Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	51193
Gene name	Zinc finger protein 639
Gene symbol	ZNF639
Synonyms (NCBI Gene)	ANC-2H01ANC_2H01ZASC1
Chromosome	3
Chromosome location	3q26.33
Summary	This gene encodes a member of the Kruppel-like zinc finger family of proteins. Amplification and overexpression of this gene have been observed in esophageal squamous cell carcinoma. The encoded protein has been shown to bind DNA in a sequence-specific ma

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Show/Hide all (192)

miRTarBase ID	miRNA	Experiments	Reference
MIRT647499	hsa-miR-548aa	HITS-CLIP	23824327
MIRT647498	hsa-miR-548ap-3p	HITS-CLIP	23824327
MIRT647497	hsa-miR-548t-3p	HITS-CLIP	23824327
MIRT647496	hsa-miR-4762-5p	HITS-CLIP	23824327
MIRT647495	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT647494	hsa-miR-4659a-5p	HITS-CLIP	23824327
MIRT647493	hsa-miR-4659b-5p	HITS-CLIP	23824327
MIRT647492	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT463083	hsa-miR-6771-3p	HITS-CLIP	23824327
MIRT463082	hsa-miR-302f	HITS-CLIP	23824327
MIRT463079	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT463078	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT463077	hsa-miR-940	HITS-CLIP	23824327
MIRT647491	hsa-miR-3929	HITS-CLIP	23824327
MIRT647490	hsa-miR-4419b	HITS-CLIP	23824327
MIRT647489	hsa-miR-4478	HITS-CLIP	23824327
MIRT463075	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT647488	hsa-miR-6746-5p	HITS-CLIP	23824327
MIRT463073	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT463072	hsa-miR-302a-5p	HITS-CLIP	23824327
MIRT463071	hsa-miR-219b-3p	HITS-CLIP	23824327
MIRT463070	hsa-miR-1827	HITS-CLIP	23824327
MIRT647487	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT647486	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT463066	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT647485	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT463065	hsa-miR-4804-3p	HITS-CLIP	23824327
MIRT463064	hsa-miR-4720-3p	HITS-CLIP	23824327
MIRT647484	hsa-miR-6771-5p	HITS-CLIP	23824327
MIRT647483	hsa-miR-665	HITS-CLIP	23824327
MIRT544836	hsa-miR-548av-3p	PAR-CLIP	21572407
MIRT544835	hsa-miR-548g-3p	PAR-CLIP	21572407
MIRT544834	hsa-miR-590-3p	PAR-CLIP	21572407
MIRT544833	hsa-miR-7849-3p	PAR-CLIP	21572407
MIRT544832	hsa-miR-200a-5p	PAR-CLIP	21572407
MIRT544831	hsa-miR-200b-5p	PAR-CLIP	21572407
MIRT544830	hsa-miR-600	PAR-CLIP	21572407
MIRT463083	hsa-miR-6771-3p	PAR-CLIP	23592263
MIRT463082	hsa-miR-302f	PAR-CLIP	23592263
MIRT463081	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT463080	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT463079	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT463078	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT463077	hsa-miR-940	PAR-CLIP	23592263
MIRT463076	hsa-miR-4257	PAR-CLIP	23592263
MIRT463075	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT463074	hsa-miR-1247-3p	PAR-CLIP	23592263
MIRT463073	hsa-miR-4649-3p	PAR-CLIP	23592263
MIRT463072	hsa-miR-302a-5p	PAR-CLIP	23592263
MIRT463071	hsa-miR-219b-3p	PAR-CLIP	23592263
MIRT463070	hsa-miR-1827	PAR-CLIP	23592263
MIRT463069	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT463068	hsa-miR-6086	PAR-CLIP	23592263
MIRT463067	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT463066	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT463065	hsa-miR-4804-3p	PAR-CLIP	23592263
MIRT463064	hsa-miR-4720-3p	PAR-CLIP	23592263
MIRT463063	hsa-miR-3612	PAR-CLIP	23592263
MIRT463062	hsa-miR-650	PAR-CLIP	23592263
MIRT463061	hsa-miR-7156-3p	PAR-CLIP	23592263
MIRT463060	hsa-miR-1301-3p	PAR-CLIP	23592263
MIRT463059	hsa-miR-5047	PAR-CLIP	23592263
MIRT647499	hsa-miR-548aa	HITS-CLIP	23824327
MIRT647498	hsa-miR-548ap-3p	HITS-CLIP	23824327
MIRT647497	hsa-miR-548t-3p	HITS-CLIP	23824327
MIRT647496	hsa-miR-4762-5p	HITS-CLIP	23824327
MIRT647495	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT647494	hsa-miR-4659a-5p	HITS-CLIP	23824327
MIRT647493	hsa-miR-4659b-5p	HITS-CLIP	23824327
MIRT647492	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT463083	hsa-miR-6771-3p	HITS-CLIP	23824327
MIRT463082	hsa-miR-302f	HITS-CLIP	23824327
MIRT463079	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT463078	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT463077	hsa-miR-940	HITS-CLIP	23824327
MIRT647491	hsa-miR-3929	HITS-CLIP	23824327
MIRT647490	hsa-miR-4419b	HITS-CLIP	23824327
MIRT647489	hsa-miR-4478	HITS-CLIP	23824327
MIRT463075	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT647488	hsa-miR-6746-5p	HITS-CLIP	23824327
