Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	51201
Gene name	ZDHHC palmitoyltransferase 2
Gene symbol	ZDHHC2
Synonyms (NCBI Gene)	DHHC2ZNF372
Chromosome	8
Chromosome location	8p22

140

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miRTarBase ID	miRNA	Experiments	Reference
MIRT021821	hsa-miR-132-3p	Microarray	17612493
MIRT024885	hsa-miR-215-5p	Microarray	19074876
MIRT026589	hsa-miR-192-5p	Microarray	19074876
MIRT450460	hsa-miR-154-3p	PAR-CLIP	22100165
MIRT450459	hsa-miR-487a-3p	PAR-CLIP	22100165
MIRT450458	hsa-miR-1279	PAR-CLIP	22100165
MIRT450457	hsa-miR-4251	PAR-CLIP	22100165
MIRT450456	hsa-miR-4329	PAR-CLIP	22100165
MIRT450455	hsa-miR-6761-5p	PAR-CLIP	22100165
MIRT450454	hsa-miR-4635	PAR-CLIP	22100165
MIRT450453	hsa-miR-5186	PAR-CLIP	22100165
MIRT450452	hsa-miR-4303	PAR-CLIP	22100165
MIRT450451	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT450450	hsa-miR-7843-3p	PAR-CLIP	22100165
MIRT450449	hsa-miR-127-5p	PAR-CLIP	22100165
MIRT450448	hsa-miR-4762-3p	PAR-CLIP	22100165
MIRT450447	hsa-miR-578	PAR-CLIP	22100165
MIRT439239	hsa-miR-541-5p	HITS-CLIP	24374217
MIRT439239	hsa-miR-541-5p	HITS-CLIP	24374217
MIRT450460	hsa-miR-154-3p	PAR-CLIP	22100165
MIRT450459	hsa-miR-487a-3p	PAR-CLIP	22100165
MIRT450458	hsa-miR-1279	PAR-CLIP	22100165
MIRT450457	hsa-miR-4251	PAR-CLIP	22100165
MIRT450456	hsa-miR-4329	PAR-CLIP	22100165
MIRT450455	hsa-miR-6761-5p	PAR-CLIP	22100165
MIRT450454	hsa-miR-4635	PAR-CLIP	22100165
MIRT450453	hsa-miR-5186	PAR-CLIP	22100165
MIRT450452	hsa-miR-4303	PAR-CLIP	22100165
MIRT450451	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT450450	hsa-miR-7843-3p	PAR-CLIP	22100165
MIRT450449	hsa-miR-127-5p	PAR-CLIP	22100165
MIRT450448	hsa-miR-4762-3p	PAR-CLIP	22100165
MIRT450447	hsa-miR-578	PAR-CLIP	22100165
MIRT1508415	hsa-miR-1236	CLIP-seq
MIRT1508416	hsa-miR-1248	CLIP-seq
MIRT1508417	hsa-miR-1914	CLIP-seq
MIRT1508418	hsa-miR-2054	CLIP-seq
MIRT1508419	hsa-miR-302f	CLIP-seq
MIRT1508420	hsa-miR-3064-3p	CLIP-seq
MIRT1508421	hsa-miR-3171	CLIP-seq
MIRT1508422	hsa-miR-3180-5p	CLIP-seq
MIRT1508423	hsa-miR-338-3p	CLIP-seq
MIRT1508424	hsa-miR-3660	CLIP-seq
MIRT1508425	hsa-miR-3667-3p	CLIP-seq
MIRT1508426	hsa-miR-380	CLIP-seq
MIRT1508427	hsa-miR-4252	CLIP-seq
MIRT1508428	hsa-miR-4256	CLIP-seq
MIRT1508429	hsa-miR-4475	CLIP-seq
MIRT1508430	hsa-miR-4502	CLIP-seq
MIRT1508431	hsa-miR-4526	CLIP-seq
MIRT1508432	hsa-miR-4530	CLIP-seq
MIRT1508433	hsa-miR-4648	CLIP-seq
MIRT1508434	hsa-miR-4654	CLIP-seq
MIRT1508435	hsa-miR-4715-3p	CLIP-seq
MIRT1508436	hsa-miR-4747-5p	CLIP-seq
MIRT1508437	hsa-miR-4769-5p	CLIP-seq
MIRT1508438	hsa-miR-4776-3p	CLIP-seq
MIRT1508439	hsa-miR-4778-5p	CLIP-seq
MIRT1508440	hsa-miR-544	CLIP-seq
MIRT1508441	hsa-miR-548ag	CLIP-seq
MIRT1508442	hsa-miR-548ai	CLIP-seq
MIRT1508443	hsa-miR-548m	CLIP-seq
MIRT1508444	hsa-miR-570	CLIP-seq
MIRT1508445	hsa-miR-630	CLIP-seq
MIRT1508446	hsa-miR-671-5p	CLIP-seq
MIRT1508447	hsa-miR-922	CLIP-seq
MIRT2153185	hsa-miR-2116	CLIP-seq
