Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	51201
Gene name Gene Name - the full gene name approved by the HGNC.	ZDHHC palmitoyltransferase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ZDHHC2
Synonyms (NCBI Gene) Gene synonyms aliases	DHHC2, ZNF372
Chromosome Chromosome number	8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	8p22

Show/Hide all(140)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021821	hsa-miR-132-3p	Microarray	17612493
MIRT024885	hsa-miR-215-5p	Microarray	19074876
MIRT026589	hsa-miR-192-5p	Microarray	19074876
MIRT450460	hsa-miR-154-3p	PAR-CLIP	22100165
MIRT450459	hsa-miR-487a-3p	PAR-CLIP	22100165
MIRT450458	hsa-miR-1279	PAR-CLIP	22100165
MIRT450457	hsa-miR-4251	PAR-CLIP	22100165
MIRT450456	hsa-miR-4329	PAR-CLIP	22100165
MIRT450455	hsa-miR-6761-5p	PAR-CLIP	22100165
MIRT450454	hsa-miR-4635	PAR-CLIP	22100165
MIRT450453	hsa-miR-5186	PAR-CLIP	22100165
MIRT450452	hsa-miR-4303	PAR-CLIP	22100165
MIRT450451	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT450450	hsa-miR-7843-3p	PAR-CLIP	22100165
MIRT450449	hsa-miR-127-5p	PAR-CLIP	22100165
MIRT450448	hsa-miR-4762-3p	PAR-CLIP	22100165
MIRT450447	hsa-miR-578	PAR-CLIP	22100165
MIRT439239	hsa-miR-541-5p	HITS-CLIP	24374217
MIRT439239	hsa-miR-541-5p	HITS-CLIP	24374217
MIRT450460	hsa-miR-154-3p	PAR-CLIP	22100165
MIRT450459	hsa-miR-487a-3p	PAR-CLIP	22100165
MIRT450458	hsa-miR-1279	PAR-CLIP	22100165
MIRT450457	hsa-miR-4251	PAR-CLIP	22100165
MIRT450456	hsa-miR-4329	PAR-CLIP	22100165
MIRT450455	hsa-miR-6761-5p	PAR-CLIP	22100165
MIRT450454	hsa-miR-4635	PAR-CLIP	22100165
MIRT450453	hsa-miR-5186	PAR-CLIP	22100165
MIRT450452	hsa-miR-4303	PAR-CLIP	22100165
MIRT450451	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT450450	hsa-miR-7843-3p	PAR-CLIP	22100165
MIRT450449	hsa-miR-127-5p	PAR-CLIP	22100165
MIRT450448	hsa-miR-4762-3p	PAR-CLIP	22100165
MIRT450447	hsa-miR-578	PAR-CLIP	22100165
MIRT1508415	hsa-miR-1236	CLIP-seq
MIRT1508416	hsa-miR-1248	CLIP-seq
MIRT1508417	hsa-miR-1914	CLIP-seq
MIRT1508418	hsa-miR-2054	CLIP-seq
MIRT1508419	hsa-miR-302f	CLIP-seq
MIRT1508420	hsa-miR-3064-3p	CLIP-seq
MIRT1508421	hsa-miR-3171	CLIP-seq
MIRT1508422	hsa-miR-3180-5p	CLIP-seq
MIRT1508423	hsa-miR-338-3p	CLIP-seq
MIRT1508424	hsa-miR-3660	CLIP-seq
MIRT1508425	hsa-miR-3667-3p	CLIP-seq
MIRT1508426	hsa-miR-380	CLIP-seq
MIRT1508427	hsa-miR-4252	CLIP-seq
MIRT1508428	hsa-miR-4256	CLIP-seq
MIRT1508429	hsa-miR-4475	CLIP-seq
MIRT1508430	hsa-miR-4502	CLIP-seq
MIRT1508431	hsa-miR-4526	CLIP-seq
MIRT1508432	hsa-miR-4530	CLIP-seq
MIRT1508433	hsa-miR-4648	CLIP-seq
MIRT1508434	hsa-miR-4654	CLIP-seq
MIRT1508435	hsa-miR-4715-3p	CLIP-seq
MIRT1508436	hsa-miR-4747-5p	CLIP-seq
MIRT1508437	hsa-miR-4769-5p	CLIP-seq
MIRT1508438	hsa-miR-4776-3p	CLIP-seq
MIRT1508439	hsa-miR-4778-5p	CLIP-seq
MIRT1508440	hsa-miR-544	CLIP-seq
