Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	5122
Gene name	Proprotein convertase subtilisin/kexin type 1
Gene symbol	PCSK1
Synonyms (NCBI Gene)	BMIQ12NEC1PC1PC1/3PC3SPC3
Chromosome	5
Chromosome location	5q15
Summary	This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein under

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miRTarBase ID	miRNA	Experiments	Reference
MIRT029995	hsa-miR-26b-5p	Microarray	19088304
MIRT530376	hsa-miR-3156-5p	PAR-CLIP	22012620
MIRT530375	hsa-miR-1179	PAR-CLIP	22012620
MIRT530374	hsa-miR-892c-5p	PAR-CLIP	22012620
MIRT530373	hsa-miR-10b-3p	PAR-CLIP	22012620
MIRT530372	hsa-miR-5100	PAR-CLIP	22012620
MIRT530371	hsa-miR-518d-5p	PAR-CLIP	22012620
MIRT530370	hsa-miR-518e-5p	PAR-CLIP	22012620
MIRT530369	hsa-miR-518f-5p	PAR-CLIP	22012620
MIRT530368	hsa-miR-519a-5p	PAR-CLIP	22012620
MIRT530367	hsa-miR-519b-5p	PAR-CLIP	22012620
MIRT530366	hsa-miR-519c-5p	PAR-CLIP	22012620
MIRT530365	hsa-miR-520c-5p	PAR-CLIP	22012620
MIRT530364	hsa-miR-522-5p	PAR-CLIP	22012620
MIRT530363	hsa-miR-523-5p	PAR-CLIP	22012620
MIRT530362	hsa-miR-526a	PAR-CLIP	22012620
MIRT530361	hsa-miR-4777-5p	PAR-CLIP	22012620
MIRT530360	hsa-miR-498	PAR-CLIP	22012620
MIRT530359	hsa-miR-3942-3p	PAR-CLIP	22012620
MIRT440020	hsa-miR-485-5p	HITS-CLIP	24374217
MIRT440018	hsa-miR-493-5p	HITS-CLIP	24374217
MIRT440019	hsa-miR-1185-2-3p	HITS-CLIP	24374217
MIRT440017	hsa-miR-1185-1-3p	HITS-CLIP	24374217
MIRT440020	hsa-miR-485-5p	HITS-CLIP	24374217
MIRT440018	hsa-miR-493-5p	HITS-CLIP	24374217
MIRT440019	hsa-miR-1185-2-3p	HITS-CLIP	24374217
MIRT440017	hsa-miR-1185-1-3p	HITS-CLIP	24374217
MIRT530376	hsa-miR-3156-5p	PAR-CLIP	22012620
MIRT530375	hsa-miR-1179	PAR-CLIP	22012620
MIRT530374	hsa-miR-892c-5p	PAR-CLIP	22012620
MIRT530373	hsa-miR-10b-3p	PAR-CLIP	22012620
MIRT530372	hsa-miR-5100	PAR-CLIP	22012620
MIRT530371	hsa-miR-518d-5p	PAR-CLIP	22012620
MIRT530370	hsa-miR-518e-5p	PAR-CLIP	22012620
MIRT530369	hsa-miR-518f-5p	PAR-CLIP	22012620
MIRT530368	hsa-miR-519a-5p	PAR-CLIP	22012620
MIRT530367	hsa-miR-519b-5p	PAR-CLIP	22012620
MIRT530366	hsa-miR-519c-5p	PAR-CLIP	22012620
MIRT530365	hsa-miR-520c-5p	PAR-CLIP	22012620
MIRT530364	hsa-miR-522-5p	PAR-CLIP	22012620
MIRT530363	hsa-miR-523-5p	PAR-CLIP	22012620
MIRT530362	hsa-miR-526a	PAR-CLIP	22012620
MIRT530361	hsa-miR-4777-5p	PAR-CLIP	22012620
MIRT530360	hsa-miR-498	PAR-CLIP	22012620
MIRT530359	hsa-miR-3942-3p	PAR-CLIP	22012620
MIRT1218408	hsa-miR-103a	CLIP-seq
MIRT1218409	hsa-miR-107	CLIP-seq
MIRT1218410	hsa-miR-134	CLIP-seq
MIRT1218411	hsa-miR-3118	CLIP-seq
MIRT1218412	hsa-miR-3164	CLIP-seq
MIRT1218413	hsa-miR-4267	CLIP-seq
MIRT1218414	hsa-miR-4269	CLIP-seq
MIRT1218415	hsa-miR-4423-5p	CLIP-seq
MIRT1218416	hsa-miR-4514	CLIP-seq
MIRT1218417	hsa-miR-4645-5p	CLIP-seq
MIRT1218418	hsa-miR-4673	CLIP-seq
MIRT1218419	hsa-miR-4692	CLIP-seq
MIRT1218420	hsa-miR-4742-5p	CLIP-seq
MIRT1218421	hsa-miR-505	CLIP-seq
MIRT1218422	hsa-miR-508-5p	CLIP-seq
MIRT1218423	hsa-miR-510	CLIP-seq
MIRT1218424	hsa-miR-512-5p	CLIP-seq
MIRT1218425	hsa-miR-543	CLIP-seq
MIRT1218426	hsa-miR-544	CLIP-seq
MIRT1218427	hsa-miR-548ac	CLIP-seq
MIRT1218428	hsa-miR-548ae	CLIP-seq
MIRT1218429	hsa-miR-548aj	CLIP-seq
MIRT1218430	hsa-miR-548am	CLIP-seq
MIRT1218431	hsa-miR-548d-3p	CLIP-seq
MIRT1218432	hsa-miR-548x	CLIP-seq
MIRT1218433	hsa-miR-548z	CLIP-seq
MIRT1218434	hsa-miR-766	CLIP-seq
MIRT1218435	hsa-miR-128	CLIP-seq
MIRT1218436	hsa-miR-140-3p	CLIP-seq
MIRT1218437	hsa-miR-148a	CLIP-seq
MIRT1218438	hsa-miR-148b	CLIP-seq
MIRT1218439	hsa-miR-152	CLIP-seq
MIRT1218440	hsa-miR-338-5p	CLIP-seq
MIRT1218441	hsa-miR-4517	CLIP-seq
MIRT1218417	hsa-miR-4645-5p	CLIP-seq
MIRT1218418	hsa-miR-4673	CLIP-seq
MIRT1218442	hsa-miR-4733-3p	CLIP-seq
MIRT1218420	hsa-miR-4742-5p	CLIP-seq
MIRT1218443	hsa-miR-4799-5p	CLIP-seq
MIRT1218444	hsa-miR-767-5p	CLIP-seq
MIRT2063199	hsa-miR-105	CLIP-seq
MIRT2063200	hsa-miR-1261	CLIP-seq
MIRT2063201	hsa-miR-3671	CLIP-seq
MIRT2063202	hsa-miR-5096	CLIP-seq
