Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	51227
Gene name Gene Name - the full gene name approved by the HGNC.	Phosphatidylinositol glycan anchor biosynthesis class P
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PIGP
Synonyms (NCBI Gene) Gene synonyms aliases	DCRC, DCRC-S, DEE55, DSCR5, DSRC, EIEE55, PIG-P
Chromosome Chromosome number	21
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	21q22.13
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes an enzyme involved in the first step of glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. The encoded protein is a compone

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miRTarBase ID	miRNA	Experiments	Reference
MIRT051515	hsa-let-7e-5p	CLASH	23622248
MIRT044441	hsa-miR-320a	CLASH	23622248
MIRT693376	hsa-miR-890	HITS-CLIP	23313552
MIRT693375	hsa-miR-103b	HITS-CLIP	23313552
MIRT693374	hsa-miR-214-5p	HITS-CLIP	23313552
MIRT693373	hsa-miR-6811-3p	HITS-CLIP	23313552
MIRT693372	hsa-miR-6514-3p	HITS-CLIP	23313552
MIRT646366	hsa-miR-22-3p	HITS-CLIP	23824327
MIRT646365	hsa-miR-5586-5p	HITS-CLIP	23824327
MIRT646364	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT646363	hsa-miR-4267	HITS-CLIP	23824327
MIRT646362	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT646361	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT646359	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT646360	hsa-miR-6882-3p	HITS-CLIP	23824327
MIRT646358	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT637353	hsa-miR-452-5p	HITS-CLIP	23824327
MIRT637352	hsa-miR-4676-3p	HITS-CLIP	23824327
MIRT637351	hsa-miR-892c-3p	HITS-CLIP	23824327
MIRT637350	hsa-miR-1208	HITS-CLIP	23824327
MIRT637349	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT637347	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT637348	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT637346	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT637345	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT637353	hsa-miR-452-5p	HITS-CLIP	23824327
MIRT637352	hsa-miR-4676-3p	HITS-CLIP	23824327
MIRT637351	hsa-miR-892c-3p	HITS-CLIP	23824327
MIRT637350	hsa-miR-1208	HITS-CLIP	23824327
MIRT637349	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT637347	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT637348	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT637346	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT637345	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT569467	hsa-miR-4724-5p	PAR-CLIP	20371350
MIRT569466	hsa-miR-4433b-3p	PAR-CLIP	20371350
MIRT569465	hsa-miR-3174	PAR-CLIP	20371350
MIRT569464	hsa-miR-4539	PAR-CLIP	20371350
MIRT569463	hsa-miR-4790-3p	PAR-CLIP	20371350
MIRT569461	hsa-miR-4513	PAR-CLIP	20371350
MIRT569462	hsa-miR-6855-3p	PAR-CLIP	20371350
MIRT569460	hsa-miR-6857-3p	PAR-CLIP	20371350
MIRT569459	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT569458	hsa-miR-4784	PAR-CLIP	20371350
MIRT569457	hsa-miR-1236-5p	PAR-CLIP	20371350
MIRT569456	hsa-miR-4765	PAR-CLIP	20371350
MIRT569455	hsa-miR-4792	PAR-CLIP	20371350
MIRT569454	hsa-miR-4710	PAR-CLIP	20371350
MIRT569453	hsa-miR-323a-5p	PAR-CLIP	20371350
MIRT569452	hsa-miR-876-3p	PAR-CLIP	20371350
MIRT569451	hsa-miR-134-5p	PAR-CLIP	20371350
MIRT569450	hsa-miR-3118	PAR-CLIP	20371350
MIRT569449	hsa-miR-3136-5p	PAR-CLIP	20371350
MIRT569447	hsa-miR-4439	PAR-CLIP	20371350
MIRT569448	hsa-miR-4689	PAR-CLIP	20371350
