Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5126
Gene name Gene Name - the full gene name approved by the HGNC.	Proprotein convertase subtilisin/kexin type 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PCSK2
Synonyms (NCBI Gene) Gene synonyms aliases	NEC 2, NEC-2, NEC2, PC2, SPC2
Chromosome Chromosome number	20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	20p12.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The protein undergoes an

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miRTarBase ID	miRNA	Experiments	Reference
MIRT483164	hsa-miR-4694-3p	HITS-CLIP	21572407
MIRT483163	hsa-miR-224-3p	HITS-CLIP	21572407
MIRT483162	hsa-miR-522-3p	HITS-CLIP	21572407
MIRT483161	hsa-miR-211-3p	HITS-CLIP	21572407
MIRT483160	hsa-miR-4270	HITS-CLIP	21572407
MIRT483159	hsa-miR-4441	HITS-CLIP	21572407
MIRT483158	hsa-miR-6754-5p	HITS-CLIP	21572407
MIRT483157	hsa-miR-3664-3p	HITS-CLIP	21572407
MIRT483156	hsa-miR-1266-5p	HITS-CLIP	21572407
MIRT483155	hsa-miR-4518	HITS-CLIP	21572407
MIRT483154	hsa-miR-1288-3p	HITS-CLIP	21572407
MIRT483153	hsa-miR-3199	HITS-CLIP	21572407
MIRT483152	hsa-miR-8052	HITS-CLIP	21572407
MIRT483151	hsa-miR-5011-3p	HITS-CLIP	21572407
MIRT483150	hsa-miR-4666b	HITS-CLIP	21572407
MIRT483149	hsa-miR-6843-3p	HITS-CLIP	21572407
MIRT483148	hsa-miR-6848-3p	HITS-CLIP	21572407
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT614875	hsa-miR-4328	HITS-CLIP	23824327
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT614875	hsa-miR-4328	HITS-CLIP	23824327
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT614875	hsa-miR-4328	HITS-CLIP	23824327
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT618721	hsa-miR-660-5p	HITS-CLIP	23824327
MIRT618720	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT614875	hsa-miR-4328	HITS-CLIP	23824327
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT614875	hsa-miR-4328	HITS-CLIP	23824327
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT614875	hsa-miR-4328	HITS-CLIP	23824327
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT483164	hsa-miR-4694-3p	PAR-CLIP	21572407
MIRT483163	hsa-miR-224-3p	PAR-CLIP	21572407
MIRT483162	hsa-miR-522-3p	PAR-CLIP	21572407
MIRT483161	hsa-miR-211-3p	PAR-CLIP	21572407
MIRT483160	hsa-miR-4270	PAR-CLIP	21572407
MIRT483159	hsa-miR-4441	PAR-CLIP	21572407
MIRT483158	hsa-miR-6754-5p	PAR-CLIP	21572407
MIRT483157	hsa-miR-3664-3p	PAR-CLIP	21572407
MIRT483156	hsa-miR-1266-5p	PAR-CLIP	21572407
MIRT483155	hsa-miR-4518	PAR-CLIP	21572407
MIRT483154	hsa-miR-1288-3p	PAR-CLIP	21572407
MIRT483153	hsa-miR-3199	PAR-CLIP	21572407
MIRT483152	hsa-miR-8052	PAR-CLIP	21572407
MIRT483151	hsa-miR-5011-3p	PAR-CLIP	21572407
MIRT483150	hsa-miR-4666b	PAR-CLIP	21572407
MIRT483149	hsa-miR-6843-3p	PAR-CLIP	21572407
MIRT483148	hsa-miR-6848-3p	PAR-CLIP	21572407
MIRT483164	hsa-miR-4694-3p	PAR-CLIP	24398324
MIRT483163	hsa-miR-224-3p	PAR-CLIP	24398324
MIRT483162	hsa-miR-522-3p	PAR-CLIP	24398324
MIRT483161	hsa-miR-211-3p	PAR-CLIP	24398324
MIRT483160	hsa-miR-4270	PAR-CLIP	24398324
MIRT483159	hsa-miR-4441	PAR-CLIP	24398324
MIRT483158	hsa-miR-6754-5p	PAR-CLIP	24398324
MIRT483157	hsa-miR-3664-3p	PAR-CLIP	24398324
MIRT483156	hsa-miR-1266-5p	PAR-CLIP	24398324
MIRT483155	hsa-miR-4518	PAR-CLIP	24398324
MIRT483154	hsa-miR-1288-3p	PAR-CLIP	24398324
MIRT483153	hsa-miR-3199	PAR-CLIP	24398324
MIRT483152	hsa-miR-8052	PAR-CLIP	24398324
MIRT483151	hsa-miR-5011-3p	PAR-CLIP	24398324
MIRT483150	hsa-miR-4666b	PAR-CLIP	24398324
MIRT483149	hsa-miR-6843-3p	PAR-CLIP	24398324
MIRT483148	hsa-miR-6848-3p	PAR-CLIP	24398324
MIRT483164	hsa-miR-4694-3p	PAR-CLIP	23592263
MIRT483163	hsa-miR-224-3p	PAR-CLIP	23592263
MIRT483162	hsa-miR-522-3p	PAR-CLIP	23592263
MIRT483161	hsa-miR-211-3p	PAR-CLIP	23592263
MIRT483160	hsa-miR-4270	PAR-CLIP	23592263
MIRT483159	hsa-miR-4441	PAR-CLIP	23592263
MIRT483158	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT483157	hsa-miR-3664-3p	PAR-CLIP	23592263
MIRT483156	hsa-miR-1266-5p	PAR-CLIP	23592263
MIRT483155	hsa-miR-4518	PAR-CLIP	23592263
MIRT483154	hsa-miR-1288-3p	PAR-CLIP	23592263
MIRT483153	hsa-miR-3199	PAR-CLIP	23592263
MIRT483152	hsa-miR-8052	PAR-CLIP	23592263
MIRT483151	hsa-miR-5011-3p	PAR-CLIP	23592263
MIRT483150	hsa-miR-4666b	PAR-CLIP	23592263
MIRT483149	hsa-miR-6843-3p	PAR-CLIP	23592263