MIRT463073	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT463072	hsa-miR-302a-5p	HITS-CLIP	23824327
MIRT463071	hsa-miR-219b-3p	HITS-CLIP	23824327
MIRT463070	hsa-miR-1827	HITS-CLIP	23824327
MIRT647487	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT647486	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT463066	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT647485	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT463065	hsa-miR-4804-3p	HITS-CLIP	23824327
MIRT463064	hsa-miR-4720-3p	HITS-CLIP	23824327
MIRT647484	hsa-miR-6771-5p	HITS-CLIP	23824327
MIRT647483	hsa-miR-665	HITS-CLIP	23824327
MIRT544836	hsa-miR-548av-3p	PAR-CLIP	21572407
MIRT544835	hsa-miR-548g-3p	PAR-CLIP	21572407
MIRT544834	hsa-miR-590-3p	PAR-CLIP	21572407
MIRT544833	hsa-miR-7849-3p	PAR-CLIP	21572407
MIRT544832	hsa-miR-200a-5p	PAR-CLIP	21572407
MIRT544831	hsa-miR-200b-5p	PAR-CLIP	21572407
MIRT544830	hsa-miR-600	PAR-CLIP	21572407
MIRT463083	hsa-miR-6771-3p	PAR-CLIP	23592263
MIRT463082	hsa-miR-302f	PAR-CLIP	23592263
MIRT463081	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT463080	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT463079	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT463078	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT463077	hsa-miR-940	PAR-CLIP	23592263
MIRT463076	hsa-miR-4257	PAR-CLIP	23592263
MIRT463075	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT463074	hsa-miR-1247-3p	PAR-CLIP	23592263
MIRT463073	hsa-miR-4649-3p	PAR-CLIP	23592263
MIRT463072	hsa-miR-302a-5p	PAR-CLIP	23592263
MIRT463071	hsa-miR-219b-3p	PAR-CLIP	23592263
MIRT463070	hsa-miR-1827	PAR-CLIP	23592263
MIRT463069	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT463068	hsa-miR-6086	PAR-CLIP	23592263
MIRT463067	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT463066	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT463065	hsa-miR-4804-3p	PAR-CLIP	23592263
MIRT463064	hsa-miR-4720-3p	PAR-CLIP	23592263
MIRT463063	hsa-miR-3612	PAR-CLIP	23592263
MIRT463062	hsa-miR-650	PAR-CLIP	23592263
MIRT463061	hsa-miR-7156-3p	PAR-CLIP	23592263
MIRT463060	hsa-miR-1301-3p	PAR-CLIP	23592263
MIRT463059	hsa-miR-5047	PAR-CLIP	23592263
MIRT1533173	hsa-miR-1285	CLIP-seq
MIRT1533174	hsa-miR-193a-3p	CLIP-seq
MIRT1533175	hsa-miR-193b	CLIP-seq
MIRT1533176	hsa-miR-29a	CLIP-seq
MIRT1533177	hsa-miR-29b	CLIP-seq
MIRT1533178	hsa-miR-29c	CLIP-seq
MIRT1533179	hsa-miR-3176	CLIP-seq
MIRT1533180	hsa-miR-3187-5p	CLIP-seq
MIRT1533181	hsa-miR-3616-5p	CLIP-seq
MIRT1533182	hsa-miR-3647-5p	CLIP-seq
MIRT1533183	hsa-miR-3689a-3p	CLIP-seq
MIRT1533184	hsa-miR-3689c	CLIP-seq
MIRT1533185	hsa-miR-3690	CLIP-seq
MIRT1533186	hsa-miR-3922-3p	CLIP-seq
MIRT1533187	hsa-miR-4254	CLIP-seq
MIRT1533188	hsa-miR-431	CLIP-seq
MIRT1533189	hsa-miR-4463	CLIP-seq
MIRT1533190	hsa-miR-4638-3p	CLIP-seq
MIRT1533191	hsa-miR-4661-5p	CLIP-seq
MIRT1533192	hsa-miR-4695-3p	CLIP-seq
MIRT1533193	hsa-miR-4728-5p	CLIP-seq
MIRT1533194	hsa-miR-4793-3p	CLIP-seq
MIRT1533195	hsa-miR-4793-5p	CLIP-seq
MIRT1533196	hsa-miR-4795-5p	CLIP-seq
MIRT1533197	hsa-miR-526b	CLIP-seq
MIRT1533198	hsa-miR-573	CLIP-seq
MIRT1533199	hsa-miR-612	CLIP-seq
MIRT1533200	hsa-miR-661	CLIP-seq
MIRT2161337	hsa-miR-3064-3p	CLIP-seq
MIRT2161338	hsa-miR-3202	CLIP-seq
MIRT1533183	hsa-miR-3689a-3p	CLIP-seq
MIRT1533184	hsa-miR-3689c	CLIP-seq
MIRT1533185	hsa-miR-3690	CLIP-seq
MIRT1533187	hsa-miR-4254	CLIP-seq
MIRT2161339	hsa-miR-4533	CLIP-seq
MIRT2161340	hsa-miR-4540	CLIP-seq
MIRT1533190	hsa-miR-4638-3p	CLIP-seq
MIRT1533193	hsa-miR-4728-5p	CLIP-seq
MIRT1533194	hsa-miR-4793-3p	CLIP-seq
MIRT1533195	hsa-miR-4793-5p	CLIP-seq
MIRT2380232	hsa-miR-1183	CLIP-seq
MIRT2380233	hsa-miR-1273e	CLIP-seq
MIRT2380234	hsa-miR-140-5p	CLIP-seq
MIRT1533174	hsa-miR-193a-3p	CLIP-seq
MIRT1533175	hsa-miR-193b	CLIP-seq
MIRT2380235	hsa-miR-3137	CLIP-seq
MIRT1533179	hsa-miR-3176	CLIP-seq
MIRT2380236	hsa-miR-3672	CLIP-seq
MIRT1533183	hsa-miR-3689a-3p	CLIP-seq
MIRT1533184	hsa-miR-3689c	CLIP-seq
MIRT2380237	hsa-miR-382	CLIP-seq
MIRT1533186	hsa-miR-3922-3p	CLIP-seq
MIRT2380238	hsa-miR-4433	CLIP-seq
MIRT1533189	hsa-miR-4463	CLIP-seq
MIRT2161339	hsa-miR-4533	CLIP-seq
MIRT2380239	hsa-miR-4645-3p	CLIP-seq
MIRT2380240	hsa-miR-4704-3p	CLIP-seq
MIRT1533193	hsa-miR-4728-5p	CLIP-seq
MIRT1533194	hsa-miR-4793-3p	CLIP-seq
MIRT2380241	hsa-miR-548a-3p	CLIP-seq
MIRT2380242	hsa-miR-548e	CLIP-seq
MIRT2380243	hsa-miR-548f	CLIP-seq
MIRT2380244	hsa-miR-548g	CLIP-seq
MIRT2380245	hsa-miR-627	CLIP-seq
MIRT2161337	hsa-miR-3064-3p	CLIP-seq
MIRT2161340	hsa-miR-4540	CLIP-seq
MIRT2161337	hsa-miR-3064-3p	CLIP-seq
MIRT2161340	hsa-miR-4540	CLIP-seq

Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000976	Function	Transcription cis-regulatory region binding	IDA	20484494
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	20484494
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	20484494
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IBA
GO:0003700	Function	DNA-binding transcription factor activity	IDA	16182284
GO:0005515	Function	Protein binding	IPI	16182284, 25416956, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IDA	14522885, 16182284
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0030307	Process	Positive regulation of cell growth	IMP	14522885
GO:0043922	Process	Host-mediated suppression of viral transcription	IMP	20484494
GO:0043923	Process	Host-mediated activation of viral transcription	IMP	20484494
GO:0045892	Process	Negative regulation of DNA-templated transcription	IBA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IDA	16182284
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	20484494
GO:0046718	Process	Symbiont entry into host cell	IDA	20484494
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
619214	30950	ENSG00000121864

Q9UID6

Protein name

Zinc finger protein 639 (Zinc finger protein ANC_2H01) (Zinc finger protein ZASC1)

Protein function

Binds DNA and may function as a transcriptional repressor.

Family and domains

Sequence

MNEYPKKRKRKTLHPSRYSDSSGISRIADGFNGIFSDHCYSVCSMRQPDLKYFDNKDDDS
DTETSNDLPKFADGIKARNRNQNYLVPSPVLRILDHTAFSTEKSADIVICDEECDSPESV
NQQTQEESPIEVHTAEDVPIAVEVHAISEDYDIETENNSSESLQDQTDEEPPAKLCKILD
KSQALNVTAQQKWPLLRANSSGLYKCELCEFNSKYFSDLKQHMILKHKRTDSNVCRVCKE
SFSTNMLLIEHAKLHEEDPYICKYCDYKTVIFENLSQHIADTHFSDHLYWCEQCDVQFSS
SSELYLHFQEHSCDEQYLCQFCEHETNDPEDLHSHVVNEHACKLIELSDKYNNGEHGQYS
LLSKITFDKCKNFFVCQVCGFRSRLHTNVNRHVAIEHTKIFPHVCDDCGKGFSSMLEYCK
HLNSHLSEGIYLCQYCEYSTGQIEDLKIHLDFKHSADLPHKCSDCLMRFGNERELISHLP
VHETT

Sequence length

485

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

ZNF639 (zinc finger protein 639)