MIRT2063203	hsa-miR-607	CLIP-seq
MIRT2291579	hsa-miR-3125	CLIP-seq
MIRT2291580	hsa-miR-3916	CLIP-seq
MIRT1218410	hsa-miR-134	CLIP-seq
MIRT1218411	hsa-miR-3118	CLIP-seq
MIRT1218412	hsa-miR-3164	CLIP-seq
MIRT1218421	hsa-miR-505	CLIP-seq
MIRT2063199	hsa-miR-105	CLIP-seq
MIRT2589174	hsa-miR-1178	CLIP-seq
MIRT2589175	hsa-miR-1237	CLIP-seq
MIRT2589176	hsa-miR-1245	CLIP-seq
MIRT2589177	hsa-miR-1245b-5p	CLIP-seq
MIRT2589178	hsa-miR-1248	CLIP-seq
MIRT2589179	hsa-miR-1252	CLIP-seq
MIRT2589180	hsa-miR-1256	CLIP-seq
MIRT2589181	hsa-miR-125a-3p	CLIP-seq
MIRT2589182	hsa-miR-1264	CLIP-seq
MIRT2589183	hsa-miR-1266	CLIP-seq
MIRT2589184	hsa-miR-1273d	CLIP-seq
MIRT2589185	hsa-miR-1273e	CLIP-seq
MIRT2589186	hsa-miR-1279	CLIP-seq
MIRT1218435	hsa-miR-128	CLIP-seq
MIRT2589187	hsa-miR-1294	CLIP-seq
MIRT2589188	hsa-miR-1295	CLIP-seq
MIRT2589189	hsa-miR-1299	CLIP-seq
MIRT2589190	hsa-miR-1305	CLIP-seq
MIRT2589191	hsa-miR-1321	CLIP-seq
MIRT2589192	hsa-miR-1323	CLIP-seq
MIRT2589193	hsa-miR-1324	CLIP-seq
MIRT1218410	hsa-miR-134	CLIP-seq
MIRT2589194	hsa-miR-141	CLIP-seq
MIRT2589195	hsa-miR-142-3p	CLIP-seq
MIRT1218437	hsa-miR-148a	CLIP-seq
MIRT1218438	hsa-miR-148b	CLIP-seq
MIRT1218439	hsa-miR-152	CLIP-seq
MIRT2589196	hsa-miR-181a	CLIP-seq
MIRT2589197	hsa-miR-181b	CLIP-seq
MIRT2589198	hsa-miR-181c	CLIP-seq
MIRT2589199	hsa-miR-181d	CLIP-seq
MIRT2589200	hsa-miR-186	CLIP-seq
MIRT2589201	hsa-miR-1912	CLIP-seq
MIRT2589202	hsa-miR-1915	CLIP-seq
MIRT2589203	hsa-miR-200a	CLIP-seq
MIRT2589204	hsa-miR-203	CLIP-seq
MIRT2589205	hsa-miR-205	CLIP-seq
MIRT2589206	hsa-miR-2052	CLIP-seq
MIRT2589207	hsa-miR-2116	CLIP-seq
MIRT2589208	hsa-miR-219-1-3p	CLIP-seq
MIRT2589209	hsa-miR-2276	CLIP-seq
MIRT2589210	hsa-miR-2278	CLIP-seq
MIRT2589211	hsa-miR-23a	CLIP-seq
MIRT2589212	hsa-miR-23b	CLIP-seq
MIRT2589213	hsa-miR-23c	CLIP-seq
MIRT2589214	hsa-miR-2909	CLIP-seq
MIRT2589215	hsa-miR-302f	CLIP-seq
MIRT2589216	hsa-miR-3064-3p	CLIP-seq
MIRT2589217	hsa-miR-3074-5p	CLIP-seq
MIRT1218411	hsa-miR-3118	CLIP-seq
MIRT2589218	hsa-miR-3120-3p	CLIP-seq
MIRT2291579	hsa-miR-3125	CLIP-seq
MIRT2589219	hsa-miR-3127-3p	CLIP-seq
MIRT2589220	hsa-miR-3133	CLIP-seq
MIRT2589221	hsa-miR-3140-3p	CLIP-seq
MIRT2589222	hsa-miR-3142	CLIP-seq
MIRT2589223	hsa-miR-3145-5p	CLIP-seq
MIRT2589224	hsa-miR-3148	CLIP-seq
MIRT2589225	hsa-miR-3152-5p	CLIP-seq
MIRT2589226	hsa-miR-3161	CLIP-seq
MIRT2589227	hsa-miR-3162-5p	CLIP-seq
MIRT1218412	hsa-miR-3164	CLIP-seq
MIRT2589228	hsa-miR-3166	CLIP-seq
MIRT2589229	hsa-miR-3170	CLIP-seq
MIRT2589230	hsa-miR-3185	CLIP-seq
MIRT2589231	hsa-miR-3194-3p	CLIP-seq
MIRT2589232	hsa-miR-3200-5p	CLIP-seq
MIRT2589233	hsa-miR-320a	CLIP-seq
MIRT2589234	hsa-miR-320b	CLIP-seq
MIRT2589235	hsa-miR-320c	CLIP-seq
MIRT2589236	hsa-miR-320d	CLIP-seq
MIRT2589237	hsa-miR-338-3p	CLIP-seq
MIRT1218440	hsa-miR-338-5p	CLIP-seq
MIRT2589238	hsa-miR-340	CLIP-seq
MIRT2589239	hsa-miR-345	CLIP-seq
MIRT2589240	hsa-miR-3529	CLIP-seq
MIRT2589241	hsa-miR-3545-3p	CLIP-seq
MIRT2589242	hsa-miR-3606	CLIP-seq
MIRT2589243	hsa-miR-3607-3p	CLIP-seq
MIRT2589244	hsa-miR-3613-3p	CLIP-seq
MIRT2589245	hsa-miR-3614-5p	CLIP-seq
MIRT2589246	hsa-miR-3646	CLIP-seq
MIRT2589247	hsa-miR-3647-3p	CLIP-seq
MIRT2589248	hsa-miR-3652	CLIP-seq
MIRT2589249	hsa-miR-3664-3p	CLIP-seq
MIRT2589250	hsa-miR-3665	CLIP-seq
MIRT2589251	hsa-miR-3670	CLIP-seq
MIRT2063201	hsa-miR-3671	CLIP-seq
MIRT2589252	hsa-miR-3673	CLIP-seq
MIRT2589253	hsa-miR-3678-3p	CLIP-seq
MIRT2589254	hsa-miR-3688-3p	CLIP-seq
MIRT2589255	hsa-miR-370	CLIP-seq
MIRT2589256	hsa-miR-371-5p	CLIP-seq
MIRT2589257	hsa-miR-379	CLIP-seq
MIRT2291580	hsa-miR-3916	CLIP-seq
MIRT2589258	hsa-miR-3928	CLIP-seq
MIRT2589259	hsa-miR-3944-5p	CLIP-seq
MIRT2589260	hsa-miR-3978	CLIP-seq
MIRT2589261	hsa-miR-4255	CLIP-seq
MIRT2589262	hsa-miR-4256	CLIP-seq
MIRT2589263	hsa-miR-4261	CLIP-seq
MIRT2589264	hsa-miR-4262	CLIP-seq
MIRT2589265	hsa-miR-4266	CLIP-seq
MIRT1218413	hsa-miR-4267	CLIP-seq
MIRT1218414	hsa-miR-4269	CLIP-seq
MIRT2589266	hsa-miR-4280	CLIP-seq