MIRT483148	hsa-miR-6848-3p	PAR-CLIP	23592263
MIRT483156	hsa-miR-1266-5p	PAR-CLIP	26701625
MIRT483156	hsa-miR-1266-5p	PAR-CLIP	26701625
MIRT483154	hsa-miR-1288-3p	PAR-CLIP	26701625
MIRT483154	hsa-miR-1288-3p	PAR-CLIP	26701625
MIRT483161	hsa-miR-211-3p	PAR-CLIP	26701625
MIRT483161	hsa-miR-211-3p	PAR-CLIP	26701625
MIRT483163	hsa-miR-224-3p	PAR-CLIP	26701625
MIRT483163	hsa-miR-224-3p	PAR-CLIP	26701625
MIRT483153	hsa-miR-3199	PAR-CLIP	26701625
MIRT483153	hsa-miR-3199	PAR-CLIP	26701625
MIRT483157	hsa-miR-3664-3p	PAR-CLIP	26701625
MIRT483157	hsa-miR-3664-3p	PAR-CLIP	26701625
MIRT483160	hsa-miR-4270	PAR-CLIP	26701625
MIRT483160	hsa-miR-4270	PAR-CLIP	26701625
MIRT483159	hsa-miR-4441	PAR-CLIP	26701625
MIRT483159	hsa-miR-4441	PAR-CLIP	26701625
MIRT483155	hsa-miR-4518	PAR-CLIP	26701625
MIRT483155	hsa-miR-4518	PAR-CLIP	26701625
MIRT483150	hsa-miR-4666b	PAR-CLIP	26701625
MIRT483150	hsa-miR-4666b	PAR-CLIP	26701625
MIRT483164	hsa-miR-4694-3p	PAR-CLIP	26701625
MIRT483164	hsa-miR-4694-3p	PAR-CLIP	26701625
MIRT483151	hsa-miR-5011-3p	PAR-CLIP	26701625
MIRT483151	hsa-miR-5011-3p	PAR-CLIP	26701625
MIRT483162	hsa-miR-522-3p	PAR-CLIP	26701625
MIRT483162	hsa-miR-522-3p	PAR-CLIP	26701625
MIRT483158	hsa-miR-6754-5p	PAR-CLIP	26701625
MIRT483158	hsa-miR-6754-5p	PAR-CLIP	26701625
MIRT483149	hsa-miR-6843-3p	PAR-CLIP	26701625
MIRT483149	hsa-miR-6843-3p	PAR-CLIP	26701625
MIRT483148	hsa-miR-6848-3p	PAR-CLIP	26701625
MIRT483148	hsa-miR-6848-3p	PAR-CLIP	26701625
MIRT483152	hsa-miR-8052	PAR-CLIP	26701625
MIRT483152	hsa-miR-8052	PAR-CLIP	26701625
MIRT610273	hsa-miR-144-5p	HITS-CLIP	27418678
MIRT610273	hsa-miR-144-5p	HITS-CLIP	27418678
MIRT610273	hsa-miR-144-5p	HITS-CLIP	27418678
MIRT610273	hsa-miR-144-5p	HITS-CLIP	27418678
MIRT610273	hsa-miR-144-5p	HITS-CLIP	27418678
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	27418678
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	27418678
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	27418678
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	27418678
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	27418678
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	27418678
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	27418678
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	27418678
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	27418678
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	27418678
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	27418678
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	27418678
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	27418678
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	27418678
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	27418678
MIRT610269	hsa-miR-335-3p	HITS-CLIP	27418678
MIRT610269	hsa-miR-335-3p	HITS-CLIP	27418678
MIRT610269	hsa-miR-335-3p	HITS-CLIP	27418678
MIRT610269	hsa-miR-335-3p	HITS-CLIP	27418678
MIRT610269	hsa-miR-335-3p	HITS-CLIP	27418678
MIRT614875	hsa-miR-4328	HITS-CLIP	27418678
MIRT614875	hsa-miR-4328	HITS-CLIP	27418678
MIRT614875	hsa-miR-4328	HITS-CLIP	27418678
MIRT614875	hsa-miR-4328	HITS-CLIP	27418678
MIRT614875	hsa-miR-4328	HITS-CLIP	27418678
MIRT738878	hsa-miR-1288	HITS-CLIP	33718276
MIRT483160	hsa-miR-4270	HITS-CLIP	33718276
MIRT483155	hsa-miR-4518	HITS-CLIP	33718276
MIRT483164	hsa-miR-4694-3p	HITS-CLIP	33718276
MIRT483164	hsa-miR-4694-3p	HITS-CLIP	21572407
MIRT483163	hsa-miR-224-3p	HITS-CLIP	21572407
MIRT483162	hsa-miR-522-3p	HITS-CLIP	21572407
MIRT483161	hsa-miR-211-3p	HITS-CLIP	21572407
MIRT483160	hsa-miR-4270	HITS-CLIP	21572407
MIRT483159	hsa-miR-4441	HITS-CLIP	21572407
MIRT483158	hsa-miR-6754-5p	HITS-CLIP	21572407
MIRT483157	hsa-miR-3664-3p	HITS-CLIP	21572407
MIRT483156	hsa-miR-1266-5p	HITS-CLIP	21572407
MIRT483155	hsa-miR-4518	HITS-CLIP	21572407
MIRT483154	hsa-miR-1288-3p	HITS-CLIP	21572407
MIRT483153	hsa-miR-3199	HITS-CLIP	21572407
MIRT483152	hsa-miR-8052	HITS-CLIP	21572407
MIRT483151	hsa-miR-5011-3p	HITS-CLIP	21572407
MIRT483150	hsa-miR-4666b	HITS-CLIP	21572407
MIRT483149	hsa-miR-6843-3p	HITS-CLIP	21572407
MIRT483148	hsa-miR-6848-3p	HITS-CLIP	21572407
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT614875	hsa-miR-4328	HITS-CLIP	23824327
