NUSAP1 (nucleolar and spindle associated protein 1)

Gene

• Entrez ID: 51203
• Gene name: Nucleolar and spindle associated protein 1
• Gene symbol: NUSAP1
• Synonyms (NCBI Gene): ANKT, BM037, LNP, NUSAP, PRO0310p1, Q0310, SAPL
• Chromosome: 15
• Chromosome location: 15q15.1
• Summary: NUSAP1 is a nucleolar-spindle-associated protein that plays a role in spindle microtubule organization (Raemaekers et al., 2003 [PubMed 12963707]).[supplied by OMIM, Jun 2009]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT052111	hsa-let-7b-5p	CLASH	23622248
MIRT1200221	hsa-miR-1252	CLIP-seq
MIRT1200222	hsa-miR-186	CLIP-seq
MIRT1200223	hsa-miR-3163	CLIP-seq
MIRT1200224	hsa-miR-3662	CLIP-seq
MIRT1200225	hsa-miR-4261	CLIP-seq
MIRT1200226	hsa-miR-4496	CLIP-seq
MIRT1200227	hsa-miR-4733-5p	CLIP-seq
MIRT1200228	hsa-miR-4802-3p	CLIP-seq
MIRT1200229	hsa-miR-494	CLIP-seq
MIRT1200230	hsa-miR-548aa	CLIP-seq
MIRT1200231	hsa-miR-548ac	CLIP-seq
MIRT1200232	hsa-miR-548ae	CLIP-seq
MIRT1200233	hsa-miR-548aj	CLIP-seq
MIRT1200234	hsa-miR-548am	CLIP-seq
MIRT1200235	hsa-miR-548d-3p	CLIP-seq
MIRT1200236	hsa-miR-548x	CLIP-seq
MIRT1200237	hsa-miR-548z	CLIP-seq
MIRT1200238	hsa-miR-587	CLIP-seq
MIRT1200239	hsa-miR-10a	CLIP-seq
MIRT1200240	hsa-miR-10b	CLIP-seq
MIRT1200241	hsa-miR-1185	CLIP-seq
MIRT1200221	hsa-miR-1252	CLIP-seq
MIRT1200242	hsa-miR-128	CLIP-seq
MIRT1200243	hsa-miR-1285	CLIP-seq
MIRT1200244	hsa-miR-2277-3p	CLIP-seq
MIRT1200245	hsa-miR-3117-5p	CLIP-seq
MIRT1200246	hsa-miR-3120-3p	CLIP-seq
MIRT1200247	hsa-miR-3145-3p	CLIP-seq
MIRT1200223	hsa-miR-3163	CLIP-seq
MIRT1200248	hsa-miR-3187-5p	CLIP-seq
MIRT1200249	hsa-miR-339-5p	CLIP-seq
MIRT1200250	hsa-miR-3605-5p	CLIP-seq
MIRT1200251	hsa-miR-3613-3p	CLIP-seq
MIRT1200252	hsa-miR-3679-5p	CLIP-seq
MIRT1200225	hsa-miR-4261	CLIP-seq
MIRT1200253	hsa-miR-4275	CLIP-seq
MIRT1200254	hsa-miR-4282	CLIP-seq
MIRT1200255	hsa-miR-4421	CLIP-seq
MIRT1200226	hsa-miR-4496	CLIP-seq
MIRT1200256	hsa-miR-4524	CLIP-seq
MIRT1200257	hsa-miR-4666-5p	CLIP-seq
MIRT1200258	hsa-miR-4672	CLIP-seq
MIRT1200259	hsa-miR-4725-5p	CLIP-seq
MIRT1200260	hsa-miR-4786-5p	CLIP-seq
MIRT1200228	hsa-miR-4802-3p	CLIP-seq
MIRT1200229	hsa-miR-494	CLIP-seq
MIRT1200261	hsa-miR-504	CLIP-seq
MIRT1200262	hsa-miR-5096	CLIP-seq
MIRT1200263	hsa-miR-520d-5p	CLIP-seq
MIRT1200264	hsa-miR-524-5p	CLIP-seq
MIRT1200265	hsa-miR-545	CLIP-seq
MIRT1200266	hsa-miR-548a-3p	CLIP-seq
MIRT1200267	hsa-miR-548e	CLIP-seq
MIRT1200268	hsa-miR-548f	CLIP-seq
MIRT1200269	hsa-miR-548p	CLIP-seq
MIRT1200270	hsa-miR-593	CLIP-seq
MIRT1200271	hsa-miR-612	CLIP-seq
MIRT1200272	hsa-miR-661	CLIP-seq
MIRT1200273	hsa-miR-769-5p	CLIP-seq
MIRT1200274	hsa-miR-887	CLIP-seq
MIRT1200245	hsa-miR-3117-5p	CLIP-seq
MIRT2057999	hsa-miR-3156-5p	CLIP-seq
MIRT1200223	hsa-miR-3163	CLIP-seq
MIRT2058000	hsa-miR-3919	CLIP-seq
MIRT2058001	hsa-miR-3942-3p	CLIP-seq
MIRT1200256	hsa-miR-4524	CLIP-seq
MIRT1200258	hsa-miR-4672	CLIP-seq
MIRT2058002	hsa-miR-4756-3p	CLIP-seq
MIRT1200238	hsa-miR-587	CLIP-seq
MIRT1200221	hsa-miR-1252	CLIP-seq
MIRT1200225	hsa-miR-4261	CLIP-seq
MIRT1200226	hsa-miR-4496	CLIP-seq
MIRT1200228	hsa-miR-4802-3p	CLIP-seq
MIRT1200229	hsa-miR-494	CLIP-seq
MIRT2455567	hsa-miR-3976	CLIP-seq
MIRT2455568	hsa-miR-4693-3p	CLIP-seq
MIRT2455569	hsa-miR-4709-3p	CLIP-seq
MIRT2584291	hsa-miR-3148	CLIP-seq
MIRT1200254	hsa-miR-4282	CLIP-seq
MIRT1200263	hsa-miR-520d-5p	CLIP-seq
MIRT1200264	hsa-miR-524-5p	CLIP-seq
MIRT2584291	hsa-miR-3148	CLIP-seq
MIRT1200254	hsa-miR-4282	CLIP-seq
MIRT1200263	hsa-miR-520d-5p	CLIP-seq
MIRT1200264	hsa-miR-524-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000070	Process	Mitotic sister chromatid segregation	IDA	12963707
GO:0000226	Process	Microtubule cytoskeleton organization	IEA
GO:0000281	Process	Mitotic cytokinesis	IBA
GO:0000281	Process	Mitotic cytokinesis	IDA	12963707
GO:0000281	Process	Mitotic cytokinesis	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674
GO:0005515	Function	Protein binding	IPI	25416956, 39212774
GO:0005634	Component	Nucleus	IEA
GO:0005694	Component	Chromosome	IEA
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005819	Component	Spindle	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0007076	Process	Mitotic chromosome condensation	IBA
GO:0007076	Process	Mitotic chromosome condensation	IDA	12963707
GO:0008017	Function	Microtubule binding	IBA
GO:0008017	Function	Microtubule binding	IEA
GO:0040001	Process	Establishment of mitotic spindle localization	IBA
GO:0040001	Process	Establishment of mitotic spindle localization	IDA	12963707
GO:0040001	Process	Establishment of mitotic spindle localization	IEA
GO:0045840	Process	Positive regulation of mitotic nuclear division	IDA	12963707
GO:0051301	Process	Cell division	IEA
GO:0072686	Component	Mitotic spindle	IBA
GO:0072686	Component	Mitotic spindle	IEA