MIRT2589267	hsa-miR-4282	CLIP-seq
MIRT2589268	hsa-miR-4307	CLIP-seq
MIRT2589269	hsa-miR-4310	CLIP-seq
MIRT2589270	hsa-miR-433	CLIP-seq
MIRT2589271	hsa-miR-4422	CLIP-seq
MIRT1218415	hsa-miR-4423-5p	CLIP-seq
MIRT2589272	hsa-miR-4426	CLIP-seq
MIRT2589273	hsa-miR-4427	CLIP-seq
MIRT2589274	hsa-miR-4429	CLIP-seq
MIRT2589275	hsa-miR-4430	CLIP-seq
MIRT2589276	hsa-miR-4437	CLIP-seq
MIRT2589277	hsa-miR-4451	CLIP-seq
MIRT2589278	hsa-miR-4461	CLIP-seq
MIRT2589279	hsa-miR-4481	CLIP-seq
MIRT2589280	hsa-miR-4501	CLIP-seq
MIRT2589281	hsa-miR-4505	CLIP-seq
MIRT1218416	hsa-miR-4514	CLIP-seq
MIRT1218441	hsa-miR-4517	CLIP-seq
MIRT2589282	hsa-miR-4518	CLIP-seq
MIRT2589283	hsa-miR-452	CLIP-seq
MIRT2589284	hsa-miR-4642	CLIP-seq
MIRT1218417	hsa-miR-4645-5p	CLIP-seq
MIRT2589285	hsa-miR-4647	CLIP-seq
MIRT2589286	hsa-miR-4650-3p	CLIP-seq
MIRT2589287	hsa-miR-4652-3p	CLIP-seq
MIRT2589288	hsa-miR-4659a-5p	CLIP-seq
MIRT2589289	hsa-miR-4659b-5p	CLIP-seq
MIRT2589290	hsa-miR-4662b	CLIP-seq
MIRT2589291	hsa-miR-4670-3p	CLIP-seq
MIRT1218418	hsa-miR-4673	CLIP-seq
MIRT2589292	hsa-miR-4674	CLIP-seq
MIRT2589293	hsa-miR-4676-3p	CLIP-seq
MIRT2589294	hsa-miR-4677-5p	CLIP-seq
MIRT2589295	hsa-miR-4680-3p	CLIP-seq
MIRT2589296	hsa-miR-4680-5p	CLIP-seq
MIRT2589297	hsa-miR-4684-5p	CLIP-seq
MIRT1218419	hsa-miR-4692	CLIP-seq
MIRT2589298	hsa-miR-4693-3p	CLIP-seq
MIRT2589299	hsa-miR-4698	CLIP-seq
MIRT2589300	hsa-miR-4700-3p	CLIP-seq
MIRT2589301	hsa-miR-4709-3p	CLIP-seq
MIRT2589302	hsa-miR-4710	CLIP-seq
MIRT2589303	hsa-miR-4715-5p	CLIP-seq
MIRT2589304	hsa-miR-4717-3p	CLIP-seq
MIRT2589305	hsa-miR-4719	CLIP-seq
MIRT2589306	hsa-miR-4722-3p	CLIP-seq
MIRT2589307	hsa-miR-4724-3p	CLIP-seq
MIRT2589308	hsa-miR-4726-3p	CLIP-seq
MIRT2589309	hsa-miR-4731-3p	CLIP-seq
MIRT2589310	hsa-miR-4731-5p	CLIP-seq
MIRT1218442	hsa-miR-4733-3p	CLIP-seq
MIRT2589311	hsa-miR-4733-5p	CLIP-seq
MIRT2589312	hsa-miR-4738-3p	CLIP-seq
MIRT2589313	hsa-miR-4739	CLIP-seq
MIRT1218420	hsa-miR-4742-5p	CLIP-seq
MIRT2589314	hsa-miR-4745-5p	CLIP-seq
MIRT2589315	hsa-miR-4756-5p	CLIP-seq
MIRT2589316	hsa-miR-4760-3p	CLIP-seq
MIRT2589317	hsa-miR-4762-3p	CLIP-seq
MIRT2589318	hsa-miR-4765	CLIP-seq
MIRT2589319	hsa-miR-4771	CLIP-seq
MIRT2589320	hsa-miR-4772-3p	CLIP-seq
MIRT2589321	hsa-miR-4774-3p	CLIP-seq
MIRT2589322	hsa-miR-4776-3p	CLIP-seq
MIRT2589323	hsa-miR-4778-5p	CLIP-seq
MIRT2589324	hsa-miR-4782-5p	CLIP-seq
MIRT2589325	hsa-miR-4786-3p	CLIP-seq
MIRT2589326	hsa-miR-4795-3p	CLIP-seq
MIRT2589327	hsa-miR-4797-5p	CLIP-seq
MIRT1218443	hsa-miR-4799-5p	CLIP-seq
MIRT2589328	hsa-miR-4801	CLIP-seq
MIRT2589329	hsa-miR-4802-3p	CLIP-seq
MIRT2589330	hsa-miR-490-5p	CLIP-seq
MIRT2589331	hsa-miR-494	CLIP-seq
MIRT1218421	hsa-miR-505	CLIP-seq
MIRT1218422	hsa-miR-508-5p	CLIP-seq
MIRT1218423	hsa-miR-510	CLIP-seq
MIRT1218424	hsa-miR-512-5p	CLIP-seq
MIRT2589332	hsa-miR-516b	CLIP-seq
MIRT2589333	hsa-miR-518a-5p	CLIP-seq
MIRT2589334	hsa-miR-522	CLIP-seq
MIRT2589335	hsa-miR-526b	CLIP-seq
MIRT2589336	hsa-miR-527	CLIP-seq
MIRT2589337	hsa-miR-532-5p	CLIP-seq
MIRT1218425	hsa-miR-543	CLIP-seq
MIRT2589338	hsa-miR-545	CLIP-seq
MIRT2589339	hsa-miR-548a-3p	CLIP-seq
MIRT2589340	hsa-miR-548b-3p	CLIP-seq
MIRT2589341	hsa-miR-548e	CLIP-seq
MIRT2589342	hsa-miR-548f	CLIP-seq
MIRT2589343	hsa-miR-548g	CLIP-seq
MIRT2589344	hsa-miR-548o	CLIP-seq
MIRT2589345	hsa-miR-548v	CLIP-seq
MIRT2589346	hsa-miR-571	CLIP-seq
MIRT2589347	hsa-miR-576-3p	CLIP-seq
MIRT2589348	hsa-miR-576-5p	CLIP-seq
MIRT2589349	hsa-miR-578	CLIP-seq
MIRT2589350	hsa-miR-580	CLIP-seq
MIRT2589351	hsa-miR-582-5p	CLIP-seq
MIRT2589352	hsa-miR-600	CLIP-seq
MIRT2063203	hsa-miR-607	CLIP-seq
MIRT2589353	hsa-miR-627	CLIP-seq
MIRT2589354	hsa-miR-647	CLIP-seq
MIRT2589355	hsa-miR-651	CLIP-seq
MIRT2589356	hsa-miR-656	CLIP-seq
MIRT2589357	hsa-miR-659	CLIP-seq
MIRT2589358	hsa-miR-671-5p	CLIP-seq
MIRT2589359	hsa-miR-759	CLIP-seq
MIRT1218434	hsa-miR-766	CLIP-seq
MIRT1218444	hsa-miR-767-5p	CLIP-seq
MIRT2589360	hsa-miR-873	CLIP-seq
MIRT2589361	hsa-miR-875-3p	CLIP-seq
