SLC25A37 (solute carrier family 25 member 37)

Gene

• Entrez ID: 51312
• Gene name: Solute carrier family 25 member 37
• Gene symbol: SLC25A37
• Synonyms (NCBI Gene): HT015, MFRN, MFRN1, MSC, MSCP, PRO1278, PRO1584, PRO2217
• Chromosome: 8
• Chromosome location: 8p21.2
• Summary: SLC25A37 is a solute carrier localized in the mitochondrial inner membrane. It functions as an essential iron importer for the synthesis of mitochondrial heme and iron-sulfur clusters (summary by Chen et al., 2009 [PubMed 19805291]).[supplied by OMIM, Jan

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT025959	hsa-miR-7-5p	Sequencing	20371350
MIRT050876	hsa-miR-17-5p	CLASH	23622248
MIRT676302	hsa-miR-582-3p	HITS-CLIP	23824327
MIRT676301	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT676300	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT676299	hsa-miR-6504-3p	HITS-CLIP	23824327
MIRT676298	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT676297	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT676296	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT676295	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT676294	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT676293	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT676292	hsa-miR-1976	HITS-CLIP	23824327
MIRT676291	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT676290	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT676289	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT676288	hsa-miR-5095	HITS-CLIP	23824327
MIRT676287	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT676286	hsa-miR-4279	HITS-CLIP	23824327
MIRT676285	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT505627	hsa-miR-3617-5p	PAR-CLIP	23446348
MIRT505626	hsa-miR-641	PAR-CLIP	23446348
MIRT505625	hsa-miR-18a-5p	PAR-CLIP	23446348
MIRT505624	hsa-miR-18b-5p	PAR-CLIP	23446348
MIRT505623	hsa-miR-4735-3p	PAR-CLIP	23446348
MIRT505622	hsa-miR-4476	PAR-CLIP	23446348
MIRT505621	hsa-miR-6876-5p	PAR-CLIP	23446348
MIRT505620	hsa-miR-766-5p	PAR-CLIP	23446348
MIRT505619	hsa-miR-7154-3p	PAR-CLIP	23446348
MIRT505618	hsa-miR-765	PAR-CLIP	23446348
MIRT505617	hsa-miR-6894-5p	PAR-CLIP	23446348
MIRT505616	hsa-miR-365a-5p	PAR-CLIP	23446348
MIRT505615	hsa-miR-365b-5p	PAR-CLIP	23446348
MIRT505614	hsa-miR-3144-5p	PAR-CLIP	23446348
MIRT505613	hsa-miR-3191-3p	PAR-CLIP	23446348
MIRT505612	hsa-miR-4652-5p	PAR-CLIP	23446348
MIRT505611	hsa-miR-636	PAR-CLIP	23446348
MIRT505610	hsa-miR-6505-5p	PAR-CLIP	23446348
MIRT505609	hsa-miR-4443	PAR-CLIP	23446348
MIRT172810	hsa-miR-6515-5p	PAR-CLIP	23446348
MIRT505608	hsa-miR-6810-5p	PAR-CLIP	23446348
MIRT172788	hsa-miR-181a-5p	HITS-CLIP	22473208
MIRT172789	hsa-miR-181b-5p	HITS-CLIP	22473208
MIRT172791	hsa-miR-181c-5p	HITS-CLIP	22473208
MIRT172794	hsa-miR-181d-5p	HITS-CLIP	22473208
MIRT739575	hsa-miR-4676-3p	HITS-CLIP	27418678
MIRT739575	hsa-miR-4676-3p	HITS-CLIP	27418678
MIRT739575	hsa-miR-4676-3p	HITS-CLIP	27418678
MIRT739575	hsa-miR-4676-3p	HITS-CLIP	27418678
MIRT739575	hsa-miR-4676-3p	HITS-CLIP	27418678
MIRT739575	hsa-miR-4676-3p	HITS-CLIP	27418678
MIRT739577	hsa-miR-4693-5p	HITS-CLIP	27418678
MIRT739577	hsa-miR-4693-5p	HITS-CLIP	27418678
MIRT739577	hsa-miR-4693-5p	HITS-CLIP	27418678
MIRT739577	hsa-miR-4693-5p	HITS-CLIP	27418678
