Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5127
Gene name Gene Name - the full gene name approved by the HGNC.
Cyclin dependent kinase 16
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CDK16
Synonyms (NCBI Gene) Gene synonyms aliases
PCTAIRE, PCTAIRE1, PCTGAIRE, PCTK1
Chromosome Chromosome number
X
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
Xp11.3
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from th
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT050576 hsa-miR-20a-5p CLASH 23622248
MIRT037393 hsa-miR-744-5p CLASH 23622248
MIRT109926 hsa-miR-92a-3p HITS-CLIP 22473208
MIRT109929 hsa-miR-92b-3p HITS-CLIP 22473208
MIRT109924 hsa-miR-32-5p HITS-CLIP 22473208
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000307 Component Cyclin-dependent protein kinase holoenzyme complex IPI 19524571
GO:0004672 Function Protein kinase activity IEA
GO:0004674 Function Protein serine/threonine kinase activity IDA 22184064, 22796189
GO:0004674 Function Protein serine/threonine kinase activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
311550 8749 ENSG00000102225
Protein
UniProt ID Q00536
Protein name Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1)
Protein function Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron
PDB 3MTL , 5G6V
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 165 446 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Detected in pancreas islets (at protein level). Detected in brain and pancreas. {ECO:0000269|PubMed:22798068}.
Sequence
MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSAR
GPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSL
PADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVY
KGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVF
EYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGEL
KLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRP
LFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGA
DLLTKLLQFEGRNRISAEDAMKHPFF
LSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS
MPDSGRPAFRVVDTEF
Sequence length 496
Interactions View interactions
<
Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Mental retardation intellectual disability N/A N/A GenCC
Neurodevelopmental Disorders X-linked complex neurodevelopmental disorder N/A N/A GenCC
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 37061713
Autism Spectrum Disorder Associate 36323681
Breast Neoplasms Associate 25790448
Carcinogenesis Associate 25790448
Carcinoma Non Small Cell Lung Associate 31882554
Carcinoma Ovarian Epithelial Stimulate 26546806
Colorectal Neoplasms Associate 37373155
Intellectual Disability Associate 36323681
Kidney Neoplasms Associate 30411496
Lung Neoplasms Associate 29344296, 34687270