MIRT2589362	hsa-miR-889	CLIP-seq
MIRT2589363	hsa-miR-921	CLIP-seq
MIRT2589364	hsa-miR-924	CLIP-seq
MIRT2589365	hsa-miR-944	CLIP-seq
MIRT2063199	hsa-miR-105	CLIP-seq
MIRT2589174	hsa-miR-1178	CLIP-seq
MIRT2589175	hsa-miR-1237	CLIP-seq
MIRT2589176	hsa-miR-1245	CLIP-seq
MIRT2589177	hsa-miR-1245b-5p	CLIP-seq
MIRT2589178	hsa-miR-1248	CLIP-seq
MIRT2589179	hsa-miR-1252	CLIP-seq
MIRT2589180	hsa-miR-1256	CLIP-seq
MIRT2589181	hsa-miR-125a-3p	CLIP-seq
MIRT2687274	hsa-miR-1262	CLIP-seq
MIRT2589182	hsa-miR-1264	CLIP-seq
MIRT2589183	hsa-miR-1266	CLIP-seq
MIRT2589184	hsa-miR-1273d	CLIP-seq
MIRT2589185	hsa-miR-1273e	CLIP-seq
MIRT2589186	hsa-miR-1279	CLIP-seq
MIRT1218435	hsa-miR-128	CLIP-seq
MIRT2589187	hsa-miR-1294	CLIP-seq
MIRT2589188	hsa-miR-1295	CLIP-seq
MIRT2589189	hsa-miR-1299	CLIP-seq
MIRT2589190	hsa-miR-1305	CLIP-seq
MIRT2589191	hsa-miR-1321	CLIP-seq
MIRT2589192	hsa-miR-1323	CLIP-seq
MIRT2589193	hsa-miR-1324	CLIP-seq
MIRT1218410	hsa-miR-134	CLIP-seq
MIRT2589194	hsa-miR-141	CLIP-seq
MIRT2589195	hsa-miR-142-3p	CLIP-seq
MIRT1218437	hsa-miR-148a	CLIP-seq
MIRT1218438	hsa-miR-148b	CLIP-seq
MIRT1218439	hsa-miR-152	CLIP-seq
MIRT2589196	hsa-miR-181a	CLIP-seq
MIRT2589197	hsa-miR-181b	CLIP-seq
MIRT2589198	hsa-miR-181c	CLIP-seq
MIRT2589199	hsa-miR-181d	CLIP-seq
MIRT2589200	hsa-miR-186	CLIP-seq
MIRT2589202	hsa-miR-1915	CLIP-seq
MIRT2589203	hsa-miR-200a	CLIP-seq
MIRT2589204	hsa-miR-203	CLIP-seq
MIRT2589205	hsa-miR-205	CLIP-seq
MIRT2589206	hsa-miR-2052	CLIP-seq
MIRT2589207	hsa-miR-2116	CLIP-seq
MIRT2589208	hsa-miR-219-1-3p	CLIP-seq
MIRT2589209	hsa-miR-2276	CLIP-seq
MIRT2589211	hsa-miR-23a	CLIP-seq
MIRT2589212	hsa-miR-23b	CLIP-seq
MIRT2589213	hsa-miR-23c	CLIP-seq
MIRT2589214	hsa-miR-2909	CLIP-seq
MIRT2589215	hsa-miR-302f	CLIP-seq
MIRT2589216	hsa-miR-3064-3p	CLIP-seq
MIRT2589217	hsa-miR-3074-5p	CLIP-seq
MIRT1218411	hsa-miR-3118	CLIP-seq
MIRT2589218	hsa-miR-3120-3p	CLIP-seq
MIRT2291579	hsa-miR-3125	CLIP-seq
MIRT2589219	hsa-miR-3127-3p	CLIP-seq
MIRT2589220	hsa-miR-3133	CLIP-seq
MIRT2589221	hsa-miR-3140-3p	CLIP-seq
MIRT2589222	hsa-miR-3142	CLIP-seq
MIRT2589223	hsa-miR-3145-5p	CLIP-seq
MIRT2589224	hsa-miR-3148	CLIP-seq
MIRT2589225	hsa-miR-3152-5p	CLIP-seq
MIRT2589226	hsa-miR-3161	CLIP-seq
MIRT2589227	hsa-miR-3162-5p	CLIP-seq
MIRT1218412	hsa-miR-3164	CLIP-seq
MIRT2589228	hsa-miR-3166	CLIP-seq
MIRT2589229	hsa-miR-3170	CLIP-seq
MIRT2589230	hsa-miR-3185	CLIP-seq
MIRT2589231	hsa-miR-3194-3p	CLIP-seq
MIRT2589232	hsa-miR-3200-5p	CLIP-seq
MIRT2589233	hsa-miR-320a	CLIP-seq
MIRT2589234	hsa-miR-320b	CLIP-seq
MIRT2589235	hsa-miR-320c	CLIP-seq
MIRT2589236	hsa-miR-320d	CLIP-seq
MIRT2589237	hsa-miR-338-3p	CLIP-seq
MIRT1218440	hsa-miR-338-5p	CLIP-seq
MIRT2589240	hsa-miR-3529	CLIP-seq
MIRT2589241	hsa-miR-3545-3p	CLIP-seq
MIRT2589242	hsa-miR-3606	CLIP-seq
MIRT2589244	hsa-miR-3613-3p	CLIP-seq
MIRT2589245	hsa-miR-3614-5p	CLIP-seq
MIRT2589246	hsa-miR-3646	CLIP-seq
MIRT2589247	hsa-miR-3647-3p	CLIP-seq
MIRT2589248	hsa-miR-3652	CLIP-seq
MIRT2589249	hsa-miR-3664-3p	CLIP-seq
MIRT2589251	hsa-miR-3670	CLIP-seq
MIRT2063201	hsa-miR-3671	CLIP-seq
MIRT2589252	hsa-miR-3673	CLIP-seq
MIRT2589253	hsa-miR-3678-3p	CLIP-seq
MIRT2589254	hsa-miR-3688-3p	CLIP-seq
MIRT2589255	hsa-miR-370	CLIP-seq
MIRT2589256	hsa-miR-371-5p	CLIP-seq
MIRT2589257	hsa-miR-379	CLIP-seq
MIRT2291580	hsa-miR-3916	CLIP-seq
MIRT2589258	hsa-miR-3928	CLIP-seq
MIRT2589259	hsa-miR-3944-5p	CLIP-seq
MIRT2589260	hsa-miR-3978	CLIP-seq
MIRT2589261	hsa-miR-4255	CLIP-seq
MIRT2589263	hsa-miR-4261	CLIP-seq
MIRT2589264	hsa-miR-4262	CLIP-seq
MIRT2589265	hsa-miR-4266	CLIP-seq
MIRT1218413	hsa-miR-4267	CLIP-seq
MIRT1218414	hsa-miR-4269	CLIP-seq
MIRT2589266	hsa-miR-4280	CLIP-seq
MIRT2589267	hsa-miR-4282	CLIP-seq
MIRT2589268	hsa-miR-4307	CLIP-seq
MIRT2589269	hsa-miR-4310	CLIP-seq
MIRT2589270	hsa-miR-433	CLIP-seq
MIRT2589271	hsa-miR-4422	CLIP-seq
MIRT1218415	hsa-miR-4423-5p	CLIP-seq
MIRT2589272	hsa-miR-4426	CLIP-seq
MIRT2589273	hsa-miR-4427	CLIP-seq