MIRT739577	hsa-miR-4693-5p	HITS-CLIP	27418678
MIRT739577	hsa-miR-4693-5p	HITS-CLIP	27418678
MIRT739121	hsa-miR-513a-3p	HITS-CLIP	27418678
MIRT739121	hsa-miR-513a-3p	HITS-CLIP	27418678
MIRT739121	hsa-miR-513a-3p	HITS-CLIP	27418678
MIRT739121	hsa-miR-513a-3p	HITS-CLIP	27418678
MIRT739575	hsa-miR-4676-3p	HITS-CLIP	28735896
MIRT739575	hsa-miR-4676-3p	HITS-CLIP	28735896
MIRT739575	hsa-miR-4676-3p	HITS-CLIP	28735896
MIRT739575	hsa-miR-4676-3p	HITS-CLIP	28735896
MIRT739577	hsa-miR-4693-5p	HITS-CLIP	28735896
MIRT739577	hsa-miR-4693-5p	HITS-CLIP	28735896
MIRT739577	hsa-miR-4693-5p	HITS-CLIP	28735896
MIRT739577	hsa-miR-4693-5p	HITS-CLIP	28735896
MIRT739121	hsa-miR-513a-3p	HITS-CLIP	28735896
MIRT676302	hsa-miR-582-3p	HITS-CLIP	23824327
MIRT676301	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT676300	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT676299	hsa-miR-6504-3p	HITS-CLIP	23824327
MIRT676298	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT676297	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT676296	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT676295	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT676294	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT676293	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT676292	hsa-miR-1976	HITS-CLIP	23824327
MIRT676291	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT676290	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT676289	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT676288	hsa-miR-5095	HITS-CLIP	23824327
MIRT676287	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT676286	hsa-miR-4279	HITS-CLIP	23824327
MIRT676285	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT505627	hsa-miR-3617-5p	PAR-CLIP	23446348
MIRT505626	hsa-miR-641	PAR-CLIP	23446348
MIRT505625	hsa-miR-18a-5p	PAR-CLIP	23446348
MIRT505624	hsa-miR-18b-5p	PAR-CLIP	23446348
MIRT505623	hsa-miR-4735-3p	PAR-CLIP	23446348
MIRT505622	hsa-miR-4476	PAR-CLIP	23446348
MIRT505621	hsa-miR-6876-5p	PAR-CLIP	23446348
MIRT505620	hsa-miR-766-5p	PAR-CLIP	23446348
MIRT505619	hsa-miR-7154-3p	PAR-CLIP	23446348
MIRT505618	hsa-miR-765	PAR-CLIP	23446348
MIRT505617	hsa-miR-6894-5p	PAR-CLIP	23446348
MIRT505616	hsa-miR-365a-5p	PAR-CLIP	23446348
MIRT505615	hsa-miR-365b-5p	PAR-CLIP	23446348
MIRT505614	hsa-miR-3144-5p	PAR-CLIP	23446348
MIRT505613	hsa-miR-3191-3p	PAR-CLIP	23446348
MIRT505612	hsa-miR-4652-5p	PAR-CLIP	23446348
MIRT505611	hsa-miR-636	PAR-CLIP	23446348
MIRT505610	hsa-miR-6505-5p	PAR-CLIP	23446348
MIRT505609	hsa-miR-4443	PAR-CLIP	23446348
MIRT172810	hsa-miR-6515-5p	PAR-CLIP	23446348
MIRT505608	hsa-miR-6810-5p	PAR-CLIP	23446348
MIRT1356598	hsa-miR-124	CLIP-seq
MIRT1356599	hsa-miR-1256	CLIP-seq
MIRT1356600	hsa-miR-1297	CLIP-seq
MIRT1356601	hsa-miR-1470	CLIP-seq
MIRT1356602	hsa-miR-181a	CLIP-seq
MIRT1356603	hsa-miR-181b	CLIP-seq
MIRT1356604	hsa-miR-181c	CLIP-seq
MIRT1356605	hsa-miR-181d	CLIP-seq
MIRT1356606	hsa-miR-2110	CLIP-seq
MIRT1356607	hsa-miR-22	CLIP-seq
MIRT1356608	hsa-miR-2682	CLIP-seq
MIRT1356609	hsa-miR-26a	CLIP-seq
MIRT1356610	hsa-miR-26b	CLIP-seq
MIRT1356611	hsa-miR-3065-3p	CLIP-seq
MIRT1356612	hsa-miR-3127-3p	CLIP-seq
MIRT1356613	hsa-miR-3150a-3p	CLIP-seq
MIRT1356614	hsa-miR-3175	CLIP-seq
MIRT1356615	hsa-miR-3183	CLIP-seq
MIRT1356616	hsa-miR-3184	CLIP-seq