MIRT1508441	hsa-miR-548ag	CLIP-seq
MIRT1508442	hsa-miR-548ai	CLIP-seq
MIRT1508443	hsa-miR-548m	CLIP-seq
MIRT1508444	hsa-miR-570	CLIP-seq
MIRT1508445	hsa-miR-630	CLIP-seq
MIRT1508446	hsa-miR-671-5p	CLIP-seq
MIRT1508447	hsa-miR-922	CLIP-seq
MIRT2153185	hsa-miR-2116	CLIP-seq
MIRT1508422	hsa-miR-3180-5p	CLIP-seq
MIRT2153186	hsa-miR-3662	CLIP-seq
MIRT2153187	hsa-miR-4677-5p	CLIP-seq
MIRT2153188	hsa-miR-889	CLIP-seq
MIRT2373444	hsa-miR-3128	CLIP-seq
MIRT2373445	hsa-miR-331-5p	CLIP-seq
MIRT2373446	hsa-miR-4678	CLIP-seq
MIRT2373447	hsa-miR-4720-5p	CLIP-seq
MIRT2373448	hsa-miR-4799-3p	CLIP-seq
MIRT2397327	hsa-miR-653	CLIP-seq
MIRT2434931	hsa-miR-1297	CLIP-seq
MIRT2434932	hsa-miR-26a	CLIP-seq
MIRT2434933	hsa-miR-26b	CLIP-seq
MIRT2434934	hsa-miR-4424	CLIP-seq
MIRT2434935	hsa-miR-4444	CLIP-seq
MIRT2434936	hsa-miR-4465	CLIP-seq
MIRT2434937	hsa-miR-513a-3p	CLIP-seq
MIRT2434938	hsa-miR-548a-5p	CLIP-seq
MIRT2434939	hsa-miR-548ab	CLIP-seq
MIRT1508441	hsa-miR-548ag	CLIP-seq
MIRT1508442	hsa-miR-548ai	CLIP-seq
MIRT2434940	hsa-miR-548ak	CLIP-seq
MIRT2434941	hsa-miR-548b-5p	CLIP-seq
MIRT2434942	hsa-miR-548c-5p	CLIP-seq
MIRT2434943	hsa-miR-548d-5p	CLIP-seq
MIRT2434944	hsa-miR-548h	CLIP-seq
MIRT2434945	hsa-miR-548i	CLIP-seq
MIRT2434946	hsa-miR-548j	CLIP-seq
MIRT2434947	hsa-miR-548k	CLIP-seq
MIRT2434948	hsa-miR-548l	CLIP-seq
MIRT1508443	hsa-miR-548m	CLIP-seq
MIRT2434949	hsa-miR-548w	CLIP-seq
MIRT2434950	hsa-miR-548y	CLIP-seq
MIRT2434951	hsa-miR-559	CLIP-seq
MIRT2666198	hsa-miR-101	CLIP-seq
MIRT2666199	hsa-miR-132	CLIP-seq
MIRT2666200	hsa-miR-212	CLIP-seq
MIRT2666201	hsa-miR-3153	CLIP-seq
MIRT2666202	hsa-miR-3163	CLIP-seq
MIRT2666203	hsa-miR-3679-3p	CLIP-seq
MIRT2666204	hsa-miR-410	CLIP-seq
MIRT2666205	hsa-miR-4318	CLIP-seq
MIRT2666206	hsa-miR-4421	CLIP-seq
MIRT2666207	hsa-miR-4446-5p	CLIP-seq
MIRT1508433	hsa-miR-4648	CLIP-seq
MIRT1508434	hsa-miR-4654	CLIP-seq
MIRT2666208	hsa-miR-4668-3p	CLIP-seq
MIRT2666209	hsa-miR-4668-5p	CLIP-seq
MIRT2666210	hsa-miR-4688	CLIP-seq
MIRT2666211	hsa-miR-4753-3p	CLIP-seq
MIRT2666212	hsa-miR-4768-5p	CLIP-seq
MIRT1508437	hsa-miR-4769-5p	CLIP-seq
MIRT2666213	hsa-miR-548c-3p	CLIP-seq
MIRT2666214	hsa-miR-548u	CLIP-seq
MIRT2666215	hsa-miR-605	CLIP-seq
MIRT2666216	hsa-miR-642a	CLIP-seq
MIRT2666217	hsa-miR-944	CLIP-seq
MIRT2666198	hsa-miR-101	CLIP-seq
MIRT2666199	hsa-miR-132	CLIP-seq
MIRT2666200	hsa-miR-212	CLIP-seq
MIRT2666201	hsa-miR-3153	CLIP-seq
MIRT2666202	hsa-miR-3163	CLIP-seq
MIRT2666204	hsa-miR-410	CLIP-seq
MIRT2666205	hsa-miR-4318	CLIP-seq
MIRT1508433	hsa-miR-4648	CLIP-seq
MIRT1508434	hsa-miR-4654	CLIP-seq
MIRT2666209	hsa-miR-4668-5p	CLIP-seq
MIRT2666210	hsa-miR-4688	CLIP-seq
MIRT2666211	hsa-miR-4753-3p	CLIP-seq
MIRT2666212	hsa-miR-4768-5p	CLIP-seq
MIRT1508437	hsa-miR-4769-5p	CLIP-seq
MIRT2666214	hsa-miR-548u	CLIP-seq
MIRT2666217	hsa-miR-944	CLIP-seq

