-485-5p	CLIP-seq
MIRT1239005	hsa-miR-508-5p	CLIP-seq
MIRT1239006	hsa-miR-548c-3p	CLIP-seq
MIRT1239011	hsa-miR-663	CLIP-seq
MIRT1239013	hsa-miR-766	CLIP-seq
MIRT2594933	hsa-miR-940	CLIP-seq
MIRT1238971	hsa-miR-1285	CLIP-seq
MIRT2594925	hsa-miR-1827	CLIP-seq
MIRT1238973	hsa-miR-1908	CLIP-seq
MIRT2594926	hsa-miR-3165	CLIP-seq
MIRT1238978	hsa-miR-3613-3p	CLIP-seq
MIRT1238980	hsa-miR-3622b-5p	CLIP-seq
MIRT2594927	hsa-miR-3665	CLIP-seq
MIRT1238985	hsa-miR-371-5p	CLIP-seq
MIRT1238986	hsa-miR-371b-5p	CLIP-seq
MIRT1238988	hsa-miR-3945	CLIP-seq
MIRT1238989	hsa-miR-4252	CLIP-seq
MIRT1238990	hsa-miR-4253	CLIP-seq
MIRT2594928	hsa-miR-4293	CLIP-seq
MIRT2687992	hsa-miR-4426	CLIP-seq
MIRT2594929	hsa-miR-4433	CLIP-seq
MIRT1238993	hsa-miR-4459	CLIP-seq
MIRT2687993	hsa-miR-4647	CLIP-seq
MIRT2687994	hsa-miR-4662b	CLIP-seq
MIRT1238998	hsa-miR-4684-5p	CLIP-seq
MIRT2594930	hsa-miR-4736	CLIP-seq
MIRT2594931	hsa-miR-4768-3p	CLIP-seq
MIRT2594932	hsa-miR-4786-5p	CLIP-seq
MIRT1239003	hsa-miR-4793-3p	CLIP-seq
MIRT1239005	hsa-miR-508-5p	CLIP-seq
MIRT1239006	hsa-miR-548c-3p	CLIP-seq
MIRT1239011	hsa-miR-663	CLIP-seq
MIRT1239013	hsa-miR-766	CLIP-seq
MIRT2594933	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003682	Function	Chromatin binding	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0006366	Process	Transcription by RNA polymerase II	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0009409	Process	Response to cold	IEA
GO:0035578	Component	Azurophil granule lumen	TAS
GO:0040015	Process	Negative regulation of multicellular organism growth	IEA
GO:0042742	Process	Defense response to bacterium	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0050873	Process	Brown fat cell differentiation	IEA
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	IEA
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	ISS	21982742

Other IDs

• MIM: 607515
• HGNC: 19254
• e!Ensembl: ENSG00000145287

Protein

• UniProt ID: Q9NZF1
• Protein name: Placenta-specific gene 8 protein (Protein C15)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04749	PLAC8	26 → 105	PLAC8 family	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed at high levels in plasmacytoid dendritic cells. High expression in spleen, lymph nodes, peripheral blood leukocytes, and bone marrow, with lower expression in thymus, appendix, and fetal liver.
• Sequence:

  MQAQAPVVVVTQPGVGPGPAPQNSNWQTGMCDCFSDCGVCLCGTFCFPCLGCQVAADMNE
  CCLCGTSVAMRTLYRTRYGIPGSICDDYMATLCCPHCTLCQIKRDINRRRAMRTF

• Sequence length: 115

Pathways

Reactome:

Neutrophil degranulation