MIRT1508422	hsa-miR-3180-5p	CLIP-seq
MIRT2153186	hsa-miR-3662	CLIP-seq
MIRT2153187	hsa-miR-4677-5p	CLIP-seq
MIRT2153188	hsa-miR-889	CLIP-seq
MIRT2373444	hsa-miR-3128	CLIP-seq
MIRT2373445	hsa-miR-331-5p	CLIP-seq
MIRT2373446	hsa-miR-4678	CLIP-seq
MIRT2373447	hsa-miR-4720-5p	CLIP-seq
MIRT2373448	hsa-miR-4799-3p	CLIP-seq
MIRT2397327	hsa-miR-653	CLIP-seq
MIRT2434931	hsa-miR-1297	CLIP-seq
MIRT2434932	hsa-miR-26a	CLIP-seq
MIRT2434933	hsa-miR-26b	CLIP-seq
MIRT2434934	hsa-miR-4424	CLIP-seq
MIRT2434935	hsa-miR-4444	CLIP-seq
MIRT2434936	hsa-miR-4465	CLIP-seq
MIRT2434937	hsa-miR-513a-3p	CLIP-seq
MIRT2434938	hsa-miR-548a-5p	CLIP-seq
MIRT2434939	hsa-miR-548ab	CLIP-seq
MIRT1508441	hsa-miR-548ag	CLIP-seq
MIRT1508442	hsa-miR-548ai	CLIP-seq
MIRT2434940	hsa-miR-548ak	CLIP-seq
MIRT2434941	hsa-miR-548b-5p	CLIP-seq
MIRT2434942	hsa-miR-548c-5p	CLIP-seq
MIRT2434943	hsa-miR-548d-5p	CLIP-seq
MIRT2434944	hsa-miR-548h	CLIP-seq
MIRT2434945	hsa-miR-548i	CLIP-seq
MIRT2434946	hsa-miR-548j	CLIP-seq
MIRT2434947	hsa-miR-548k	CLIP-seq
MIRT2434948	hsa-miR-548l	CLIP-seq
MIRT1508443	hsa-miR-548m	CLIP-seq
MIRT2434949	hsa-miR-548w	CLIP-seq
MIRT2434950	hsa-miR-548y	CLIP-seq
MIRT2434951	hsa-miR-559	CLIP-seq
MIRT2666198	hsa-miR-101	CLIP-seq
MIRT2666199	hsa-miR-132	CLIP-seq
MIRT2666200	hsa-miR-212	CLIP-seq
MIRT2666201	hsa-miR-3153	CLIP-seq
MIRT2666202	hsa-miR-3163	CLIP-seq
MIRT2666203	hsa-miR-3679-3p	CLIP-seq
MIRT2666204	hsa-miR-410	CLIP-seq
MIRT2666205	hsa-miR-4318	CLIP-seq
MIRT2666206	hsa-miR-4421	CLIP-seq
MIRT2666207	hsa-miR-4446-5p	CLIP-seq
MIRT1508433	hsa-miR-4648	CLIP-seq
MIRT1508434	hsa-miR-4654	CLIP-seq
MIRT2666208	hsa-miR-4668-3p	CLIP-seq
MIRT2666209	hsa-miR-4668-5p	CLIP-seq
MIRT2666210	hsa-miR-4688	CLIP-seq
MIRT2666211	hsa-miR-4753-3p	CLIP-seq
MIRT2666212	hsa-miR-4768-5p	CLIP-seq
MIRT1508437	hsa-miR-4769-5p	CLIP-seq
MIRT2666213	hsa-miR-548c-3p	CLIP-seq
MIRT2666214	hsa-miR-548u	CLIP-seq
MIRT2666215	hsa-miR-605	CLIP-seq
MIRT2666216	hsa-miR-642a	CLIP-seq
MIRT2666217	hsa-miR-944	CLIP-seq
MIRT2666198	hsa-miR-101	CLIP-seq
MIRT2666199	hsa-miR-132	CLIP-seq
MIRT2666200	hsa-miR-212	CLIP-seq
MIRT2666201	hsa-miR-3153	CLIP-seq
MIRT2666202	hsa-miR-3163	CLIP-seq
MIRT2666204	hsa-miR-410	CLIP-seq
MIRT2666205	hsa-miR-4318	CLIP-seq
MIRT1508433	hsa-miR-4648	CLIP-seq
MIRT1508434	hsa-miR-4654	CLIP-seq
MIRT2666209	hsa-miR-4668-5p	CLIP-seq
MIRT2666210	hsa-miR-4688	CLIP-seq
MIRT2666211	hsa-miR-4753-3p	CLIP-seq
MIRT2666212	hsa-miR-4768-5p	CLIP-seq
MIRT1508437	hsa-miR-4769-5p	CLIP-seq
MIRT2666214	hsa-miR-548u	CLIP-seq
MIRT2666217	hsa-miR-944	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0005768	Component	Endosome	IEA
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA	16647879
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	22034844
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005794	Component	Golgi apparatus	IBA
GO:0005794	Component	Golgi apparatus	IDA	16647879, 18508921, 22034844
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0006612	Process	Protein targeting to membrane	IBA