Show/Hide all(34)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0005783	Component	Endoplasmic reticulum	IBA	21873635
GO:0005783	Component	Endoplasmic reticulum	IDA	16647879
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	22034844
GO:0005794	Component	Golgi apparatus	IBA	21873635
GO:0005794	Component	Golgi apparatus	IDA	16647879, 18508921, 22034844
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IEA
GO:0006612	Process	Protein targeting to membrane	IBA	21873635
GO:0014069	Component	Postsynaptic density	ISS
GO:0016188	Process	Synaptic vesicle maturation	IBA	21873635
GO:0016409	Function	Palmitoyltransferase activity	IDA	23034182
GO:0016409	Function	Palmitoyltransferase activity	TAS
GO:0018215	Process	Protein phosphopantetheinylation	IEA
GO:0018230	Process	Peptidyl-L-cysteine S-palmitoylation	IBA	21873635
GO:0018230	Process	Peptidyl-L-cysteine S-palmitoylation	IDA	23793055
GO:0018230	Process	Peptidyl-L-cysteine S-palmitoylation	IMP	18296695, 18508921, 22034844
GO:0018345	Process	Protein palmitoylation	IDA	23034182
GO:0019706	Function	Protein-cysteine S-palmitoyltransferase activity	IBA	21873635
GO:0019706	Function	Protein-cysteine S-palmitoyltransferase activity	IDA	23793055
GO:0022407	Process	Regulation of cell-cell adhesion	IMP	18508921
GO:0042176	Process	Regulation of protein catabolic process	IMP	18508921
GO:0042803	Function	Protein homodimerization activity	IDA	23793055
GO:0044267	Process	Cellular protein metabolic process	TAS
GO:0048168	Process	Regulation of neuronal synaptic plasticity	ISS
GO:0055038	Component	Recycling endosome membrane	IEA
GO:0072659	Process	Protein localization to plasma membrane	ISS
GO:0098837	Component	Postsynaptic recycling endosome	ISS
GO:1900273	Process	Positive regulation of long-term synaptic potentiation	ISS
GO:1903076	Process	Regulation of protein localization to plasma membrane	IMP	18296695
GO:1903539	Process	Protein localization to postsynaptic membrane	ISS
GO:1904719	Process	Positive regulation of AMPA glutamate receptor clustering	ISS
GO:1905751	Process	Positive regulation of endosome to plasma membrane protein transport	ISS