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT614875	hsa-miR-4328	HITS-CLIP	23824327
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT614875	hsa-miR-4328	HITS-CLIP	23824327
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT618721	hsa-miR-660-5p	HITS-CLIP	23824327
MIRT618720	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT614875	hsa-miR-4328	HITS-CLIP	23824327
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT614875	hsa-miR-4328	HITS-CLIP	23824327
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT614875	hsa-miR-4328	HITS-CLIP	23824327
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT610273	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT610272	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT610271	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT610270	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT610269	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT483164	hsa-miR-4694-3p	PAR-CLIP	21572407
MIRT483163	hsa-miR-224-3p	PAR-CLIP	21572407
MIRT483162	hsa-miR-522-3p	PAR-CLIP	21572407
MIRT483161	hsa-miR-211-3p	PAR-CLIP	21572407
MIRT483160	hsa-miR-4270	PAR-CLIP	21572407
MIRT483159	hsa-miR-4441	PAR-CLIP	21572407
MIRT483158	hsa-miR-6754-5p	PAR-CLIP	21572407
MIRT483157	hsa-miR-3664-3p	PAR-CLIP	21572407
MIRT483156	hsa-miR-1266-5p	PAR-CLIP	21572407
MIRT483155	hsa-miR-4518	PAR-CLIP	21572407
MIRT483154	hsa-miR-1288-3p	PAR-CLIP	21572407
MIRT483153	hsa-miR-3199	PAR-CLIP	21572407
MIRT483152	hsa-miR-8052	PAR-CLIP	21572407
MIRT483151	hsa-miR-5011-3p	PAR-CLIP	21572407
MIRT483150	hsa-miR-4666b	PAR-CLIP	21572407
MIRT483149	hsa-miR-6843-3p	PAR-CLIP	21572407
MIRT483148	hsa-miR-6848-3p	PAR-CLIP	21572407
MIRT483164	hsa-miR-4694-3p	PAR-CLIP	24398324
MIRT483163	hsa-miR-224-3p	PAR-CLIP	24398324
MIRT483162	hsa-miR-522-3p	PAR-CLIP	24398324
MIRT483161	hsa-miR-211-3p	PAR-CLIP	24398324
MIRT483160	hsa-miR-4270	PAR-CLIP	24398324
MIRT483159	hsa-miR-4441	PAR-CLIP	24398324
MIRT483158	hsa-miR-6754-5p	PAR-CLIP	24398324
MIRT483157	hsa-miR-3664-3p	PAR-CLIP	24398324
MIRT483156	hsa-miR-1266-5p	PAR-CLIP	24398324
MIRT483155	hsa-miR-4518	PAR-CLIP	24398324
MIRT483154	hsa-miR-1288-3p	PAR-CLIP	24398324
MIRT483153	hsa-miR-3199	PAR-CLIP	24398324
MIRT483152	hsa-miR-8052	PAR-CLIP	24398324
MIRT483151	hsa-miR-5011-3p	PAR-CLIP	24398324
MIRT483150	hsa-miR-4666b	PAR-CLIP	24398324
MIRT483149	hsa-miR-6843-3p	PAR-CLIP	24398324
MIRT483148	hsa-miR-6848-3p	PAR-CLIP	24398324
MIRT483164	hsa-miR-4694-3p	PAR-CLIP	23592263
MIRT483163	hsa-miR-224-3p	PAR-CLIP	23592263
MIRT483162	hsa-miR-522-3p	PAR-CLIP	23592263
MIRT483161	hsa-miR-211-3p	PAR-CLIP	23592263
MIRT483160	hsa-miR-4270	PAR-CLIP	23592263
MIRT483159	hsa-miR-4441	PAR-CLIP	23592263
MIRT483158	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT483157	hsa-miR-3664-3p	PAR-CLIP	23592263
MIRT483156	hsa-miR-1266-5p	PAR-CLIP	23592263
MIRT483155	hsa-miR-4518	PAR-CLIP	23592263
MIRT483154	hsa-miR-1288-3p	PAR-CLIP	23592263
MIRT483153	hsa-miR-3199	PAR-CLIP	23592263
MIRT483152	hsa-miR-8052	PAR-CLIP	23592263
MIRT483151	hsa-miR-5011-3p	PAR-CLIP	23592263
MIRT483150	hsa-miR-4666b	PAR-CLIP	23592263
MIRT483149	hsa-miR-6843-3p	PAR-CLIP	23592263
MIRT483148	hsa-miR-6848-3p	PAR-CLIP	23592263
MIRT738879	hsa-miR-1266	CLIP-seq
MIRT738880	hsa-miR-522	CLIP-seq
MIRT738879	hsa-miR-1266	CLIP-seq
MIRT1218467	hsa-miR-200b	CLIP-seq
MIRT1218468	hsa-miR-200c	CLIP-seq
MIRT1218469	hsa-miR-2355-5p	CLIP-seq
MIRT1218470	hsa-miR-3124-3p	CLIP-seq
MIRT1218471	hsa-miR-3613-3p	CLIP-seq
MIRT1218472	hsa-miR-3646	CLIP-seq
MIRT1218473	hsa-miR-3662	CLIP-seq
MIRT1218474	hsa-miR-3679-3p	CLIP-seq
MIRT1218475	hsa-miR-3690	CLIP-seq
MIRT1218476	hsa-miR-374c	CLIP-seq
MIRT1218477	hsa-miR-4254	CLIP-seq
MIRT1218478	hsa-miR-429	CLIP-seq
MIRT1218479	hsa-miR-4753-3p	CLIP-seq
MIRT738880	hsa-miR-522	CLIP-seq
MIRT1218480	hsa-miR-655	CLIP-seq
MIRT738879	hsa-miR-1266	CLIP-seq
MIRT738880	hsa-miR-522	CLIP-seq
MIRT738879	hsa-miR-1266	CLIP-seq
MIRT738880	hsa-miR-522	CLIP-seq
MIRT738879	hsa-miR-1266	CLIP-seq
MIRT738880	hsa-miR-522	CLIP-seq
MIRT738879	hsa-miR-1266	CLIP-seq
MIRT738880	hsa-miR-522	CLIP-seq
MIRT2589366	hsa-miR-1253	CLIP-seq
MIRT2589367	hsa-miR-1303	CLIP-seq
MIRT2589368	hsa-miR-3123	CLIP-seq
MIRT2589369	hsa-miR-3925-5p	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
EGR1	Activation	9359835

