FKBP11 (FKBP prolyl isomerase 11)

Gene

• Entrez ID: 51303
• Gene name: FKBP prolyl isomerase 11
• Gene symbol: FKBP11
• Synonyms (NCBI Gene): FKBP19
• Chromosome: 12
• Chromosome location: 12q13.12
• Summary: FKBP11 belongs to the FKBP family of peptidyl-prolyl cis/trans isomerases, which catalyze the folding of proline-containing polypeptides. The peptidyl-prolyl isomerase activity of FKBP proteins is inhibited by the immunosuppressant compounds FK506 and rap

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT997156	hsa-miR-1825	CLIP-seq
MIRT997157	hsa-miR-199a-5p	CLIP-seq
MIRT997158	hsa-miR-199b-5p	CLIP-seq
MIRT997159	hsa-miR-4436b-3p	CLIP-seq
MIRT997156	hsa-miR-1825	CLIP-seq
MIRT997157	hsa-miR-199a-5p	CLIP-seq
MIRT997158	hsa-miR-199b-5p	CLIP-seq
MIRT1995693	hsa-miR-3674	CLIP-seq
MIRT997159	hsa-miR-4436b-3p	CLIP-seq
MIRT1995694	hsa-miR-4651	CLIP-seq
MIRT1995695	hsa-miR-608	CLIP-seq
MIRT1995696	hsa-miR-642b	CLIP-seq
MIRT997156	hsa-miR-1825	CLIP-seq
MIRT997157	hsa-miR-199a-5p	CLIP-seq
MIRT997158	hsa-miR-199b-5p	CLIP-seq
MIRT2229644	hsa-miR-3153	CLIP-seq
MIRT2229645	hsa-miR-3192	CLIP-seq
MIRT1995693	hsa-miR-3674	CLIP-seq
MIRT2229646	hsa-miR-4255	CLIP-seq
MIRT2229647	hsa-miR-4314	CLIP-seq
MIRT997159	hsa-miR-4436b-3p	CLIP-seq
MIRT2229648	hsa-miR-4646-5p	CLIP-seq
MIRT2229649	hsa-miR-4668-5p	CLIP-seq
MIRT1995696	hsa-miR-642b	CLIP-seq
MIRT2388011	hsa-miR-1236	CLIP-seq
MIRT2449703	hsa-miR-186	CLIP-seq
MIRT2449704	hsa-miR-3613-3p	CLIP-seq
MIRT2449705	hsa-miR-371-5p	CLIP-seq
MIRT2449706	hsa-miR-371b-5p	CLIP-seq
MIRT2449707	hsa-miR-4738-3p	CLIP-seq
MIRT2388011	hsa-miR-1236	CLIP-seq
MIRT2533568	hsa-miR-125a-5p	CLIP-seq
MIRT2533569	hsa-miR-125b	CLIP-seq
MIRT2533570	hsa-miR-3134	CLIP-seq
MIRT2533571	hsa-miR-3612	CLIP-seq
MIRT2533572	hsa-miR-3929	CLIP-seq
MIRT2533573	hsa-miR-4319	CLIP-seq
MIRT2533574	hsa-miR-4419b	CLIP-seq
MIRT2533575	hsa-miR-4443	CLIP-seq
MIRT2533576	hsa-miR-4478	CLIP-seq
MIRT2533577	hsa-miR-4534	CLIP-seq
MIRT2533578	hsa-miR-4732-3p	CLIP-seq
MIRT2533579	hsa-miR-4802-5p	CLIP-seq
MIRT2533580	hsa-miR-485-5p	CLIP-seq
MIRT2533581	hsa-miR-593	CLIP-seq
MIRT2533582	hsa-miR-650	CLIP-seq
MIRT2533583	hsa-miR-670	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000413	Process	Protein peptidyl-prolyl isomerization	IEA
GO:0003755	Function	Peptidyl-prolyl cis-trans isomerase activity	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016021	Component	Integral component of membrane	IEA

Other IDs

• MIM: 610571
• HGNC: 18624
• e!Ensembl: ENSG00000134285

Protein

• UniProt ID: Q9NYL4
• Protein name: Peptidyl-prolyl cis-trans isomerase FKBP11 (PPIase FKBP11) (EC 5.2.1.8) (19 kDa FK506-binding protein) (19 kDa FKBP) (FKBP-19) (FK506-binding protein 11) (FKBP-11) (Rotamase)
• Protein function: PPIases accelerate the folding of proteins during protein synthesis.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00254	FKBP_C	50 → 141	FKBP-type peptidyl-prolyl cis-trans isomerase	Domain

• Sequence:

  MTLRPSLLPLHLLLLLLLSAAVCRAEAGLETESPVRTLQVETLVEPPEPCAEPAAFGDTL
  HIHYTGSLVDGRIIDTSLTRDPLVIELGQKQVIPGLEQSLLDMCVGEKRRAIIPSHLAYG
  KRGFPPSVPADAVVQYDVELIALIRANYWLKLVKGILPLVGMAMVPALLGLIGYHLYRKA
  NRPKVSKKKLKEEKRNKSKKK

• Sequence length: 201

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Lung adenocarcinoma	Adenocarcinoma of lung (disorder)	rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370, rs760043106, rs1057519788, rs1131692238, rs1131692237, rs1554350382	27602772

Associations from Text Mining
Disease Name	Relationship Type	References
Carcinoma Hepatocellular	Stimulate	37248890
Idiopathic Pulmonary Fibrosis	Stimulate	35456020
Neoplasm Metastasis	Associate	36457129
Osteosarcoma	Associate	37014329