Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	51312
Gene name Gene Name - the full gene name approved by the HGNC.	Solute carrier family 25 member 37
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SLC25A37
Synonyms (NCBI Gene) Gene synonyms aliases	HT015, MFRN, MFRN1, MSC, MSCP, PRO1278, PRO1584, PRO2217
Chromosome Chromosome number	8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	8p21.2
Summary Summary of gene provided in NCBI Entrez Gene.	SLC25A37 is a solute carrier localized in the mitochondrial inner membrane. It functions as an essential iron importer for the synthesis of mitochondrial heme and iron-sulfur clusters (summary by Chen et al., 2009 [PubMed 19805291]).[supplied by OMIM, Jan

Show/Hide all(199)

miRTarBase ID	miRNA	Experiments	Reference
MIRT025959	hsa-miR-7-5p	Sequencing	20371350
MIRT050876	hsa-miR-17-5p	CLASH	23622248
MIRT676302	hsa-miR-582-3p	HITS-CLIP	23824327
MIRT676301	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT676300	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT676299	hsa-miR-6504-3p	HITS-CLIP	23824327
MIRT676298	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT676297	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT676296	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT676295	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT676294	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT676293	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT676292	hsa-miR-1976	HITS-CLIP	23824327
MIRT676291	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT676290	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT676289	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT676288	hsa-miR-5095	HITS-CLIP	23824327
MIRT676287	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT676286	hsa-miR-4279	HITS-CLIP	23824327
MIRT676285	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT505627	hsa-miR-3617-5p	PAR-CLIP	23446348
MIRT505626	hsa-miR-641	PAR-CLIP	23446348
MIRT505625	hsa-miR-18a-5p	PAR-CLIP	23446348
MIRT505624	hsa-miR-18b-5p	PAR-CLIP	23446348
MIRT505623	hsa-miR-4735-3p	PAR-CLIP	23446348
MIRT505622	hsa-miR-4476	PAR-CLIP	23446348
MIRT505621	hsa-miR-6876-5p	PAR-CLIP	23446348
MIRT505620	hsa-miR-766-5p	PAR-CLIP	23446348
MIRT505619	hsa-miR-7154-3p	PAR-CLIP	23446348
MIRT505618	hsa-miR-765	PAR-CLIP	23446348
MIRT505617	hsa-miR-6894-5p	PAR-CLIP	23446348
MIRT505616	hsa-miR-365a-5p	PAR-CLIP	23446348
MIRT505615	hsa-miR-365b-5p	PAR-CLIP	23446348
MIRT505614	hsa-miR-3144-5p	PAR-CLIP	23446348
MIRT505613	hsa-miR-3191-3p	PAR-CLIP	23446348
MIRT505612	hsa-miR-4652-5p	PAR-CLIP	23446348
MIRT505611	hsa-miR-636	PAR-CLIP	23446348
MIRT505610	hsa-miR-6505-5p	PAR-CLIP	23446348
MIRT505609	hsa-miR-4443	PAR-CLIP	23446348
MIRT172810	hsa-miR-6515-5p	PAR-CLIP	23446348
MIRT505608	hsa-miR-6810-5p	PAR-CLIP	23446348
MIRT172788	hsa-miR-181a-5p	HITS-CLIP	22473208
MIRT172789	hsa-miR-181b-5p	HITS-CLIP	22473208
MIRT172791	hsa-miR-181c-5p	HITS-CLIP	22473208
MIRT172794	hsa-miR-181d-5p	HITS-CLIP	22473208
MIRT739575	hsa-miR-4676-3p	HITS-CLIP	27418678