MIRT1356617	hsa-miR-3192	CLIP-seq
MIRT1356618	hsa-miR-326	CLIP-seq
MIRT1356619	hsa-miR-330-5p	CLIP-seq
MIRT1356620	hsa-miR-3613-3p	CLIP-seq
MIRT1356621	hsa-miR-3620	CLIP-seq
MIRT1356622	hsa-miR-3691-3p	CLIP-seq
MIRT1356623	hsa-miR-3714	CLIP-seq
MIRT1356624	hsa-miR-3910	CLIP-seq
MIRT1356625	hsa-miR-423-5p	CLIP-seq
MIRT1356626	hsa-miR-4262	CLIP-seq
MIRT1356627	hsa-miR-4314	CLIP-seq
MIRT1356628	hsa-miR-4420	CLIP-seq
MIRT1356629	hsa-miR-4465	CLIP-seq
MIRT1356630	hsa-miR-4489	CLIP-seq
MIRT1356631	hsa-miR-449c	CLIP-seq
MIRT739576	hsa-miR-452	CLIP-seq
MIRT1356632	hsa-miR-4521	CLIP-seq
MIRT1356633	hsa-miR-4646-5p	CLIP-seq
MIRT1356634	hsa-miR-4659a-3p	CLIP-seq
MIRT1356635	hsa-miR-4659b-3p	CLIP-seq
MIRT1356636	hsa-miR-4667-3p	CLIP-seq
MIRT1356637	hsa-miR-4723-3p	CLIP-seq
MIRT1356638	hsa-miR-4738-3p	CLIP-seq
MIRT1356639	hsa-miR-506	CLIP-seq
MIRT1356640	hsa-miR-516b	CLIP-seq
MIRT1356641	hsa-miR-642a	CLIP-seq
MIRT1356642	hsa-miR-720	CLIP-seq
MIRT1356643	hsa-miR-939	CLIP-seq
MIRT1356644	hsa-miR-940	CLIP-seq
MIRT739576	hsa-miR-452	CLIP-seq
MIRT739576	hsa-miR-452	CLIP-seq
MIRT739576	hsa-miR-452	CLIP-seq
MIRT739576	hsa-miR-452	CLIP-seq
MIRT739576	hsa-miR-452	CLIP-seq
MIRT739576	hsa-miR-452	CLIP-seq
MIRT739576	hsa-miR-452	CLIP-seq
MIRT739576	hsa-miR-452	CLIP-seq
MIRT1356602	hsa-miR-181a	CLIP-seq
MIRT1356603	hsa-miR-181b	CLIP-seq
MIRT1356604	hsa-miR-181c	CLIP-seq
MIRT1356605	hsa-miR-181d	CLIP-seq
MIRT1356620	hsa-miR-3613-3p	CLIP-seq
MIRT1356626	hsa-miR-4262	CLIP-seq
MIRT739576	hsa-miR-452	CLIP-seq
MIRT2105662	hsa-miR-4719	CLIP-seq
MIRT1356602	hsa-miR-181a	CLIP-seq
MIRT1356603	hsa-miR-181b	CLIP-seq
MIRT1356604	hsa-miR-181c	CLIP-seq
MIRT1356605	hsa-miR-181d	CLIP-seq
MIRT1356622	hsa-miR-3691-3p	CLIP-seq
MIRT1356626	hsa-miR-4262	CLIP-seq
MIRT739576	hsa-miR-452	CLIP-seq
MIRT2105662	hsa-miR-4719	CLIP-seq
MIRT1356602	hsa-miR-181a	CLIP-seq
MIRT1356603	hsa-miR-181b	CLIP-seq
MIRT1356604	hsa-miR-181c	CLIP-seq
MIRT1356605	hsa-miR-181d	CLIP-seq
MIRT1356607	hsa-miR-22	CLIP-seq
MIRT1356616	hsa-miR-3184	CLIP-seq
MIRT1356625	hsa-miR-423-5p	CLIP-seq
MIRT1356626	hsa-miR-4262	CLIP-seq
MIRT1356630	hsa-miR-4489	CLIP-seq
MIRT739576	hsa-miR-452	CLIP-seq
MIRT1356638	hsa-miR-4738-3p	CLIP-seq
MIRT1356640	hsa-miR-516b	CLIP-seq
MIRT739576	hsa-miR-452	CLIP-seq
MIRT739576	hsa-miR-452	CLIP-seq
MIRT739576	hsa-miR-452	CLIP-seq
MIRT2624232	hsa-miR-3667-3p	CLIP-seq
MIRT1356622	hsa-miR-3691-3p	CLIP-seq
MIRT2624233	hsa-miR-4421	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005381	Function	Iron ion transmembrane transporter activity	IDA	35513392
GO:0005381	Function	Iron ion transmembrane transporter activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IEA
GO:0005739	Component	Mitochondrion	ISS
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006826	Process	Iron ion transport	IEA
GO:0015093	Function	Ferrous iron transmembrane transporter activity	IBA
GO:0016020	Component	Membrane	IEA
GO:0031966	Component	Mitochondrial membrane	IBA
GO:0046985	Process	Positive regulation of hemoglobin biosynthetic process	IEA
GO:0046985	Process	Positive regulation of hemoglobin biosynthetic process	ISS
GO:0048250	Process	Iron import into the mitochondrion	IBA
GO:0048250	Process	Iron import into the mitochondrion	IEA
GO:0048250	Process	Iron import into the mitochondrion	IMP	35513392