Show/Hide all(34)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004175	Function	Endopeptidase activity	IEA
GO:0004252	Function	Serine-type endopeptidase activity	IBA
GO:0004252	Function	Serine-type endopeptidase activity	IDA	7626024
GO:0004252	Function	Serine-type endopeptidase activity	IEA
GO:0005515	Function	Protein binding	IPI	7913882, 32814053
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	9020868, 28719828
GO:0005615	Component	Extracellular space	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0006508	Process	Proteolysis	IDA	7626024
GO:0006508	Process	Proteolysis	IEA
GO:0006508	Process	Proteolysis	IEA
GO:0007399	Process	Nervous system development	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008236	Function	Serine-type peptidase activity	IEA
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IDA	8034613
GO:0016485	Process	Protein processing	IEA
GO:0016486	Process	Peptide hormone processing	IBA
GO:0016486	Process	Peptide hormone processing	IDA	28719828
GO:0016486	Process	Peptide hormone processing	IEA
GO:0016540	Process	Protein autoprocessing	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030070	Process	Insulin processing	IDA	7626024
GO:0030070	Process	Insulin processing	IEA
GO:0030133	Component	Transport vesicle	IEA
GO:0030141	Component	Secretory granule	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0034230	Process	Enkephalin processing	IEA
GO:0034230	Process	Enkephalin processing	ISS
GO:0034231	Process	Islet amyloid polypeptide processing	ISS
GO:0043005	Component	Neuron projection	IBA
GO:0070013	Component	Intracellular organelle lumen	IEA