MIRT739575	hsa-miR-4676-3p	HITS-CLIP	27418678
MIRT739575	hsa-miR-4676-3p	HITS-CLIP	27418678
MIRT739575	hsa-miR-4676-3p	HITS-CLIP	27418678
MIRT739575	hsa-miR-4676-3p	HITS-CLIP	27418678
MIRT739575	hsa-miR-4676-3p	HITS-CLIP	27418678
MIRT739577	hsa-miR-4693-5p	HITS-CLIP	27418678
MIRT739577	hsa-miR-4693-5p	HITS-CLIP	27418678
MIRT739577	hsa-miR-4693-5p	HITS-CLIP	27418678
MIRT739577	hsa-miR-4693-5p	HITS-CLIP	27418678
MIRT739577	hsa-miR-4693-5p	HITS-CLIP	27418678
MIRT739577	hsa-miR-4693-5p	HITS-CLIP	27418678
MIRT739121	hsa-miR-513a-3p	HITS-CLIP	27418678
MIRT739121	hsa-miR-513a-3p	HITS-CLIP	27418678
MIRT739121	hsa-miR-513a-3p	HITS-CLIP	27418678
MIRT739121	hsa-miR-513a-3p	HITS-CLIP	27418678
MIRT739575	hsa-miR-4676-3p	HITS-CLIP	28735896
MIRT739575	hsa-miR-4676-3p	HITS-CLIP	28735896
MIRT739575	hsa-miR-4676-3p	HITS-CLIP	28735896
MIRT739575	hsa-miR-4676-3p	HITS-CLIP	28735896
MIRT739577	hsa-miR-4693-5p	HITS-CLIP	28735896
MIRT739577	hsa-miR-4693-5p	HITS-CLIP	28735896
MIRT739577	hsa-miR-4693-5p	HITS-CLIP	28735896
MIRT739577	hsa-miR-4693-5p	HITS-CLIP	28735896
MIRT739121	hsa-miR-513a-3p	HITS-CLIP	28735896
MIRT676302	hsa-miR-582-3p	HITS-CLIP	23824327
MIRT676301	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT676300	hsa-miR-552-3p	HITS-CLIP	23824327
MIRT676299	hsa-miR-6504-3p	HITS-CLIP	23824327
MIRT676298	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT676297	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT676296	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT676295	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT676294	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT676293	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT676292	hsa-miR-1976	HITS-CLIP	23824327
MIRT676291	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT676290	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT676289	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT676288	hsa-miR-5095	HITS-CLIP	23824327
MIRT676287	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT676286	hsa-miR-4279	HITS-CLIP	23824327
MIRT676285	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT505627	hsa-miR-3617-5p	PAR-CLIP	23446348
MIRT505626	hsa-miR-641	PAR-CLIP	23446348
MIRT505625	hsa-miR-18a-5p	PAR-CLIP	23446348
MIRT505624	hsa-miR-18b-5p	PAR-CLIP	23446348
MIRT505623	hsa-miR-4735-3p	PAR-CLIP	23446348
MIRT505622	hsa-miR-4476	PAR-CLIP	23446348
MIRT505621	hsa-miR-6876-5p	PAR-CLIP	23446348
MIRT505620	hsa-miR-766-5p	PAR-CLIP	23446348
MIRT505619	hsa-miR-7154-3p	PAR-CLIP	23446348
MIRT505618	hsa-miR-765	PAR-CLIP	23446348
MIRT505617	hsa-miR-6894-5p	PAR-CLIP	23446348
MIRT505616	hsa-miR-365a-5p	PAR-CLIP	23446348
MIRT505615	hsa-miR-365b-5p	PAR-CLIP	23446348
MIRT505614	hsa-miR-3144-5p	PAR-CLIP	23446348
MIRT505613	hsa-miR-3191-3p	PAR-CLIP	23446348
MIRT505612	hsa-miR-4652-5p	PAR-CLIP	23446348
MIRT505611	hsa-miR-636	PAR-CLIP	23446348
MIRT505610	hsa-miR-6505-5p	PAR-CLIP	23446348
MIRT505609	hsa-miR-4443	PAR-CLIP	23446348
MIRT172810	hsa-miR-6515-5p	PAR-CLIP	23446348
MIRT505608	hsa-miR-6810-5p	PAR-CLIP	23446348
MIRT1356598	hsa-miR-124	CLIP-seq