MIRT2589274	hsa-miR-4429	CLIP-seq
MIRT2589275	hsa-miR-4430	CLIP-seq
MIRT2589276	hsa-miR-4437	CLIP-seq
MIRT2589277	hsa-miR-4451	CLIP-seq
MIRT2589278	hsa-miR-4461	CLIP-seq
MIRT2589280	hsa-miR-4501	CLIP-seq
MIRT2589281	hsa-miR-4505	CLIP-seq
MIRT1218416	hsa-miR-4514	CLIP-seq
MIRT1218441	hsa-miR-4517	CLIP-seq
MIRT2589282	hsa-miR-4518	CLIP-seq
MIRT2589283	hsa-miR-452	CLIP-seq
MIRT2589284	hsa-miR-4642	CLIP-seq
MIRT1218417	hsa-miR-4645-5p	CLIP-seq
MIRT2589285	hsa-miR-4647	CLIP-seq
MIRT2589286	hsa-miR-4650-3p	CLIP-seq
MIRT2589287	hsa-miR-4652-3p	CLIP-seq
MIRT2589288	hsa-miR-4659a-5p	CLIP-seq
MIRT2589289	hsa-miR-4659b-5p	CLIP-seq
MIRT2589290	hsa-miR-4662b	CLIP-seq
MIRT2589291	hsa-miR-4670-3p	CLIP-seq
MIRT1218418	hsa-miR-4673	CLIP-seq
MIRT2589292	hsa-miR-4674	CLIP-seq
MIRT2589293	hsa-miR-4676-3p	CLIP-seq
MIRT2589294	hsa-miR-4677-5p	CLIP-seq
MIRT2589295	hsa-miR-4680-3p	CLIP-seq
MIRT2589296	hsa-miR-4680-5p	CLIP-seq
MIRT2589297	hsa-miR-4684-5p	CLIP-seq
MIRT1218419	hsa-miR-4692	CLIP-seq
MIRT2589298	hsa-miR-4693-3p	CLIP-seq
MIRT2589299	hsa-miR-4698	CLIP-seq
MIRT2589300	hsa-miR-4700-3p	CLIP-seq
MIRT2687275	hsa-miR-4701-3p	CLIP-seq
MIRT2589301	hsa-miR-4709-3p	CLIP-seq
MIRT2589302	hsa-miR-4710	CLIP-seq
MIRT2589303	hsa-miR-4715-5p	CLIP-seq
MIRT2589304	hsa-miR-4717-3p	CLIP-seq
MIRT2589305	hsa-miR-4719	CLIP-seq
MIRT2589307	hsa-miR-4724-3p	CLIP-seq
MIRT2589308	hsa-miR-4726-3p	CLIP-seq
MIRT2589309	hsa-miR-4731-3p	CLIP-seq
MIRT2589310	hsa-miR-4731-5p	CLIP-seq
MIRT1218442	hsa-miR-4733-3p	CLIP-seq
MIRT2589311	hsa-miR-4733-5p	CLIP-seq
MIRT2589312	hsa-miR-4738-3p	CLIP-seq
MIRT2589313	hsa-miR-4739	CLIP-seq
MIRT1218420	hsa-miR-4742-5p	CLIP-seq
MIRT2589315	hsa-miR-4756-5p	CLIP-seq
MIRT2589316	hsa-miR-4760-3p	CLIP-seq
MIRT2589318	hsa-miR-4765	CLIP-seq
MIRT2589319	hsa-miR-4771	CLIP-seq
MIRT2589320	hsa-miR-4772-3p	CLIP-seq
MIRT2589321	hsa-miR-4774-3p	CLIP-seq
MIRT2589322	hsa-miR-4776-3p	CLIP-seq
MIRT2589323	hsa-miR-4778-5p	CLIP-seq
MIRT2589324	hsa-miR-4782-5p	CLIP-seq
MIRT2589325	hsa-miR-4786-3p	CLIP-seq
MIRT2589326	hsa-miR-4795-3p	CLIP-seq
MIRT2589327	hsa-miR-4797-5p	CLIP-seq
MIRT1218443	hsa-miR-4799-5p	CLIP-seq
MIRT2589328	hsa-miR-4801	CLIP-seq
MIRT2589329	hsa-miR-4802-3p	CLIP-seq
MIRT2589330	hsa-miR-490-5p	CLIP-seq
MIRT2589331	hsa-miR-494	CLIP-seq
MIRT1218421	hsa-miR-505	CLIP-seq
MIRT1218422	hsa-miR-508-5p	CLIP-seq
MIRT1218423	hsa-miR-510	CLIP-seq
MIRT1218424	hsa-miR-512-5p	CLIP-seq
MIRT2589332	hsa-miR-516b	CLIP-seq
MIRT2589333	hsa-miR-518a-5p	CLIP-seq
MIRT2589334	hsa-miR-522	CLIP-seq
MIRT2589335	hsa-miR-526b	CLIP-seq
MIRT2589336	hsa-miR-527	CLIP-seq
MIRT2589337	hsa-miR-532-5p	CLIP-seq
MIRT1218425	hsa-miR-543	CLIP-seq
MIRT2589338	hsa-miR-545	CLIP-seq
MIRT2589339	hsa-miR-548a-3p	CLIP-seq
MIRT1218427	hsa-miR-548ac	CLIP-seq
MIRT1218428	hsa-miR-548ae	CLIP-seq
MIRT1218429	hsa-miR-548aj	CLIP-seq
MIRT1218430	hsa-miR-548am	CLIP-seq
MIRT2589340	hsa-miR-548b-3p	CLIP-seq
MIRT1218431	hsa-miR-548d-3p	CLIP-seq
MIRT2589341	hsa-miR-548e	CLIP-seq
MIRT2589342	hsa-miR-548f	CLIP-seq
MIRT2589343	hsa-miR-548g	CLIP-seq
MIRT2589344	hsa-miR-548o	CLIP-seq
MIRT2589345	hsa-miR-548v	CLIP-seq
MIRT1218432	hsa-miR-548x	CLIP-seq
MIRT1218433	hsa-miR-548z	CLIP-seq
MIRT2589346	hsa-miR-571	CLIP-seq
MIRT2589347	hsa-miR-576-3p	CLIP-seq
MIRT2589348	hsa-miR-576-5p	CLIP-seq
MIRT2589349	hsa-miR-578	CLIP-seq
MIRT2589350	hsa-miR-580	CLIP-seq
MIRT2589351	hsa-miR-582-5p	CLIP-seq
MIRT2589352	hsa-miR-600	CLIP-seq
MIRT2063203	hsa-miR-607	CLIP-seq
MIRT2589353	hsa-miR-627	CLIP-seq
MIRT2589354	hsa-miR-647	CLIP-seq
MIRT2589355	hsa-miR-651	CLIP-seq
MIRT2589356	hsa-miR-656	CLIP-seq
MIRT2589357	hsa-miR-659	CLIP-seq
MIRT2589358	hsa-miR-671-5p	CLIP-seq
MIRT2589359	hsa-miR-759	CLIP-seq
MIRT1218434	hsa-miR-766	CLIP-seq
MIRT1218444	hsa-miR-767-5p	CLIP-seq
MIRT2589360	hsa-miR-873	CLIP-seq
MIRT2589361	hsa-miR-875-3p	CLIP-seq
MIRT2589362	hsa-miR-889	CLIP-seq
MIRT2589363	hsa-miR-921	CLIP-seq
MIRT2589364	hsa-miR-924	CLIP-seq
MIRT2589365	hsa-miR-944	CLIP-seq

