Gene Gene information from NCBI Gene database.
Entrez ID 51200
Gene name Carboxypeptidase A4
Gene symbol CPA4
Synonyms (NCBI Gene)
CPA3
Chromosome 7
Chromosome location 7q32.2
Summary This gene is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and
miRNA miRNA information provided by mirtarbase database.
438
miRTarBase ID miRNA Experiments Reference
MIRT027514 hsa-miR-98-5p Microarray 19088304
MIRT029046 hsa-miR-26b-5p Microarray 19088304
MIRT625299 hsa-miR-8485 HITS-CLIP 23313552
MIRT625298 hsa-miR-6715a-3p HITS-CLIP 23313552
MIRT625299 hsa-miR-8485 HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
18
GO ID Ontology Definition Evidence Reference
GO:0004180 Function Carboxypeptidase activity IEA
GO:0004181 Function Metallocarboxypeptidase activity IBA
GO:0004181 Function Metallocarboxypeptidase activity IDA 20385563
GO:0004181 Function Metallocarboxypeptidase activity IEA
GO:0004181 Function Metallocarboxypeptidase activity NAS 10383164
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607635 15740 ENSG00000128510
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UI42
Protein name Carboxypeptidase A4 (EC 3.4.17.-) (Carboxypeptidase A3)
Protein function Metalloprotease that cleaves hydrophobic C-terminal residues with a preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val (PubMed:20385563). May function in peptide hormone and/or neuropeptide catabolism (PubMed:20385563). {ECO:0000269|PubMed:203
PDB 2BO9 , 2BOA , 2PCU , 4A94 , 4BD9
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02244 Propep_M14 27 101 Carboxypeptidase activation peptide Domain
PF00246 Peptidase_M14 129 408 Zinc carboxypeptidase Domain
Tissue specificity TISSUE SPECIFICITY: Fetal expression in the adrenal gland, brain, heart, intestine, kidney, liver and lung. Except for fetal brain that shows no imprinting, expression was found preferentially from the maternal allele.
Sequence
Sequence length 421
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
CPA4-related disorder Likely benign rs145012020 RCV003960679
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Breast Neoplasms Associate 30628666, 30875843, 33746592
Carcinoma Non Small Cell Lung Associate 33934493, 34233564
Colorectal Neoplasms Associate 27780921
Fetal Growth Retardation Associate 12676894
Neoplasm Metastasis Associate 27780921, 30875843, 34233564
Neoplasms Associate 30628666, 30875843
Personality Disorders Associate 19245716, 33746592
Prostatic Neoplasms Associate 19245716, 22144497
Silver Russell Syndrome Associate 12676894
Tertiary Lymphoid Structures Associate 27780921