Other IDs

• MIM: 612818
• HGNC: 18538
• e!Ensembl: ENSG00000137804

Protein

• UniProt ID: Q9BXS6
• Protein name: Nucleolar and spindle-associated protein 1 (NuSAP)
• Protein function: Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them. {ECO:0000250, ECO:0000269|PubMed:1296
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF16006	NUSAP	158 → 436	Nucleolar and spindle-associated protein	Family

• Sequence:

  MIIPSLEELDSLKYSDLQNLAKSLGLRANLRATKLLKALKGYIKHEARKGNENQDESQTS
  ASSCDETEIQISNQEEAERQPLGHVTKTRRRCKTVRVDPDSQQNHSEIKISNPTEFQNHE
  KQESQDLRATAKVPSPPDEHQEAENAVSSGNRDSKVPSEGKKSLYTDESSKPGKNKRTAI
  TTPNFKKLHEAHFKEMESIDQYIERKKKHFEEHNSMNELKQQPINKGGVRTPVPPRGRLS
  VASTPISQRRSQGRSCGPASQSTLGLKGSLKRSAISAAKTGVRFSAATKDNEHKRSLTKT
  PARKSAHVTVSGGTPKGEAVLGTHKLKTITGNSAAVITPFKLTTEATQTPVSNKKPVFDL
  KASLSRPLNYEPHKGKLKPWGQSKENNYLNQHVNRINFYKKTYKQPHLQTKEEQRKKREQ
  ERKEKKAKVLGMRRGLILAED

• Sequence length: 441

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