MIRT569446	hsa-miR-6858-5p	PAR-CLIP	20371350
MIRT569445	hsa-miR-7855-5p	PAR-CLIP	20371350
MIRT569467	hsa-miR-4724-5p	PAR-CLIP	20371350
MIRT569466	hsa-miR-4433b-3p	PAR-CLIP	20371350
MIRT569465	hsa-miR-3174	PAR-CLIP	20371350
MIRT569464	hsa-miR-4539	PAR-CLIP	20371350
MIRT569463	hsa-miR-4790-3p	PAR-CLIP	20371350
MIRT569461	hsa-miR-4513	PAR-CLIP	20371350
MIRT569462	hsa-miR-6855-3p	PAR-CLIP	20371350
MIRT569460	hsa-miR-6857-3p	PAR-CLIP	20371350
MIRT569459	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT569458	hsa-miR-4784	PAR-CLIP	20371350
MIRT569457	hsa-miR-1236-5p	PAR-CLIP	20371350
MIRT569456	hsa-miR-4765	PAR-CLIP	20371350
MIRT569455	hsa-miR-4792	PAR-CLIP	20371350
MIRT569454	hsa-miR-4710	PAR-CLIP	20371350
MIRT569453	hsa-miR-323a-5p	PAR-CLIP	20371350
MIRT569452	hsa-miR-876-3p	PAR-CLIP	20371350
MIRT569451	hsa-miR-134-5p	PAR-CLIP	20371350
MIRT569450	hsa-miR-3118	PAR-CLIP	20371350
MIRT569449	hsa-miR-3136-5p	PAR-CLIP	20371350
MIRT569447	hsa-miR-4439	PAR-CLIP	20371350
MIRT569448	hsa-miR-4689	PAR-CLIP	20371350
MIRT569446	hsa-miR-6858-5p	PAR-CLIP	20371350
MIRT569445	hsa-miR-7855-5p	PAR-CLIP	20371350
MIRT516658	hsa-miR-590-3p	PAR-CLIP	23446348
MIRT516657	hsa-miR-4524b-3p	PAR-CLIP	23446348
MIRT516652	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT516655	hsa-miR-4735-5p	PAR-CLIP	23446348
MIRT516656	hsa-miR-4524a-3p	PAR-CLIP	23446348
MIRT516653	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT516654	hsa-miR-4775	PAR-CLIP	23446348
MIRT516652	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT516651	hsa-miR-2113	PAR-CLIP	23446348
MIRT516650	hsa-miR-5010-3p	PAR-CLIP	23446348
MIRT456820	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT456821	hsa-miR-7515	PAR-CLIP	23592263
MIRT456819	hsa-miR-3179	PAR-CLIP	23592263
MIRT456818	hsa-miR-4708-3p	PAR-CLIP	23592263
MIRT456817	hsa-miR-298	PAR-CLIP	23592263
MIRT456816	hsa-miR-6828-5p	PAR-CLIP	23592263
MIRT456815	hsa-miR-4271	PAR-CLIP	23592263
MIRT456814	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT456813	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT456812	hsa-miR-6864-5p	PAR-CLIP	23592263
MIRT693376	hsa-miR-890	HITS-CLIP	23313552
MIRT693375	hsa-miR-103b	HITS-CLIP	23313552
MIRT693374	hsa-miR-214-5p	HITS-CLIP	23313552
MIRT693373	hsa-miR-6811-3p	HITS-CLIP	23313552
MIRT693372	hsa-miR-6514-3p	HITS-CLIP	23313552
MIRT646366	hsa-miR-22-3p	HITS-CLIP	23824327
MIRT646365	hsa-miR-5586-5p	HITS-CLIP	23824327
MIRT646364	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT646363	hsa-miR-4267	HITS-CLIP	23824327
MIRT646362	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT646361	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT646359	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT646360	hsa-miR-6882-3p	HITS-CLIP	23824327
MIRT646358	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT637353	hsa-miR-452-5p	HITS-CLIP	23824327
MIRT637352	hsa-miR-4676-3p	HITS-CLIP	23824327
MIRT637351	hsa-miR-892c-3p	HITS-CLIP	23824327
MIRT637350	hsa-miR-1208	HITS-CLIP	23824327
MIRT637349	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT637347	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT637348	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT637346	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT637345	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT637353	hsa-miR-452-5p	HITS-CLIP	23824327
MIRT637352	hsa-miR-4676-3p	HITS-CLIP	23824327
MIRT637351	hsa-miR-892c-3p	HITS-CLIP	23824327