GO:0007416	Process	Synapse assembly	IBA
GO:0007416	Process	Synapse assembly	IEA
GO:0007416	Process	Synapse assembly	IMP	25589740
GO:0014069	Component	Postsynaptic density	IEA
GO:0014069	Component	Postsynaptic density	ISS
GO:0016020	Component	Membrane	IEA
GO:0016188	Process	Synaptic vesicle maturation	IBA
GO:0016409	Function	Palmitoyltransferase activity	IDA	23034182
GO:0016409	Function	Palmitoyltransferase activity	IEA
GO:0016409	Function	Palmitoyltransferase activity	TAS
GO:0016740	Function	Transferase activity	IEA
GO:0016746	Function	Acyltransferase activity	IEA
GO:0018230	Process	Peptidyl-L-cysteine S-palmitoylation	IDA	23793055
GO:0018230	Process	Peptidyl-L-cysteine S-palmitoylation	IMP	18296695, 18508921, 22034844
GO:0019705	Function	Protein-cysteine S-myristoyltransferase activity	IEA
GO:0019706	Function	Protein-cysteine S-palmitoyltransferase activity	IBA
GO:0019706	Function	Protein-cysteine S-palmitoyltransferase activity	IDA	23793055
GO:0019706	Function	Protein-cysteine S-palmitoyltransferase activity	IEA
GO:0022407	Process	Regulation of cell-cell adhesion	IMP	18508921
GO:0042176	Process	Regulation of protein catabolic process	IMP	18508921
GO:0042803	Function	Protein homodimerization activity	IDA	23793055
GO:0045202	Component	Synapse	IEA
GO:0048168	Process	Regulation of neuronal synaptic plasticity	IEA
GO:0048168	Process	Regulation of neuronal synaptic plasticity	ISS
GO:0055038	Component	Recycling endosome membrane	IEA
GO:0072659	Process	Protein localization to plasma membrane	IEA
GO:0072659	Process	Protein localization to plasma membrane	ISS
GO:0098837	Component	Postsynaptic recycling endosome	IEA
GO:0098837	Component	Postsynaptic recycling endosome	IMP	25589740
GO:0098837	Component	Postsynaptic recycling endosome	ISS
GO:0098944	Component	Postsynaptic recycling endosome membrane	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0140439	Function	Protein-cysteine S-stearoyltransferase activity	IEA
GO:0150054	Process	Regulation of postsynaptic neurotransmitter receptor diffusion trapping	IEA
GO:1900273	Process	Positive regulation of long-term synaptic potentiation	IEA
GO:1900273	Process	Positive regulation of long-term synaptic potentiation	ISS
GO:1903044	Process	Protein localization to membrane raft	IEA
GO:1903044	Process	Protein localization to membrane raft	IMP	25589740
GO:1903076	Process	Regulation of protein localization to plasma membrane	IMP	18296695
GO:1903539	Process	Protein localization to postsynaptic membrane	IEA
GO:1903539	Process	Protein localization to postsynaptic membrane	ISS
GO:1904719	Process	Positive regulation of AMPA glutamate receptor clustering	IEA
GO:1904719	Process	Positive regulation of AMPA glutamate receptor clustering	ISS
GO:1905751	Process	Positive regulation of endosome to plasma membrane protein transport	IEA
GO:1905751	Process	Positive regulation of endosome to plasma membrane protein transport	ISS