Show/Hide all (4)

Transcription factor	Regulation	Reference
ATF1	Activation	8999965
CREB1	Activation	8999965
PAX6	Activation	19034419
REST	Unknown	19118055

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004175	Function	Endopeptidase activity	IEA
GO:0004252	Function	Serine-type endopeptidase activity	IBA
GO:0004252	Function	Serine-type endopeptidase activity	IEA
GO:0004252	Function	Serine-type endopeptidase activity	ISS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	8397508
GO:0005615	Component	Extracellular space	IEA
GO:0006508	Process	Proteolysis	IEA
GO:0006508	Process	Proteolysis	TAS	9207799
GO:0007267	Process	Cell-cell signaling	TAS	9207799
GO:0008233	Function	Peptidase activity	IEA
GO:0008236	Function	Serine-type peptidase activity	IEA
GO:0016020	Component	Membrane	IBA
GO:0016485	Process	Protein processing	IEA
GO:0016486	Process	Peptide hormone processing	IBA
GO:0016486	Process	Peptide hormone processing	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030070	Process	Insulin processing	IEA
GO:0030133	Component	Transport vesicle	IEA
GO:0030141	Component	Secretory granule	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0034774	Component	Secretory granule lumen	IEA
GO:0034774	Component	Secretory granule lumen	TAS
GO:0042802	Function	Identical protein binding	IEA
GO:0043005	Component	Neuron projection	IBA
GO:0043043	Process	Peptide biosynthetic process	IEA
GO:0043043	Process	Peptide biosynthetic process	ISS

