Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	51209
Gene name	RAB9B, member RAS oncogene family
Gene symbol	RAB9B
Synonyms (NCBI Gene)	RAB9LRab-9L
Chromosome	X
Chromosome location	Xq22.2
Summary	This gene encodes a member of a subfamily of RAS small guanosine triphosphate (GTP)-binding proteins that regulate membrane trafficking. The encoded protein may be involved in endosome-to-Golgi transport. [provided by RefSeq, Jan 2010]

141

Show/Hide all (141)

miRTarBase ID	miRNA	Experiments	Reference
MIRT000804	hsa-miR-15a-5p	proteomics analysis	18362358
MIRT000803	hsa-miR-16-5p	proteomics analysis	18362358
MIRT000769	hsa-miR-224-5p	MicroarrayNorthern blot	16331254
MIRT639787	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT622536	hsa-miR-888-5p	HITS-CLIP	23824327
MIRT622535	hsa-miR-380-3p	HITS-CLIP	23824327
MIRT622534	hsa-miR-105-5p	HITS-CLIP	23824327
MIRT622533	hsa-miR-7853-5p	HITS-CLIP	23824327
MIRT622532	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT639786	hsa-miR-4775	HITS-CLIP	23824327
MIRT622531	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT639787	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT622536	hsa-miR-888-5p	HITS-CLIP	23824327
MIRT622535	hsa-miR-380-3p	HITS-CLIP	23824327
MIRT622534	hsa-miR-105-5p	HITS-CLIP	23824327
MIRT622533	hsa-miR-7853-5p	HITS-CLIP	23824327
MIRT622532	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT639786	hsa-miR-4775	HITS-CLIP	23824327
MIRT622531	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT622536	hsa-miR-888-5p	HITS-CLIP	23824327
MIRT622535	hsa-miR-380-3p	HITS-CLIP	23824327
MIRT622534	hsa-miR-105-5p	HITS-CLIP	23824327
MIRT622533	hsa-miR-7853-5p	HITS-CLIP	23824327
MIRT622532	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT622531	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT622536	hsa-miR-888-5p	HITS-CLIP	23824327
MIRT622535	hsa-miR-380-3p	HITS-CLIP	23824327
MIRT622534	hsa-miR-105-5p	HITS-CLIP	23824327
MIRT622533	hsa-miR-7853-5p	HITS-CLIP	23824327
MIRT622532	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT622531	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT639787	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT622536	hsa-miR-888-5p	HITS-CLIP	23824327
MIRT622535	hsa-miR-380-3p	HITS-CLIP	23824327
MIRT622534	hsa-miR-105-5p	HITS-CLIP	23824327
MIRT622533	hsa-miR-7853-5p	HITS-CLIP	23824327
MIRT622532	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT639786	hsa-miR-4775	HITS-CLIP	23824327
MIRT622531	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT639787	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT622536	hsa-miR-888-5p	HITS-CLIP	23824327
MIRT622535	hsa-miR-380-3p	HITS-CLIP	23824327
MIRT622534	hsa-miR-105-5p	HITS-CLIP	23824327
MIRT622533	hsa-miR-7853-5p	HITS-CLIP	23824327
MIRT622532	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT639786	hsa-miR-4775	HITS-CLIP	23824327
MIRT622531	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT622536	hsa-miR-888-5p	HITS-CLIP	23824327
MIRT622535	hsa-miR-380-3p	HITS-CLIP	23824327
MIRT622534	hsa-miR-105-5p	HITS-CLIP	23824327
MIRT622533	hsa-miR-7853-5p	HITS-CLIP	23824327
MIRT622532	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT622531	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT622536	hsa-miR-888-5p	HITS-CLIP	23824327
