GMIP (GEM interacting protein)

Gene

• Entrez ID: 51291
• Gene name: GEM interacting protein
• Gene symbol: GMIP
• Synonyms (NCBI Gene): ARHGAP46
• Chromosome: 19
• Chromosome location: 19p13.11
• Summary: This gene encodes a member of the ARHGAP family of Rho/Rac/Cdc42-like GTPase activating proteins. The encoded protein interacts with the Ras-related protein Gem through its N-terminal domain. Separately, it interacts with RhoA through a RhoGAP domain, and

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1022679	hsa-miR-1275	CLIP-seq
MIRT1022680	hsa-miR-1285	CLIP-seq
MIRT1022681	hsa-miR-3115	CLIP-seq
MIRT1022682	hsa-miR-3121-3p	CLIP-seq
MIRT1022683	hsa-miR-3151	CLIP-seq
MIRT1022684	hsa-miR-3187-5p	CLIP-seq
MIRT1022685	hsa-miR-3665	CLIP-seq
MIRT1022686	hsa-miR-378g	CLIP-seq
MIRT1022687	hsa-miR-3934	CLIP-seq
MIRT1022688	hsa-miR-412	CLIP-seq
MIRT1022689	hsa-miR-4447	CLIP-seq
MIRT1022690	hsa-miR-4472	CLIP-seq
MIRT1022691	hsa-miR-4486	CLIP-seq
MIRT1022692	hsa-miR-4514	CLIP-seq
MIRT1022693	hsa-miR-4525	CLIP-seq
MIRT1022694	hsa-miR-4665-5p	CLIP-seq
MIRT1022695	hsa-miR-4692	CLIP-seq
MIRT1022696	hsa-miR-4723-5p	CLIP-seq
MIRT1022697	hsa-miR-4736	CLIP-seq
MIRT1022698	hsa-miR-491-5p	CLIP-seq
MIRT1022699	hsa-miR-513b	CLIP-seq
MIRT1022700	hsa-miR-612	CLIP-seq
MIRT1022701	hsa-miR-625	CLIP-seq
MIRT1022702	hsa-miR-940	CLIP-seq
MIRT2003113	hsa-miR-125a-5p	CLIP-seq
MIRT2003114	hsa-miR-125b	CLIP-seq
MIRT1022679	hsa-miR-1275	CLIP-seq
MIRT1022683	hsa-miR-3151	CLIP-seq
MIRT1022685	hsa-miR-3665	CLIP-seq
MIRT1022687	hsa-miR-3934	CLIP-seq
MIRT2003115	hsa-miR-3973	CLIP-seq
MIRT2003116	hsa-miR-4319	CLIP-seq
MIRT1022689	hsa-miR-4447	CLIP-seq
MIRT1022690	hsa-miR-4472	CLIP-seq
MIRT1022692	hsa-miR-4514	CLIP-seq
MIRT1022693	hsa-miR-4525	CLIP-seq
MIRT1022694	hsa-miR-4665-5p	CLIP-seq
MIRT1022695	hsa-miR-4692	CLIP-seq
MIRT1022696	hsa-miR-4723-5p	CLIP-seq
MIRT1022697	hsa-miR-4736	CLIP-seq
MIRT1022698	hsa-miR-491-5p	CLIP-seq
MIRT2003117	hsa-miR-548p	CLIP-seq
MIRT2003118	hsa-miR-562	CLIP-seq
MIRT1022701	hsa-miR-625	CLIP-seq
MIRT1022702	hsa-miR-940	CLIP-seq
MIRT2236137	hsa-let-7a	CLIP-seq
MIRT2236138	hsa-let-7b	CLIP-seq
MIRT2236139	hsa-let-7c	CLIP-seq
MIRT2236140	hsa-let-7d	CLIP-seq
MIRT2236141	hsa-let-7e	CLIP-seq
MIRT2236142	hsa-let-7f	CLIP-seq
MIRT2236143	hsa-let-7g	CLIP-seq
MIRT2236144	hsa-let-7i	CLIP-seq
MIRT2236145	hsa-miR-1226	CLIP-seq
MIRT1022681	hsa-miR-3115	CLIP-seq
MIRT2236146	hsa-miR-3187-3p	CLIP-seq
MIRT2236147	hsa-miR-338-3p	CLIP-seq
MIRT2236148	hsa-miR-3545-3p	CLIP-seq
MIRT2236149	hsa-miR-3689a-3p	CLIP-seq
MIRT2236150	hsa-miR-3689c	CLIP-seq
MIRT1022687	hsa-miR-3934	CLIP-seq
MIRT2003115	hsa-miR-3973	CLIP-seq
MIRT2236151	hsa-miR-4435	CLIP-seq
MIRT2236152	hsa-miR-4458	CLIP-seq
MIRT2236153	hsa-miR-4500	CLIP-seq
MIRT2236154	hsa-miR-4680-5p	CLIP-seq
MIRT2236155	hsa-miR-4701-5p	CLIP-seq
MIRT2236156	hsa-miR-4728-5p	CLIP-seq
MIRT2236157	hsa-miR-541	CLIP-seq
MIRT2003117	hsa-miR-548p	CLIP-seq
MIRT2236158	hsa-miR-548s	CLIP-seq
MIRT2003118	hsa-miR-562	CLIP-seq
MIRT2236159	hsa-miR-588	CLIP-seq
MIRT2236160	hsa-miR-609	CLIP-seq
MIRT2236161	hsa-miR-634	CLIP-seq
MIRT2236162	hsa-miR-654-5p	CLIP-seq
MIRT2236163	hsa-miR-98	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005096	Function	GTPase activator activity	IBA	21873635
GO:0005096	Function	GTPase activator activity	IDA	12093360
GO:0005515	Function	Protein binding	IPI	12093360, 32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA
GO:0034260	Process	Negative regulation of GTPase activity	IBA	21873635
GO:0034260	Process	Negative regulation of GTPase activity	IDA	12093360
GO:0035556	Process	Intracellular signal transduction	IDA	12093360
GO:0046872	Function	Metal ion binding	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS
GO:0090630	Process	Activation of GTPase activity	IBA	21873635