MIM	HGNC	e!Ensembl
162150	8743	ENSG00000175426

P29120

Protein name

Neuroendocrine convertase 1 (NEC 1) (EC 3.4.21.93) (Prohormone convertase 1) (Proprotein convertase 1) (PC1)

Protein function

Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16470	S8_pro-domain	34 → 110	Peptidase S8 pro-domain	Domain
PF00082	Peptidase_S8	158 → 442	Subtilase family	Domain
PF01483	P_proprotein	504 → 591	Proprotein convertase P-domain	Family
PF12177	Proho_convert	713 → 751	Prohormone convertase enzyme	Domain

Sequence

MERRAWSLQCTAFVLFCAWCALNSAKAKRQFVNEWAAEIPGGPEAASAIAEELGYDLLGQ
IGSLENHYLFKHKNHPRRSRRSAFHITKRLSDDDRVIWAEQQYEKERSKRSALRDSALNL
FNDPMWNQQWYLQDTRMTAALPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYAN
YDPEASYDFNDNDHDPFPRYDPTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRM
LDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKG
SIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSGDY
TDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPL
ANNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRSVPEKKECVVKDNDFEPRALK
ANGEVIIEIPTRACEGQENAIKSLEHVQFEATIEYSRRGDLHVTLTSAAGTSTVLLAERE
RDTSPNGFKNWDFMSVHTWGENPIGTWTLRITDMSGRIQNEGRIVNWKLILHGTSSQPEH
MKQPRVYTSYNTVQNDRRGVEKMVDPGEEQPTQENPKENTLVSKSPSSSSVGGRRDELEE
GAPSQAMLRLLQSAFSKNSPPKQSPKKSPSAKLNIPYENFYEALEKLNKPSQLKDSEDSL
YNDYVDVFYNTKPYKHRDDRLLQALVDILNEEN

Sequence length

753

Interactions

View interactions

	Reactome
			Peptide hormone biosynthesis Synthesis, secretion, and deacylation of Ghrelin