MIM	HGNC	e!Ensembl
618621	18469	ENSG00000104219

Protein

UniProt ID

Q9UIJ5

Protein name

Palmitoyltransferase ZDHHC2 (EC 2.3.1.225) (Acyltransferase ZDHHC2) (EC 2.3.1.-) (Reduced expression associated with metastasis protein) (Ream) (Reduced expression in cancer protein) (Rec) (Zinc finger DHHC domain-containing protein 2) (DHHC-2) (Zinc fing

Protein function

Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PubMed:18296695, PubMed:18508921, PubMed:19144824, PubMed:21343290, PubMed:22034844, PubMed:2379305

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01529	DHHC	123 → 249	DHHC palmitoyltransferase	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed (PubMed:10918388, PubMed:22034844). Reduced expression in colorectal cancers with liver metastasis (PubMed:10918388). {ECO:0000269|PubMed:10918388, ECO:0000269|PubMed:22034844}.

Sequence

MAPSGPGSSARRRCRRVLYWIPVVFITLLLGWSYYAYAIQLCIVSMENTGEQVVCLMAYH
LLFAMFVWSYWKTIFTLPMNPSKEFHLSYAEKDLLEREPRGEAHQEVLRRAAKDLPIYTR
TMSGAIRYCDRCQLIKPDRCHHCSVCDKCILKMDHHCPWVNNCVGFSNYKFFLLFLAYSL
LYCLFIAATDLQYFIKFWTNGLPDTQAKFHIMFLFFAAAMFSVSLSSLFGYHCWLVSKNK
STLEAFRSPVFRHGTDKNGFSLGFSKNMRQVFGDEKKYWLLPIFSSLGDGCSFPTCLVNQ
DPEQASTPAGLNSTAKNLENHQFPAKPLRESQSHLLTDSQSWTESSINPGKCKAGMSNPA
LTMENET

Sequence length

367

Interactions

View interactions

	Reactome
			Surfactant metabolism

Show/Hide Causal Diseases (4)

Disease term	Disease name	dbSNP ID	References
Causal
Colorectal cancer	Colorectal Carcinoma	rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800 View all (467 more)
Hypertension	Hypertensive disease	rs13306026	27802415
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297	27903959
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	26198764, 30285260, 28991256

Show/Hide Text Mining Associations (16)

Disease Name	Relationship Type	References
Associations from Text Mining
Carcinogenesis	Associate	19144824
Carcinoma Hepatocellular	Associate	24863391
Carcinoma Hepatocellular	Inhibit	24995331
Castleman Disease	Associate	34686774
Cognition Disorders	Associate	33757599
Cystitis Interstitial	Associate	19144824
Glioblastoma	Associate	30628650
Leiomyoma	Associate	36948524
Leukemia Myeloid Acute	Associate	29688850
Leukemia Myelomonocytic Acute	Associate	29688850
Lymphatic Metastasis	Inhibit	23457560
Neoplasm Metastasis	Inhibit	23457560, 24995331
Neoplasms	Associate	16270321, 23457560, 36948524
Neoplasms	Inhibit	19144824, 24995331
Ovarian Neoplasms	Associate	16270321
Stomach Neoplasms	Inhibit	23457560

ZDHHC2 (zDHHC palmitoyltransferase 2)