GMIP (GEM interacting protein)

Gene

• Entrez ID: 51291
• Gene name: GEM interacting protein
• Gene symbol: GMIP
• Synonyms (NCBI Gene): ARHGAP46
• Chromosome: 19
• Chromosome location: 19p13.11
• Summary: This gene encodes a member of the ARHGAP family of Rho/Rac/Cdc42-like GTPase activating proteins. The encoded protein interacts with the Ras-related protein Gem through its N-terminal domain. Separately, it interacts with RhoA through a RhoGAP domain, and

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1022679	hsa-miR-1275	CLIP-seq
MIRT1022680	hsa-miR-1285	CLIP-seq
MIRT1022681	hsa-miR-3115	CLIP-seq
MIRT1022682	hsa-miR-3121-3p	CLIP-seq
MIRT1022683	hsa-miR-3151	CLIP-seq
MIRT1022684	hsa-miR-3187-5p	CLIP-seq
MIRT1022685	hsa-miR-3665	CLIP-seq
MIRT1022686	hsa-miR-378g	CLIP-seq
MIRT1022687	hsa-miR-3934	CLIP-seq
MIRT1022688	hsa-miR-412	CLIP-seq
MIRT1022689	hsa-miR-4447	CLIP-seq
MIRT1022690	hsa-miR-4472	CLIP-seq
MIRT1022691	hsa-miR-4486	CLIP-seq
MIRT1022692	hsa-miR-4514	CLIP-seq
MIRT1022693	hsa-miR-4525	CLIP-seq
MIRT1022694	hsa-miR-4665-5p	CLIP-seq
MIRT1022695	hsa-miR-4692	CLIP-seq
MIRT1022696	hsa-miR-4723-5p	CLIP-seq
MIRT1022697	hsa-miR-4736	CLIP-seq
MIRT1022698	hsa-miR-491-5p	CLIP-seq
MIRT1022699	hsa-miR-513b	CLIP-seq
MIRT1022700	hsa-miR-612	CLIP-seq
MIRT1022701	hsa-miR-625	CLIP-seq
MIRT1022702	hsa-miR-940	CLIP-seq
MIRT2003113	hsa-miR-125a-5p	CLIP-seq
MIRT2003114	hsa-miR-125b	CLIP-seq
MIRT1022679	hsa-miR-1275	CLIP-seq
MIRT1022683	hsa-miR-3151	CLIP-seq
MIRT1022685	hsa-miR-3665	CLIP-seq
MIRT1022687	hsa-miR-3934	CLIP-seq
MIRT2003115	hsa-miR-3973	CLIP-seq
MIRT2003116	hsa-miR-4319	CLIP-seq
MIRT1022689	hsa-miR-4447	CLIP-seq
MIRT1022690	hsa-miR-4472	CLIP-seq
MIRT1022692	hsa-miR-4514	CLIP-seq
MIRT1022693	hsa-miR-4525	CLIP-seq
MIRT1022694	hsa-miR-4665-5p	CLIP-seq
MIRT1022695	hsa-miR-4692	CLIP-seq
MIRT1022696	hsa-miR-4723-5p	CLIP-seq
MIRT1022697	hsa-miR-4736	CLIP-seq
MIRT1022698	hsa-miR-491-5p	CLIP-seq
MIRT2003117	hsa-miR-548p	CLIP-seq
MIRT2003118	hsa-miR-562	CLIP-seq
MIRT1022701	hsa-miR-625	CLIP-seq
MIRT1022702	hsa-miR-940	CLIP-seq
MIRT2236137	hsa-let-7a	CLIP-seq
MIRT2236138	hsa-let-7b	CLIP-seq
MIRT2236139	hsa-let-7c	CLIP-seq
MIRT2236140	hsa-let-7d	CLIP-seq
MIRT2236141	hsa-let-7e	CLIP-seq
MIRT2236142	hsa-let-7f	CLIP-seq
MIRT2236143	hsa-let-7g	CLIP-seq
MIRT2236144	hsa-let-7i	CLIP-seq
MIRT2236145	hsa-miR-1226	CLIP-seq
MIRT1022681	hsa-miR-3115	CLIP-seq
MIRT2236146	hsa-miR-3187-3p	CLIP-seq
MIRT2236147	hsa-miR-338-3p	CLIP-seq
MIRT2236148	hsa-miR-3545-3p	CLIP-seq
MIRT2236149	hsa-miR-3689a-3p	CLIP-seq
MIRT2236150	hsa-miR-3689c	CLIP-seq
MIRT1022687	hsa-miR-3934	CLIP-seq
MIRT2003115	hsa-miR-3973	CLIP-seq
MIRT2236151	hsa-miR-4435	CLIP-seq
MIRT2236152	hsa-miR-4458	CLIP-seq
MIRT2236153	hsa-miR-4500	CLIP-seq
MIRT2236154	hsa-miR-4680-5p	CLIP-seq
MIRT2236155	hsa-miR-4701-5p	CLIP-seq
MIRT2236156	hsa-miR-4728-5p	CLIP-seq
MIRT2236157	hsa-miR-541	CLIP-seq
MIRT2003117	hsa-miR-548p	CLIP-seq
MIRT2236158	hsa-miR-548s	CLIP-seq
MIRT2003118	hsa-miR-562	CLIP-seq
MIRT2236159	hsa-miR-588	CLIP-seq
MIRT2236160	hsa-miR-609	CLIP-seq
MIRT2236161	hsa-miR-634	CLIP-seq
MIRT2236162	hsa-miR-654-5p	CLIP-seq
MIRT2236163	hsa-miR-98	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IDA	12093360
GO:0005096	Function	GTPase activator activity	IEA
GO:0005096	Function	GTPase activator activity	TAS
GO:0005515	Function	Protein binding	IPI	12093360, 32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0007165	Process	Signal transduction	IEA
GO:0007264	Process	Small GTPase-mediated signal transduction	IDA	12093360
GO:0008270	Function	Zinc ion binding	IEA
GO:0035556	Process	Intracellular signal transduction	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS
GO:0051058	Process	Negative regulation of small GTPase mediated signal transduction	IBA