MIM	HGNC	e!Ensembl
618621	18469	ENSG00000104219

Q9UIJ5

Protein name

Palmitoyltransferase ZDHHC2 (EC 2.3.1.225) (Acyltransferase ZDHHC2) (EC 2.3.1.-) (Reduced expression associated with metastasis protein) (Ream) (Reduced expression in cancer protein) (Rec) (Zinc finger DHHC domain-containing protein 2) (DHHC-2) (Zinc fing

Protein function

Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PubMed:18296695, PubMed:18508921, PubMed:19144824, PubMed:21343290, PubMed:22034844, PubMed:2379305

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01529	DHHC	123 → 249	DHHC palmitoyltransferase	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed (PubMed:10918388, PubMed:22034844). Reduced expression in colorectal cancers with liver metastasis (PubMed:10918388). {ECO:0000269|PubMed:10918388, ECO:0000269|PubMed:22034844}.

Sequence

MAPSGPGSSARRRCRRVLYWIPVVFITLLLGWSYYAYAIQLCIVSMENTGEQVVCLMAYH
LLFAMFVWSYWKTIFTLPMNPSKEFHLSYAEKDLLEREPRGEAHQEVLRRAAKDLPIYTR
TMSGAIRYCDRCQLIKPDRCHHCSVCDKCILKMDHHCPWVNNCVGFSNYKFFLLFLAYSL
LYCLFIAATDLQYFIKFWTNGLPDTQAKFHIMFLFFAAAMFSVSLSSLFGYHCWLVSKNK
STLEAFRSPVFRHGTDKNGFSLGFSKNMRQVFGDEKKYWLLPIFSSLGDGCSFPTCLVNQ
DPEQASTPAGLNSTAKNLENHQFPAKPLRESQSHLLTDSQSWTESSINPGKCKAGMSNPA
LTMENET

Sequence length

367

Interactions

View interactions

	Reactome
			Surfactant metabolism

ZDHHC2 (zDHHC palmitoyltransferase 2)