MIRT637350	hsa-miR-1208	HITS-CLIP	23824327
MIRT637349	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT637347	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT637348	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT637346	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT637345	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT569467	hsa-miR-4724-5p	PAR-CLIP	20371350
MIRT569466	hsa-miR-4433b-3p	PAR-CLIP	20371350
MIRT569465	hsa-miR-3174	PAR-CLIP	20371350
MIRT569464	hsa-miR-4539	PAR-CLIP	20371350
MIRT569463	hsa-miR-4790-3p	PAR-CLIP	20371350
MIRT569461	hsa-miR-4513	PAR-CLIP	20371350
MIRT569462	hsa-miR-6855-3p	PAR-CLIP	20371350
MIRT569460	hsa-miR-6857-3p	PAR-CLIP	20371350
MIRT569459	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT569458	hsa-miR-4784	PAR-CLIP	20371350
MIRT569457	hsa-miR-1236-5p	PAR-CLIP	20371350
MIRT569456	hsa-miR-4765	PAR-CLIP	20371350
MIRT569455	hsa-miR-4792	PAR-CLIP	20371350
MIRT569454	hsa-miR-4710	PAR-CLIP	20371350
MIRT569453	hsa-miR-323a-5p	PAR-CLIP	20371350
MIRT569452	hsa-miR-876-3p	PAR-CLIP	20371350
MIRT569451	hsa-miR-134-5p	PAR-CLIP	20371350
MIRT569450	hsa-miR-3118	PAR-CLIP	20371350
MIRT569449	hsa-miR-3136-5p	PAR-CLIP	20371350
MIRT569447	hsa-miR-4439	PAR-CLIP	20371350
MIRT569448	hsa-miR-4689	PAR-CLIP	20371350
MIRT569446	hsa-miR-6858-5p	PAR-CLIP	20371350
MIRT569445	hsa-miR-7855-5p	PAR-CLIP	20371350
MIRT569467	hsa-miR-4724-5p	PAR-CLIP	20371350
MIRT569466	hsa-miR-4433b-3p	PAR-CLIP	20371350
MIRT569465	hsa-miR-3174	PAR-CLIP	20371350
MIRT569464	hsa-miR-4539	PAR-CLIP	20371350
MIRT569463	hsa-miR-4790-3p	PAR-CLIP	20371350
MIRT569461	hsa-miR-4513	PAR-CLIP	20371350
MIRT569462	hsa-miR-6855-3p	PAR-CLIP	20371350
MIRT569460	hsa-miR-6857-3p	PAR-CLIP	20371350
MIRT569459	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT569458	hsa-miR-4784	PAR-CLIP	20371350
MIRT569457	hsa-miR-1236-5p	PAR-CLIP	20371350
MIRT569456	hsa-miR-4765	PAR-CLIP	20371350
MIRT569455	hsa-miR-4792	PAR-CLIP	20371350
MIRT569454	hsa-miR-4710	PAR-CLIP	20371350
MIRT569453	hsa-miR-323a-5p	PAR-CLIP	20371350
MIRT569452	hsa-miR-876-3p	PAR-CLIP	20371350
MIRT569451	hsa-miR-134-5p	PAR-CLIP	20371350
MIRT569450	hsa-miR-3118	PAR-CLIP	20371350
MIRT569449	hsa-miR-3136-5p	PAR-CLIP	20371350
MIRT569447	hsa-miR-4439	PAR-CLIP	20371350
MIRT569448	hsa-miR-4689	PAR-CLIP	20371350
MIRT569446	hsa-miR-6858-5p	PAR-CLIP	20371350
MIRT569445	hsa-miR-7855-5p	PAR-CLIP	20371350
MIRT516658	hsa-miR-590-3p	PAR-CLIP	23446348
MIRT516657	hsa-miR-4524b-3p	PAR-CLIP	23446348
MIRT516652	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT516655	hsa-miR-4735-5p	PAR-CLIP	23446348
MIRT516656	hsa-miR-4524a-3p	PAR-CLIP	23446348
MIRT516653	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT516654	hsa-miR-4775	PAR-CLIP	23446348
MIRT516652	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT516651	hsa-miR-2113	PAR-CLIP	23446348
MIRT516650	hsa-miR-5010-3p	PAR-CLIP	23446348
MIRT456820	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT456821	hsa-miR-7515	PAR-CLIP	23592263
MIRT456819	hsa-miR-3179	PAR-CLIP	23592263
MIRT456818	hsa-miR-4708-3p	PAR-CLIP	23592263
MIRT456817	hsa-miR-298	PAR-CLIP	23592263
MIRT456816	hsa-miR-6828-5p	PAR-CLIP	23592263
MIRT456815	hsa-miR-4271	PAR-CLIP	23592263
MIRT456814	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT456813	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT456812	hsa-miR-6864-5p	PAR-CLIP	23592263
MIRT2068683	hsa-miR-664	CLIP-seq