Other IDs

• MIM: 610387
• HGNC: 29786
• e!Ensembl: ENSG00000147454

Protein

• UniProt ID: Q9NYZ2
• Protein name: Mitoferrin-1 (Mitochondrial iron transporter 1) (Mitochondrial solute carrier protein) (Solute carrier family 25 member 37)
• Protein function: Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00153	Mito_carr	41 → 136	Mitochondrial carrier protein	Family
  PF00153	Mito_carr	139 → 230	Mitochondrial carrier protein	Family
  PF00153	Mito_carr	230 → 331	Mitochondrial carrier protein	Family

• Sequence:

  MELRSGSVGSQAVARRMDGDSRDGGGGKDATGSEDYENLPTSASVSTHMTAGAMAGILEH
  SVMYPVDSVKTRMQSLSPDPKAQYTSIYGALKKIMRTEGFWRPLRGVNVMIMGAGPAHAM
  YFACYENMKRTLNDVFHHQGNSHLANGIAGSMATLLHDAVMNPAEVVKQRLQMYNSQHRS
  AISCIRTVWRTEGLGAFYRSYTTQLTMNIPFQSIHFITYEFLQEQVNPHRTYNPQSHIIS
  GGLAGALAAAATTPLDVCKTLLNTQENVALSLANISGRLSGMANAFRTVYQLNGLAGYFK
  GIQARVIYQMPSTAISWSVYEFFKYFLTKRQLENRAPY

• Sequence length: 338