MIRT1356599	hsa-miR-1256	CLIP-seq
MIRT1356600	hsa-miR-1297	CLIP-seq
MIRT1356601	hsa-miR-1470	CLIP-seq
MIRT1356602	hsa-miR-181a	CLIP-seq
MIRT1356603	hsa-miR-181b	CLIP-seq
MIRT1356604	hsa-miR-181c	CLIP-seq
MIRT1356605	hsa-miR-181d	CLIP-seq
MIRT1356606	hsa-miR-2110	CLIP-seq
MIRT1356607	hsa-miR-22	CLIP-seq
MIRT1356608	hsa-miR-2682	CLIP-seq
MIRT1356609	hsa-miR-26a	CLIP-seq
MIRT1356610	hsa-miR-26b	CLIP-seq
MIRT1356611	hsa-miR-3065-3p	CLIP-seq
MIRT1356612	hsa-miR-3127-3p	CLIP-seq
MIRT1356613	hsa-miR-3150a-3p	CLIP-seq
MIRT1356614	hsa-miR-3175	CLIP-seq
MIRT1356615	hsa-miR-3183	CLIP-seq
MIRT1356616	hsa-miR-3184	CLIP-seq
MIRT1356617	hsa-miR-3192	CLIP-seq
MIRT1356618	hsa-miR-326	CLIP-seq
MIRT1356619	hsa-miR-330-5p	CLIP-seq
MIRT1356620	hsa-miR-3613-3p	CLIP-seq
MIRT1356621	hsa-miR-3620	CLIP-seq
MIRT1356622	hsa-miR-3691-3p	CLIP-seq
MIRT1356623	hsa-miR-3714	CLIP-seq
MIRT1356624	hsa-miR-3910	CLIP-seq
MIRT1356625	hsa-miR-423-5p	CLIP-seq
MIRT1356626	hsa-miR-4262	CLIP-seq
MIRT1356627	hsa-miR-4314	CLIP-seq
MIRT1356628	hsa-miR-4420	CLIP-seq
MIRT1356629	hsa-miR-4465	CLIP-seq
MIRT1356630	hsa-miR-4489	CLIP-seq
MIRT1356631	hsa-miR-449c	CLIP-seq
MIRT739576	hsa-miR-452	CLIP-seq
MIRT1356632	hsa-miR-4521	CLIP-seq
MIRT1356633	hsa-miR-4646-5p	CLIP-seq
MIRT1356634	hsa-miR-4659a-3p	CLIP-seq
MIRT1356635	hsa-miR-4659b-3p	CLIP-seq
MIRT1356636	hsa-miR-4667-3p	CLIP-seq
MIRT1356637	hsa-miR-4723-3p	CLIP-seq
MIRT1356638	hsa-miR-4738-3p	CLIP-seq
MIRT1356639	hsa-miR-506	CLIP-seq
MIRT1356640	hsa-miR-516b	CLIP-seq
MIRT1356641	hsa-miR-642a	CLIP-seq
MIRT1356642	hsa-miR-720	CLIP-seq
MIRT1356643	hsa-miR-939	CLIP-seq
MIRT1356644	hsa-miR-940	CLIP-seq
MIRT739576	hsa-miR-452	CLIP-seq
MIRT739576	hsa-miR-452	CLIP-seq
MIRT739576	hsa-miR-452	CLIP-seq
MIRT739576	hsa-miR-452	CLIP-seq
MIRT739576	hsa-miR-452	CLIP-seq
MIRT739576	hsa-miR-452	CLIP-seq
MIRT739576	hsa-miR-452	CLIP-seq
MIRT739576	hsa-miR-452	CLIP-seq
MIRT1356602	hsa-miR-181a	CLIP-seq
MIRT1356603	hsa-miR-181b	CLIP-seq
MIRT1356604	hsa-miR-181c	CLIP-seq
MIRT1356605	hsa-miR-181d	CLIP-seq
MIRT1356620	hsa-miR-3613-3p	CLIP-seq
MIRT1356626	hsa-miR-4262	CLIP-seq
MIRT739576	hsa-miR-452	CLIP-seq
MIRT2105662	hsa-miR-4719	CLIP-seq
MIRT1356602	hsa-miR-181a	CLIP-seq
MIRT1356603	hsa-miR-181b	CLIP-seq
MIRT1356604	hsa-miR-181c	CLIP-seq
MIRT1356605	hsa-miR-181d	CLIP-seq
MIRT1356622	hsa-miR-3691-3p	CLIP-seq
MIRT1356626	hsa-miR-4262	CLIP-seq
MIRT739576	hsa-miR-452	CLIP-seq
MIRT2105662	hsa-miR-4719	CLIP-seq
MIRT1356602	hsa-miR-181a	CLIP-seq
MIRT1356603	hsa-miR-181b	CLIP-seq
MIRT1356604	hsa-miR-181c	CLIP-seq
MIRT1356605	hsa-miR-181d	CLIP-seq
MIRT1356607	hsa-miR-22	CLIP-seq
MIRT1356616	hsa-miR-3184	CLIP-seq
MIRT1356625	hsa-miR-423-5p	CLIP-seq
MIRT1356626	hsa-miR-4262	CLIP-seq
MIRT1356630	hsa-miR-4489	CLIP-seq
MIRT739576	hsa-miR-452	CLIP-seq
MIRT1356638	hsa-miR-4738-3p	CLIP-seq
MIRT1356640	hsa-miR-516b	CLIP-seq
MIRT739576	hsa-miR-452	CLIP-seq
MIRT739576	hsa-miR-452	CLIP-seq
MIRT739576	hsa-miR-452	CLIP-seq
MIRT2624232	hsa-miR-3667-3p	CLIP-seq
MIRT1356622	hsa-miR-3691-3p	CLIP-seq
MIRT2624233	hsa-miR-4421	CLIP-seq