Show/Hide all(13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000506	Component	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	IDA	10944123, 16162815
GO:0000506	Component	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	IPI	16162815
GO:0005515	Function	Protein binding	IPI	10944123, 16162815, 32296183, 32814053, 33961781
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	16162815
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006506	Process	GPI anchor biosynthetic process	IBA
GO:0006506	Process	GPI anchor biosynthetic process	IDA	16162815
GO:0006506	Process	GPI anchor biosynthetic process	IEA
GO:0006506	Process	GPI anchor biosynthetic process	IMP	28334793
GO:0016020	Component	Membrane	IEA
GO:0017176	Function	Phosphatidylinositol N-acetylglucosaminyltransferase activity	IDA	10944123
GO:0017176	Function	Phosphatidylinositol N-acetylglucosaminyltransferase activity	IEA

MIM	HGNC	e!Ensembl
605938	3046	ENSG00000185808

Protein

UniProt ID

P57054

Protein name

Phosphatidylinositol N-acetylglucosaminyltransferase subunit P (Down syndrome critical region protein 5) (Down syndrome critical region protein C) (Phosphatidylinositol-glycan biosynthesis class P protein) (PIG-P)

Protein function

Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynth

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08510	PIG-P	35 → 148	PIG-P	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous.

Sequence

MVPRSTSLTLIVFLFHRLSKAPGKMVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFI
PESWLNSLGLTYWPQKYWAVALPVYLLIAIVIGYVLLFGINMMSTSPLDSIHTITDNYAK
NQQQKKYQEEAIPALRDISISEVNQMFFLAAKELYTKN

Sequence length

158

Interactions

View interactions

	KEGG		Reactome
	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Metabolic pathways		Synthesis of glycosylphosphatidylinositol (GPI)

Show/Hide Causal Diseases (1)

Disease merge term	Disease name	dbSNP ID	References
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Epileptic Encephalopathy	early infantile epileptic encephalopathy with suppression bursts	rs778481061, rs768633670	N/A

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Developmental And Epileptic Encephalopathy	genetic developmental and epileptic encephalopathy	N/A	N/A	GenCC
Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome	multiple congenital anomalies-hypotonia-seizures syndrome	N/A	N/A	GenCC

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Developmental Disabilities	Associate	31139695
Down Syndrome	Associate	34127780
Down Syndrome Critical Region	Associate	10907851
Epileptic Encephalopathy Early Infantile 3	Associate	31139695
Seizures	Associate	31139695

PIGP (phosphatidylinositol glycan anchor biosynthesis class P)