Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	51310
Gene name Gene Name - the full gene name approved by the HGNC.	Solute carrier family 22 member 17
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SLC22A17
Synonyms (NCBI Gene) Gene synonyms aliases	24p3R, BOCT, BOIT, NGALR, NGALR2, NGALR3, hBOIT
Chromosome Chromosome number	14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	14q11.2

Show/Hide all(71)

miRTarBase ID	miRNA	Experiments	Reference
MIRT675003	hsa-miR-3529-3p	HITS-CLIP	23824327
MIRT675002	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT675003	hsa-miR-3529-3p	HITS-CLIP	23824327
MIRT675002	hsa-miR-5195-5p	HITS-CLIP	23824327
MIRT1354387	hsa-miR-1257	CLIP-seq
MIRT1354388	hsa-miR-15a	CLIP-seq
MIRT1354389	hsa-miR-15b	CLIP-seq
MIRT1354390	hsa-miR-16	CLIP-seq
MIRT1354391	hsa-miR-195	CLIP-seq
MIRT1354392	hsa-miR-330-3p	CLIP-seq
MIRT1354393	hsa-miR-3926	CLIP-seq
MIRT1354394	hsa-miR-424	CLIP-seq
MIRT1354395	hsa-miR-497	CLIP-seq
MIRT1354396	hsa-miR-518a-5p	CLIP-seq
MIRT1354397	hsa-miR-527	CLIP-seq
MIRT1354398	hsa-miR-548s	CLIP-seq
MIRT2329468	hsa-miR-511	CLIP-seq
MIRT2623747	hsa-miR-1285	CLIP-seq
MIRT2623748	hsa-miR-1293	CLIP-seq
MIRT2623749	hsa-miR-147	CLIP-seq
MIRT2623750	hsa-miR-2278	CLIP-seq
MIRT2623751	hsa-miR-3064-3p	CLIP-seq
MIRT2623752	hsa-miR-3162-3p	CLIP-seq
MIRT2623753	hsa-miR-3165	CLIP-seq
MIRT2623754	hsa-miR-3173-5p	CLIP-seq
MIRT2623755	hsa-miR-3187-5p	CLIP-seq
MIRT2623756	hsa-miR-3194-5p	CLIP-seq
MIRT2623757	hsa-miR-3672	CLIP-seq
MIRT2623758	hsa-miR-3691-5p	CLIP-seq
MIRT2623759	hsa-miR-378g	CLIP-seq
MIRT2623760	hsa-miR-3911	CLIP-seq
MIRT2623761	hsa-miR-4258	CLIP-seq
MIRT2623762	hsa-miR-4264	CLIP-seq
MIRT2623763	hsa-miR-4265	CLIP-seq
MIRT2623764	hsa-miR-4296	CLIP-seq
MIRT2623765	hsa-miR-4297	CLIP-seq
MIRT2623766	hsa-miR-4314	CLIP-seq
MIRT2623767	hsa-miR-4322	CLIP-seq
MIRT2623768	hsa-miR-4417	CLIP-seq
MIRT2623769	hsa-miR-4483	CLIP-seq
MIRT2623770	hsa-miR-4486	CLIP-seq
MIRT2623771	hsa-miR-451b	CLIP-seq
MIRT2623772	hsa-miR-4640-5p	CLIP-seq
MIRT2623773	hsa-miR-4652-3p	CLIP-seq
MIRT2623774	hsa-miR-4715-3p	CLIP-seq
MIRT2623775	hsa-miR-4726-5p	CLIP-seq
MIRT2623776	hsa-miR-4764-5p	CLIP-seq
MIRT2623777	hsa-miR-4778-3p	CLIP-seq
MIRT2623778	hsa-miR-494	CLIP-seq
MIRT2623779	hsa-miR-510	CLIP-seq
MIRT2623780	hsa-miR-512-5p	CLIP-seq
MIRT2623781	hsa-miR-612	CLIP-seq
MIRT2623782	hsa-miR-622	CLIP-seq
MIRT2623783	hsa-miR-644	CLIP-seq
MIRT2623747	hsa-miR-1285	CLIP-seq
MIRT2623751	hsa-miR-3064-3p	CLIP-seq
MIRT2623752	hsa-miR-3162-3p	CLIP-seq
MIRT2623754	hsa-miR-3173-5p	CLIP-seq
MIRT2623755	hsa-miR-3187-5p	CLIP-seq
MIRT2623757	hsa-miR-3672	CLIP-seq
MIRT2623759	hsa-miR-378g	CLIP-seq
MIRT2623762	hsa-miR-4264	CLIP-seq
MIRT2623765	hsa-miR-4297	CLIP-seq
MIRT2623766	hsa-miR-4314	CLIP-seq
MIRT2623770	hsa-miR-4486	CLIP-seq
MIRT2623774	hsa-miR-4715-3p	CLIP-seq
MIRT2623777	hsa-miR-4778-3p	CLIP-seq
MIRT2623779	hsa-miR-510	CLIP-seq
MIRT2623780	hsa-miR-512-5p	CLIP-seq
MIRT2623781	hsa-miR-612	CLIP-seq
MIRT2623782	hsa-miR-622	CLIP-seq

Show/Hide all(10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004888	Function	Transmembrane signaling receptor activity	ISS
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005774	Component	Vacuolar membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IDA	17253959
GO:0006879	Process	Cellular iron ion homeostasis	TAS
GO:0015891	Process	Siderophore transport	ISS
GO:0022857	Function	Transmembrane transporter activity	TAS
GO:0031301	Component	Integral component of organelle membrane	IDA	17253959
GO:0055085	Process	Transmembrane transport	IEA

MIM	HGNC	e!Ensembl
611461	23095	ENSG00000092096

Protein

UniProt ID

Q8WUG5

Protein name

Solute carrier family 22 member 17 (24p3 receptor) (24p3R) (Brain-type organic cation transporter) (Lipocalin-2 receptor) (Neutrophil gelatinase-associated lipocalin receptor) (NgalR)

Protein function

Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentr

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00083	Sugar_tr	89 → 507	Sugar (and other) transporter	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in brain.

Sequence

MASDPIFTLAPPLHCHYGAFPPNASGWEQPPNASGVSVASAALAASAASRVATSTDPSCS
GFAPPDFNHCLKDWDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGY
PADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELC
DPTQRLRVALAGELVGVGGHFLFLGLALVSKDWRFLQRMITAPCILFLFYGWPGLFLESA
RWLIVKRQIEEAQSVLRILAERNRPHGQMLGEEAQEALQDLENTCPLPATSSFSFASLLN
YRNIWKNLLILGFTNFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVD
RFGRRGILLLSMTLTGIASLVLLGLWDCEHPIFPTVWAQQGNPNRDLNEAAITTFSVLGL
FSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLA
ACALLCILSIMLLPETKRKLLPEVLRDGELCRRPSLLRQPPPTRCDHVPLLATPNPAL

Sequence length

538

Interactions

View interactions

	Reactome
			Iron uptake and transport

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Esophagus neoplasm	Malignant neoplasm of esophagus	rs28934578, rs121918714, rs1567556006, rs1575166666	21642993

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References
Associations from Text Mining
Melanoma Cutaneous Malignant	Inhibit	39358721
Neoplasms	Associate	39358721
Stomach Neoplasms	Associate	32164594

SLC22A17 (solute carrier family 22 member 17)