Other IDs

• MIM: 609694
• HGNC: 24852
• e!Ensembl: ENSG00000089639

Protein

• UniProt ID: Q9P107
• Protein name: GEM-interacting protein (GMIP)
• Protein function: Stimulates, in vitro and in vivo, the GTPase activity of RhoA.
• PDB: 3QWE
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00620	RhoGAP	565 → 728	RhoGAP domain	Domain

• Sequence:

  MDAAEPGLPPGPEGRKRYSDIFRSLDNLEISLGNVTLEMLAGDPLLSEDPEPDKTPTATV
  TNEASCWSGPSPEGPVPLTGEELDLRLIRTKGGVDAALEYAKTWSRYAKELLAWTEKRAS
  YELEFAKSTMKIAEAGKVSIQQQSHMPLQYIYTLFLEHDLSLGTLAMETVAQQKRDYYQP
  LAAKRTEIEKWRKEFKEQWMKEQKRMNEAVQALRRAQLQYVQRSEDLRARSQGSPEDSAP
  QASPGPSKQQERRRRSREEAQAKAQEAEALYQACVREANARQQDLEIAKQRIVSHVRKLV
  FQGDEVLRRVTLSLFGLRGAQAERGPRAFAALAECCAPFEPGQRYQEFVRALRPEAPPPP
  PPAFSFQEFLPSLNSSPLDIRKKLSGPLPPRLDENSAEPGPWEDPGTGWRWQGTPGPTPG
  SDVDSVGGGSESRSLDSPTSSPGAGTRQLVKASSTGTESSDDFEERDPDLGDGLENGLGS
  PFGKWTLSSAAQTHQLRRLRGPAKCRECEAFMVSGTECEECFLTCHKRCLETLLILCGHR
  RLPARTPLFGVDFLQLPRDFPEEVPFVVTKCTAEIEHRALDVQGIYRVSGSRVRVERLCQ
  AFENGRALVELSGNSPHDVSSVLKRFLQELTEPVIPFHLYDAFISLAKTLHADPGDDPGT
  PSPSPEVIRSLKTLLVQLPDSNYNTLRHLVAHLFRVAARFMENKMSANNLGIVFGPTLLR
  PPDGPRAASAIPVTCLLDSGHQAQLVEFLIVHYEQIFGMDELPQATEPPPQDSSPAPGPL
  TTSSQPPPPHLDPDSQPPVLASDPGPDPQHHSTLEQHPTATPTEIPTPQSDQREDVAEDT
  KDGGGEVSSQGPEDSLLGTQSRGHFSRQPVKYPRGGVRPVTHQLSSLALVASKLCEETPI
  TSVPRGSLRGRGPSPAAASPEGSPLRRTPLPKHFEITQETARLLSKLDSEAVPRATCCPD
  VQPEEAEDHL

• Sequence length: 970

Pathways

Reactome:

Rho GTPase cycle

Associated diseases

Unknown
Disease term	Disease name	Evidence	References	Source
Mental depression	Unipolar Depression, Major Depressive Disorder		16086184	ClinVar
Metabolic Syndrome	Metabolic Syndrome			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Cerebral Hemorrhage	Associate	32474671