PCOLCE (procollagen C-endopeptidase enhancer)

Gene
Gene Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5118
Gene name Gene Name - the full gene name approved by the HGNC.
Procollagen C-endopeptidase enhancer
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PCOLCE
Synonyms (NCBI Gene) Gene synonyms aliases
PCPE, PCPE-1, PCPE1
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7q22.1
Summary Summary of gene provided in NCBI Entrez Gene.
Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino- and carboxyl-terminal peptide extensions known as N- and C-propeptides, respectively, which are cleaved, upon secretion of procoll
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Pathways
Show/Hide all(11)
GO ID Ontology Definition Evidence Reference
GO:0005201 Function Extracellular matrix structural constituent RCA 20551380
GO:0005515 Function Protein binding IPI 20207734, 20979576, 24117177, 25286301, 28106549
GO:0005518 Function Collagen binding IDA 12393877
GO:0005576 Component Extracellular region HDA 27068509
GO:0005615 Component Extracellular space HDA 20551380
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Pathways
MIM HGNC e!Ensembl
600270 8738 ENSG00000106333
Protein
Gene Gene ontology Other IDs Protein Pathways
UniProt ID Q15113
Protein name Procollagen C-endopeptidase enhancer 1 (Procollagen COOH-terminal proteinase enhancer 1) (PCPE-1) (Procollagen C-proteinase enhancer 1) (Type 1 procollagen C-proteinase enhancer protein) (Type I procollagen COOH-terminal proteinase enhancer)
Protein function Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity.; C-terminal processed part of PCPE (CT-PCPE) may have an metalloproteinase inhibitory activity.
PDB 1UAP , 6FZV , 6FZW , 9EN2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00431 CUB 37 → 146 CUB domain Domain
PF00431 CUB 159 → 270 CUB domain Domain
PF01759 NTR 330 → 434 UNC-6/NTR/C345C module Domain
Sequence
Sequence length 449
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Protein Pathways
  Reactome
    Collagen biosynthesis and modifying enzymes
Crosslinking of collagen fibrils