MIM	HGNC	e!Ensembl
162151	8744	ENSG00000125851

Protein

UniProt ID

P16519

Protein name

Neuroendocrine convertase 2 (NEC 2) (EC 3.4.21.94) (KEX2-like endoprotease 2) (Prohormone convertase 2) (Proprotein convertase 2) (PC2)

Protein function

Serine endopeptidase which is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells. {ECO:00002

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16470	S8_pro-domain	33 → 109	Peptidase S8 pro-domain	Domain
PF00082	Peptidase_S8	158 → 445	Subtilase family	Domain
PF01483	P_proprotein	504 → 591	Proprotein convertase P-domain	Family

Sequence

MKGGCVSQWKAAAGFLFCVMVFASAERPVFTNHFLVELHKGGEDKARQVAAEHGFGVRKL
PFAEGLYHFYHNGLAKAKRRRSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDIN
MNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASN
YNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRM
LDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGK
GSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK
RNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRN
QLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIP
STGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRP
RDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLHGTQSAPYI
DQVVRDYQSKLAMSKKEELEEELDEAVERSLKSILNKN

Sequence length

638

Interactions

View interactions

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Eosinophilia	Eosinophilic esophagitis	N/A	N/A	GWAS
Insomnia	Insomnia	N/A	N/A	GWAS
Restless Legs Syndrome	Restless legs syndrome	N/A	N/A	GWAS

Show/Hide Text Mining Associations (28)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
ACTH Secreting Pituitary Adenoma	Associate	31319379
Adenoma	Associate	7747813
Amish lethal microcephaly	Associate	28719828
Amyotrophic Lateral Sclerosis	Associate	22470424
Atherosclerosis	Associate	17903303
Carcinoid Tumor	Stimulate	32794589
Crohn Disease	Associate	21383526
Diabetes Mellitus	Associate	26607656, 28719828, 29739359
Diabetes Mellitus Type 1	Associate	36201618
Diabetes Mellitus Type 2	Associate	17618154, 24705588, 26607656, 26634513, 28719828, 40141237
Diabetic Retinopathy	Associate	29739359
Esophageal Neoplasms	Associate	36588538
Hyperglycemia	Inhibit	23985558
Inflammation	Inhibit	31442418
Insulinoma	Associate	2154467
Kidney Failure Chronic	Associate	17618154
Lung Neoplasms	Inhibit	23409034
Neoplasm Metastasis	Associate	16293189
Neoplasms	Associate	16293189, 18661512, 23409034, 32794589
Neoplasms Adipose Tissue	Associate	37106328
Neuroendocrine Tumors	Associate	32794589
Obesity	Associate	24932808, 30926952
Paraganglioma	Stimulate	32794589
Pheochromocytoma	Associate	32794589
Pituitary Neoplasms	Associate	7747813
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	24658822
Thyroid Neoplasms	Associate	18661512
Thyroiditis	Associate	18661512

PCSK2 (proprotein convertase subtilisin/kexin type 2)