Other IDs

• MIM: 609694
• HGNC: 24852
• e!Ensembl: ENSG00000089639

Protein

• UniProt ID: Q9P107
• Protein name: GEM-interacting protein (GMIP)
• Protein function: Stimulates, in vitro and in vivo, the GTPase activity of RhoA.
• PDB: 3QWE
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00620	RhoGAP	565 → 728	RhoGAP domain	Domain

• Sequence:

  MDAAEPGLPPGPEGRKRYSDIFRSLDNLEISLGNVTLEMLAGDPLLSEDPEPDKTPTATV
  TNEASCWSGPSPEGPVPLTGEELDLRLIRTKGGVDAALEYAKTWSRYAKELLAWTEKRAS
  YELEFAKSTMKIAEAGKVSIQQQSHMPLQYIYTLFLEHDLSLGTLAMETVAQQKRDYYQP
  LAAKRTEIEKWRKEFKEQWMKEQKRMNEAVQALRRAQLQYVQRSEDLRARSQGSPEDSAP
  QASPGPSKQQERRRRSREEAQAKAQEAEALYQACVREANARQQDLEIAKQRIVSHVRKLV
  FQGDEVLRRVTLSLFGLRGAQAERGPRAFAALAECCAPFEPGQRYQEFVRALRPEAPPPP
  PPAFSFQEFLPSLNSSPLDIRKKLSGPLPPRLDENSAEPGPWEDPGTGWRWQGTPGPTPG
  SDVDSVGGGSESRSLDSPTSSPGAGTRQLVKASSTGTESSDDFEERDPDLGDGLENGLGS
  PFGKWTLSSAAQTHQLRRLRGPAKCRECEAFMVSGTECEECFLTCHKRCLETLLILCGHR
  RLPARTPLFGVDFLQLPRDFPEEVPFVVTKCTAEIEHRALDVQGIYRVSGSRVRVERLCQ
  AFENGRALVELSGNSPHDVSSVLKRFLQELTEPVIPFHLYDAFISLAKTLHADPGDDPGT
  PSPSPEVIRSLKTLLVQLPDSNYNTLRHLVAHLFRVAARFMENKMSANNLGIVFGPTLLR
  PPDGPRAASAIPVTCLLDSGHQAQLVEFLIVHYEQIFGMDELPQATEPPPQDSSPAPGPL
  TTSSQPPPPHLDPDSQPPVLASDPGPDPQHHSTLEQHPTATPTEIPTPQSDQREDVAEDT
  KDGGGEVSSQGPEDSLLGTQSRGHFSRQPVKYPRGGVRPVTHQLSSLALVASKLCEETPI
  TSVPRGSLRGRGPSPAAASPEGSPLRRTPLPKHFEITQETARLLSKLDSEAVPRATCCPD
  VQPEEAEDHL

• Sequence length: 970

Pathways

Reactome:

Rho GTPase cycle