MIRT622535	hsa-miR-380-3p	HITS-CLIP	23824327
MIRT622534	hsa-miR-105-5p	HITS-CLIP	23824327
MIRT622533	hsa-miR-7853-5p	HITS-CLIP	23824327
MIRT622532	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT622531	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT1286088	hsa-miR-132	CLIP-seq
MIRT1286089	hsa-miR-136	CLIP-seq
MIRT1286090	hsa-miR-200b	CLIP-seq
MIRT1286091	hsa-miR-200c	CLIP-seq
MIRT1286092	hsa-miR-203	CLIP-seq
MIRT1286093	hsa-miR-2114	CLIP-seq
MIRT1286094	hsa-miR-212	CLIP-seq
MIRT1286095	hsa-miR-219-1-3p	CLIP-seq
MIRT1286096	hsa-miR-3154	CLIP-seq
MIRT1286097	hsa-miR-3163	CLIP-seq
MIRT1286098	hsa-miR-3179	CLIP-seq
MIRT1286099	hsa-miR-3187-3p	CLIP-seq
MIRT1286100	hsa-miR-3190	CLIP-seq
MIRT1286101	hsa-miR-361-5p	CLIP-seq
MIRT1286102	hsa-miR-3909	CLIP-seq
MIRT1286103	hsa-miR-3926	CLIP-seq
MIRT1286104	hsa-miR-4256	CLIP-seq
MIRT1286105	hsa-miR-4277	CLIP-seq
MIRT1286106	hsa-miR-4282	CLIP-seq
MIRT1286107	hsa-miR-429	CLIP-seq
MIRT1286108	hsa-miR-4307	CLIP-seq
MIRT1286109	hsa-miR-4435	CLIP-seq
MIRT1286110	hsa-miR-4640-5p	CLIP-seq
MIRT1286111	hsa-miR-4701-5p	CLIP-seq
MIRT1286112	hsa-miR-4704-3p	CLIP-seq
MIRT1286113	hsa-miR-4726-5p	CLIP-seq
MIRT1286114	hsa-miR-4731-3p	CLIP-seq
MIRT1286115	hsa-miR-4752	CLIP-seq
MIRT1286116	hsa-miR-4777-3p	CLIP-seq
MIRT1286117	hsa-miR-4778-3p	CLIP-seq
MIRT1286118	hsa-miR-4801	CLIP-seq
MIRT1286119	hsa-miR-548s	CLIP-seq
MIRT1286120	hsa-miR-571	CLIP-seq
MIRT1286121	hsa-miR-577	CLIP-seq
MIRT1286122	hsa-miR-579	CLIP-seq
MIRT1286123	hsa-miR-588	CLIP-seq
MIRT1286124	hsa-miR-642a	CLIP-seq
MIRT1286125	hsa-miR-875-5p	CLIP-seq
MIRT1552865	hsa-miR-4324	CLIP-seq
MIRT2084852	hsa-miR-1245b-3p	CLIP-seq
MIRT2084853	hsa-miR-3120-5p	CLIP-seq
MIRT2084854	hsa-miR-3675-3p	CLIP-seq
MIRT2084855	hsa-miR-4652-3p	CLIP-seq
MIRT2084856	hsa-miR-488	CLIP-seq
MIRT2084857	hsa-miR-582-5p	CLIP-seq
MIRT2084858	hsa-miR-668	CLIP-seq
MIRT2310197	hsa-miR-1208	CLIP-seq
MIRT2310198	hsa-miR-1224-3p	CLIP-seq
MIRT2310199	hsa-miR-1260	CLIP-seq
MIRT2310200	hsa-miR-1260b	CLIP-seq
MIRT2310201	hsa-miR-1280	CLIP-seq
MIRT2310202	hsa-miR-1343	CLIP-seq
MIRT2310203	hsa-miR-15a	CLIP-seq
MIRT2310204	hsa-miR-15b	CLIP-seq
MIRT2310205	hsa-miR-16	CLIP-seq
MIRT2310206	hsa-miR-195	CLIP-seq
MIRT2310207	hsa-miR-3065-3p	CLIP-seq
MIRT2310208	hsa-miR-3127-3p	CLIP-seq
MIRT2310209	hsa-miR-3135	CLIP-seq
MIRT2310210	hsa-miR-3176	CLIP-seq
MIRT2310211	hsa-miR-3667-3p	CLIP-seq
MIRT2310212	hsa-miR-3668	CLIP-seq
MIRT2310213	hsa-miR-3922-3p	CLIP-seq
MIRT2310214	hsa-miR-3973	CLIP-seq
MIRT2310215	hsa-miR-424	CLIP-seq
MIRT2310216	hsa-miR-4436b-5p	CLIP-seq
MIRT2310217	hsa-miR-4520a-3p	CLIP-seq
MIRT2310218	hsa-miR-4520b-3p	CLIP-seq
MIRT2310219	hsa-miR-4524	CLIP-seq
MIRT2310220	hsa-miR-455-3p	CLIP-seq
MIRT2310221	hsa-miR-4640-3p	CLIP-seq
MIRT2310222	hsa-miR-4703-3p	CLIP-seq
MIRT2084856	hsa-miR-488	CLIP-seq
MIRT2310223	hsa-miR-497	CLIP-seq
MIRT2310224	hsa-miR-503	CLIP-seq
MIRT2310225	hsa-miR-520g	CLIP-seq
MIRT2310226	hsa-miR-520h	CLIP-seq
MIRT2310227	hsa-miR-549	CLIP-seq
MIRT2310228	hsa-miR-584	CLIP-seq
MIRT2310229	hsa-miR-630	CLIP-seq
MIRT2310230	hsa-miR-646	CLIP-seq
MIRT2310222	hsa-miR-4703-3p	CLIP-seq

Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003924	Function	GTPase activity	IEA
GO:0003925	Function	G protein activity	IDA	8164745
GO:0003925	Function	G protein activity	IEA
GO:0005515	Function	Protein binding	IPI	19490898, 20048159
GO:0005525	Function	GTP binding	IEA
GO:0005764	Component	Lysosome	IBA
GO:0005770	Component	Late endosome	IBA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006898	Process	Receptor-mediated endocytosis	IDA	8164745
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0019003	Function	GDP binding	IDA	20937701
GO:0030667	Component	Secretory granule membrane	TAS
GO:0030670	Component	Phagocytic vesicle membrane	IEA
GO:0031090	Component	Organelle membrane	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0032482	Process	Rab protein signal transduction	IEA
GO:0042147	Process	Retrograde transport, endosome to Golgi	IBA
GO:0042802	Function	Identical protein binding	IEA
GO:0045335	Component	Phagocytic vesicle	IBA
GO:0045335	Component	Phagocytic vesicle	IDA	21255211
GO:0045335	Component	Phagocytic vesicle	IEA

MIM	HGNC	e!Ensembl
300285	14090	ENSG00000123570

Q9NP90

Protein name

Ras-related protein Rab-9B (EC 3.6.5.2) (Rab-9-like protein) (Rab-9L)

Protein function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to r

PDB

2OCB

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00071	Ras	9 → 174	Ras family	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:11043518}.

Sequence

MSGKSLLLKVILLGDGGVGKSSLMNRYVTNKFDSQAFHTIGVEFLNRDLEVDGRFVTLQI
WDTAGQERFKSLRTPFYRGADCCLLTFSVDDRQSFENLGNWQKEFIYYADVKDPEHFPFV
VLGNKVDKEDRQVTTEEAQTWCMENGDYPYLETSAKDDTNVTVAFEEAVRQVLAVEEQLE
HCMLGHTIDLNSGSKAGSSCC

Sequence length

201

Interactions

View interactions

	KEGG		Reactome
	Salmonella infection Measles		Neutrophil degranulation Retrograde transport at the Trans-Golgi-Network RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
AUDITORY NEUROPATHY SPECTRUM DISORDER	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INTELLECTUAL DISABILITY	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PELIZAEUS-MERZBACHER DISEASE	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PELIZAEUS-MERZBACHER DISEASE, ATYPICAL	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SPASTIC PARAPLEGIA 2, X-LINKED	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SPASTIC PARAPLEGIA, HEREDITARY	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Lymphohistiocytosis Hemophagocytic	Associate	35902954	★★★★★ ★☆☆☆☆ Found in Text Mining only

RAB9B (RAB9B, member RAS oncogene family)