Gene Gene information from NCBI Gene database.
Entrez ID 5127
Gene name Cyclin dependent kinase 16
Gene symbol CDK16
Synonyms (NCBI Gene)
PCTAIREPCTAIRE1PCTGAIREPCTK1
Chromosome X
Chromosome location Xp11.3
Summary The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from th
miRNA miRNA information provided by mirtarbase database.
430
miRTarBase ID miRNA Experiments Reference
MIRT050576 hsa-miR-20a-5p CLASH 23622248
MIRT037393 hsa-miR-744-5p CLASH 23622248
MIRT109926 hsa-miR-92a-3p HITS-CLIP 22473208
MIRT109929 hsa-miR-92b-3p HITS-CLIP 22473208
MIRT109924 hsa-miR-32-5p HITS-CLIP 22473208
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
46
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000307 Component Cyclin-dependent protein kinase holoenzyme complex IPI 19524571
GO:0004672 Function Protein kinase activity IEA
GO:0004674 Function Protein serine/threonine kinase activity IDA 22184064, 22796189
GO:0004674 Function Protein serine/threonine kinase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
311550 8749 ENSG00000102225
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q00536
Protein name Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1)
Protein function Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron
PDB 3MTL , 5G6V
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 165 446 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Detected in pancreas islets (at protein level). Detected in brain and pancreas. {ECO:0000269|PubMed:22798068}.
Sequence
MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSAR
GPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSL
PADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVY
KGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVF
EYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGEL
KLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRP
LFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGA
DLLTKLLQFEGRNRISAEDAMKHPFF
LSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS
MPDSGRPAFRVVDTEF
Sequence length 496
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
19
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia Uncertain significance rs145117961 RCV005886275
CDK16-related disorder Benign; Uncertain significance; Likely benign rs727503843, rs1937178226, rs145164365, rs5952422, rs5953015, rs149245456, rs146600180, rs2521840145 RCV003907441
RCV003408440
RCV003929193
RCV003974577
RCV003979839
RCV003927367
RCV003929520
RCV003969817
CDK16-related Intellectual Disability Uncertain significance rs1937418084 RCV004799443
Cervical cancer Uncertain significance rs145117961 RCV005886278
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 37061713
Autism Spectrum Disorder Associate 36323681
Breast Neoplasms Associate 25790448
Carcinogenesis Associate 25790448
Carcinoma Non Small Cell Lung Associate 31882554
Carcinoma Ovarian Epithelial Stimulate 26546806
Colorectal Neoplasms Associate 37373155
Intellectual Disability Associate 36323681
Kidney Neoplasms Associate 30411496
Lung Neoplasms Associate 29344296, 34687270