Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
51200
Gene name Gene Name - the full gene name approved by the HGNC.
Carboxypeptidase A4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CPA4
Synonyms (NCBI Gene) Gene synonyms aliases
CPA3
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7q32.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT027514 hsa-miR-98-5p Microarray 19088304
MIRT029046 hsa-miR-26b-5p Microarray 19088304
MIRT625299 hsa-miR-8485 HITS-CLIP 23313552
MIRT625298 hsa-miR-6715a-3p HITS-CLIP 23313552
MIRT625299 hsa-miR-8485 HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004181 Function Metallocarboxypeptidase activity IBA 21873635
GO:0004181 Function Metallocarboxypeptidase activity NAS 10383164
GO:0005575 Component Cellular_component ND
GO:0005615 Component Extracellular space IBA 21873635
GO:0006508 Process Proteolysis IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
607635 15740 ENSG00000128510
Protein
UniProt ID Q9UI42
Protein name Carboxypeptidase A4 (EC 3.4.17.-) (Carboxypeptidase A3)
Protein function Metalloprotease that cleaves hydrophobic C-terminal residues with a preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val (PubMed:20385563). May function in peptide hormone and/or neuropeptide catabolism (PubMed:20385563). {ECO:0000269|PubMed:203
PDB 2BO9 , 2BOA , 2PCU , 4A94 , 4BD9
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02244 Propep_M14 27 101 Carboxypeptidase activation peptide Domain
PF00246 Peptidase_M14 129 408 Zinc carboxypeptidase Domain
Tissue specificity TISSUE SPECIFICITY: Fetal expression in the adrenal gland, brain, heart, intestine, kidney, liver and lung. Except for fetal brain that shows no imprinting, expression was found preferentially from the maternal allele.
Sequence
Sequence length 421
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Rheumatoid arthritis Rheumatoid Arthritis rs587776843 30891314
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 30628666, 30875843, 33746592
Carcinoma Non Small Cell Lung Associate 33934493, 34233564
Colorectal Neoplasms Associate 27780921
Fetal Growth Retardation Associate 12676894
Neoplasm Metastasis Associate 27780921, 30875843, 34233564
Neoplasms Associate 30628666, 30875843
Personality Disorders Associate 19245716, 33746592
Prostatic Neoplasms Associate 19245716, 22144497
Silver Russell Syndrome Associate 12676894
Tertiary Lymphoid Structures Associate 27780921