297

Show/Hide Causal Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Body mass index quantitative trait locus 12	Likely pathogenic; Pathogenic	rs2531505680	RCV003441152
Obesity due to prohormone convertase I deficiency	Pathogenic; Likely pathogenic	rs2112419752, rs1168396288, rs150991567, rs771457696, rs145558922, rs1480597482, rs1301652826, rs2531459837, rs2531513538, rs2531505680, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824 View all (3 more)	RCV001784811 RCV001807939 RCV001808251 RCV001823847 RCV002291322 RCV002291323 RCV002306253 RCV002306254 RCV002306255 RCV003227576 RCV003441152 RCV000015081 RCV000015082 RCV000015083 RCV000015084 RCV000015085 RCV000995597 RCV000995598 RCV001290206
PCSK1-related disorder	Likely pathogenic	rs1464398432, rs567641208, rs1359353262	RCV004747117 RCV003901767 RCV003939801

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Monogenic Non-Syndromic Obesity	Uncertain significance; Likely benign; Benign; Conflicting classifications of pathogenicity	rs886060874, rs886060876, rs2882298, rs6556922, rs373852338, rs886060882, rs373041583, rs886060885, rs6234, rs6236, rs538803955, rs199951150, rs886060877, rs189919167, rs182581645 View all (36 more)	RCV000342865 RCV000333819 RCV000342580 RCV000307358 RCV000272141 RCV000323230 RCV000260656 RCV000331249 RCV000397598 RCV000298180 RCV000397585 RCV000395731 RCV000270498 RCV000290620 RCV000279298 RCV000395776 RCV000370187 RCV000259909 RCV000374499 RCV000294746 RCV000318486 RCV000383668 RCV000291728 RCV000368049 RCV000328137 RCV000323901 RCV000318260 RCV000349980 RCV000299659 RCV000384857 RCV000376944 RCV000387259 RCV000345988 RCV000358756 RCV000305580 RCV000288016 RCV000304198 RCV000322441 RCV000334856 RCV000390603 RCV000313031 RCV000307699 RCV000371861 RCV000353213 RCV000358567 RCV000406522 RCV000363149 RCV000283894 RCV000272404 RCV000358669 RCV000404347
Thymoma	Benign	rs3792746	RCV005919757
Uterine corpus endometrial carcinoma	Uncertain significance	rs527304866	RCV005926446

Show/Hide Text Mining Associations (65)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Acidosis	Associate	34068683
ACTH Secreting Pituitary Adenoma	Associate	17917309, 31319379
Adenocarcinoma	Associate	34646089
Alopecia Neurologic Defects and Endocrinopathy Syndrome	Associate	34068683, 36822744
Alzheimer Disease	Associate	32967721, 34393677
Atrial Fibrillation	Associate	31959406
Autism Spectrum Disorder	Associate	33387879, 34573415
Autoimmune enteropathy	Associate	32081864
Breast Neoplasms	Associate	36705562
Carcinoid Tumor	Associate	1547893
Cerebral Hemorrhage	Associate	34780106
Cognition Disorders	Inhibit	32967721
Colorectal Neoplasms	Associate	21251323, 26446941, 34608882
Coronary Artery Disease	Associate	24489861
Diabetes Insipidus	Associate	24280991
Diabetes Insipidus Neurogenic	Associate	23562752
Diabetes Mellitus	Associate	23383060, 24932808, 36997916
Diabetes Mellitus Type 1	Inhibit	28877460
Diabetes Mellitus Type 1	Associate	31442418
Diabetes Mellitus Type 2	Associate	22389004, 23890480, 24489861, 24705588, 31250990, 36822744
Diabetes Mellitus Type 2	Inhibit	25892189
Diarrhea	Associate	25272002
Diarrhea 4 Malabsorptive Congenital	Associate	23562752, 24280991, 34068683
Disruptive Impulse Control and Conduct Disorders	Associate	34097736
Dwarfism Pituitary	Associate	23562752
Dyslipidemias	Associate	31250990
Enteritis	Associate	25272002
Eunuchism	Associate	23562752
Glucose Intolerance	Associate	21935364, 28271036
Glucose Metabolism Disorders	Associate	20534142
Growth Disorders	Associate	23562752
Hemorrhagic Fever with Renal Syndrome	Associate	35059462
Hyperglycemia	Inhibit	23985558
Hyperphagia	Associate	23562752, 24280991
Immunologic Deficiency Syndromes	Associate	34068683
Inflammation	Inhibit	31442418
Inflammation	Associate	34780106
Insulin Resistance	Associate	19875984
Lung Neoplasms	Associate	1547893, 23409034, 9166946
Malabsorption Syndromes	Associate	23562752
Mental Disorders	Associate	31600226
Metabolic Diseases	Associate	23383060, 37761915
Metabolic Syndrome	Associate	37761915
Neoplasm Metastasis	Associate	16293189
Neoplasms	Associate	16293189, 30673970, 34671197
Neoplasms	Stimulate	23409034, 33299884
Nonsyndromic Holoprosencephaly	Associate	1547893
Obesity	Associate	19164386, 19528091, 19875984, 20498726, 20534142, 21311511, 21720444, 21873549, 22210313, 22737226, 23383060, 23562752, 23800642, 24135795, 24626232 View all (21 more)
Obesity Morbid	Associate	28377240
Osteoarthritis	Inhibit	39261869
Overweight	Associate	20498726, 26680480
Penis agenesis	Associate	24280991
Polycystic Kidney Autosomal Dominant	Associate	29706351
Polycystic Ovary Syndrome	Associate	22389004, 28271036, 31250990
Prader Willi Syndrome	Associate	35442499
Primary Immunodeficiency Diseases	Associate	32081864
Proprotein Convertase 1 3 Deficiency	Associate	23562752
Proprotein Convertase 1 3 Deficiency	Inhibit	24135795
Prostatic Neoplasms	Associate	27835608
Prostatic Neoplasms	Stimulate	34646089
Prostatitis	Associate	26011939
Sarcoma Alveolar Soft Part	Associate	19146682
Small Cell Lung Carcinoma	Associate	1547893, 9166946
Urinary Bladder Neoplasms	Inhibit	40531358
Weight Loss	Associate	39743445

PCSK1 (proprotein convertase subtilisin/kexin type 1)