Show/Hide all(17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005381	Function	Iron ion transmembrane transporter activity	IDA	35513392
GO:0005381	Function	Iron ion transmembrane transporter activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IEA
GO:0005739	Component	Mitochondrion	ISS
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006826	Process	Iron ion transport	IEA
GO:0015093	Function	Ferrous iron transmembrane transporter activity	IBA
GO:0016020	Component	Membrane	IEA
GO:0031966	Component	Mitochondrial membrane	IBA
GO:0046985	Process	Positive regulation of hemoglobin biosynthetic process	IEA
GO:0046985	Process	Positive regulation of hemoglobin biosynthetic process	ISS
GO:0048250	Process	Iron import into the mitochondrion	IBA
GO:0048250	Process	Iron import into the mitochondrion	IEA
GO:0048250	Process	Iron import into the mitochondrion	IMP	35513392

MIM	HGNC	e!Ensembl
610387	29786	ENSG00000147454

Protein

UniProt ID

Q9NYZ2

Protein name

Mitoferrin-1 (Mitochondrial iron transporter 1) (Mitochondrial solute carrier protein) (Solute carrier family 25 member 37)

Protein function

Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00153	Mito_carr	41 → 136	Mitochondrial carrier protein	Family
PF00153	Mito_carr	139 → 230	Mitochondrial carrier protein	Family
PF00153	Mito_carr	230 → 331	Mitochondrial carrier protein	Family

Sequence

MELRSGSVGSQAVARRMDGDSRDGGGGKDATGSEDYENLPTSASVSTHMTAGAMAGILEH
SVMYPVDSVKTRMQSLSPDPKAQYTSIYGALKKIMRTEGFWRPLRGVNVMIMGAGPAHAM
YFACYENMKRTLNDVFHHQGNSHLANGIAGSMATLLHDAVMNPAEVVKQRLQMYNSQHRS
AISCIRTVWRTEGLGAFYRSYTTQLTMNIPFQSIHFITYEFLQEQVNPHRTYNPQSHIIS
GGLAGALAAAATTPLDVCKTLLNTQENVALSLANISGRLSGMANAFRTVYQLNGLAGYFK
GIQARVIYQMPSTAISWSVYEFFKYFLTKRQLENRAPY

Sequence length

338

Interactions

View interactions

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Hypothyroidism	Hypothyroidism	N/A	N/A	GWAS
Mental Depression	Major depressive disorder	N/A	N/A	GWAS
Prostate cancer	Prostate cancer	N/A	N/A	GWAS

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Anemia Refractory	Associate	25955609
Carcinoma Renal Cell	Associate	37304236
Coronary Artery Disease	Associate	33686958
DNA Virus Infections	Associate	33276460
Fatigue	Associate	23047795, 24786901
Hypoxia	Stimulate	19187226
Mitochondrial Diseases	Associate	39337531
Neoplasms	Associate	40447904
Prostatic Neoplasms	Associate	23047795
Protoporphyria Erythropoietic	Associate	30391163

SLC25A37 (solute carrier family 25 member 37)